LeishMANIAdb
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Carbonic anhydrase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Carbonic anhydrase-like protein
Gene product:
carbonic anhydrase-like protein
Species:
Leishmania mexicana
UniProt:
E9AZK8_LEIMU
TriTrypDb:
LmxM.28.0480
Length:
614

Annotations

LeishMANIAdb annotations

Carbonic anhydrase protein (luminal). Based on its distant eukaryotic relatives, it probably has a signal peptide on its N-terminus and a membrane anchor at the C-terminus

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 6, no: 0
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

E9AZK8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZK8

Function

Biological processes
Term Name Level Count
GO:0006730 one-carbon metabolic process 3 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0044237 cellular metabolic process 2 1
GO:0044281 small molecule metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0004089 carbonate dehydratase activity 5 7
GO:0005488 binding 1 7
GO:0008270 zinc ion binding 6 7
GO:0016829 lyase activity 2 7
GO:0016835 carbon-oxygen lyase activity 3 7
GO:0016836 hydro-lyase activity 4 7
GO:0043167 ion binding 2 7
GO:0043169 cation binding 3 7
GO:0046872 metal ion binding 4 7
GO:0046914 transition metal ion binding 5 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 283 287 PF00656 0.312
CLV_NRD_NRD_1 578 580 PF00675 0.487
CLV_NRD_NRD_1 72 74 PF00675 0.488
CLV_PCSK_KEX2_1 186 188 PF00082 0.429
CLV_PCSK_KEX2_1 2 4 PF00082 0.555
CLV_PCSK_KEX2_1 221 223 PF00082 0.457
CLV_PCSK_KEX2_1 499 501 PF00082 0.783
CLV_PCSK_KEX2_1 578 580 PF00082 0.487
CLV_PCSK_KEX2_1 72 74 PF00082 0.488
CLV_PCSK_PC1ET2_1 186 188 PF00082 0.429
CLV_PCSK_PC1ET2_1 2 4 PF00082 0.555
CLV_PCSK_PC1ET2_1 221 223 PF00082 0.488
CLV_PCSK_PC1ET2_1 499 501 PF00082 0.783
CLV_PCSK_SKI1_1 101 105 PF00082 0.465
CLV_PCSK_SKI1_1 187 191 PF00082 0.467
CLV_PCSK_SKI1_1 308 312 PF00082 0.447
CLV_PCSK_SKI1_1 316 320 PF00082 0.713
CLV_PCSK_SKI1_1 529 533 PF00082 0.619
DEG_APCC_DBOX_1 554 562 PF00400 0.329
DEG_Nend_UBRbox_1 1 4 PF02207 0.474
DEG_SPOP_SBC_1 394 398 PF00917 0.510
DEG_SPOP_SBC_1 478 482 PF00917 0.527
DEG_SPOP_SBC_1 483 487 PF00917 0.582
DOC_CYCLIN_yCln2_LP_2 272 278 PF00134 0.288
DOC_CYCLIN_yCln2_LP_2 415 421 PF00134 0.426
DOC_MAPK_gen_1 184 194 PF00069 0.405
DOC_MAPK_gen_1 575 583 PF00069 0.671
DOC_MAPK_gen_1 72 79 PF00069 0.288
DOC_MAPK_HePTP_8 182 194 PF00069 0.247
DOC_MAPK_MEF2A_6 165 173 PF00069 0.242
DOC_MAPK_MEF2A_6 185 194 PF00069 0.235
DOC_MAPK_MEF2A_6 555 563 PF00069 0.270
DOC_MAPK_MEF2A_6 62 69 PF00069 0.297
DOC_PP1_RVXF_1 1 7 PF00149 0.437
DOC_PP1_RVXF_1 306 312 PF00149 0.247
DOC_PP1_RVXF_1 93 99 PF00149 0.271
DOC_PP2B_LxvP_1 415 418 PF13499 0.423
DOC_PP4_FxxP_1 124 127 PF00568 0.199
DOC_PP4_FxxP_1 46 49 PF00568 0.434
DOC_USP7_MATH_1 242 246 PF00917 0.264
DOC_USP7_MATH_1 336 340 PF00917 0.447
DOC_USP7_MATH_1 341 345 PF00917 0.459
DOC_USP7_MATH_1 434 438 PF00917 0.582
DOC_USP7_MATH_1 446 450 PF00917 0.579
DOC_USP7_MATH_1 458 462 PF00917 0.452
DOC_USP7_MATH_1 49 53 PF00917 0.476
DOC_USP7_MATH_1 530 534 PF00917 0.478
DOC_USP7_MATH_1 541 545 PF00917 0.481
DOC_USP7_MATH_2 588 594 PF00917 0.571
DOC_USP7_MATH_2 84 90 PF00917 0.199
DOC_USP7_UBL2_3 499 503 PF12436 0.442
DOC_USP7_UBL2_3 62 66 PF12436 0.199
DOC_WW_Pin1_4 266 271 PF00397 0.304
DOC_WW_Pin1_4 353 358 PF00397 0.465
DOC_WW_Pin1_4 373 378 PF00397 0.488
DOC_WW_Pin1_4 388 393 PF00397 0.534
DOC_WW_Pin1_4 395 400 PF00397 0.630
DOC_WW_Pin1_4 436 441 PF00397 0.434
DOC_WW_Pin1_4 45 50 PF00397 0.438
DOC_WW_Pin1_4 468 473 PF00397 0.527
DOC_WW_Pin1_4 474 479 PF00397 0.496
DOC_WW_Pin1_4 72 77 PF00397 0.286
LIG_14-3-3_CanoR_1 222 230 PF00244 0.268
LIG_14-3-3_CanoR_1 3 7 PF00244 0.402
LIG_14-3-3_CanoR_1 384 394 PF00244 0.608
LIG_14-3-3_CanoR_1 401 410 PF00244 0.439
LIG_14-3-3_CanoR_1 529 535 PF00244 0.449
LIG_14-3-3_CanoR_1 53 57 PF00244 0.403
LIG_14-3-3_CanoR_1 602 611 PF00244 0.621
LIG_14-3-3_CanoR_1 95 105 PF00244 0.248
LIG_eIF4E_1 39 45 PF01652 0.437
LIG_FHA_1 177 183 PF00498 0.291
LIG_FHA_1 225 231 PF00498 0.301
LIG_FHA_1 257 263 PF00498 0.373
LIG_FHA_1 266 272 PF00498 0.216
LIG_FHA_1 39 45 PF00498 0.393
LIG_FHA_1 437 443 PF00498 0.475
LIG_FHA_1 606 612 PF00498 0.697
LIG_FHA_2 469 475 PF00498 0.526
LIG_FHA_2 489 495 PF00498 0.489
LIG_FHA_2 52 58 PF00498 0.415
LIG_Integrin_isoDGR_2 306 308 PF01839 0.457
LIG_LIR_Apic_2 121 127 PF02991 0.199
LIG_LIR_Gen_1 528 539 PF02991 0.390
LIG_LIR_Gen_1 55 65 PF02991 0.355
LIG_LIR_Gen_1 78 87 PF02991 0.268
LIG_LIR_Nem_3 148 154 PF02991 0.332
LIG_LIR_Nem_3 244 249 PF02991 0.296
LIG_LIR_Nem_3 528 534 PF02991 0.395
LIG_LIR_Nem_3 55 61 PF02991 0.359
LIG_LIR_Nem_3 63 67 PF02991 0.277
LIG_LIR_Nem_3 78 82 PF02991 0.281
LIG_NBox_RRM_1 6 16 PF00076 0.444
LIG_PCNA_yPIPBox_3 184 195 PF02747 0.283
LIG_PCNA_yPIPBox_3 233 243 PF02747 0.199
LIG_Pex14_2 329 333 PF04695 0.438
LIG_SH2_CRK 58 62 PF00017 0.389
LIG_SH2_GRB2like 58 61 PF00017 0.340
LIG_SH2_NCK_1 548 552 PF00017 0.426
LIG_SH2_STAT5 246 249 PF00017 0.268
LIG_SH2_STAT5 422 425 PF00017 0.518
LIG_SH2_STAT5 58 61 PF00017 0.334
LIG_SH2_STAT5 582 585 PF00017 0.670
LIG_SH3_3 136 142 PF00018 0.312
LIG_SH3_3 407 413 PF00018 0.441
LIG_SH3_3 418 424 PF00018 0.473
LIG_SUMO_SIM_anti_2 231 238 PF11976 0.337
LIG_SUMO_SIM_anti_2 367 374 PF11976 0.414
LIG_SUMO_SIM_par_1 14 20 PF11976 0.376
LIG_SUMO_SIM_par_1 268 274 PF11976 0.288
LIG_SUMO_SIM_par_1 367 374 PF11976 0.500
LIG_SxIP_EBH_1 233 243 PF03271 0.288
LIG_TRAF2_1 105 108 PF00917 0.288
MOD_CDC14_SPxK_1 356 359 PF00782 0.518
MOD_CDC14_SPxK_1 398 401 PF00782 0.594
MOD_CDK_SPxK_1 353 359 PF00069 0.513
MOD_CDK_SPxK_1 395 401 PF00069 0.593
MOD_CK1_1 120 126 PF00069 0.338
MOD_CK1_1 176 182 PF00069 0.302
MOD_CK1_1 204 210 PF00069 0.289
MOD_CK1_1 235 241 PF00069 0.309
MOD_CK1_1 373 379 PF00069 0.651
MOD_CK1_1 449 455 PF00069 0.563
MOD_CK1_1 468 474 PF00069 0.749
MOD_CK1_1 48 54 PF00069 0.547
MOD_CK1_1 484 490 PF00069 0.632
MOD_CK1_1 509 515 PF00069 0.800
MOD_CK1_1 522 528 PF00069 0.425
MOD_CK1_1 593 599 PF00069 0.497
MOD_CK1_1 605 611 PF00069 0.474
MOD_CK1_1 75 81 PF00069 0.327
MOD_CK2_1 30 36 PF00069 0.604
MOD_CK2_1 444 450 PF00069 0.740
MOD_Cter_Amidation 70 73 PF01082 0.329
MOD_GlcNHglycan 25 28 PF01048 0.565
MOD_GlcNHglycan 314 319 PF01048 0.505
MOD_GlcNHglycan 380 383 PF01048 0.724
MOD_GlcNHglycan 41 44 PF01048 0.557
MOD_GlcNHglycan 428 432 PF01048 0.569
MOD_GlcNHglycan 442 445 PF01048 0.620
MOD_GlcNHglycan 446 449 PF01048 0.600
MOD_GlcNHglycan 450 454 PF01048 0.580
MOD_GlcNHglycan 466 470 PF01048 0.695
MOD_GlcNHglycan 494 498 PF01048 0.790
MOD_GlcNHglycan 595 598 PF01048 0.585
MOD_GlcNHglycan 98 101 PF01048 0.233
MOD_GSK3_1 145 152 PF00069 0.341
MOD_GSK3_1 197 204 PF00069 0.312
MOD_GSK3_1 224 231 PF00069 0.286
MOD_GSK3_1 376 383 PF00069 0.649
MOD_GSK3_1 436 443 PF00069 0.618
MOD_GSK3_1 444 451 PF00069 0.580
MOD_GSK3_1 45 52 PF00069 0.543
MOD_GSK3_1 464 471 PF00069 0.584
MOD_GSK3_1 473 480 PF00069 0.735
MOD_GSK3_1 481 488 PF00069 0.664
MOD_GSK3_1 489 496 PF00069 0.708
MOD_GSK3_1 525 532 PF00069 0.619
MOD_GSK3_1 603 610 PF00069 0.618
MOD_N-GLC_1 143 148 PF02516 0.302
MOD_N-GLC_1 202 207 PF02516 0.302
MOD_N-GLC_1 232 237 PF02516 0.205
MOD_N-GLC_1 322 327 PF02516 0.537
MOD_N-GLC_1 341 346 PF02516 0.559
MOD_N-GLC_1 402 407 PF02516 0.539
MOD_N-GLC_1 434 439 PF02516 0.592
MOD_NEK2_1 143 148 PF00069 0.302
MOD_NEK2_1 17 22 PF00069 0.592
MOD_NEK2_1 173 178 PF00069 0.302
MOD_NEK2_1 196 201 PF00069 0.307
MOD_NEK2_1 465 470 PF00069 0.571
MOD_NEK2_1 542 547 PF00069 0.496
MOD_NEK2_1 561 566 PF00069 0.203
MOD_NEK2_1 568 573 PF00069 0.349
MOD_NEK2_1 67 72 PF00069 0.352
MOD_NEK2_1 96 101 PF00069 0.274
MOD_NEK2_2 224 229 PF00069 0.302
MOD_NEK2_2 530 535 PF00069 0.475
MOD_PIKK_1 106 112 PF00454 0.286
MOD_PK_1 535 541 PF00069 0.493
MOD_PKA_1 2 8 PF00069 0.399
MOD_PKA_2 2 8 PF00069 0.400
MOD_PKA_2 242 248 PF00069 0.320
MOD_PKA_2 52 58 PF00069 0.488
MOD_Plk_1 106 112 PF00069 0.329
MOD_Plk_1 143 149 PF00069 0.271
MOD_Plk_1 232 238 PF00069 0.204
MOD_Plk_1 314 320 PF00069 0.469
MOD_Plk_1 336 342 PF00069 0.575
MOD_Plk_2-3 30 36 PF00069 0.570
MOD_Plk_4 232 238 PF00069 0.333
MOD_Plk_4 242 248 PF00069 0.355
MOD_Plk_4 30 36 PF00069 0.570
MOD_Plk_4 365 371 PF00069 0.510
MOD_Plk_4 522 528 PF00069 0.539
MOD_Plk_4 561 567 PF00069 0.231
MOD_ProDKin_1 266 272 PF00069 0.352
MOD_ProDKin_1 353 359 PF00069 0.581
MOD_ProDKin_1 373 379 PF00069 0.611
MOD_ProDKin_1 388 394 PF00069 0.669
MOD_ProDKin_1 395 401 PF00069 0.811
MOD_ProDKin_1 436 442 PF00069 0.534
MOD_ProDKin_1 45 51 PF00069 0.539
MOD_ProDKin_1 468 474 PF00069 0.666
MOD_ProDKin_1 72 78 PF00069 0.328
MOD_SUMO_rev_2 506 512 PF00179 0.528
TRG_DiLeu_BaEn_1 232 237 PF01217 0.262
TRG_DiLeu_BaLyEn_6 305 310 PF01217 0.329
TRG_ENDOCYTIC_2 58 61 PF00928 0.402
TRG_ER_diArg_1 577 579 PF00400 0.609
TRG_NLS_MonoCore_2 498 503 PF00514 0.546
TRG_NLS_MonoExtC_3 498 503 PF00514 0.594
TRG_NLS_MonoExtN_4 184 189 PF00514 0.259
TRG_Pf-PMV_PEXEL_1 112 116 PF00026 0.273
TRG_Pf-PMV_PEXEL_1 165 170 PF00026 0.302

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBI8 Leptomonas seymouri 46% 97%
A0A3Q8IDR5 Leishmania donovani 80% 98%
A4HG87 Leishmania braziliensis 57% 100%
A4I3A0 Leishmania infantum 79% 98%
Q4Q8M3 Leishmania major 77% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS