WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZK7_LEIMU

TriTrypDb:

LmxM.28.0470

Length:

796

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZK7

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006356	regulation of transcription by RNA polymerase I	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045943	positive regulation of transcription by RNA polymerase I	8	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1
GO:2000232	regulation of rRNA processing	6	1
GO:2000234	positive regulation of rRNA processing	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	739	743	PF00656	0.613
CLV_NRD_NRD_1	105	107	PF00675	0.645
CLV_NRD_NRD_1	249	251	PF00675	0.433
CLV_NRD_NRD_1	28	30	PF00675	0.553
CLV_NRD_NRD_1	479	481	PF00675	0.411
CLV_NRD_NRD_1	572	574	PF00675	0.400
CLV_NRD_NRD_1	654	656	PF00675	0.516
CLV_NRD_NRD_1	793	795	PF00675	0.617
CLV_PCSK_FUR_1	477	481	PF00082	0.404
CLV_PCSK_KEX2_1	105	107	PF00082	0.676
CLV_PCSK_KEX2_1	249	251	PF00082	0.433
CLV_PCSK_KEX2_1	453	455	PF00082	0.291
CLV_PCSK_KEX2_1	476	478	PF00082	0.461
CLV_PCSK_KEX2_1	479	481	PF00082	0.386
CLV_PCSK_KEX2_1	572	574	PF00082	0.400
CLV_PCSK_KEX2_1	588	590	PF00082	0.405
CLV_PCSK_KEX2_1	654	656	PF00082	0.516
CLV_PCSK_KEX2_1	793	795	PF00082	0.525
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.298
CLV_PCSK_PC1ET2_1	476	478	PF00082	0.495
CLV_PCSK_PC1ET2_1	588	590	PF00082	0.377
CLV_PCSK_SKI1_1	29	33	PF00082	0.286
CLV_PCSK_SKI1_1	306	310	PF00082	0.489
CLV_PCSK_SKI1_1	346	350	PF00082	0.265
CLV_PCSK_SKI1_1	479	483	PF00082	0.337
CLV_PCSK_SKI1_1	53	57	PF00082	0.452
CLV_PCSK_SKI1_1	589	593	PF00082	0.367
CLV_PCSK_SKI1_1	735	739	PF00082	0.564
CLV_Separin_Metazoa	651	655	PF03568	0.404
DEG_APCC_DBOX_1	554	562	PF00400	0.394
DEG_APCC_DBOX_1	660	668	PF00400	0.504
DEG_Nend_UBRbox_3	1	3	PF02207	0.575
DEG_SCF_FBW7_1	318	323	PF00400	0.353
DEG_SPOP_SBC_1	46	50	PF00917	0.380
DOC_CKS1_1	503	508	PF01111	0.532
DOC_CKS1_1	516	521	PF01111	0.349
DOC_MAPK_gen_1	249	257	PF00069	0.407
DOC_MAPK_gen_1	306	312	PF00069	0.477
DOC_MAPK_MEF2A_6	249	257	PF00069	0.466
DOC_MAPK_MEF2A_6	371	378	PF00069	0.466
DOC_MAPK_MEF2A_6	466	474	PF00069	0.446
DOC_PP1_RVXF_1	587	594	PF00149	0.319
DOC_PP2B_LxvP_1	689	692	PF13499	0.512
DOC_PP4_FxxP_1	22	25	PF00568	0.342
DOC_USP7_MATH_1	152	156	PF00917	0.588
DOC_USP7_MATH_1	320	324	PF00917	0.415
DOC_USP7_MATH_1	464	468	PF00917	0.414
DOC_USP7_MATH_1	517	521	PF00917	0.421
DOC_USP7_MATH_1	530	534	PF00917	0.363
DOC_USP7_MATH_1	6	10	PF00917	0.464
DOC_USP7_MATH_1	640	644	PF00917	0.643
DOC_USP7_MATH_1	657	661	PF00917	0.485
DOC_USP7_MATH_1	699	703	PF00917	0.691
DOC_USP7_MATH_1	707	711	PF00917	0.487
DOC_USP7_MATH_1	90	94	PF00917	0.656
DOC_USP7_MATH_1	96	100	PF00917	0.672
DOC_USP7_MATH_2	552	558	PF00917	0.288
DOC_USP7_UBL2_3	26	30	PF12436	0.391
DOC_WW_Pin1_4	154	159	PF00397	0.723
DOC_WW_Pin1_4	235	240	PF00397	0.432
DOC_WW_Pin1_4	269	274	PF00397	0.379
DOC_WW_Pin1_4	316	321	PF00397	0.447
DOC_WW_Pin1_4	370	375	PF00397	0.529
DOC_WW_Pin1_4	407	412	PF00397	0.558
DOC_WW_Pin1_4	460	465	PF00397	0.368
DOC_WW_Pin1_4	502	507	PF00397	0.641
DOC_WW_Pin1_4	515	520	PF00397	0.345
DOC_WW_Pin1_4	574	579	PF00397	0.480
DOC_WW_Pin1_4	86	91	PF00397	0.644
LIG_14-3-3_CanoR_1	209	215	PF00244	0.496
LIG_14-3-3_CanoR_1	346	356	PF00244	0.522
LIG_14-3-3_CanoR_1	426	432	PF00244	0.341
LIG_14-3-3_CanoR_1	479	485	PF00244	0.331
LIG_14-3-3_CanoR_1	555	559	PF00244	0.298
LIG_Actin_WH2_2	649	667	PF00022	0.515
LIG_APCC_ABBA_1	253	258	PF00400	0.430
LIG_BRCT_BRCA1_1	532	536	PF00533	0.329
LIG_Clathr_ClatBox_1	254	258	PF01394	0.459
LIG_CtBP_PxDLS_1	239	243	PF00389	0.249
LIG_FHA_1	120	126	PF00498	0.578
LIG_FHA_1	186	192	PF00498	0.343
LIG_FHA_1	205	211	PF00498	0.505
LIG_FHA_1	332	338	PF00498	0.378
LIG_FHA_1	361	367	PF00498	0.431
LIG_FHA_1	456	462	PF00498	0.458
LIG_FHA_1	523	529	PF00498	0.395
LIG_FHA_1	566	572	PF00498	0.458
LIG_FHA_1	620	626	PF00498	0.378
LIG_FHA_1	629	635	PF00498	0.357
LIG_FHA_1	78	84	PF00498	0.538
LIG_FHA_2	170	176	PF00498	0.422
LIG_FHA_2	347	353	PF00498	0.452
LIG_FHA_2	496	502	PF00498	0.579
LIG_FHA_2	596	602	PF00498	0.449
LIG_FHA_2	62	68	PF00498	0.400
LIG_LIR_Apic_2	447	451	PF02991	0.406
LIG_LIR_Apic_2	501	506	PF02991	0.531
LIG_LIR_Apic_2	775	781	PF02991	0.471
LIG_LIR_Gen_1	200	210	PF02991	0.477
LIG_LIR_Gen_1	430	439	PF02991	0.391
LIG_LIR_Gen_1	554	563	PF02991	0.337
LIG_LIR_LC3C_4	188	192	PF02991	0.440
LIG_LIR_LC3C_4	363	367	PF02991	0.324
LIG_LIR_Nem_3	200	206	PF02991	0.374
LIG_LIR_Nem_3	430	434	PF02991	0.335
LIG_LIR_Nem_3	554	559	PF02991	0.434
LIG_LIR_Nem_3	684	689	PF02991	0.377
LIG_LIR_Nem_3	732	737	PF02991	0.503
LIG_MYND_1	221	225	PF01753	0.491
LIG_PCNA_yPIPBox_3	135	145	PF02747	0.416
LIG_Pex14_2	202	206	PF04695	0.398
LIG_Pex14_2	265	269	PF04695	0.360
LIG_REV1ctd_RIR_1	731	739	PF16727	0.666
LIG_SH2_CRK	448	452	PF00017	0.419
LIG_SH2_CRK	503	507	PF00017	0.584
LIG_SH2_CRK	778	782	PF00017	0.453
LIG_SH2_NCK_1	778	782	PF00017	0.432
LIG_SH2_PTP2	256	259	PF00017	0.349
LIG_SH2_SRC	256	259	PF00017	0.356
LIG_SH2_STAP1	149	153	PF00017	0.367
LIG_SH2_STAP1	397	401	PF00017	0.373
LIG_SH2_STAT3	391	394	PF00017	0.521
LIG_SH2_STAT3	545	548	PF00017	0.488
LIG_SH2_STAT5	181	184	PF00017	0.512
LIG_SH2_STAT5	256	259	PF00017	0.478
LIG_SH2_STAT5	287	290	PF00017	0.371
LIG_SH2_STAT5	391	394	PF00017	0.521
LIG_SH2_STAT5	45	48	PF00017	0.433
LIG_SH2_STAT5	565	568	PF00017	0.532
LIG_SH2_STAT5	778	781	PF00017	0.455
LIG_SH2_STAT5	790	793	PF00017	0.491
LIG_SH3_1	84	90	PF00018	0.419
LIG_SH3_3	190	196	PF00018	0.414
LIG_SH3_3	212	218	PF00018	0.558
LIG_SH3_3	219	225	PF00018	0.498
LIG_SH3_3	256	262	PF00018	0.494
LIG_SH3_3	384	390	PF00018	0.341
LIG_SH3_3	406	412	PF00018	0.504
LIG_SH3_3	435	441	PF00018	0.468
LIG_SH3_3	458	464	PF00018	0.497
LIG_SH3_3	572	578	PF00018	0.497
LIG_SH3_3	695	701	PF00018	0.557
LIG_SH3_3	84	90	PF00018	0.460
LIG_SUMO_SIM_anti_2	188	194	PF11976	0.350
LIG_SUMO_SIM_anti_2	292	299	PF11976	0.363
LIG_SUMO_SIM_par_1	292	299	PF11976	0.347
LIG_SUMO_SIM_par_1	334	341	PF11976	0.443
LIG_SUMO_SIM_par_1	467	473	PF11976	0.329
LIG_TYR_ITIM	254	259	PF00017	0.313
LIG_UBA3_1	138	145	PF00899	0.392
LIG_WRC_WIRS_1	170	175	PF05994	0.446
LIG_WRC_WIRS_1	431	436	PF05994	0.500
LIG_WRC_WIRS_1	730	735	PF05994	0.665
LIG_WW_3	410	414	PF00397	0.480
MOD_CDC14_SPxK_1	410	413	PF00782	0.547
MOD_CDC14_SPxK_1	463	466	PF00782	0.419
MOD_CDK_SPxK_1	407	413	PF00069	0.561
MOD_CDK_SPxK_1	460	466	PF00069	0.422
MOD_CDK_SPxxK_3	574	581	PF00069	0.442
MOD_CK1_1	163	169	PF00069	0.524
MOD_CK1_1	204	210	PF00069	0.490
MOD_CK1_1	238	244	PF00069	0.484
MOD_CK1_1	331	337	PF00069	0.388
MOD_CK1_1	395	401	PF00069	0.484
MOD_CK1_1	427	433	PF00069	0.448
MOD_CK1_1	529	535	PF00069	0.281
MOD_CK1_1	611	617	PF00069	0.363
MOD_CK2_1	169	175	PF00069	0.417
MOD_CK2_1	346	352	PF00069	0.487
MOD_CK2_1	400	406	PF00069	0.443
MOD_CK2_1	595	601	PF00069	0.548
MOD_CK2_1	604	610	PF00069	0.390
MOD_CK2_1	61	67	PF00069	0.439
MOD_CK2_1	629	635	PF00069	0.392
MOD_CK2_1	699	705	PF00069	0.689
MOD_CK2_1	92	98	PF00069	0.699
MOD_Cter_Amidation	247	250	PF01082	0.415
MOD_Cter_Amidation	477	480	PF01082	0.420
MOD_Cter_Amidation	586	589	PF01082	0.358
MOD_GlcNHglycan	154	157	PF01048	0.616
MOD_GlcNHglycan	162	165	PF01048	0.532
MOD_GlcNHglycan	210	213	PF01048	0.523
MOD_GlcNHglycan	282	286	PF01048	0.373
MOD_GlcNHglycan	322	325	PF01048	0.416
MOD_GlcNHglycan	466	469	PF01048	0.512
MOD_GlcNHglycan	49	52	PF01048	0.475
MOD_GlcNHglycan	528	531	PF01048	0.384
MOD_GlcNHglycan	616	619	PF01048	0.349
MOD_GlcNHglycan	713	716	PF01048	0.724
MOD_GlcNHglycan	94	97	PF01048	0.687
MOD_GSK3_1	107	114	PF00069	0.710
MOD_GSK3_1	159	166	PF00069	0.544
MOD_GSK3_1	204	211	PF00069	0.497
MOD_GSK3_1	231	238	PF00069	0.453
MOD_GSK3_1	281	288	PF00069	0.473
MOD_GSK3_1	316	323	PF00069	0.448
MOD_GSK3_1	328	335	PF00069	0.300
MOD_GSK3_1	395	402	PF00069	0.409
MOD_GSK3_1	430	437	PF00069	0.498
MOD_GSK3_1	460	467	PF00069	0.392
MOD_GSK3_1	495	502	PF00069	0.529
MOD_GSK3_1	511	518	PF00069	0.348
MOD_GSK3_1	522	529	PF00069	0.355
MOD_GSK3_1	604	611	PF00069	0.468
MOD_GSK3_1	707	714	PF00069	0.767
MOD_GSK3_1	73	80	PF00069	0.470
MOD_GSK3_1	736	743	PF00069	0.668
MOD_GSK3_1	755	762	PF00069	0.635
MOD_GSK3_1	781	788	PF00069	0.472
MOD_GSK3_1	86	93	PF00069	0.551
MOD_N-GLC_1	36	41	PF02516	0.434
MOD_N-GLC_1	422	427	PF02516	0.376
MOD_N-GLC_1	511	516	PF02516	0.418
MOD_N-GLC_1	657	662	PF02516	0.480
MOD_NEK2_1	159	164	PF00069	0.426
MOD_NEK2_1	201	206	PF00069	0.396
MOD_NEK2_1	240	245	PF00069	0.329
MOD_NEK2_1	281	286	PF00069	0.533
MOD_NEK2_1	328	333	PF00069	0.470
MOD_NEK2_1	36	41	PF00069	0.533
MOD_NEK2_1	399	404	PF00069	0.436
MOD_NEK2_1	422	427	PF00069	0.438
MOD_NEK2_1	434	439	PF00069	0.385
MOD_NEK2_1	592	597	PF00069	0.486
MOD_NEK2_1	619	624	PF00069	0.473
MOD_NEK2_1	628	633	PF00069	0.468
MOD_NEK2_1	77	82	PF00069	0.447
MOD_NEK2_2	61	66	PF00069	0.534
MOD_PIKK_1	389	395	PF00454	0.375
MOD_PIKK_1	400	406	PF00454	0.443
MOD_PIKK_1	455	461	PF00454	0.414
MOD_PIKK_1	517	523	PF00454	0.528
MOD_PIKK_1	565	571	PF00454	0.425
MOD_PIKK_1	6	12	PF00454	0.406
MOD_PIKK_1	740	746	PF00454	0.624
MOD_PK_1	79	85	PF00069	0.473
MOD_PKA_2	208	214	PF00069	0.500
MOD_PKA_2	216	222	PF00069	0.588
MOD_PKA_2	290	296	PF00069	0.430
MOD_PKA_2	554	560	PF00069	0.370
MOD_Plk_1	15	21	PF00069	0.408
MOD_Plk_1	511	517	PF00069	0.514
MOD_Plk_1	530	536	PF00069	0.221
MOD_Plk_1	608	614	PF00069	0.326
MOD_Plk_1	61	67	PF00069	0.408
MOD_Plk_1	620	626	PF00069	0.463
MOD_Plk_1	628	634	PF00069	0.464
MOD_Plk_1	657	663	PF00069	0.476
MOD_Plk_1	735	741	PF00069	0.657
MOD_Plk_2-3	629	635	PF00069	0.447
MOD_Plk_2-3	736	742	PF00069	0.668
MOD_Plk_4	121	127	PF00069	0.501
MOD_Plk_4	201	207	PF00069	0.374
MOD_Plk_4	290	296	PF00069	0.467
MOD_Plk_4	392	398	PF00069	0.459
MOD_Plk_4	434	440	PF00069	0.460
MOD_Plk_4	457	463	PF00069	0.471
MOD_Plk_4	601	607	PF00069	0.423
MOD_Plk_4	61	67	PF00069	0.431
MOD_Plk_4	620	626	PF00069	0.342
MOD_Plk_4	629	635	PF00069	0.349
MOD_Plk_4	699	705	PF00069	0.622
MOD_Plk_4	729	735	PF00069	0.664
MOD_Plk_4	781	787	PF00069	0.455
MOD_ProDKin_1	154	160	PF00069	0.726
MOD_ProDKin_1	235	241	PF00069	0.437
MOD_ProDKin_1	269	275	PF00069	0.379
MOD_ProDKin_1	316	322	PF00069	0.452
MOD_ProDKin_1	370	376	PF00069	0.522
MOD_ProDKin_1	407	413	PF00069	0.560
MOD_ProDKin_1	460	466	PF00069	0.378
MOD_ProDKin_1	502	508	PF00069	0.630
MOD_ProDKin_1	515	521	PF00069	0.349
MOD_ProDKin_1	574	580	PF00069	0.481
MOD_ProDKin_1	86	92	PF00069	0.656
TRG_AP2beta_CARGO_1	200	209	PF09066	0.415
TRG_DiLeu_BaEn_1	292	297	PF01217	0.337
TRG_DiLeu_BaEn_1	554	559	PF01217	0.280
TRG_DiLeu_BaEn_1	629	634	PF01217	0.364
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.458
TRG_DiLeu_BaLyEn_6	438	443	PF01217	0.392
TRG_ENDOCYTIC_2	181	184	PF00928	0.395
TRG_ENDOCYTIC_2	203	206	PF00928	0.402
TRG_ENDOCYTIC_2	256	259	PF00928	0.324
TRG_ENDOCYTIC_2	431	434	PF00928	0.374
TRG_ER_diArg_1	477	480	PF00400	0.448
TRG_ER_diArg_1	571	573	PF00400	0.396
TRG_ER_diArg_1	653	655	PF00400	0.514
TRG_ER_diArg_1	793	795	PF00400	0.532
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.276

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4K6	Leptomonas seymouri	68%	97%
A0A0S4J855	Bodo saltans	34%	100%
A0A1X0NYJ9	Trypanosomatidae	42%	100%
A0A3Q8IGL7	Leishmania donovani	93%	100%
A0A422P1N8	Trypanosoma rangeli	42%	100%
A4HG86	Leishmania braziliensis	82%	100%
A4I3A1	Leishmania infantum	92%	100%
D0A824	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	95%
Q4Q8M4	Leishmania major	92%	100%