TFIIS N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZK6_LEIMU

TriTrypDb:

LmxM.28.0460

Length:

310

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZK6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	277	281	PF00656	0.641
CLV_C14_Caspase3-7	303	307	PF00656	0.737
CLV_C14_Caspase3-7	44	48	PF00656	0.630
CLV_NRD_NRD_1	54	56	PF00675	0.707
CLV_PCSK_FUR_1	52	56	PF00082	0.750
CLV_PCSK_KEX2_1	29	31	PF00082	0.633
CLV_PCSK_KEX2_1	51	53	PF00082	0.752
CLV_PCSK_KEX2_1	54	56	PF00082	0.749
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.647
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.752
CLV_PCSK_SKI1_1	22	26	PF00082	0.656
DEG_Nend_UBRbox_2	1	3	PF02207	0.667
DEG_SPOP_SBC_1	301	305	PF00917	0.722
DOC_CKS1_1	140	145	PF01111	0.701
DOC_CKS1_1	242	247	PF01111	0.705
DOC_MAPK_gen_1	181	189	PF00069	0.658
DOC_USP7_MATH_1	259	263	PF00917	0.687
DOC_USP7_MATH_1	268	272	PF00917	0.758
DOC_USP7_MATH_1	301	305	PF00917	0.722
DOC_USP7_MATH_1	41	45	PF00917	0.755
DOC_USP7_MATH_1	46	50	PF00917	0.717
DOC_USP7_MATH_1	53	57	PF00917	0.545
DOC_USP7_UBL2_3	284	288	PF12436	0.687
DOC_WW_Pin1_4	139	144	PF00397	0.715
DOC_WW_Pin1_4	157	162	PF00397	0.425
DOC_WW_Pin1_4	241	246	PF00397	0.694
LIG_BIR_III_4	47	51	PF00653	0.519
LIG_BRCT_BRCA1_1	286	290	PF00533	0.651
LIG_CSL_BTD_1	140	143	PF09270	0.713
LIG_EH1_1	146	154	PF00400	0.497
LIG_FHA_1	184	190	PF00498	0.714
LIG_FHA_1	208	214	PF00498	0.661
LIG_FHA_1	258	264	PF00498	0.680
LIG_FHA_2	169	175	PF00498	0.680
LIG_FHA_2	190	196	PF00498	0.696
LIG_FHA_2	241	247	PF00498	0.721
LIG_PCNA_yPIPBox_3	11	25	PF02747	0.496
LIG_SH2_SRC	147	150	PF00017	0.656
LIG_SH2_STAT3	107	110	PF00017	0.636
LIG_SH2_STAT5	107	110	PF00017	0.542
LIG_SH3_2	242	247	PF14604	0.701
LIG_SH3_3	123	129	PF00018	0.671
LIG_SH3_3	239	245	PF00018	0.708
LIG_SH3_4	284	291	PF00018	0.676
LIG_SUMO_SIM_par_1	210	217	PF11976	0.595
LIG_TRAF2_1	66	69	PF00917	0.723
MOD_CDK_SPxK_1	241	247	PF00069	0.721
MOD_CK1_1	156	162	PF00069	0.660
MOD_CK1_1	166	172	PF00069	0.649
MOD_CK1_1	20	26	PF00069	0.656
MOD_CK1_1	266	272	PF00069	0.762
MOD_CK1_1	39	45	PF00069	0.598
MOD_CK2_1	168	174	PF00069	0.634
MOD_CK2_1	302	308	PF00069	0.748
MOD_Cter_Amidation	49	52	PF01082	0.740
MOD_GlcNHglycan	129	132	PF01048	0.620
MOD_GlcNHglycan	236	239	PF01048	0.660
MOD_GlcNHglycan	25	28	PF01048	0.694
MOD_GlcNHglycan	270	273	PF01048	0.737
MOD_GlcNHglycan	276	279	PF01048	0.745
MOD_GlcNHglycan	296	299	PF01048	0.406
MOD_GlcNHglycan	43	46	PF01048	0.487
MOD_GlcNHglycan	47	51	PF01048	0.669
MOD_GlcNHglycan	55	58	PF01048	0.517
MOD_GlcNHglycan	78	81	PF01048	0.691
MOD_GSK3_1	153	160	PF00069	0.593
MOD_GSK3_1	16	23	PF00069	0.715
MOD_GSK3_1	259	266	PF00069	0.695
MOD_GSK3_1	268	275	PF00069	0.620
MOD_GSK3_1	284	291	PF00069	0.702
MOD_GSK3_1	35	42	PF00069	0.695
MOD_N-GLC_1	17	22	PF02516	0.691
MOD_N-GLC_1	76	81	PF02516	0.751
MOD_NEK2_1	168	173	PF00069	0.644
MOD_NEK2_1	183	188	PF00069	0.599
MOD_NEK2_1	7	12	PF00069	0.620
MOD_PIKK_1	231	237	PF00454	0.686
MOD_PKA_2	183	189	PF00069	0.655
MOD_PKA_2	272	278	PF00069	0.805
MOD_PKA_2	53	59	PF00069	0.739
MOD_PKA_2	7	13	PF00069	0.704
MOD_Plk_1	16	22	PF00069	0.629
MOD_Plk_4	163	169	PF00069	0.670
MOD_Plk_4	248	254	PF00069	0.622
MOD_ProDKin_1	139	145	PF00069	0.710
MOD_ProDKin_1	157	163	PF00069	0.424
MOD_ProDKin_1	241	247	PF00069	0.695
TRG_ER_diArg_1	52	55	PF00400	0.753
TRG_NLS_MonoCore_2	50	55	PF00514	0.744
TRG_NLS_MonoExtC_3	50	55	PF00514	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV17	Leptomonas seymouri	63%	98%
A0A1X0NYL0	Trypanosomatidae	32%	100%
A0A3Q8IDN4	Leishmania donovani	92%	100%
A4HG85	Leishmania braziliensis	80%	100%
A4I3A2	Leishmania infantum	91%	100%
D0A825	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4Q8M5	Leishmania major	91%	100%