Putative ribonuclease II-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DIS3-like exonuclease, putative

Species:

Leishmania mexicana

UniProt:

E9AZK5_LEIMU

TriTrypDb:

LmxM.28.0450

Length:

941

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000178	exosome (RNase complex)	4	1
GO:0000932	P-body	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1905354	exoribonuclease complex	3	1

Expansion

Sequence features

E9AZK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZK5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0004540	RNA nuclease activity	4	11
GO:0005488	binding	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0000175	3'-5'-RNA exonuclease activity	7	1
GO:0004527	exonuclease activity	5	3
GO:0004532	RNA exonuclease activity	5	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.589
CLV_C14_Caspase3-7	308	312	PF00656	0.470
CLV_C14_Caspase3-7	491	495	PF00656	0.516
CLV_C14_Caspase3-7	99	103	PF00656	0.563
CLV_NRD_NRD_1	306	308	PF00675	0.232
CLV_NRD_NRD_1	334	336	PF00675	0.321
CLV_NRD_NRD_1	365	367	PF00675	0.340
CLV_NRD_NRD_1	558	560	PF00675	0.285
CLV_NRD_NRD_1	569	571	PF00675	0.253
CLV_NRD_NRD_1	650	652	PF00675	0.232
CLV_NRD_NRD_1	852	854	PF00675	0.710
CLV_NRD_NRD_1	927	929	PF00675	0.513
CLV_PCSK_KEX2_1	156	158	PF00082	0.515
CLV_PCSK_KEX2_1	167	169	PF00082	0.431
CLV_PCSK_KEX2_1	18	20	PF00082	0.551
CLV_PCSK_KEX2_1	306	308	PF00082	0.235
CLV_PCSK_KEX2_1	365	367	PF00082	0.323
CLV_PCSK_KEX2_1	558	560	PF00082	0.292
CLV_PCSK_KEX2_1	569	571	PF00082	0.271
CLV_PCSK_KEX2_1	650	652	PF00082	0.232
CLV_PCSK_KEX2_1	753	755	PF00082	0.411
CLV_PCSK_KEX2_1	852	854	PF00082	0.685
CLV_PCSK_KEX2_1	927	929	PF00082	0.551
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.515
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.431
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.430
CLV_PCSK_PC1ET2_1	753	755	PF00082	0.411
CLV_PCSK_PC7_1	923	929	PF00082	0.465
CLV_PCSK_SKI1_1	164	168	PF00082	0.510
CLV_PCSK_SKI1_1	291	295	PF00082	0.529
CLV_PCSK_SKI1_1	356	360	PF00082	0.316
CLV_PCSK_SKI1_1	397	401	PF00082	0.232
CLV_PCSK_SKI1_1	503	507	PF00082	0.296
CLV_PCSK_SKI1_1	572	576	PF00082	0.281
CLV_PCSK_SKI1_1	662	666	PF00082	0.240
CLV_PCSK_SKI1_1	709	713	PF00082	0.514
CLV_PCSK_SKI1_1	753	757	PF00082	0.443
CLV_PCSK_SKI1_1	863	867	PF00082	0.538
DEG_APCC_DBOX_1	862	870	PF00400	0.431
DEG_Nend_UBRbox_2	1	3	PF02207	0.366
DOC_ANK_TNKS_1	852	859	PF00023	0.716
DOC_CKS1_1	240	245	PF01111	0.472
DOC_CKS1_1	679	684	PF01111	0.444
DOC_CYCLIN_yCln2_LP_2	59	65	PF00134	0.474
DOC_MAPK_DCC_7	167	175	PF00069	0.415
DOC_MAPK_gen_1	167	175	PF00069	0.401
DOC_MAPK_gen_1	18	27	PF00069	0.411
DOC_MAPK_gen_1	44	54	PF00069	0.535
DOC_MAPK_gen_1	650	657	PF00069	0.446
DOC_MAPK_gen_1	659	667	PF00069	0.446
DOC_MAPK_gen_1	800	808	PF00069	0.515
DOC_MAPK_gen_1	907	917	PF00069	0.485
DOC_MAPK_MEF2A_6	167	175	PF00069	0.423
DOC_MAPK_MEF2A_6	659	667	PF00069	0.487
DOC_MAPK_MEF2A_6	907	915	PF00069	0.454
DOC_PP1_RVXF_1	501	507	PF00149	0.455
DOC_PP1_RVXF_1	544	551	PF00149	0.462
DOC_PP2B_LxvP_1	121	124	PF13499	0.660
DOC_PP4_FxxP_1	293	296	PF00568	0.374
DOC_PP4_FxxP_1	352	355	PF00568	0.487
DOC_PP4_FxxP_1	645	648	PF00568	0.432
DOC_USP7_MATH_1	107	111	PF00917	0.626
DOC_USP7_MATH_1	136	140	PF00917	0.490
DOC_USP7_MATH_1	264	268	PF00917	0.474
DOC_USP7_MATH_1	347	351	PF00917	0.439
DOC_USP7_MATH_1	63	67	PF00917	0.527
DOC_USP7_MATH_1	9	13	PF00917	0.566
DOC_USP7_MATH_1	90	94	PF00917	0.654
DOC_USP7_UBL2_3	482	486	PF12436	0.431
DOC_USP7_UBL2_3	843	847	PF12436	0.665
DOC_WW_Pin1_4	101	106	PF00397	0.508
DOC_WW_Pin1_4	239	244	PF00397	0.471
DOC_WW_Pin1_4	512	517	PF00397	0.560
DOC_WW_Pin1_4	644	649	PF00397	0.455
DOC_WW_Pin1_4	678	683	PF00397	0.441
LIG_14-3-3_CanoR_1	365	373	PF00244	0.435
LIG_14-3-3_CanoR_1	383	391	PF00244	0.426
LIG_14-3-3_CanoR_1	488	493	PF00244	0.476
LIG_14-3-3_CanoR_1	572	581	PF00244	0.448
LIG_14-3-3_CanoR_1	910	914	PF00244	0.522
LIG_Actin_WH2_2	297	312	PF00022	0.499
LIG_Actin_WH2_2	480	495	PF00022	0.513
LIG_APCC_ABBA_1	892	897	PF00400	0.474
LIG_BRCT_BRCA1_1	400	404	PF00533	0.436
LIG_Clathr_ClatBox_1	403	407	PF01394	0.487
LIG_EH1_1	605	613	PF00400	0.521
LIG_EVH1_2	516	520	PF00568	0.521
LIG_FHA_1	125	131	PF00498	0.543
LIG_FHA_1	22	28	PF00498	0.526
LIG_FHA_1	240	246	PF00498	0.509
LIG_FHA_1	260	266	PF00498	0.305
LIG_FHA_1	368	374	PF00498	0.497
LIG_FHA_1	448	454	PF00498	0.503
LIG_FHA_1	644	650	PF00498	0.432
LIG_FHA_1	696	702	PF00498	0.537
LIG_FHA_1	706	712	PF00498	0.422
LIG_FHA_1	766	772	PF00498	0.451
LIG_FHA_1	807	813	PF00498	0.677
LIG_FHA_1	894	900	PF00498	0.379
LIG_FHA_1	933	939	PF00498	0.573
LIG_FHA_2	109	115	PF00498	0.624
LIG_FHA_2	124	130	PF00498	0.455
LIG_FHA_2	320	326	PF00498	0.432
LIG_FHA_2	355	361	PF00498	0.521
LIG_FHA_2	605	611	PF00498	0.521
LIG_FHA_2	625	631	PF00498	0.539
LIG_FHA_2	819	825	PF00498	0.737
LIG_FHA_2	882	888	PF00498	0.498
LIG_FHA_2	95	101	PF00498	0.682
LIG_GBD_Chelix_1	663	671	PF00786	0.370
LIG_Integrin_RGD_1	602	604	PF01839	0.214
LIG_LIR_Apic_2	148	153	PF02991	0.540
LIG_LIR_Apic_2	292	296	PF02991	0.387
LIG_LIR_Apic_2	350	355	PF02991	0.436
LIG_LIR_Apic_2	643	648	PF02991	0.432
LIG_LIR_Gen_1	385	393	PF02991	0.432
LIG_LIR_Gen_1	533	543	PF02991	0.432
LIG_LIR_Gen_1	604	612	PF02991	0.466
LIG_LIR_Gen_1	889	900	PF02991	0.451
LIG_LIR_Nem_3	191	197	PF02991	0.382
LIG_LIR_Nem_3	385	391	PF02991	0.440
LIG_LIR_Nem_3	533	538	PF02991	0.432
LIG_LIR_Nem_3	604	608	PF02991	0.474
LIG_LIR_Nem_3	776	782	PF02991	0.381
LIG_LIR_Nem_3	889	895	PF02991	0.483
LIG_LYPXL_S_1	203	207	PF13949	0.447
LIG_LYPXL_SIV_4	437	445	PF13949	0.487
LIG_LYPXL_yS_3	204	207	PF13949	0.440
LIG_NRBOX	897	903	PF00104	0.206
LIG_PCNA_yPIPBox_3	529	542	PF02747	0.462
LIG_Pex14_1	641	645	PF04695	0.446
LIG_Pex14_2	400	404	PF04695	0.432
LIG_Pex14_3	531	536	PF04695	0.446
LIG_PTB_Apo_2	275	282	PF02174	0.485
LIG_SH2_CRK	388	392	PF00017	0.454
LIG_SH2_CRK	553	557	PF00017	0.470
LIG_SH2_CRK	766	770	PF00017	0.517
LIG_SH2_NCK_1	438	442	PF00017	0.432
LIG_SH2_NCK_1	766	770	PF00017	0.467
LIG_SH2_STAP1	614	618	PF00017	0.521
LIG_SH2_STAP1	742	746	PF00017	0.420
LIG_SH2_STAP1	782	786	PF00017	0.366
LIG_SH2_STAT5	371	374	PF00017	0.510
LIG_SH2_STAT5	388	391	PF00017	0.323
LIG_SH2_STAT5	621	624	PF00017	0.441
LIG_SH2_STAT5	642	645	PF00017	0.432
LIG_SH2_STAT5	652	655	PF00017	0.432
LIG_SH2_STAT5	747	750	PF00017	0.324
LIG_SH2_STAT5	766	769	PF00017	0.471
LIG_SH3_1	375	381	PF00018	0.476
LIG_SH3_1	559	565	PF00018	0.521
LIG_SH3_1	756	762	PF00018	0.508
LIG_SH3_1	928	934	PF00018	0.476
LIG_SH3_2	378	383	PF14604	0.459
LIG_SH3_2	562	567	PF14604	0.521
LIG_SH3_3	240	246	PF00018	0.544
LIG_SH3_3	375	381	PF00018	0.459
LIG_SH3_3	510	516	PF00018	0.499
LIG_SH3_3	559	565	PF00018	0.500
LIG_SH3_3	634	640	PF00018	0.529
LIG_SH3_3	676	682	PF00018	0.587
LIG_SH3_3	756	762	PF00018	0.483
LIG_SH3_3	928	934	PF00018	0.572
LIG_SUMO_SIM_anti_2	767	773	PF11976	0.443
LIG_SUMO_SIM_anti_2	896	903	PF11976	0.446
LIG_SUMO_SIM_par_1	311	319	PF11976	0.516
LIG_SUMO_SIM_par_1	448	454	PF11976	0.523
LIG_SUMO_SIM_par_1	896	903	PF11976	0.370
LIG_TRAF2_1	126	129	PF00917	0.556
LIG_TRAF2_1	586	589	PF00917	0.492
LIG_TRAF2_1	884	887	PF00917	0.530
LIG_TYR_ITIM	551	556	PF00017	0.329
LIG_UBA3_1	480	486	PF00899	0.277
LIG_UBA3_1	593	599	PF00899	0.379
LIG_UBA3_1	748	756	PF00899	0.479
LIG_WRC_WIRS_1	253	258	PF05994	0.483
LIG_WRPW_2	197	200	PF00400	0.452
MOD_CDC14_SPxK_1	647	650	PF00782	0.275
MOD_CDK_SPK_2	239	244	PF00069	0.471
MOD_CDK_SPxK_1	644	650	PF00069	0.275
MOD_CDK_SPxxK_3	644	651	PF00069	0.275
MOD_CK1_1	225	231	PF00069	0.501
MOD_CK1_1	367	373	PF00069	0.432
MOD_CK1_1	382	388	PF00069	0.299
MOD_CK1_1	515	521	PF00069	0.359
MOD_CK1_1	92	98	PF00069	0.712
MOD_CK2_1	123	129	PF00069	0.576
MOD_CK2_1	145	151	PF00069	0.577
MOD_CK2_1	294	300	PF00069	0.497
MOD_CK2_1	583	589	PF00069	0.360
MOD_CK2_1	604	610	PF00069	0.380
MOD_CK2_1	713	719	PF00069	0.350
MOD_CK2_1	785	791	PF00069	0.474
MOD_CK2_1	881	887	PF00069	0.452
MOD_CK2_1	933	939	PF00069	0.550
MOD_CK2_1	94	100	PF00069	0.726
MOD_Cter_Amidation	304	307	PF01082	0.389
MOD_GlcNHglycan	134	137	PF01048	0.515
MOD_GlcNHglycan	296	299	PF01048	0.393
MOD_GlcNHglycan	400	403	PF01048	0.332
MOD_GlcNHglycan	55	58	PF01048	0.510
MOD_GlcNHglycan	585	588	PF01048	0.401
MOD_GlcNHglycan	715	718	PF01048	0.496
MOD_GlcNHglycan	733	736	PF01048	0.478
MOD_GlcNHglycan	782	785	PF01048	0.487
MOD_GlcNHglycan	815	818	PF01048	0.721
MOD_GlcNHglycan	86	89	PF01048	0.688
MOD_GSK3_1	132	139	PF00069	0.590
MOD_GSK3_1	270	277	PF00069	0.498
MOD_GSK3_1	38	45	PF00069	0.515
MOD_GSK3_1	411	418	PF00069	0.401
MOD_GSK3_1	425	432	PF00069	0.419
MOD_GSK3_1	512	519	PF00069	0.465
MOD_GSK3_1	579	586	PF00069	0.326
MOD_GSK3_1	640	647	PF00069	0.285
MOD_GSK3_1	736	743	PF00069	0.497
MOD_GSK3_1	818	825	PF00069	0.736
MOD_GSK3_1	89	96	PF00069	0.692
MOD_N-GLC_1	132	137	PF02516	0.564
MOD_N-GLC_1	222	227	PF02516	0.435
MOD_N-GLC_1	274	279	PF02516	0.432
MOD_N-GLC_1	367	372	PF02516	0.401
MOD_N-GLC_1	38	43	PF02516	0.468
MOD_N-GLC_1	794	799	PF02516	0.564
MOD_N-GLC_1	93	98	PF02516	0.678
MOD_N-GLC_2	726	728	PF02516	0.504
MOD_NEK2_1	398	403	PF00069	0.275
MOD_NEK2_1	42	47	PF00069	0.463
MOD_NEK2_1	425	430	PF00069	0.275
MOD_NEK2_1	612	617	PF00069	0.336
MOD_NEK2_1	740	745	PF00069	0.464
MOD_NEK2_1	765	770	PF00069	0.520
MOD_NEK2_1	794	799	PF00069	0.490
MOD_NEK2_1	902	907	PF00069	0.511
MOD_PIKK_1	74	80	PF00454	0.328
MOD_PIKK_1	822	828	PF00454	0.541
MOD_PKA_2	309	315	PF00069	0.393
MOD_PKA_2	364	370	PF00069	0.299
MOD_PKA_2	382	388	PF00069	0.260
MOD_PKA_2	43	49	PF00069	0.481
MOD_PKA_2	909	915	PF00069	0.531
MOD_PKB_1	19	27	PF00069	0.381
MOD_Plk_1	136	142	PF00069	0.482
MOD_Plk_1	222	228	PF00069	0.287
MOD_Plk_1	258	264	PF00069	0.530
MOD_Plk_1	291	297	PF00069	0.558
MOD_Plk_1	347	353	PF00069	0.275
MOD_Plk_1	367	373	PF00069	0.123
MOD_Plk_1	38	44	PF00069	0.489
MOD_Plk_1	447	453	PF00069	0.271
MOD_Plk_1	736	742	PF00069	0.349
MOD_Plk_2-3	279	285	PF00069	0.468
MOD_Plk_2-3	604	610	PF00069	0.393
MOD_Plk_2-3	785	791	PF00069	0.462
MOD_Plk_4	145	151	PF00069	0.351
MOD_Plk_4	21	27	PF00069	0.480
MOD_Plk_4	222	228	PF00069	0.401
MOD_Plk_4	252	258	PF00069	0.533
MOD_Plk_4	367	373	PF00069	0.390
MOD_Plk_4	38	44	PF00069	0.496
MOD_Plk_4	425	431	PF00069	0.275
MOD_Plk_4	447	453	PF00069	0.301
MOD_Plk_4	516	522	PF00069	0.329
MOD_Plk_4	612	618	PF00069	0.410
MOD_Plk_4	767	773	PF00069	0.410
MOD_Plk_4	775	781	PF00069	0.452
MOD_Plk_4	785	791	PF00069	0.508
MOD_Plk_4	868	874	PF00069	0.520
MOD_Plk_4	933	939	PF00069	0.547
MOD_ProDKin_1	101	107	PF00069	0.508
MOD_ProDKin_1	239	245	PF00069	0.466
MOD_ProDKin_1	512	518	PF00069	0.455
MOD_ProDKin_1	644	650	PF00069	0.308
MOD_ProDKin_1	678	684	PF00069	0.438
MOD_SUMO_rev_2	390	399	PF00179	0.353
TRG_AP2beta_CARGO_1	533	542	PF09066	0.275
TRG_DiLeu_BaEn_1	533	538	PF01217	0.299
TRG_DiLeu_BaEn_1	776	781	PF01217	0.466
TRG_DiLeu_BaEn_1	897	902	PF01217	0.427
TRG_DiLeu_BaEn_4	386	392	PF01217	0.384
TRG_DiLeu_BaEn_4	533	539	PF01217	0.320
TRG_ENDOCYTIC_2	194	197	PF00928	0.385
TRG_ENDOCYTIC_2	204	207	PF00928	0.367
TRG_ENDOCYTIC_2	388	391	PF00928	0.324
TRG_ENDOCYTIC_2	553	556	PF00928	0.329
TRG_ENDOCYTIC_2	614	617	PF00928	0.331
TRG_ENDOCYTIC_2	642	645	PF00928	0.275
TRG_ENDOCYTIC_2	652	655	PF00928	0.275
TRG_ENDOCYTIC_2	766	769	PF00928	0.521
TRG_ENDOCYTIC_2	803	806	PF00928	0.501
TRG_ER_diArg_1	430	433	PF00400	0.295
TRG_ER_diArg_1	557	559	PF00400	0.390
TRG_ER_diArg_1	568	570	PF00400	0.401
TRG_ER_diArg_1	649	651	PF00400	0.276
TRG_ER_diArg_1	851	853	PF00400	0.759
TRG_ER_diArg_1	927	929	PF00400	0.493
TRG_NES_CRM1_1	763	776	PF08389	0.408
TRG_NES_CRM1_1	893	908	PF08389	0.470
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	307	311	PF00026	0.275
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ70	Leptomonas seymouri	60%	99%
A0A0S4KIX9	Bodo saltans	36%	100%
A0A1X0NYL5	Trypanosomatidae	41%	97%
A0A3Q8IHX8	Leishmania donovani	93%	100%
A0A422P1Q3	Trypanosoma rangeli	40%	100%
A0JN80	Bos taurus	27%	89%
A2RV18	Danio rerio	28%	89%
A4HG84	Leishmania braziliensis	81%	99%
A4I3A3	Leishmania infantum	93%	100%
D0A826	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
O14040	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P0DM58	Arabidopsis thaliana	30%	89%
Q08162	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	94%
Q0P4R5	Xenopus tropicalis	27%	91%
Q0V9R3	Xenopus tropicalis	30%	100%
Q0WPN0	Arabidopsis thaliana	30%	89%
Q4Q8M6	Leishmania major	92%	100%
Q5R5N8	Pongo abelii	27%	89%
Q5U2P0	Rattus norvegicus	27%	89%
Q6GN11	Xenopus laevis	27%	90%
Q8C0S1	Mus musculus	27%	89%
Q8TF46	Homo sapiens	28%	89%