Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZK4_LEIMU

TriTrypDb:

LmxM.28.0440

Length:

774

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZK4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.605
CLV_C14_Caspase3-7	284	288	PF00656	0.578
CLV_C14_Caspase3-7	407	411	PF00656	0.482
CLV_C14_Caspase3-7	537	541	PF00656	0.451
CLV_NRD_NRD_1	177	179	PF00675	0.541
CLV_NRD_NRD_1	275	277	PF00675	0.574
CLV_NRD_NRD_1	372	374	PF00675	0.438
CLV_NRD_NRD_1	493	495	PF00675	0.614
CLV_NRD_NRD_1	630	632	PF00675	0.491
CLV_PCSK_KEX2_1	177	179	PF00082	0.608
CLV_PCSK_KEX2_1	275	277	PF00082	0.574
CLV_PCSK_KEX2_1	307	309	PF00082	0.542
CLV_PCSK_KEX2_1	371	373	PF00082	0.440
CLV_PCSK_KEX2_1	570	572	PF00082	0.560
CLV_PCSK_KEX2_1	629	631	PF00082	0.466
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.542
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.560
CLV_PCSK_SKI1_1	158	162	PF00082	0.674
CLV_PCSK_SKI1_1	163	167	PF00082	0.573
CLV_PCSK_SKI1_1	455	459	PF00082	0.557
CLV_PCSK_SKI1_1	464	468	PF00082	0.637
DOC_CDC14_PxL_1	688	696	PF14671	0.414
DOC_CKS1_1	503	508	PF01111	0.532
DOC_CKS1_1	654	659	PF01111	0.577
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.573
DOC_CYCLIN_yCln2_LP_2	503	509	PF00134	0.544
DOC_MAPK_gen_1	275	282	PF00069	0.548
DOC_MAPK_gen_1	583	592	PF00069	0.522
DOC_MAPK_gen_1	6	15	PF00069	0.640
DOC_MAPK_MEF2A_6	439	447	PF00069	0.572
DOC_MAPK_MEF2A_6	583	592	PF00069	0.477
DOC_MAPK_MEF2A_6	6	15	PF00069	0.640
DOC_MAPK_MEF2A_6	681	688	PF00069	0.551
DOC_PP1_RVXF_1	10	16	PF00149	0.647
DOC_PP2B_LxvP_1	443	446	PF13499	0.574
DOC_PP2B_LxvP_1	518	521	PF13499	0.443
DOC_PP2B_LxvP_1	605	608	PF13499	0.489
DOC_PP2B_LxvP_1	694	697	PF13499	0.460
DOC_PP4_FxxP_1	212	215	PF00568	0.588
DOC_USP7_MATH_1	102	106	PF00917	0.660
DOC_USP7_MATH_1	183	187	PF00917	0.625
DOC_USP7_MATH_1	249	253	PF00917	0.751
DOC_USP7_MATH_1	29	33	PF00917	0.632
DOC_USP7_MATH_1	546	550	PF00917	0.575
DOC_USP7_MATH_1	576	580	PF00917	0.704
DOC_USP7_MATH_1	706	710	PF00917	0.616
DOC_USP7_MATH_1	738	742	PF00917	0.541
DOC_USP7_UBL2_3	8	12	PF12436	0.612
DOC_WW_Pin1_4	106	111	PF00397	0.619
DOC_WW_Pin1_4	126	131	PF00397	0.472
DOC_WW_Pin1_4	153	158	PF00397	0.585
DOC_WW_Pin1_4	234	239	PF00397	0.520
DOC_WW_Pin1_4	25	30	PF00397	0.656
DOC_WW_Pin1_4	339	344	PF00397	0.508
DOC_WW_Pin1_4	405	410	PF00397	0.621
DOC_WW_Pin1_4	502	507	PF00397	0.464
DOC_WW_Pin1_4	616	621	PF00397	0.497
DOC_WW_Pin1_4	653	658	PF00397	0.570
DOC_WW_Pin1_4	749	754	PF00397	0.520
LIG_14-3-3_CanoR_1	163	168	PF00244	0.504
LIG_14-3-3_CanoR_1	197	203	PF00244	0.504
LIG_14-3-3_CanoR_1	313	319	PF00244	0.409
LIG_14-3-3_CanoR_1	373	383	PF00244	0.506
LIG_14-3-3_CanoR_1	455	461	PF00244	0.521
LIG_14-3-3_CanoR_1	550	556	PF00244	0.361
LIG_14-3-3_CanoR_1	574	584	PF00244	0.599
LIG_14-3-3_CanoR_1	646	654	PF00244	0.542
LIG_14-3-3_CanoR_1	710	718	PF00244	0.630
LIG_14-3-3_CanoR_1	737	747	PF00244	0.516
LIG_Actin_WH2_2	298	315	PF00022	0.443
LIG_Actin_WH2_2	359	377	PF00022	0.524
LIG_BIR_III_2	154	158	PF00653	0.581
LIG_BIR_III_4	16	20	PF00653	0.575
LIG_BIR_III_4	508	512	PF00653	0.423
LIG_BRCT_BRCA1_1	104	108	PF00533	0.493
LIG_BRCT_BRCA1_1	146	150	PF00533	0.552
LIG_BRCT_BRCA1_1	195	199	PF00533	0.585
LIG_BRCT_BRCA1_1	664	668	PF00533	0.612
LIG_Clathr_ClatBox_1	602	606	PF01394	0.461
LIG_Clathr_ClatBox_1	623	627	PF01394	0.565
LIG_CSL_BTD_1	518	521	PF09270	0.443
LIG_EVH1_2	620	624	PF00568	0.518
LIG_FHA_1	333	339	PF00498	0.581
LIG_FHA_1	392	398	PF00498	0.497
LIG_FHA_1	400	406	PF00498	0.544
LIG_FHA_1	435	441	PF00498	0.629
LIG_FHA_1	457	463	PF00498	0.591
LIG_FHA_1	465	471	PF00498	0.580
LIG_FHA_1	498	504	PF00498	0.583
LIG_FHA_1	649	655	PF00498	0.672
LIG_FHA_2	139	145	PF00498	0.459
LIG_FHA_2	228	234	PF00498	0.603
LIG_FHA_2	255	261	PF00498	0.451
LIG_FHA_2	343	349	PF00498	0.520
LIG_FHA_2	503	509	PF00498	0.495
LIG_FHA_2	552	558	PF00498	0.514
LIG_FHA_2	728	734	PF00498	0.530
LIG_GBD_Chelix_1	164	172	PF00786	0.468
LIG_GBD_Chelix_1	707	715	PF00786	0.426
LIG_Integrin_RGD_1	681	683	PF01839	0.529
LIG_LIR_Apic_2	210	215	PF02991	0.603
LIG_LIR_Apic_2	223	229	PF02991	0.552
LIG_LIR_Gen_1	166	176	PF02991	0.504
LIG_LIR_Gen_1	196	207	PF02991	0.528
LIG_LIR_Gen_1	354	363	PF02991	0.420
LIG_LIR_Gen_1	687	696	PF02991	0.523
LIG_LIR_Nem_3	166	172	PF02991	0.499
LIG_LIR_Nem_3	196	202	PF02991	0.569
LIG_LIR_Nem_3	221	227	PF02991	0.700
LIG_LIR_Nem_3	354	359	PF02991	0.408
LIG_LIR_Nem_3	687	691	PF02991	0.490
LIG_NRBOX	167	173	PF00104	0.540
LIG_NRP_CendR_1	771	774	PF00754	0.562
LIG_PCNA_yPIPBox_3	346	356	PF02747	0.363
LIG_PTB_Apo_2	206	213	PF02174	0.554
LIG_SH2_CRK	169	173	PF00017	0.495
LIG_SH2_CRK	277	281	PF00017	0.618
LIG_SH2_CRK	531	535	PF00017	0.710
LIG_SH2_NCK_1	41	45	PF00017	0.616
LIG_SH2_STAP1	116	120	PF00017	0.541
LIG_SH2_STAP1	383	387	PF00017	0.479
LIG_SH2_STAP1	41	45	PF00017	0.677
LIG_SH2_STAP1	614	618	PF00017	0.391
LIG_SH2_STAT5	175	178	PF00017	0.632
LIG_SH3_1	268	274	PF00018	0.643
LIG_SH3_2	270	275	PF14604	0.672
LIG_SH3_3	23	29	PF00018	0.622
LIG_SH3_3	267	273	PF00018	0.580
LIG_SH3_3	524	530	PF00018	0.534
LIG_SH3_3	589	595	PF00018	0.545
LIG_SH3_3	651	657	PF00018	0.536
LIG_SH3_CIN85_PxpxPR_1	270	275	PF14604	0.663
LIG_SUMO_SIM_anti_2	278	284	PF11976	0.607
LIG_SUMO_SIM_par_1	393	402	PF11976	0.452
LIG_SUMO_SIM_par_1	561	566	PF11976	0.303
LIG_SUMO_SIM_par_1	601	606	PF11976	0.352
LIG_TRAF2_1	230	233	PF00917	0.565
LIG_TYR_ITIM	167	172	PF00017	0.532
LIG_WW_3	272	276	PF00397	0.567
MOD_CDK_SPK_2	153	158	PF00069	0.585
MOD_CDK_SPxK_1	653	659	PF00069	0.610
MOD_CDK_SPxxK_3	339	346	PF00069	0.504
MOD_CK1_1	153	159	PF00069	0.539
MOD_CK1_1	254	260	PF00069	0.520
MOD_CK1_1	281	287	PF00069	0.524
MOD_CK1_1	314	320	PF00069	0.352
MOD_CK1_1	342	348	PF00069	0.489
MOD_CK1_1	408	414	PF00069	0.638
MOD_CK1_1	456	462	PF00069	0.584
MOD_CK1_1	579	585	PF00069	0.593
MOD_CK1_1	647	653	PF00069	0.685
MOD_CK1_1	662	668	PF00069	0.489
MOD_CK1_1	699	705	PF00069	0.593
MOD_CK1_1	81	87	PF00069	0.510
MOD_CK1_1	97	103	PF00069	0.600
MOD_CK2_1	138	144	PF00069	0.477
MOD_CK2_1	183	189	PF00069	0.629
MOD_CK2_1	227	233	PF00069	0.562
MOD_CK2_1	401	407	PF00069	0.547
MOD_CK2_1	727	733	PF00069	0.531
MOD_GlcNHglycan	2	5	PF01048	0.637
MOD_GlcNHglycan	204	207	PF01048	0.581
MOD_GlcNHglycan	251	254	PF01048	0.532
MOD_GlcNHglycan	31	34	PF01048	0.520
MOD_GlcNHglycan	389	392	PF01048	0.495
MOD_GlcNHglycan	455	458	PF01048	0.719
MOD_GlcNHglycan	660	664	PF01048	0.580
MOD_GlcNHglycan	740	743	PF01048	0.510
MOD_GlcNHglycan	8	11	PF01048	0.610
MOD_GlcNHglycan	99	102	PF01048	0.653
MOD_GSK3_1	102	109	PF00069	0.629
MOD_GSK3_1	144	151	PF00069	0.559
MOD_GSK3_1	198	205	PF00069	0.493
MOD_GSK3_1	247	254	PF00069	0.595
MOD_GSK3_1	25	32	PF00069	0.649
MOD_GSK3_1	328	335	PF00069	0.527
MOD_GSK3_1	387	394	PF00069	0.444
MOD_GSK3_1	399	406	PF00069	0.504
MOD_GSK3_1	497	504	PF00069	0.634
MOD_GSK3_1	575	582	PF00069	0.705
MOD_GSK3_1	644	651	PF00069	0.522
MOD_GSK3_1	696	703	PF00069	0.582
MOD_GSK3_1	706	713	PF00069	0.551
MOD_GSK3_1	723	730	PF00069	0.487
MOD_GSK3_1	81	88	PF00069	0.588
MOD_N-GLC_1	210	215	PF02516	0.575
MOD_N-GLC_1	357	362	PF02516	0.432
MOD_N-GLC_1	644	649	PF02516	0.560
MOD_N-GLC_1	65	70	PF02516	0.626
MOD_N-GLC_1	723	728	PF02516	0.431
MOD_N-GLC_2	292	294	PF02516	0.443
MOD_NEK2_1	171	176	PF00069	0.433
MOD_NEK2_1	202	207	PF00069	0.523
MOD_NEK2_1	426	431	PF00069	0.443
MOD_NEK2_1	644	649	PF00069	0.572
MOD_NEK2_1	762	767	PF00069	0.362
MOD_NEK2_2	49	54	PF00069	0.614
MOD_PIKK_1	456	462	PF00454	0.576
MOD_PKA_1	6	12	PF00069	0.549
MOD_PKA_2	374	380	PF00069	0.510
MOD_PKA_2	736	742	PF00069	0.535
MOD_PKA_2	78	84	PF00069	0.569
MOD_PKB_1	373	381	PF00069	0.508
MOD_Plk_1	220	226	PF00069	0.599
MOD_Plk_1	357	363	PF00069	0.439
MOD_Plk_1	399	405	PF00069	0.560
MOD_Plk_1	426	432	PF00069	0.450
MOD_Plk_1	579	585	PF00069	0.512
MOD_Plk_1	644	650	PF00069	0.564
MOD_Plk_2-3	401	407	PF00069	0.516
MOD_Plk_4	163	169	PF00069	0.510
MOD_Plk_4	171	177	PF00069	0.507
MOD_Plk_4	198	204	PF00069	0.500
MOD_Plk_4	237	243	PF00069	0.518
MOD_Plk_4	278	284	PF00069	0.531
MOD_Plk_4	34	40	PF00069	0.625
MOD_Plk_4	351	357	PF00069	0.474
MOD_Plk_4	391	397	PF00069	0.494
MOD_Plk_4	49	55	PF00069	0.663
MOD_Plk_4	551	557	PF00069	0.553
MOD_Plk_4	598	604	PF00069	0.461
MOD_Plk_4	717	723	PF00069	0.669
MOD_ProDKin_1	106	112	PF00069	0.617
MOD_ProDKin_1	126	132	PF00069	0.473
MOD_ProDKin_1	153	159	PF00069	0.576
MOD_ProDKin_1	234	240	PF00069	0.522
MOD_ProDKin_1	25	31	PF00069	0.646
MOD_ProDKin_1	339	345	PF00069	0.506
MOD_ProDKin_1	405	411	PF00069	0.616
MOD_ProDKin_1	502	508	PF00069	0.458
MOD_ProDKin_1	616	622	PF00069	0.509
MOD_ProDKin_1	653	659	PF00069	0.576
MOD_ProDKin_1	749	755	PF00069	0.509
MOD_SUMO_rev_2	213	222	PF00179	0.605
MOD_SUMO_rev_2	342	352	PF00179	0.562
TRG_DiLeu_BaEn_1	639	644	PF01217	0.528
TRG_DiLeu_BaLyEn_6	618	623	PF01217	0.497
TRG_DiLeu_BaLyEn_6	707	712	PF01217	0.604
TRG_ENDOCYTIC_2	169	172	PF00928	0.527
TRG_ENDOCYTIC_2	277	280	PF00928	0.541
TRG_ENDOCYTIC_2	614	617	PF00928	0.393
TRG_ER_diArg_1	176	178	PF00400	0.590
TRG_ER_diArg_1	263	266	PF00400	0.655
TRG_ER_diArg_1	274	276	PF00400	0.527
TRG_ER_diArg_1	370	373	PF00400	0.437
TRG_ER_diArg_1	629	631	PF00400	0.534
TRG_NES_CRM1_1	364	379	PF08389	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI4	Leptomonas seymouri	43%	99%
A0A3S7X198	Leishmania donovani	86%	100%
A4HG83	Leishmania braziliensis	67%	99%
A4I3A4	Leishmania infantum	86%	100%
Q4Q8M7	Leishmania major	86%	100%