Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZK3_LEIMU

TriTrypDb:

LmxM.28.0430

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZK3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.455
CLV_C14_Caspase3-7	88	92	PF00656	0.563
CLV_PCSK_KEX2_1	115	117	PF00082	0.568
CLV_PCSK_KEX2_1	70	72	PF00082	0.499
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.568
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.499
CLV_PCSK_SKI1_1	122	126	PF00082	0.457
CLV_PCSK_SKI1_1	236	240	PF00082	0.637
CLV_PCSK_SKI1_1	281	285	PF00082	0.460
CLV_PCSK_SKI1_1	327	331	PF00082	0.428
CLV_PCSK_SKI1_1	372	376	PF00082	0.479
CLV_PCSK_SKI1_1	389	393	PF00082	0.350
CLV_PCSK_SKI1_1	39	43	PF00082	0.488
CLV_PCSK_SKI1_1	8	12	PF00082	0.511
DEG_SCF_FBW7_1	254	259	PF00400	0.766
DEG_SPOP_SBC_1	249	253	PF00917	0.512
DOC_CKS1_1	185	190	PF01111	0.574
DOC_MAPK_DCC_7	378	388	PF00069	0.447
DOC_MAPK_gen_1	276	285	PF00069	0.595
DOC_MAPK_gen_1	380	388	PF00069	0.569
DOC_MAPK_gen_1	412	420	PF00069	0.423
DOC_MAPK_gen_1	8	18	PF00069	0.537
DOC_MAPK_MEF2A_6	380	388	PF00069	0.451
DOC_MAPK_MEF2A_6	54	63	PF00069	0.464
DOC_PP1_RVXF_1	105	111	PF00149	0.461
DOC_USP7_MATH_1	249	253	PF00917	0.760
DOC_USP7_MATH_1	264	268	PF00917	0.672
DOC_USP7_MATH_1	34	38	PF00917	0.567
DOC_USP7_UBL2_3	236	240	PF12436	0.722
DOC_USP7_UBL2_3	406	410	PF12436	0.511
DOC_USP7_UBL2_3	50	54	PF12436	0.484
DOC_USP7_UBL2_3	66	70	PF12436	0.490
DOC_WW_Pin1_4	184	189	PF00397	0.571
DOC_WW_Pin1_4	250	255	PF00397	0.761
DOC_WW_Pin1_4	297	302	PF00397	0.700
LIG_14-3-3_CanoR_1	281	286	PF00244	0.558
LIG_14-3-3_CanoR_1	350	354	PF00244	0.543
LIG_14-3-3_CanoR_1	82	87	PF00244	0.575
LIG_APCC_ABBA_1	22	27	PF00400	0.364
LIG_BIR_II_1	1	5	PF00653	0.574
LIG_BRCT_BRCA1_1	19	23	PF00533	0.458
LIG_BRCT_BRCA1_1	384	388	PF00533	0.500
LIG_BRCT_BRCA1_1	54	58	PF00533	0.532
LIG_FHA_1	101	107	PF00498	0.421
LIG_FHA_1	136	142	PF00498	0.301
LIG_FHA_1	205	211	PF00498	0.509
LIG_FHA_1	219	225	PF00498	0.389
LIG_FHA_1	253	259	PF00498	0.780
LIG_FHA_1	307	313	PF00498	0.380
LIG_FHA_1	366	372	PF00498	0.540
LIG_FHA_1	63	69	PF00498	0.430
LIG_FHA_1	76	82	PF00498	0.334
LIG_FHA_2	185	191	PF00498	0.564
LIG_FHA_2	240	246	PF00498	0.781
LIG_FHA_2	74	80	PF00498	0.301
LIG_LIR_Apic_2	184	188	PF02991	0.569
LIG_LIR_Gen_1	109	117	PF02991	0.395
LIG_LIR_Gen_1	325	332	PF02991	0.457
LIG_LIR_Gen_1	334	343	PF02991	0.359
LIG_LIR_Gen_1	83	91	PF02991	0.488
LIG_LIR_Nem_3	109	113	PF02991	0.378
LIG_LIR_Nem_3	325	331	PF02991	0.478
LIG_LIR_Nem_3	334	340	PF02991	0.359
LIG_LIR_Nem_3	385	391	PF02991	0.459
LIG_LIR_Nem_3	55	61	PF02991	0.414
LIG_LIR_Nem_3	83	89	PF02991	0.465
LIG_SH2_CRK	185	189	PF00017	0.575
LIG_SH2_NCK_1	185	189	PF00017	0.591
LIG_SH2_STAP1	195	199	PF00017	0.586
LIG_SH2_STAP1	308	312	PF00017	0.522
LIG_SH2_STAT5	185	188	PF00017	0.528
LIG_SH2_STAT5	195	198	PF00017	0.466
LIG_SH2_STAT5	25	28	PF00017	0.425
LIG_SH2_STAT5	308	311	PF00017	0.465
LIG_SH3_3	221	227	PF00018	0.523
LIG_SH3_3	355	361	PF00018	0.567
LIG_SH3_4	410	417	PF00018	0.549
LIG_SH3_4	50	57	PF00018	0.504
LIG_SUMO_SIM_par_1	397	403	PF11976	0.452
LIG_TRAF2_1	241	244	PF00917	0.599
LIG_UBA3_1	398	406	PF00899	0.423
MOD_CK1_1	120	126	PF00069	0.496
MOD_CK1_1	184	190	PF00069	0.570
MOD_CK1_1	252	258	PF00069	0.734
MOD_CK1_1	259	265	PF00069	0.684
MOD_CK1_1	300	306	PF00069	0.671
MOD_CK1_1	37	43	PF00069	0.489
MOD_CK1_1	44	50	PF00069	0.481
MOD_CK1_1	75	81	PF00069	0.528
MOD_CK2_1	184	190	PF00069	0.542
MOD_CK2_1	360	366	PF00069	0.493
MOD_CK2_1	384	390	PF00069	0.476
MOD_CK2_1	73	79	PF00069	0.292
MOD_GlcNHglycan	119	122	PF01048	0.489
MOD_GlcNHglycan	261	264	PF01048	0.726
MOD_GlcNHglycan	304	307	PF01048	0.595
MOD_GlcNHglycan	324	327	PF01048	0.482
MOD_GlcNHglycan	36	39	PF01048	0.497
MOD_GlcNHglycan	46	49	PF01048	0.430
MOD_GlcNHglycan	55	58	PF01048	0.242
MOD_GSK3_1	248	255	PF00069	0.796
MOD_GSK3_1	264	271	PF00069	0.602
MOD_GSK3_1	281	288	PF00069	0.493
MOD_GSK3_1	302	309	PF00069	0.507
MOD_GSK3_1	316	323	PF00069	0.402
MOD_GSK3_1	327	334	PF00069	0.214
MOD_GSK3_1	33	40	PF00069	0.459
MOD_GSK3_1	390	397	PF00069	0.530
MOD_GSK3_1	71	78	PF00069	0.419
MOD_GSK3_1	80	87	PF00069	0.457
MOD_N-GLC_1	264	269	PF02516	0.736
MOD_N-GLC_1	281	286	PF02516	0.504
MOD_NEK2_1	117	122	PF00069	0.559
MOD_NEK2_1	125	130	PF00069	0.398
MOD_NEK2_1	154	159	PF00069	0.584
MOD_NEK2_1	181	186	PF00069	0.558
MOD_NEK2_1	191	196	PF00069	0.541
MOD_NEK2_1	218	223	PF00069	0.424
MOD_NEK2_1	320	325	PF00069	0.484
MOD_NEK2_1	405	410	PF00069	0.392
MOD_NEK2_1	42	47	PF00069	0.455
MOD_NEK2_1	52	57	PF00069	0.431
MOD_NEK2_1	73	78	PF00069	0.451
MOD_NEK2_1	81	86	PF00069	0.551
MOD_NEK2_2	349	354	PF00069	0.529
MOD_NEK2_2	384	389	PF00069	0.517
MOD_PIKK_1	154	160	PF00454	0.463
MOD_PIKK_1	256	262	PF00454	0.742
MOD_PKA_2	349	355	PF00069	0.542
MOD_PKA_2	81	87	PF00069	0.569
MOD_Plk_1	108	114	PF00069	0.385
MOD_Plk_1	154	160	PF00069	0.493
MOD_Plk_1	268	274	PF00069	0.603
MOD_Plk_1	281	287	PF00069	0.545
MOD_Plk_2-3	268	274	PF00069	0.419
MOD_Plk_2-3	394	400	PF00069	0.272
MOD_Plk_4	120	126	PF00069	0.424
MOD_Plk_4	17	23	PF00069	0.474
MOD_Plk_4	218	224	PF00069	0.420
MOD_Plk_4	37	43	PF00069	0.450
MOD_Plk_4	394	400	PF00069	0.536
MOD_ProDKin_1	184	190	PF00069	0.570
MOD_ProDKin_1	250	256	PF00069	0.758
MOD_ProDKin_1	297	303	PF00069	0.694
MOD_SUMO_rev_2	243	249	PF00179	0.788
MOD_SUMO_rev_2	271	280	PF00179	0.650
TRG_ENDOCYTIC_2	147	150	PF00928	0.417
TRG_ENDOCYTIC_2	25	28	PF00928	0.388
TRG_NES_CRM1_1	390	403	PF08389	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJS3	Leptomonas seymouri	53%	100%
A0A1X0NYM7	Trypanosomatidae	30%	87%
A0A3R7KQG6	Trypanosoma rangeli	38%	95%
A0A3S7X164	Leishmania donovani	90%	100%
A4I3A5	Leishmania infantum	90%	100%
D0A828	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4Q8M8	Leishmania major	89%	100%
V5B0U4	Trypanosoma cruzi	33%	90%