LeishMANIAdb
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Katanin p60 ATPase-containing subunit A1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Katanin p60 ATPase-containing subunit A1
Gene product:
serine peptidase, Clan SJ, family S16, putative
Species:
Leishmania mexicana
UniProt:
E9AZK1_LEIMU
TriTrypDb:
LmxM.28.0400
Length:
541

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 13
GO:0005874 microtubule 6 12
GO:0099080 supramolecular complex 2 12
GO:0099081 supramolecular polymer 3 12
GO:0099512 supramolecular fiber 4 12
GO:0099513 polymeric cytoskeletal fiber 5 12
GO:0110165 cellular anatomical entity 1 16
GO:0000815 ESCRT III complex 3 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0032991 protein-containing complex 1 1
GO:0036452 ESCRT complex 2 1
GO:0097014 ciliary plasm 5 1
GO:0098796 membrane protein complex 2 1
GO:0099568 cytoplasmic region 3 1
GO:0005856 cytoskeleton 5 1
GO:0015630 microtubule cytoskeleton 6 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0051286 cell tip 3 1
GO:0060187 cell pole 2 1
GO:0016020 membrane 2 3

Expansion

Sequence features

E9AZK1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZK1

Function

Biological processes
Term Name Level Count
GO:0000226 microtubule cytoskeleton organization 3 12
GO:0006996 organelle organization 4 13
GO:0007010 cytoskeleton organization 5 12
GO:0007017 microtubule-based process 2 12
GO:0009987 cellular process 1 13
GO:0016043 cellular component organization 3 13
GO:0051013 microtubule severing 4 12
GO:0071840 cellular component organization or biogenesis 2 13
GO:0006810 transport 3 1
GO:0007033 vacuole organization 5 1
GO:0009894 regulation of catabolic process 4 1
GO:0010506 regulation of autophagy 6 1
GO:0016192 vesicle-mediated transport 4 1
GO:0016197 endosomal transport 4 1
GO:0019222 regulation of metabolic process 3 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031329 regulation of cellular catabolic process 5 1
GO:0046907 intracellular transport 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 16
GO:0003824 catalytic activity 1 16
GO:0005488 binding 1 16
GO:0005515 protein binding 2 12
GO:0005524 ATP binding 5 16
GO:0008017 microtubule binding 5 12
GO:0008092 cytoskeletal protein binding 3 12
GO:0008568 microtubule severing ATPase activity 2 12
GO:0015631 tubulin binding 4 12
GO:0016462 pyrophosphatase activity 5 16
GO:0016787 hydrolase activity 2 16
GO:0016817 hydrolase activity, acting on acid anhydrides 3 16
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 16
GO:0016853 isomerase activity 2 12
GO:0016887 ATP hydrolysis activity 7 16
GO:0017076 purine nucleotide binding 4 16
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 16
GO:0030554 adenyl nucleotide binding 5 16
GO:0032553 ribonucleotide binding 3 16
GO:0032555 purine ribonucleotide binding 4 16
GO:0032559 adenyl ribonucleotide binding 5 16
GO:0035639 purine ribonucleoside triphosphate binding 4 16
GO:0036094 small molecule binding 2 16
GO:0043167 ion binding 2 16
GO:0043168 anion binding 3 16
GO:0097159 organic cyclic compound binding 2 16
GO:0097367 carbohydrate derivative binding 2 16
GO:0140096 catalytic activity, acting on a protein 2 12
GO:0140657 ATP-dependent activity 1 12
GO:0140776 protein-containing complex destabilizing activity 1 12
GO:1901265 nucleoside phosphate binding 3 16
GO:1901363 heterocyclic compound binding 2 16

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 356 360 PF00656 0.285
CLV_MEL_PAP_1 182 188 PF00089 0.481
CLV_NRD_NRD_1 287 289 PF00675 0.380
CLV_NRD_NRD_1 375 377 PF00675 0.264
CLV_NRD_NRD_1 414 416 PF00675 0.270
CLV_NRD_NRD_1 479 481 PF00675 0.219
CLV_NRD_NRD_1 86 88 PF00675 0.600
CLV_PCSK_KEX2_1 266 268 PF00082 0.447
CLV_PCSK_KEX2_1 287 289 PF00082 0.380
CLV_PCSK_KEX2_1 375 377 PF00082 0.264
CLV_PCSK_KEX2_1 413 415 PF00082 0.270
CLV_PCSK_KEX2_1 418 420 PF00082 0.270
CLV_PCSK_KEX2_1 479 481 PF00082 0.249
CLV_PCSK_KEX2_1 85 87 PF00082 0.599
CLV_PCSK_PC1ET2_1 266 268 PF00082 0.447
CLV_PCSK_PC1ET2_1 418 420 PF00082 0.219
CLV_PCSK_PC1ET2_1 85 87 PF00082 0.517
CLV_PCSK_PC7_1 414 420 PF00082 0.270
CLV_PCSK_SKI1_1 224 228 PF00082 0.435
CLV_PCSK_SKI1_1 26 30 PF00082 0.408
CLV_PCSK_SKI1_1 266 270 PF00082 0.345
CLV_PCSK_SKI1_1 291 295 PF00082 0.270
CLV_PCSK_SKI1_1 303 307 PF00082 0.270
CLV_PCSK_SKI1_1 339 343 PF00082 0.270
CLV_PCSK_SKI1_1 375 379 PF00082 0.270
CLV_PCSK_SKI1_1 439 443 PF00082 0.372
CLV_PCSK_SKI1_1 480 484 PF00082 0.345
DEG_APCC_DBOX_1 429 437 PF00400 0.287
DEG_APCC_KENBOX_2 490 494 PF00400 0.365
DEG_Nend_UBRbox_3 1 3 PF02207 0.404
DOC_CYCLIN_RxL_1 336 343 PF00134 0.270
DOC_MAPK_gen_1 112 121 PF00069 0.446
DOC_MAPK_gen_1 413 424 PF00069 0.285
DOC_MAPK_gen_1 439 449 PF00069 0.338
DOC_MAPK_gen_1 534 541 PF00069 0.439
DOC_MAPK_MEF2A_6 112 121 PF00069 0.446
DOC_MAPK_MEF2A_6 415 424 PF00069 0.270
DOC_PP1_RVXF_1 337 343 PF00149 0.219
DOC_PP2B_PxIxI_1 114 120 PF00149 0.448
DOC_PP4_FxxP_1 78 81 PF00568 0.504
DOC_USP7_MATH_1 158 162 PF00917 0.549
DOC_USP7_MATH_1 203 207 PF00917 0.611
DOC_USP7_MATH_1 309 313 PF00917 0.232
DOC_USP7_UBL2_3 11 15 PF12436 0.311
DOC_USP7_UBL2_3 220 224 PF12436 0.502
DOC_USP7_UBL2_3 435 439 PF12436 0.331
DOC_USP7_UBL2_3 483 487 PF12436 0.235
DOC_WW_Pin1_4 167 172 PF00397 0.523
DOC_WW_Pin1_4 175 180 PF00397 0.492
DOC_WW_Pin1_4 319 324 PF00397 0.219
LIG_14-3-3_CanoR_1 116 122 PF00244 0.712
LIG_14-3-3_CanoR_1 160 169 PF00244 0.611
LIG_14-3-3_CanoR_1 185 195 PF00244 0.668
LIG_14-3-3_CanoR_1 53 58 PF00244 0.383
LIG_14-3-3_CanoR_1 96 106 PF00244 0.700
LIG_APCC_ABBA_1 75 80 PF00400 0.421
LIG_BRCT_BRCA1_1 169 173 PF00533 0.515
LIG_BRCT_BRCA1_1 205 209 PF00533 0.431
LIG_BRCT_BRCA1_1 350 354 PF00533 0.270
LIG_CtBP_PxDLS_1 505 509 PF00389 0.222
LIG_deltaCOP1_diTrp_1 531 537 PF00928 0.219
LIG_FHA_1 226 232 PF00498 0.365
LIG_FHA_1 350 356 PF00498 0.219
LIG_FHA_1 390 396 PF00498 0.339
LIG_FHA_1 41 47 PF00498 0.354
LIG_FHA_1 436 442 PF00498 0.303
LIG_FHA_1 465 471 PF00498 0.264
LIG_FHA_2 253 259 PF00498 0.481
LIG_FHA_2 487 493 PF00498 0.377
LIG_FHA_2 69 75 PF00498 0.373
LIG_Integrin_RGD_1 331 333 PF01839 0.232
LIG_LIR_Gen_1 164 174 PF02991 0.505
LIG_LIR_Gen_1 255 262 PF02991 0.311
LIG_LIR_Gen_1 446 456 PF02991 0.233
LIG_LIR_Gen_1 52 61 PF02991 0.451
LIG_LIR_Nem_3 141 146 PF02991 0.627
LIG_LIR_Nem_3 164 169 PF02991 0.509
LIG_LIR_Nem_3 255 259 PF02991 0.321
LIG_LIR_Nem_3 281 286 PF02991 0.347
LIG_LIR_Nem_3 316 321 PF02991 0.269
LIG_LIR_Nem_3 446 452 PF02991 0.271
LIG_LIR_Nem_3 52 57 PF02991 0.465
LIG_LYPXL_S_1 274 278 PF13949 0.300
LIG_LYPXL_yS_3 275 278 PF13949 0.304
LIG_MYND_1 276 280 PF01753 0.314
LIG_NRBOX 451 457 PF00104 0.250
LIG_PDZ_Class_2 536 541 PF00595 0.511
LIG_Pex14_1 533 537 PF04695 0.219
LIG_SH2_CRK 166 170 PF00017 0.658
LIG_SH2_CRK 283 287 PF00017 0.418
LIG_SH2_CRK 296 300 PF00017 0.268
LIG_SH2_CRK 32 36 PF00017 0.448
LIG_SH2_NCK_1 166 170 PF00017 0.508
LIG_SH2_PTP2 421 424 PF00017 0.270
LIG_SH2_SRC 348 351 PF00017 0.232
LIG_SH2_STAT5 22 25 PF00017 0.380
LIG_SH2_STAT5 421 424 PF00017 0.271
LIG_SH3_3 101 107 PF00018 0.459
LIG_SH3_3 146 152 PF00018 0.529
LIG_SH3_3 166 172 PF00018 0.601
LIG_SH3_3 194 200 PF00018 0.558
LIG_SH3_3 228 234 PF00018 0.339
LIG_SH3_3 270 276 PF00018 0.338
LIG_TRAF2_1 234 237 PF00917 0.370
LIG_TYR_ITIM 273 278 PF00017 0.295
LIG_UBA3_1 433 439 PF00899 0.321
LIG_UBA3_1 475 483 PF00899 0.291
LIG_WW_3 182 186 PF00397 0.656
MOD_CK1_1 120 126 PF00069 0.659
MOD_CK1_1 127 133 PF00069 0.553
MOD_CK1_1 161 167 PF00069 0.711
MOD_CK1_1 175 181 PF00069 0.592
MOD_CK1_1 187 193 PF00069 0.493
MOD_CK1_1 225 231 PF00069 0.561
MOD_CK1_1 322 328 PF00069 0.281
MOD_CK1_1 4 10 PF00069 0.419
MOD_CK1_1 97 103 PF00069 0.652
MOD_CK2_1 486 492 PF00069 0.377
MOD_CK2_1 68 74 PF00069 0.466
MOD_CK2_1 96 102 PF00069 0.683
MOD_GlcNHglycan 123 126 PF01048 0.676
MOD_GlcNHglycan 160 163 PF01048 0.675
MOD_GlcNHglycan 174 177 PF01048 0.560
MOD_GlcNHglycan 192 195 PF01048 0.614
MOD_GlcNHglycan 224 227 PF01048 0.604
MOD_GlcNHglycan 461 464 PF01048 0.367
MOD_GlcNHglycan 99 102 PF01048 0.696
MOD_GSK3_1 117 124 PF00069 0.600
MOD_GSK3_1 158 165 PF00069 0.586
MOD_GSK3_1 174 181 PF00069 0.468
MOD_GSK3_1 184 191 PF00069 0.541
MOD_GSK3_1 210 217 PF00069 0.589
MOD_GSK3_1 309 316 PF00069 0.296
MOD_GSK3_1 49 56 PF00069 0.495
MOD_N-GLC_1 127 132 PF02516 0.502
MOD_N-GLC_1 314 319 PF02516 0.228
MOD_N-GLC_1 506 511 PF02516 0.222
MOD_N-GLC_1 94 99 PF02516 0.541
MOD_NEK2_1 1 6 PF00069 0.483
MOD_NEK2_1 121 126 PF00069 0.625
MOD_NEK2_1 174 179 PF00069 0.478
MOD_NEK2_1 186 191 PF00069 0.457
MOD_NEK2_1 399 404 PF00069 0.270
MOD_NEK2_2 31 36 PF00069 0.379
MOD_NEK2_2 314 319 PF00069 0.219
MOD_NEK2_2 474 479 PF00069 0.219
MOD_PIKK_1 450 456 PF00454 0.344
MOD_PIKK_1 68 74 PF00454 0.362
MOD_PKA_2 184 190 PF00069 0.654
MOD_PKA_2 68 74 PF00069 0.362
MOD_PKA_2 95 101 PF00069 0.678
MOD_Plk_1 127 133 PF00069 0.505
MOD_Plk_1 314 320 PF00069 0.275
MOD_Plk_1 37 43 PF00069 0.301
MOD_Plk_1 485 491 PF00069 0.250
MOD_Plk_2-3 486 492 PF00069 0.250
MOD_Plk_4 301 307 PF00069 0.285
MOD_Plk_4 314 320 PF00069 0.276
MOD_Plk_4 349 355 PF00069 0.268
MOD_Plk_4 377 383 PF00069 0.238
MOD_Plk_4 53 59 PF00069 0.468
MOD_ProDKin_1 167 173 PF00069 0.509
MOD_ProDKin_1 175 181 PF00069 0.493
MOD_ProDKin_1 319 325 PF00069 0.219
MOD_SUMO_rev_2 258 268 PF00179 0.320
TRG_DiLeu_BaEn_1 238 243 PF01217 0.333
TRG_DiLeu_BaEn_1 264 269 PF01217 0.327
TRG_DiLeu_BaEn_2 73 79 PF01217 0.524
TRG_DiLeu_LyEn_5 264 269 PF01217 0.444
TRG_ENDOCYTIC_2 166 169 PF00928 0.511
TRG_ENDOCYTIC_2 275 278 PF00928 0.347
TRG_ENDOCYTIC_2 283 286 PF00928 0.384
TRG_ENDOCYTIC_2 32 35 PF00928 0.293
TRG_ENDOCYTIC_2 421 424 PF00928 0.270
TRG_ER_diArg_1 286 288 PF00400 0.353
TRG_ER_diArg_1 412 415 PF00400 0.270
TRG_ER_diArg_1 478 480 PF00400 0.219
TRG_NLS_MonoCore_2 112 117 PF00514 0.646
TRG_NLS_MonoExtC_3 111 116 PF00514 0.548
TRG_NLS_MonoExtN_4 112 117 PF00514 0.552
TRG_Pf-PMV_PEXEL_1 266 270 PF00026 0.294
TRG_Pf-PMV_PEXEL_1 339 343 PF00026 0.247
TRG_Pf-PMV_PEXEL_1 44 48 PF00026 0.377

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HRH8 Leptomonas seymouri 69% 99%
A0A0S4IUM1 Bodo saltans 51% 91%
A0A1X0NYV7 Trypanosomatidae 56% 96%
A0A1X0P983 Trypanosomatidae 42% 100%
A0A3Q8IHU1 Leishmania donovani 32% 100%
A0A3Q8IJS0 Leishmania donovani 32% 100%
A0A3S7X163 Leishmania donovani 92% 100%
A0A3S7X2R4 Leishmania donovani 42% 100%
A0A422P1K0 Trypanosoma rangeli 56% 97%
A4H6T6 Leishmania braziliensis 36% 100%
A4HG81 Leishmania braziliensis 83% 95%
A4HME8 Leishmania braziliensis 34% 100%
A4HPV3 Leishmania braziliensis 35% 100%
A4I3C0 Leishmania infantum 93% 90%
A4I4W4 Leishmania infantum 42% 100%
A4IB20 Leishmania infantum 32% 100%
A4IE38 Leishmania infantum 32% 100%
B2RYN7 Rattus norvegicus 38% 93%
B3M301 Drosophila ananassae 40% 70%
B3P8A3 Drosophila erecta 40% 71%
B4HGG6 Drosophila sechellia 40% 71%
B4NBP4 Drosophila willistoni 41% 70%
B4PL32 Drosophila yakuba 40% 71%
B4QSF0 Drosophila simulans 40% 71%
C9ZK16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 66%
D0A833 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 98%
E9AEB2 Leishmania major 42% 100%
E9AEU9 Leishmania major 32% 100%
E9ALH4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9ATM0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B605 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
O75449 Homo sapiens 41% 100%
Q05AS3 Xenopus tropicalis 38% 90%
Q0IIR9 Xenopus tropicalis 41% 100%
Q1HGK7 Gallus gallus 42% 100%
Q4Q0X8 Leishmania major 32% 100%
Q4Q8N0 Leishmania major 94% 100%
Q5ZK92 Gallus gallus 40% 88%
Q6AZT2 Xenopus laevis 39% 90%
Q6NW58 Danio rerio 39% 95%
Q8I0P1 Drosophila melanogaster 40% 71%
Q9ERZ6 Mus musculus 30% 71%
Q9PUL2 Xenopus laevis 42% 100%
Q9SEX2 Arabidopsis thaliana 41% 100%
V5B0U7 Trypanosoma cruzi 56% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS