Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleus and spindle associated protein 1, putative

Species:

Leishmania mexicana

UniProt:

E9AZK0_LEIMU

TriTrypDb:

LmxM.28.0390

Length:

929

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005819	spindle	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZK0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	606	610	PF00656	0.559
CLV_NRD_NRD_1	14	16	PF00675	0.729
CLV_NRD_NRD_1	158	160	PF00675	0.567
CLV_NRD_NRD_1	411	413	PF00675	0.586
CLV_NRD_NRD_1	447	449	PF00675	0.596
CLV_NRD_NRD_1	484	486	PF00675	0.646
CLV_NRD_NRD_1	735	737	PF00675	0.498
CLV_NRD_NRD_1	827	829	PF00675	0.590
CLV_NRD_NRD_1	846	848	PF00675	0.407
CLV_NRD_NRD_1	871	873	PF00675	0.623
CLV_NRD_NRD_1	879	881	PF00675	0.620
CLV_NRD_NRD_1	900	902	PF00675	0.644
CLV_PCSK_FUR_1	11	15	PF00082	0.740
CLV_PCSK_FUR_1	877	881	PF00082	0.667
CLV_PCSK_KEX2_1	13	15	PF00082	0.756
CLV_PCSK_KEX2_1	158	160	PF00082	0.531
CLV_PCSK_KEX2_1	328	330	PF00082	0.561
CLV_PCSK_KEX2_1	410	412	PF00082	0.610
CLV_PCSK_KEX2_1	447	449	PF00082	0.634
CLV_PCSK_KEX2_1	549	551	PF00082	0.544
CLV_PCSK_KEX2_1	735	737	PF00082	0.501
CLV_PCSK_KEX2_1	827	829	PF00082	0.589
CLV_PCSK_KEX2_1	871	873	PF00082	0.559
CLV_PCSK_KEX2_1	879	881	PF00082	0.581
CLV_PCSK_KEX2_1	899	901	PF00082	0.326
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.561
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.640
CLV_PCSK_PC1ET2_1	899	901	PF00082	0.656
CLV_PCSK_PC7_1	407	413	PF00082	0.364
CLV_PCSK_PC7_1	823	829	PF00082	0.570
CLV_PCSK_SKI1_1	207	211	PF00082	0.665
CLV_PCSK_SKI1_1	237	241	PF00082	0.540
CLV_PCSK_SKI1_1	242	246	PF00082	0.519
CLV_PCSK_SKI1_1	307	311	PF00082	0.608
CLV_PCSK_SKI1_1	317	321	PF00082	0.570
CLV_PCSK_SKI1_1	329	333	PF00082	0.532
CLV_PCSK_SKI1_1	458	462	PF00082	0.573
CLV_PCSK_SKI1_1	481	485	PF00082	0.561
CLV_PCSK_SKI1_1	553	557	PF00082	0.629
CLV_PCSK_SKI1_1	605	609	PF00082	0.631
CLV_PCSK_SKI1_1	656	660	PF00082	0.586
CLV_PCSK_SKI1_1	673	677	PF00082	0.375
CLV_PCSK_SKI1_1	847	851	PF00082	0.600
DEG_APCC_DBOX_1	604	612	PF00400	0.656
DOC_CDC14_PxL_1	41	49	PF14671	0.473
DOC_CKS1_1	113	118	PF01111	0.537
DOC_CKS1_1	55	60	PF01111	0.726
DOC_CYCLIN_yCln2_LP_2	800	806	PF00134	0.677
DOC_MAPK_gen_1	105	113	PF00069	0.597
DOC_MAPK_gen_1	158	164	PF00069	0.549
DOC_MAPK_gen_1	407	417	PF00069	0.577
DOC_MAPK_gen_1	549	556	PF00069	0.656
DOC_MAPK_gen_1	720	729	PF00069	0.563
DOC_MAPK_MEF2A_6	158	166	PF00069	0.540
DOC_MAPK_MEF2A_6	410	419	PF00069	0.637
DOC_MAPK_NFAT4_5	412	420	PF00069	0.341
DOC_PP1_RVXF_1	551	557	PF00149	0.666
DOC_USP7_MATH_1	198	202	PF00917	0.594
DOC_USP7_MATH_1	487	491	PF00917	0.571
DOC_USP7_MATH_1	562	566	PF00917	0.611
DOC_USP7_MATH_1	6	10	PF00917	0.720
DOC_USP7_MATH_1	603	607	PF00917	0.627
DOC_USP7_MATH_1	703	707	PF00917	0.409
DOC_USP7_MATH_1	757	761	PF00917	0.698
DOC_USP7_MATH_1	79	83	PF00917	0.584
DOC_WW_Pin1_4	112	117	PF00397	0.547
DOC_WW_Pin1_4	46	51	PF00397	0.701
DOC_WW_Pin1_4	54	59	PF00397	0.685
DOC_WW_Pin1_4	67	72	PF00397	0.687
DOC_WW_Pin1_4	804	809	PF00397	0.424
LIG_14-3-3_CanoR_1	207	212	PF00244	0.593
LIG_14-3-3_CanoR_1	220	227	PF00244	0.579
LIG_14-3-3_CanoR_1	362	368	PF00244	0.561
LIG_14-3-3_CanoR_1	410	419	PF00244	0.539
LIG_14-3-3_CanoR_1	671	680	PF00244	0.598
LIG_14-3-3_CanoR_1	704	708	PF00244	0.421
LIG_BIR_II_1	1	5	PF00653	0.721
LIG_BRCT_BRCA1_1	759	763	PF00533	0.660
LIG_CaM_IQ_9	907	922	PF13499	0.650
LIG_Clathr_ClatBox_1	416	420	PF01394	0.589
LIG_deltaCOP1_diTrp_1	573	582	PF00928	0.509
LIG_deltaCOP1_diTrp_1	713	717	PF00928	0.608
LIG_FHA_1	124	130	PF00498	0.557
LIG_FHA_1	151	157	PF00498	0.597
LIG_FHA_1	386	392	PF00498	0.656
LIG_FHA_1	546	552	PF00498	0.631
LIG_FHA_1	55	61	PF00498	0.735
LIG_FHA_1	786	792	PF00498	0.591
LIG_FHA_2	113	119	PF00498	0.640
LIG_FHA_2	238	244	PF00498	0.618
LIG_HCF-1_HBM_1	383	386	PF13415	0.351
LIG_LIR_Gen_1	216	226	PF02991	0.564
LIG_LIR_Gen_1	250	261	PF02991	0.575
LIG_LIR_Gen_1	383	393	PF02991	0.551
LIG_LIR_Gen_1	420	429	PF02991	0.589
LIG_LIR_Gen_1	430	438	PF02991	0.566
LIG_LIR_Gen_1	706	715	PF02991	0.588
LIG_LIR_Nem_3	216	221	PF02991	0.570
LIG_LIR_Nem_3	250	256	PF02991	0.574
LIG_LIR_Nem_3	383	389	PF02991	0.546
LIG_LIR_Nem_3	420	425	PF02991	0.586
LIG_LIR_Nem_3	430	436	PF02991	0.590
LIG_LIR_Nem_3	573	578	PF02991	0.645
LIG_LIR_Nem_3	621	625	PF02991	0.577
LIG_LIR_Nem_3	674	680	PF02991	0.455
LIG_LIR_Nem_3	706	711	PF02991	0.523
LIG_LIR_Nem_3	713	718	PF02991	0.511
LIG_Pex14_2	578	582	PF04695	0.446
LIG_RPA_C_Fungi	674	686	PF08784	0.554
LIG_SH2_CRK	386	390	PF00017	0.583
LIG_SH2_NCK_1	708	712	PF00017	0.526
LIG_SH2_NCK_1	755	759	PF00017	0.721
LIG_SH2_SRC	225	228	PF00017	0.652
LIG_SH2_SRC	708	711	PF00017	0.599
LIG_SH2_SRC	755	758	PF00017	0.716
LIG_SH2_STAP1	144	148	PF00017	0.642
LIG_SH2_STAP1	225	229	PF00017	0.563
LIG_SH2_STAP1	680	684	PF00017	0.635
LIG_SH2_STAP1	708	712	PF00017	0.580
LIG_SH2_STAP1	715	719	PF00017	0.594
LIG_SH2_STAT3	171	174	PF00017	0.599
LIG_SH2_STAT3	227	230	PF00017	0.652
LIG_SH2_STAT3	642	645	PF00017	0.622
LIG_SH2_STAT5	186	189	PF00017	0.538
LIG_SH2_STAT5	352	355	PF00017	0.627
LIG_SH2_STAT5	624	627	PF00017	0.539
LIG_SH3_1	13	19	PF00018	0.743
LIG_SH3_3	13	19	PF00018	0.743
LIG_SH3_3	49	55	PF00018	0.724
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.583
LIG_SUMO_SIM_par_1	195	203	PF11976	0.566
LIG_SUMO_SIM_par_1	415	421	PF11976	0.617
LIG_SUMO_SIM_par_1	815	822	PF11976	0.560
LIG_TRAF2_1	125	128	PF00917	0.476
LIG_TRAF2_1	284	287	PF00917	0.580
LIG_TRAF2_1	521	524	PF00917	0.594
LIG_TRAF2_1	588	591	PF00917	0.606
LIG_TRAF2_1	593	596	PF00917	0.661
LIG_TRAF2_1	615	618	PF00917	0.612
LIG_TRAF2_1	743	746	PF00917	0.632
LIG_TRAF2_1	830	833	PF00917	0.568
LIG_WRC_WIRS_1	419	424	PF05994	0.322
MOD_CDK_SPxxK_3	112	119	PF00069	0.543
MOD_CK1_1	131	137	PF00069	0.636
MOD_CK1_1	25	31	PF00069	0.705
MOD_CK1_1	772	778	PF00069	0.678
MOD_CK1_1	891	897	PF00069	0.561
MOD_CK2_1	112	118	PF00069	0.625
MOD_CK2_1	122	128	PF00069	0.517
MOD_CK2_1	143	149	PF00069	0.592
MOD_CK2_1	237	243	PF00069	0.618
MOD_CK2_1	277	283	PF00069	0.642
MOD_CK2_1	703	709	PF00069	0.595
MOD_CK2_1	740	746	PF00069	0.654
MOD_CK2_1	867	873	PF00069	0.643
MOD_CMANNOS	714	717	PF00535	0.634
MOD_Cter_Amidation	326	329	PF01082	0.590
MOD_Cter_Amidation	445	448	PF01082	0.641
MOD_GlcNHglycan	28	31	PF01048	0.597
MOD_GlcNHglycan	322	325	PF01048	0.613
MOD_GlcNHglycan	489	492	PF01048	0.529
MOD_GlcNHglycan	514	517	PF01048	0.529
MOD_GlcNHglycan	564	567	PF01048	0.677
MOD_GlcNHglycan	605	608	PF01048	0.599
MOD_GlcNHglycan	700	704	PF01048	0.574
MOD_GlcNHglycan	809	812	PF01048	0.559
MOD_GlcNHglycan	856	859	PF01048	0.495
MOD_GSK3_1	18	25	PF00069	0.760
MOD_GSK3_1	26	33	PF00069	0.762
MOD_GSK3_1	277	284	PF00069	0.690
MOD_GSK3_1	46	53	PF00069	0.661
MOD_GSK3_1	578	585	PF00069	0.446
MOD_GSK3_1	699	706	PF00069	0.493
MOD_GSK3_1	867	874	PF00069	0.651
MOD_GSK3_1	882	889	PF00069	0.653
MOD_LATS_1	235	241	PF00433	0.572
MOD_LATS_1	852	858	PF00433	0.407
MOD_N-GLC_1	247	252	PF02516	0.608
MOD_NEK2_1	277	282	PF00069	0.693
MOD_NEK2_1	578	583	PF00069	0.605
MOD_NEK2_1	699	704	PF00069	0.624
MOD_NEK2_1	886	891	PF00069	0.603
MOD_NEK2_2	385	390	PF00069	0.532
MOD_NEK2_2	6	11	PF00069	0.647
MOD_NEK2_2	703	708	PF00069	0.328
MOD_OFUCOSY	579	586	PF10250	0.633
MOD_PIKK_1	248	254	PF00454	0.617
MOD_PIKK_1	530	536	PF00454	0.583
MOD_PIKK_1	650	656	PF00454	0.564
MOD_PIKK_1	688	694	PF00454	0.650
MOD_PIKK_1	769	775	PF00454	0.569
MOD_PIKK_1	888	894	PF00454	0.582
MOD_PKA_1	410	416	PF00069	0.595
MOD_PKA_1	871	877	PF00069	0.491
MOD_PKA_2	123	129	PF00069	0.632
MOD_PKA_2	219	225	PF00069	0.564
MOD_PKA_2	30	36	PF00069	0.728
MOD_PKA_2	363	369	PF00069	0.558
MOD_PKA_2	410	416	PF00069	0.595
MOD_PKA_2	65	71	PF00069	0.694
MOD_PKA_2	703	709	PF00069	0.577
MOD_PKA_2	871	877	PF00069	0.615
MOD_PKB_1	15	23	PF00069	0.733
MOD_PKB_1	528	536	PF00069	0.582
MOD_Plk_1	248	254	PF00069	0.617
MOD_Plk_2-3	128	134	PF00069	0.643
MOD_Plk_2-3	150	156	PF00069	0.638
MOD_Plk_4	143	149	PF00069	0.627
MOD_Plk_4	385	391	PF00069	0.571
MOD_Plk_4	468	474	PF00069	0.551
MOD_Plk_4	703	709	PF00069	0.330
MOD_Plk_4	757	763	PF00069	0.653
MOD_ProDKin_1	112	118	PF00069	0.544
MOD_ProDKin_1	46	52	PF00069	0.703
MOD_ProDKin_1	54	60	PF00069	0.689
MOD_ProDKin_1	67	73	PF00069	0.683
MOD_ProDKin_1	804	810	PF00069	0.417
MOD_SUMO_rev_2	617	625	PF00179	0.507
MOD_SUMO_rev_2	908	916	PF00179	0.644
TRG_DiLeu_BaEn_1	262	267	PF01217	0.687
TRG_DiLeu_BaEn_1	725	730	PF01217	0.602
TRG_DiLeu_BaEn_2	758	764	PF01217	0.443
TRG_DiLeu_BaLyEn_6	527	532	PF01217	0.583
TRG_DiLeu_LyEn_5	725	730	PF01217	0.646
TRG_ENDOCYTIC_2	386	389	PF00928	0.585
TRG_ENDOCYTIC_2	708	711	PF00928	0.567
TRG_ENDOCYTIC_2	715	718	PF00928	0.521
TRG_ER_diArg_1	11	14	PF00400	0.759
TRG_ER_diArg_1	137	140	PF00400	0.524
TRG_ER_diArg_1	15	18	PF00400	0.741
TRG_ER_diArg_1	157	159	PF00400	0.316
TRG_ER_diArg_1	290	293	PF00400	0.650
TRG_ER_diArg_1	339	342	PF00400	0.516
TRG_ER_diArg_1	356	359	PF00400	0.499
TRG_ER_diArg_1	410	412	PF00400	0.577
TRG_ER_diArg_1	447	449	PF00400	0.650
TRG_ER_diArg_1	528	531	PF00400	0.528
TRG_ER_diArg_1	735	737	PF00400	0.520
TRG_ER_diArg_1	741	744	PF00400	0.528
TRG_ER_diArg_1	879	881	PF00400	0.649
TRG_ER_diArg_1	900	902	PF00400	0.585
TRG_NES_CRM1_1	89	100	PF08389	0.478
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.677
TRG_Pf-PMV_PEXEL_1	530	534	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	735	739	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	900	904	PF00026	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB25	Leptomonas seymouri	57%	100%
A0A1X0NYM1	Trypanosomatidae	26%	100%
A0A3Q8ICZ1	Leishmania donovani	90%	100%
A0A3R7NTV6	Trypanosoma rangeli	29%	100%
A4HG80	Leishmania braziliensis	81%	100%
A4I3C1	Leishmania infantum	90%	100%
D0A834	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
Q4Q8N1	Leishmania major	90%	100%
V5BKX1	Trypanosoma cruzi	28%	100%