Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZJ5_LEIMU

TriTrypDb:

LmxM.28.0340

Length:

1153

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZJ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.453
CLV_C14_Caspase3-7	42	46	PF00656	0.466
CLV_C14_Caspase3-7	841	845	PF00656	0.431
CLV_C14_Caspase3-7	978	982	PF00656	0.247
CLV_NRD_NRD_1	10	12	PF00675	0.450
CLV_NRD_NRD_1	1011	1013	PF00675	0.364
CLV_NRD_NRD_1	239	241	PF00675	0.438
CLV_NRD_NRD_1	392	394	PF00675	0.302
CLV_NRD_NRD_1	468	470	PF00675	0.433
CLV_NRD_NRD_1	481	483	PF00675	0.470
CLV_NRD_NRD_1	60	62	PF00675	0.516
CLV_NRD_NRD_1	902	904	PF00675	0.515
CLV_NRD_NRD_1	969	971	PF00675	0.407
CLV_PCSK_KEX2_1	10	12	PF00082	0.473
CLV_PCSK_KEX2_1	1011	1013	PF00082	0.409
CLV_PCSK_KEX2_1	239	241	PF00082	0.438
CLV_PCSK_KEX2_1	392	394	PF00082	0.341
CLV_PCSK_KEX2_1	468	470	PF00082	0.433
CLV_PCSK_KEX2_1	481	483	PF00082	0.470
CLV_PCSK_KEX2_1	60	62	PF00082	0.479
CLV_PCSK_KEX2_1	889	891	PF00082	0.336
CLV_PCSK_KEX2_1	902	904	PF00082	0.515
CLV_PCSK_PC1ET2_1	889	891	PF00082	0.336
CLV_PCSK_SKI1_1	10	14	PF00082	0.431
CLV_PCSK_SKI1_1	1105	1109	PF00082	0.409
CLV_PCSK_SKI1_1	220	224	PF00082	0.588
CLV_PCSK_SKI1_1	240	244	PF00082	0.264
CLV_PCSK_SKI1_1	370	374	PF00082	0.686
CLV_PCSK_SKI1_1	407	411	PF00082	0.503
CLV_PCSK_SKI1_1	469	473	PF00082	0.456
CLV_PCSK_SKI1_1	636	640	PF00082	0.264
CLV_PCSK_SKI1_1	786	790	PF00082	0.418
DEG_APCC_DBOX_1	1104	1112	PF00400	0.369
DEG_APCC_DBOX_1	1121	1129	PF00400	0.384
DEG_APCC_DBOX_1	239	247	PF00400	0.384
DEG_APCC_DBOX_1	468	476	PF00400	0.452
DEG_APCC_DBOX_1	59	67	PF00400	0.506
DEG_SPOP_SBC_1	160	164	PF00917	0.400
DEG_SPOP_SBC_1	372	376	PF00917	0.585
DOC_CKS1_1	87	92	PF01111	0.617
DOC_CYCLIN_RxL_1	754	765	PF00134	0.331
DOC_CYCLIN_yCln2_LP_2	12	18	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	901	907	PF00134	0.365
DOC_MAPK_gen_1	123	132	PF00069	0.479
DOC_MAPK_gen_1	294	304	PF00069	0.440
DOC_MAPK_MEF2A_6	23	30	PF00069	0.368
DOC_MAPK_NFAT4_5	23	31	PF00069	0.345
DOC_PP2B_LxvP_1	12	15	PF13499	0.401
DOC_PP2B_LxvP_1	693	696	PF13499	0.407
DOC_PP2B_LxvP_1	789	792	PF13499	0.404
DOC_PP2B_LxvP_1	946	949	PF13499	0.418
DOC_PP4_FxxP_1	87	90	PF00568	0.485
DOC_USP7_MATH_1	1021	1025	PF00917	0.474
DOC_USP7_MATH_1	202	206	PF00917	0.590
DOC_USP7_MATH_1	328	332	PF00917	0.424
DOC_USP7_MATH_1	360	364	PF00917	0.626
DOC_USP7_MATH_1	372	376	PF00917	0.536
DOC_USP7_MATH_1	566	570	PF00917	0.496
DOC_USP7_MATH_1	59	63	PF00917	0.513
DOC_USP7_MATH_1	593	597	PF00917	0.363
DOC_USP7_MATH_1	626	630	PF00917	0.317
DOC_USP7_MATH_1	680	684	PF00917	0.434
DOC_USP7_MATH_1	745	749	PF00917	0.488
DOC_USP7_MATH_1	770	774	PF00917	0.475
DOC_USP7_MATH_1	920	924	PF00917	0.416
DOC_USP7_UBL2_3	971	975	PF12436	0.381
DOC_WW_Pin1_4	197	202	PF00397	0.588
DOC_WW_Pin1_4	204	209	PF00397	0.611
DOC_WW_Pin1_4	262	267	PF00397	0.570
DOC_WW_Pin1_4	48	53	PF00397	0.622
DOC_WW_Pin1_4	577	582	PF00397	0.473
DOC_WW_Pin1_4	643	648	PF00397	0.419
DOC_WW_Pin1_4	748	753	PF00397	0.480
DOC_WW_Pin1_4	768	773	PF00397	0.378
DOC_WW_Pin1_4	86	91	PF00397	0.609
LIG_14-3-3_CanoR_1	10	15	PF00244	0.506
LIG_14-3-3_CanoR_1	100	109	PF00244	0.532
LIG_14-3-3_CanoR_1	1055	1063	PF00244	0.519
LIG_14-3-3_CanoR_1	1122	1132	PF00244	0.518
LIG_14-3-3_CanoR_1	125	133	PF00244	0.412
LIG_14-3-3_CanoR_1	294	300	PF00244	0.518
LIG_14-3-3_CanoR_1	323	333	PF00244	0.302
LIG_14-3-3_CanoR_1	387	391	PF00244	0.407
LIG_14-3-3_CanoR_1	469	477	PF00244	0.486
LIG_14-3-3_CanoR_1	511	515	PF00244	0.552
LIG_14-3-3_CanoR_1	60	64	PF00244	0.430
LIG_14-3-3_CanoR_1	762	772	PF00244	0.561
LIG_14-3-3_CanoR_1	848	854	PF00244	0.418
LIG_14-3-3_CanoR_1	890	896	PF00244	0.452
LIG_14-3-3_CanoR_1	912	917	PF00244	0.409
LIG_14-3-3_CanoR_1	960	964	PF00244	0.493
LIG_Actin_WH2_2	210	225	PF00022	0.459
LIG_Actin_WH2_2	23	39	PF00022	0.565
LIG_Actin_WH2_2	309	325	PF00022	0.535
LIG_APCC_ABBA_1	939	944	PF00400	0.314
LIG_BIR_II_1	1	5	PF00653	0.477
LIG_BIR_III_2	981	985	PF00653	0.245
LIG_BRCT_BRCA1_1	330	334	PF00533	0.472
LIG_BRCT_BRCA1_1	914	918	PF00533	0.427
LIG_BRCT_BRCA1_1	922	926	PF00533	0.468
LIG_Clathr_ClatBox_1	678	682	PF01394	0.454
LIG_deltaCOP1_diTrp_1	226	235	PF00928	0.432
LIG_EVH1_2	792	796	PF00568	0.462
LIG_FHA_1	102	108	PF00498	0.447
LIG_FHA_1	1025	1031	PF00498	0.388
LIG_FHA_1	1086	1092	PF00498	0.353
LIG_FHA_1	1134	1140	PF00498	0.559
LIG_FHA_1	119	125	PF00498	0.561
LIG_FHA_1	144	150	PF00498	0.354
LIG_FHA_1	192	198	PF00498	0.480
LIG_FHA_1	4	10	PF00498	0.538
LIG_FHA_1	426	432	PF00498	0.293
LIG_FHA_1	437	443	PF00498	0.531
LIG_FHA_1	48	54	PF00498	0.555
LIG_FHA_1	493	499	PF00498	0.531
LIG_FHA_1	558	564	PF00498	0.438
LIG_FHA_1	637	643	PF00498	0.519
LIG_FHA_1	647	653	PF00498	0.518
LIG_FHA_1	712	718	PF00498	0.397
LIG_FHA_1	739	745	PF00498	0.546
LIG_FHA_1	853	859	PF00498	0.495
LIG_FHA_1	87	93	PF00498	0.485
LIG_FHA_1	896	902	PF00498	0.371
LIG_FHA_1	936	942	PF00498	0.488
LIG_FHA_2	1039	1045	PF00498	0.562
LIG_FHA_2	1059	1065	PF00498	0.268
LIG_FHA_2	246	252	PF00498	0.458
LIG_FHA_2	283	289	PF00498	0.572
LIG_FHA_2	40	46	PF00498	0.680
LIG_FHA_2	412	418	PF00498	0.399
LIG_FHA_2	689	695	PF00498	0.507
LIG_GBD_Chelix_1	717	725	PF00786	0.517
LIG_GBD_Chelix_1	812	820	PF00786	0.365
LIG_IRF3_LxIS_1	618	625	PF10401	0.384
LIG_LIR_Apic_2	226	231	PF02991	0.499
LIG_LIR_Apic_2	510	515	PF02991	0.570
LIG_LIR_Apic_2	614	618	PF02991	0.255
LIG_LIR_Gen_1	171	181	PF02991	0.419
LIG_LIR_Gen_1	779	789	PF02991	0.437
LIG_LIR_Gen_1	794	804	PF02991	0.257
LIG_LIR_Nem_3	171	176	PF02991	0.367
LIG_LIR_Nem_3	331	337	PF02991	0.451
LIG_LIR_Nem_3	614	619	PF02991	0.355
LIG_LIR_Nem_3	779	784	PF02991	0.442
LIG_LIR_Nem_3	794	799	PF02991	0.254
LIG_LIR_Nem_3	908	914	PF02991	0.503
LIG_LIR_Nem_3	915	921	PF02991	0.468
LIG_NRBOX	630	636	PF00104	0.375
LIG_NRBOX	720	726	PF00104	0.367
LIG_NRBOX	811	817	PF00104	0.372
LIG_Pex14_1	228	232	PF04695	0.494
LIG_PTB_Apo_2	336	343	PF02174	0.449
LIG_PTB_Apo_2	962	969	PF02174	0.483
LIG_PTB_Phospho_1	336	342	PF10480	0.443
LIG_SH2_CRK	781	785	PF00017	0.467
LIG_SH2_CRK	969	973	PF00017	0.385
LIG_SH2_GRB2like	337	340	PF00017	0.439
LIG_SH2_NCK_1	342	346	PF00017	0.545
LIG_SH2_NCK_1	781	785	PF00017	0.483
LIG_SH2_STAP1	103	107	PF00017	0.426
LIG_SH2_STAP1	232	236	PF00017	0.533
LIG_SH2_STAP1	337	341	PF00017	0.434
LIG_SH2_STAT5	103	106	PF00017	0.491
LIG_SH2_STAT5	1052	1055	PF00017	0.414
LIG_SH2_STAT5	142	145	PF00017	0.517
LIG_SH2_STAT5	429	432	PF00017	0.473
LIG_SH2_STAT5	615	618	PF00017	0.348
LIG_SH3_3	488	494	PF00018	0.493
LIG_SH3_3	576	582	PF00018	0.428
LIG_SH3_3	87	93	PF00018	0.432
LIG_SUMO_SIM_anti_2	127	134	PF11976	0.457
LIG_SUMO_SIM_anti_2	171	178	PF11976	0.375
LIG_SUMO_SIM_anti_2	439	446	PF11976	0.347
LIG_SUMO_SIM_anti_2	913	918	PF11976	0.349
LIG_SUMO_SIM_par_1	1135	1140	PF11976	0.557
LIG_SUMO_SIM_par_1	309	315	PF11976	0.409
LIG_SUMO_SIM_par_1	545	551	PF11976	0.288
LIG_TRAF2_1	1140	1143	PF00917	0.496
LIG_TRAF2_1	285	288	PF00917	0.565
LIG_TRAF2_1	521	524	PF00917	0.545
LIG_TRAF2_1	599	602	PF00917	0.293
LIG_TRAF2_1	70	73	PF00917	0.376
LIG_TRAF2_1	997	1000	PF00917	0.411
LIG_UBA3_1	441	447	PF00899	0.436
MOD_CK1_1	1019	1025	PF00069	0.497
MOD_CK1_1	1058	1064	PF00069	0.472
MOD_CK1_1	1133	1139	PF00069	0.554
MOD_CK1_1	164	170	PF00069	0.425
MOD_CK1_1	374	380	PF00069	0.627
MOD_CK1_1	39	45	PF00069	0.631
MOD_CK1_1	492	498	PF00069	0.502
MOD_CK1_1	51	57	PF00069	0.472
MOD_CK1_1	510	516	PF00069	0.512
MOD_CK1_1	548	554	PF00069	0.409
MOD_CK1_1	596	602	PF00069	0.335
MOD_CK1_1	646	652	PF00069	0.346
MOD_CK1_1	688	694	PF00069	0.558
MOD_CK1_1	711	717	PF00069	0.441
MOD_CK1_1	748	754	PF00069	0.402
MOD_CK1_1	88	94	PF00069	0.524
MOD_CK1_1	894	900	PF00069	0.322
MOD_CK1_1	959	965	PF00069	0.366
MOD_CK2_1	1038	1044	PF00069	0.382
MOD_CK2_1	1137	1143	PF00069	0.504
MOD_CK2_1	282	288	PF00069	0.500
MOD_CK2_1	417	423	PF00069	0.453
MOD_CK2_1	596	602	PF00069	0.515
MOD_GlcNHglycan	1	4	PF01048	0.448
MOD_GlcNHglycan	111	114	PF01048	0.530
MOD_GlcNHglycan	1139	1142	PF01048	0.605
MOD_GlcNHglycan	326	329	PF01048	0.356
MOD_GlcNHglycan	361	365	PF01048	0.483
MOD_GlcNHglycan	419	422	PF01048	0.431
MOD_GlcNHglycan	482	485	PF01048	0.553
MOD_GlcNHglycan	491	494	PF01048	0.540
MOD_GlcNHglycan	595	598	PF01048	0.394
MOD_GlcNHglycan	624	627	PF01048	0.522
MOD_GlcNHglycan	688	691	PF01048	0.579
MOD_GlcNHglycan	747	750	PF01048	0.462
MOD_GlcNHglycan	765	768	PF01048	0.403
MOD_GlcNHglycan	772	775	PF01048	0.689
MOD_GlcNHglycan	81	84	PF01048	0.419
MOD_GlcNHglycan	827	830	PF01048	0.384
MOD_GlcNHglycan	870	873	PF01048	0.337
MOD_GSK3_1	1024	1031	PF00069	0.421
MOD_GSK3_1	111	118	PF00069	0.600
MOD_GSK3_1	1133	1140	PF00069	0.632
MOD_GSK3_1	159	166	PF00069	0.506
MOD_GSK3_1	242	249	PF00069	0.565
MOD_GSK3_1	324	331	PF00069	0.384
MOD_GSK3_1	360	367	PF00069	0.571
MOD_GSK3_1	370	377	PF00069	0.586
MOD_GSK3_1	41	48	PF00069	0.651
MOD_GSK3_1	411	418	PF00069	0.539
MOD_GSK3_1	436	443	PF00069	0.391
MOD_GSK3_1	446	453	PF00069	0.347
MOD_GSK3_1	489	496	PF00069	0.442
MOD_GSK3_1	622	629	PF00069	0.510
MOD_GSK3_1	681	688	PF00069	0.514
MOD_GSK3_1	707	714	PF00069	0.432
MOD_GSK3_1	852	859	PF00069	0.491
MOD_GSK3_1	891	898	PF00069	0.372
MOD_N-GLC_1	1038	1043	PF02516	0.369
MOD_N-GLC_1	109	114	PF02516	0.509
MOD_NEK2_1	1005	1010	PF00069	0.406
MOD_NEK2_1	109	114	PF00069	0.618
MOD_NEK2_1	1128	1133	PF00069	0.417
MOD_NEK2_1	143	148	PF00069	0.435
MOD_NEK2_1	149	154	PF00069	0.444
MOD_NEK2_1	416	421	PF00069	0.539
MOD_NEK2_1	480	485	PF00069	0.550
MOD_NEK2_1	620	625	PF00069	0.495
MOD_NEK2_1	681	686	PF00069	0.574
MOD_NEK2_1	868	873	PF00069	0.477
MOD_NEK2_1	885	890	PF00069	0.358
MOD_NEK2_1	935	940	PF00069	0.455
MOD_NEK2_1	98	103	PF00069	0.422
MOD_NEK2_2	103	108	PF00069	0.493
MOD_NEK2_2	59	64	PF00069	0.518
MOD_NEK2_2	920	925	PF00069	0.446
MOD_PIKK_1	1110	1116	PF00454	0.478
MOD_PIKK_1	1123	1129	PF00454	0.504
MOD_PIKK_1	149	155	PF00454	0.380
MOD_PIKK_1	3	9	PF00454	0.468
MOD_PIKK_1	830	836	PF00454	0.318
MOD_PIKK_1	895	901	PF00454	0.366
MOD_PK_1	1067	1073	PF00069	0.475
MOD_PKA_1	10	16	PF00069	0.512
MOD_PKA_2	10	16	PF00069	0.430
MOD_PKA_2	124	130	PF00069	0.430
MOD_PKA_2	191	197	PF00069	0.280
MOD_PKA_2	246	252	PF00069	0.511
MOD_PKA_2	36	42	PF00069	0.578
MOD_PKA_2	386	392	PF00069	0.523
MOD_PKA_2	480	486	PF00069	0.517
MOD_PKA_2	510	516	PF00069	0.476
MOD_PKA_2	59	65	PF00069	0.426
MOD_PKA_2	763	769	PF00069	0.524
MOD_PKA_2	847	853	PF00069	0.424
MOD_PKA_2	959	965	PF00069	0.366
MOD_Plk_1	1038	1044	PF00069	0.373
MOD_Plk_1	143	149	PF00069	0.340
MOD_Plk_1	318	324	PF00069	0.553
MOD_Plk_1	626	632	PF00069	0.524
MOD_Plk_1	681	687	PF00069	0.510
MOD_Plk_4	1029	1035	PF00069	0.324
MOD_Plk_4	1133	1139	PF00069	0.692
MOD_Plk_4	143	149	PF00069	0.477
MOD_Plk_4	17	23	PF00069	0.442
MOD_Plk_4	279	285	PF00069	0.305
MOD_Plk_4	328	334	PF00069	0.536
MOD_Plk_4	386	392	PF00069	0.547
MOD_Plk_4	411	417	PF00069	0.616
MOD_Plk_4	425	431	PF00069	0.285
MOD_Plk_4	437	443	PF00069	0.586
MOD_Plk_4	471	477	PF00069	0.426
MOD_Plk_4	493	499	PF00069	0.392
MOD_Plk_4	545	551	PF00069	0.462
MOD_Plk_4	682	688	PF00069	0.596
MOD_Plk_4	708	714	PF00069	0.505
MOD_Plk_4	891	897	PF00069	0.466
MOD_Plk_4	959	965	PF00069	0.498
MOD_ProDKin_1	197	203	PF00069	0.586
MOD_ProDKin_1	204	210	PF00069	0.599
MOD_ProDKin_1	262	268	PF00069	0.561
MOD_ProDKin_1	48	54	PF00069	0.611
MOD_ProDKin_1	577	583	PF00069	0.468
MOD_ProDKin_1	643	649	PF00069	0.415
MOD_ProDKin_1	748	754	PF00069	0.473
MOD_ProDKin_1	768	774	PF00069	0.374
MOD_ProDKin_1	86	92	PF00069	0.604
MOD_SUMO_for_1	22	25	PF00179	0.454
TRG_DiLeu_BaEn_1	1145	1150	PF01217	0.609
TRG_DiLeu_BaEn_4	1142	1148	PF01217	0.550
TRG_DiLeu_BaLyEn_6	600	605	PF01217	0.378
TRG_DiLeu_BaLyEn_6	615	620	PF01217	0.350
TRG_DiLeu_BaLyEn_6	754	759	PF01217	0.491
TRG_ENDOCYTIC_2	781	784	PF00928	0.431
TRG_ENDOCYTIC_2	893	896	PF00928	0.373
TRG_ENDOCYTIC_2	969	972	PF00928	0.350
TRG_ENDOCYTIC_2	995	998	PF00928	0.471
TRG_ER_diArg_1	1011	1013	PF00400	0.364
TRG_ER_diArg_1	217	220	PF00400	0.454
TRG_ER_diArg_1	270	273	PF00400	0.283
TRG_ER_diArg_1	391	393	PF00400	0.266
TRG_ER_diArg_1	480	482	PF00400	0.377
TRG_ER_diArg_1	761	764	PF00400	0.523
TRG_ER_diArg_1	9	11	PF00400	0.471
TRG_ER_diArg_1	901	903	PF00400	0.500
TRG_NES_CRM1_1	293	308	PF08389	0.515
TRG_NES_CRM1_1	930	944	PF08389	0.458
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD59	Leptomonas seymouri	46%	97%
A0A1X0NVE5	Trypanosomatidae	27%	100%
A0A3Q8IEG5	Leishmania donovani	91%	100%
A0A422N6R4	Trypanosoma rangeli	30%	100%
A4HG75	Leishmania braziliensis	79%	100%
A4I3B8	Leishmania infantum	91%	100%
D0A7T7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
Q4Q8N6	Leishmania major	90%	100%
V5B9X1	Trypanosoma cruzi	24%	100%