Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZJ3_LEIMU

TriTrypDb:

LmxM.28.0320

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZJ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.620
CLV_C14_Caspase3-7	325	329	PF00656	0.467
CLV_NRD_NRD_1	30	32	PF00675	0.594
CLV_PCSK_KEX2_1	30	32	PF00082	0.554
CLV_PCSK_KEX2_1	79	81	PF00082	0.593
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.556
CLV_PCSK_PC7_1	26	32	PF00082	0.567
CLV_PCSK_PC7_1	75	81	PF00082	0.527
CLV_PCSK_SKI1_1	102	106	PF00082	0.470
CLV_PCSK_SKI1_1	175	179	PF00082	0.468
CLV_PCSK_SKI1_1	228	232	PF00082	0.512
CLV_PCSK_SKI1_1	335	339	PF00082	0.503
DEG_MDM2_SWIB_1	292	299	PF02201	0.529
DOC_CYCLIN_yCln2_LP_2	128	134	PF00134	0.460
DOC_MAPK_MEF2A_6	228	235	PF00069	0.523
DOC_PP1_RVXF_1	165	171	PF00149	0.522
DOC_PP2B_LxvP_1	128	131	PF13499	0.428
DOC_PP2B_LxvP_1	242	245	PF13499	0.478
DOC_USP7_MATH_1	24	28	PF00917	0.532
DOC_USP7_MATH_1	245	249	PF00917	0.587
DOC_USP7_MATH_1	316	320	PF00917	0.606
DOC_WW_Pin1_4	216	221	PF00397	0.426
DOC_WW_Pin1_4	271	276	PF00397	0.498
DOC_WW_Pin1_4	278	283	PF00397	0.519
DOC_WW_Pin1_4	35	40	PF00397	0.560
LIG_14-3-3_CanoR_1	102	107	PF00244	0.506
LIG_14-3-3_CanoR_1	114	121	PF00244	0.431
LIG_Actin_WH2_2	11	28	PF00022	0.528
LIG_APCC_ABBAyCdc20_2	335	341	PF00400	0.421
LIG_BIR_II_1	1	5	PF00653	0.751
LIG_BIR_III_4	160	164	PF00653	0.340
LIG_FHA_1	125	131	PF00498	0.490
LIG_FHA_1	194	200	PF00498	0.538
LIG_FHA_1	249	255	PF00498	0.506
LIG_FHA_1	266	272	PF00498	0.197
LIG_FHA_1	278	284	PF00498	0.441
LIG_FHA_1	286	292	PF00498	0.241
LIG_FHA_1	329	335	PF00498	0.540
LIG_FHA_1	36	42	PF00498	0.489
LIG_FHA_2	106	112	PF00498	0.482
LIG_LIR_Apic_2	35	40	PF02991	0.515
LIG_LIR_Gen_1	148	159	PF02991	0.530
LIG_LIR_Gen_1	293	304	PF02991	0.546
LIG_LIR_Nem_3	148	154	PF02991	0.533
LIG_LIR_Nem_3	293	299	PF02991	0.524
LIG_PDZ_Class_1	337	342	PF00595	0.566
LIG_Pex14_2	292	296	PF04695	0.479
LIG_SH2_CRK	125	129	PF00017	0.363
LIG_SH2_SRC	151	154	PF00017	0.537
LIG_SH2_STAP1	151	155	PF00017	0.427
LIG_SH2_STAP1	195	199	PF00017	0.498
LIG_SH2_STAT3	195	198	PF00017	0.503
LIG_SH2_STAT5	195	198	PF00017	0.476
LIG_SH3_3	127	133	PF00018	0.365
LIG_SH3_3	230	236	PF00018	0.555
LIG_SH3_3	272	278	PF00018	0.461
LIG_SH3_3	280	286	PF00018	0.454
LIG_SH3_3	58	64	PF00018	0.439
LIG_SUMO_SIM_par_1	102	108	PF11976	0.392
LIG_TRAF2_1	315	318	PF00917	0.522
LIG_TRAF2_1	32	35	PF00917	0.319
LIG_TYR_ITSM	147	154	PF00017	0.490
LIG_WRC_WIRS_1	147	152	PF05994	0.487
MOD_CDK_SPK_2	216	221	PF00069	0.426
MOD_CK1_1	146	152	PF00069	0.524
MOD_CK1_1	176	182	PF00069	0.356
MOD_CK1_1	248	254	PF00069	0.556
MOD_CK1_1	265	271	PF00069	0.188
MOD_CK1_1	285	291	PF00069	0.516
MOD_CK1_1	73	79	PF00069	0.514
MOD_CK2_1	54	60	PF00069	0.546
MOD_CMANNOS	170	173	PF00535	0.397
MOD_CMANNOS	91	94	PF00535	0.518
MOD_GlcNHglycan	175	178	PF01048	0.508
MOD_GlcNHglycan	236	239	PF01048	0.559
MOD_GlcNHglycan	26	29	PF01048	0.395
MOD_GlcNHglycan	298	302	PF01048	0.586
MOD_GlcNHglycan	56	59	PF01048	0.552
MOD_GlcNHglycan	8	11	PF01048	0.649
MOD_GlcNHglycan	82	85	PF01048	0.628
MOD_GSK3_1	222	229	PF00069	0.433
MOD_GSK3_1	261	268	PF00069	0.404
MOD_GSK3_1	278	285	PF00069	0.513
MOD_NEK2_1	1	6	PF00069	0.707
MOD_NEK2_1	200	205	PF00069	0.575
MOD_NEK2_1	210	215	PF00069	0.325
MOD_NEK2_1	291	296	PF00069	0.582
MOD_NEK2_1	53	58	PF00069	0.543
MOD_NEK2_1	8	13	PF00069	0.564
MOD_NEK2_2	70	75	PF00069	0.453
MOD_PIKK_1	194	200	PF00454	0.506
MOD_Plk_1	316	322	PF00069	0.572
MOD_Plk_4	1	7	PF00069	0.738
MOD_Plk_4	102	108	PF00069	0.446
MOD_Plk_4	146	152	PF00069	0.463
MOD_Plk_4	205	211	PF00069	0.546
MOD_Plk_4	63	69	PF00069	0.418
MOD_ProDKin_1	216	222	PF00069	0.423
MOD_ProDKin_1	271	277	PF00069	0.495
MOD_ProDKin_1	278	284	PF00069	0.513
MOD_ProDKin_1	35	41	PF00069	0.550
MOD_SUMO_rev_2	72	81	PF00179	0.514
TRG_DiLeu_BaLyEn_6	250	255	PF01217	0.522
TRG_ENDOCYTIC_2	125	128	PF00928	0.367
TRG_ENDOCYTIC_2	151	154	PF00928	0.537
TRG_ER_diArg_1	167	170	PF00400	0.515
TRG_ER_diArg_1	29	31	PF00400	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEC4	Leptomonas seymouri	60%	91%
A0A1X0NW08	Trypanosomatidae	36%	100%
A0A3S7X175	Leishmania donovani	94%	100%
A0A422N6W1	Trypanosoma rangeli	34%	100%
A4HG73	Leishmania braziliensis	83%	100%
A4I3B6	Leishmania infantum	94%	100%
D0A7T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	90%
Q4Q8N8	Leishmania major	92%	100%
V5BEI5	Trypanosoma cruzi	36%	100%