Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZJ2_LEIMU

TriTrypDb:

LmxM.28.0310

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AZJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZJ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.588
CLV_NRD_NRD_1	173	175	PF00675	0.400
CLV_NRD_NRD_1	59	61	PF00675	0.523
CLV_PCSK_FUR_1	301	305	PF00082	0.313
CLV_PCSK_FUR_1	57	61	PF00082	0.563
CLV_PCSK_KEX2_1	133	135	PF00082	0.580
CLV_PCSK_KEX2_1	173	175	PF00082	0.383
CLV_PCSK_KEX2_1	303	305	PF00082	0.407
CLV_PCSK_KEX2_1	57	59	PF00082	0.535
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.454
CLV_PCSK_SKI1_1	108	112	PF00082	0.606
CLV_PCSK_SKI1_1	253	257	PF00082	0.282
CLV_PCSK_SKI1_1	28	32	PF00082	0.507
CLV_PCSK_SKI1_1	41	45	PF00082	0.409
DEG_Nend_Nbox_1	1	3	PF02207	0.575
DOC_CKS1_1	122	127	PF01111	0.449
DOC_CYCLIN_yCln2_LP_2	290	296	PF00134	0.402
DOC_MAPK_gen_1	251	258	PF00069	0.520
DOC_MAPK_MEF2A_6	145	152	PF00069	0.362
DOC_MAPK_MEF2A_6	227	235	PF00069	0.355
DOC_PP1_RVXF_1	50	57	PF00149	0.649
DOC_PP2B_LxvP_1	150	153	PF13499	0.447
DOC_PP2B_LxvP_1	256	259	PF13499	0.355
DOC_USP7_MATH_1	284	288	PF00917	0.412
DOC_USP7_UBL2_3	313	317	PF12436	0.688
DOC_WW_Pin1_4	121	126	PF00397	0.448
DOC_WW_Pin1_4	202	207	PF00397	0.391
DOC_WW_Pin1_4	236	241	PF00397	0.492
DOC_WW_Pin1_4	69	74	PF00397	0.735
LIG_BRCT_BRCA1_1	195	199	PF00533	0.381
LIG_deltaCOP1_diTrp_1	243	252	PF00928	0.634
LIG_deltaCOP1_diTrp_1	84	92	PF00928	0.676
LIG_FHA_1	159	165	PF00498	0.405
LIG_FHA_1	24	30	PF00498	0.667
LIG_FHA_2	277	283	PF00498	0.271
LIG_FHA_2	70	76	PF00498	0.747
LIG_LIR_Gen_1	269	280	PF02991	0.590
LIG_LIR_Nem_3	269	275	PF02991	0.599
LIG_LIR_Nem_3	88	93	PF02991	0.521
LIG_LYPXL_S_1	92	96	PF13949	0.480
LIG_LYPXL_yS_3	93	96	PF13949	0.480
LIG_Pex14_1	246	250	PF04695	0.639
LIG_SH2_NCK_1	272	276	PF00017	0.483
LIG_SH2_SRC	272	275	PF00017	0.486
LIG_SH2_STAP1	160	164	PF00017	0.480
LIG_SH2_STAT5	101	104	PF00017	0.379
LIG_SH2_STAT5	160	163	PF00017	0.447
LIG_SH2_STAT5	166	169	PF00017	0.594
LIG_SH3_3	119	125	PF00018	0.440
LIG_SH3_3	143	149	PF00018	0.362
LIG_SH3_3	225	231	PF00018	0.440
LIG_SUMO_SIM_anti_2	11	22	PF11976	0.677
LIG_SUMO_SIM_par_1	160	165	PF11976	0.432
LIG_TYR_ITIM	91	96	PF00017	0.440
LIG_TYR_ITIM	99	104	PF00017	0.456
MOD_CK1_1	184	190	PF00069	0.355
MOD_CK1_1	205	211	PF00069	0.360
MOD_Cter_Amidation	131	134	PF01082	0.611
MOD_GlcNHglycan	35	38	PF01048	0.495
MOD_GSK3_1	14	21	PF00069	0.684
MOD_GSK3_1	158	165	PF00069	0.344
MOD_GSK3_1	29	36	PF00069	0.689
MOD_NEK2_1	113	118	PF00069	0.421
MOD_NEK2_1	162	167	PF00069	0.406
MOD_NEK2_1	192	197	PF00069	0.474
MOD_NEK2_1	267	272	PF00069	0.411
MOD_NEK2_1	295	300	PF00069	0.334
MOD_NEK2_1	77	82	PF00069	0.735
MOD_PIKK_1	190	196	PF00454	0.490
MOD_PIKK_1	23	29	PF00454	0.726
MOD_PKA_2	6	12	PF00069	0.741
MOD_Plk_1	12	18	PF00069	0.753
MOD_Plk_1	50	56	PF00069	0.722
MOD_Plk_4	138	144	PF00069	0.389
MOD_Plk_4	14	20	PF00069	0.701
MOD_Plk_4	181	187	PF00069	0.353
MOD_Plk_4	193	199	PF00069	0.283
MOD_Plk_4	221	227	PF00069	0.484
MOD_Plk_4	267	273	PF00069	0.411
MOD_Plk_4	276	282	PF00069	0.266
MOD_Plk_4	284	290	PF00069	0.358
MOD_ProDKin_1	121	127	PF00069	0.446
MOD_ProDKin_1	202	208	PF00069	0.390
MOD_ProDKin_1	236	242	PF00069	0.491
MOD_ProDKin_1	69	75	PF00069	0.734
TRG_DiLeu_BaLyEn_6	228	233	PF01217	0.366
TRG_ENDOCYTIC_2	101	104	PF00928	0.447
TRG_ENDOCYTIC_2	272	275	PF00928	0.487
TRG_ENDOCYTIC_2	93	96	PF00928	0.447
TRG_ER_diArg_1	133	135	PF00400	0.386
TRG_ER_diArg_1	173	175	PF00400	0.583
TRG_ER_diArg_1	5	8	PF00400	0.725
TRG_ER_diArg_1	56	59	PF00400	0.726
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P732	Leptomonas seymouri	59%	92%
A0A1X0NVF3	Trypanosomatidae	31%	100%
A0A3Q8IAV0	Leishmania donovani	92%	100%
A0A3R7KTP8	Trypanosoma rangeli	34%	100%
A4HG72	Leishmania braziliensis	84%	100%
A4I3B5	Leishmania infantum	92%	100%
D0A7T4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4Q8N9	Leishmania major	91%	100%
V5DAH6	Trypanosoma cruzi	36%	100%