LeishMANIAdb
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HIT-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
HIT-type domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AZJ1_LEIMU
TriTrypDb:
LmxM.28.0300
Length:
630

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0032991 protein-containing complex 1 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0070761 pre-snoRNP complex 3 1
GO:0110165 cellular anatomical entity 1 1
GO:1990904 ribonucleoprotein complex 2 1

Expansion

Sequence features

E9AZJ1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZJ1

Function

Biological processes
Term Name Level Count
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 10 1
GO:0000470 maturation of LSU-rRNA 9 1
GO:0000491 small nucleolar ribonucleoprotein complex assembly 7 1
GO:0000492 box C/D snoRNP assembly 8 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006364 rRNA processing 8 1
GO:0006396 RNA processing 6 1
GO:0006403 RNA localization 3 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0016070 RNA metabolic process 5 1
GO:0016072 rRNA metabolic process 7 1
GO:0022607 cellular component assembly 4 1
GO:0022618 ribonucleoprotein complex assembly 6 1
GO:0033036 macromolecule localization 2 1
GO:0034470 ncRNA processing 7 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034660 ncRNA metabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043933 protein-containing complex organization 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0048254 snoRNA localization 4 1
GO:0051179 localization 1 1
GO:0065003 protein-containing complex assembly 5 1
GO:0071704 organic substance metabolic process 2 1
GO:0071826 ribonucleoprotein complex subunit organization 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 10
GO:0043167 ion binding 2 10
GO:0043169 cation binding 3 10
GO:0046872 metal ion binding 4 10
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 121 123 PF00675 0.468
CLV_NRD_NRD_1 169 171 PF00675 0.396
CLV_NRD_NRD_1 204 206 PF00675 0.439
CLV_NRD_NRD_1 216 218 PF00675 0.463
CLV_NRD_NRD_1 227 229 PF00675 0.431
CLV_NRD_NRD_1 285 287 PF00675 0.566
CLV_NRD_NRD_1 455 457 PF00675 0.551
CLV_NRD_NRD_1 506 508 PF00675 0.551
CLV_NRD_NRD_1 526 528 PF00675 0.265
CLV_NRD_NRD_1 579 581 PF00675 0.435
CLV_NRD_NRD_1 627 629 PF00675 0.616
CLV_PCSK_KEX2_1 121 123 PF00082 0.468
CLV_PCSK_KEX2_1 169 171 PF00082 0.396
CLV_PCSK_KEX2_1 203 205 PF00082 0.399
CLV_PCSK_KEX2_1 218 220 PF00082 0.411
CLV_PCSK_KEX2_1 285 287 PF00082 0.579
CLV_PCSK_KEX2_1 455 457 PF00082 0.428
CLV_PCSK_KEX2_1 508 510 PF00082 0.545
CLV_PCSK_KEX2_1 526 528 PF00082 0.511
CLV_PCSK_KEX2_1 581 583 PF00082 0.463
CLV_PCSK_KEX2_1 626 628 PF00082 0.632
CLV_PCSK_PC1ET2_1 218 220 PF00082 0.494
CLV_PCSK_PC1ET2_1 508 510 PF00082 0.597
CLV_PCSK_PC1ET2_1 581 583 PF00082 0.463
CLV_PCSK_PC7_1 199 205 PF00082 0.474
CLV_PCSK_PC7_1 522 528 PF00082 0.460
CLV_PCSK_PC7_1 577 583 PF00082 0.558
CLV_PCSK_SKI1_1 440 444 PF00082 0.437
CLV_PCSK_SKI1_1 455 459 PF00082 0.268
CLV_PCSK_SKI1_1 526 530 PF00082 0.406
CLV_PCSK_SKI1_1 553 557 PF00082 0.337
DEG_APCC_DBOX_1 260 268 PF00400 0.329
DOC_CKS1_1 405 410 PF01111 0.432
DOC_CYCLIN_yCln2_LP_2 191 197 PF00134 0.383
DOC_MAPK_gen_1 121 129 PF00069 0.381
DOC_MAPK_MEF2A_6 122 131 PF00069 0.451
DOC_MAPK_MEF2A_6 142 150 PF00069 0.299
DOC_MAPK_MEF2A_6 392 400 PF00069 0.526
DOC_PP1_RVXF_1 453 460 PF00149 0.330
DOC_PP2B_LxvP_1 191 194 PF13499 0.394
DOC_PP2B_LxvP_1 398 401 PF13499 0.386
DOC_PP4_FxxP_1 622 625 PF00568 0.680
DOC_USP7_MATH_1 180 184 PF00917 0.559
DOC_USP7_MATH_1 364 368 PF00917 0.692
DOC_USP7_MATH_1 373 377 PF00917 0.683
DOC_USP7_MATH_1 487 491 PF00917 0.497
DOC_USP7_UBL2_3 133 137 PF12436 0.423
DOC_WW_Pin1_4 404 409 PF00397 0.498
DOC_WW_Pin1_4 542 547 PF00397 0.502
DOC_WW_Pin1_4 589 594 PF00397 0.492
DOC_WW_Pin1_4 86 91 PF00397 0.657
LIG_14-3-3_CanoR_1 121 127 PF00244 0.391
LIG_14-3-3_CanoR_1 181 185 PF00244 0.533
LIG_14-3-3_CanoR_1 476 480 PF00244 0.453
LIG_14-3-3_CanoR_1 489 493 PF00244 0.586
LIG_14-3-3_CanoR_1 507 514 PF00244 0.377
LIG_14-3-3_CanoR_1 566 570 PF00244 0.344
LIG_14-3-3_CanoR_1 72 80 PF00244 0.575
LIG_14-3-3_CterR_2 626 630 PF00244 0.655
LIG_APCC_ABBA_1 129 134 PF00400 0.440
LIG_EVH1_1 398 402 PF00568 0.510
LIG_FHA_1 121 127 PF00498 0.319
LIG_FHA_1 221 227 PF00498 0.423
LIG_FHA_1 228 234 PF00498 0.367
LIG_FHA_1 300 306 PF00498 0.526
LIG_FHA_1 344 350 PF00498 0.655
LIG_FHA_2 299 305 PF00498 0.737
LIG_FHA_2 314 320 PF00498 0.824
LIG_FHA_2 325 331 PF00498 0.651
LIG_FHA_2 337 343 PF00498 0.610
LIG_FHA_2 405 411 PF00498 0.505
LIG_FHA_2 447 453 PF00498 0.329
LIG_FHA_2 479 485 PF00498 0.390
LIG_FHA_2 543 549 PF00498 0.498
LIG_LIR_Gen_1 161 166 PF02991 0.391
LIG_LIR_Gen_1 424 432 PF02991 0.446
LIG_LIR_Gen_1 445 454 PF02991 0.351
LIG_LIR_Gen_1 554 562 PF02991 0.423
LIG_LIR_Nem_3 161 165 PF02991 0.393
LIG_LIR_Nem_3 424 429 PF02991 0.447
LIG_LIR_Nem_3 438 444 PF02991 0.371
LIG_LIR_Nem_3 445 450 PF02991 0.396
LIG_LIR_Nem_3 461 466 PF02991 0.308
LIG_LIR_Nem_3 554 558 PF02991 0.372
LIG_Pex14_1 184 188 PF04695 0.496
LIG_Pex14_1 235 239 PF04695 0.310
LIG_Pex14_2 416 420 PF04695 0.448
LIG_Pex14_2 459 463 PF04695 0.312
LIG_SH2_CRK 114 118 PF00017 0.367
LIG_SH2_CRK 188 192 PF00017 0.552
LIG_SH2_CRK 287 291 PF00017 0.437
LIG_SH2_CRK 447 451 PF00017 0.410
LIG_SH2_NCK_1 114 118 PF00017 0.367
LIG_SH2_NCK_1 287 291 PF00017 0.461
LIG_SH2_PTP2 426 429 PF00017 0.428
LIG_SH2_STAP1 394 398 PF00017 0.516
LIG_SH2_STAT5 114 117 PF00017 0.363
LIG_SH2_STAT5 270 273 PF00017 0.341
LIG_SH2_STAT5 293 296 PF00017 0.640
LIG_SH2_STAT5 426 429 PF00017 0.417
LIG_SH2_STAT5 441 444 PF00017 0.303
LIG_SH2_STAT5 60 63 PF00017 0.633
LIG_SH3_3 143 149 PF00018 0.391
LIG_SH3_3 358 364 PF00018 0.624
LIG_SH3_3 393 399 PF00018 0.557
LIG_SH3_3 402 408 PF00018 0.494
LIG_SUMO_SIM_anti_2 339 346 PF11976 0.544
LIG_TRAF2_1 94 97 PF00917 0.669
LIG_TRFH_1 442 446 PF08558 0.425
MOD_CDC14_SPxK_1 592 595 PF00782 0.503
MOD_CDK_SPK_2 404 409 PF00069 0.417
MOD_CDK_SPxK_1 589 595 PF00069 0.498
MOD_CK1_1 10 16 PF00069 0.592
MOD_CK1_1 100 106 PF00069 0.582
MOD_CK1_1 151 157 PF00069 0.408
MOD_CK1_1 27 33 PF00069 0.790
MOD_CK1_1 491 497 PF00069 0.602
MOD_CK1_1 71 77 PF00069 0.617
MOD_CK1_1 86 92 PF00069 0.617
MOD_CK2_1 364 370 PF00069 0.587
MOD_CK2_1 404 410 PF00069 0.438
MOD_CK2_1 427 433 PF00069 0.384
MOD_CK2_1 446 452 PF00069 0.276
MOD_CK2_1 507 513 PF00069 0.478
MOD_CK2_1 542 548 PF00069 0.484
MOD_CK2_1 78 84 PF00069 0.686
MOD_Cter_Amidation 119 122 PF01082 0.465
MOD_GlcNHglycan 12 15 PF01048 0.558
MOD_GlcNHglycan 242 245 PF01048 0.472
MOD_GlcNHglycan 28 32 PF01048 0.701
MOD_GlcNHglycan 296 299 PF01048 0.630
MOD_GlcNHglycan 330 335 PF01048 0.633
MOD_GlcNHglycan 366 369 PF01048 0.710
MOD_GlcNHglycan 382 385 PF01048 0.535
MOD_GlcNHglycan 75 78 PF01048 0.568
MOD_GSK3_1 248 255 PF00069 0.446
MOD_GSK3_1 294 301 PF00069 0.669
MOD_GSK3_1 487 494 PF00069 0.650
MOD_GSK3_1 6 13 PF00069 0.666
MOD_GSK3_1 78 85 PF00069 0.716
MOD_N-GLC_1 221 226 PF02516 0.386
MOD_N-GLC_1 35 40 PF02516 0.676
MOD_NEK2_1 136 141 PF00069 0.474
MOD_NEK2_1 83 88 PF00069 0.648
MOD_OFUCOSY 119 124 PF10250 0.357
MOD_PIKK_1 313 319 PF00454 0.619
MOD_PIKK_1 469 475 PF00454 0.350
MOD_PIKK_1 95 101 PF00454 0.633
MOD_PK_1 122 128 PF00069 0.376
MOD_PKA_1 507 513 PF00069 0.586
MOD_PKA_2 120 126 PF00069 0.475
MOD_PKA_2 180 186 PF00069 0.511
MOD_PKA_2 227 233 PF00069 0.382
MOD_PKA_2 288 294 PF00069 0.495
MOD_PKA_2 475 481 PF00069 0.474
MOD_PKA_2 488 494 PF00069 0.378
MOD_PKA_2 518 524 PF00069 0.462
MOD_PKA_2 565 571 PF00069 0.313
MOD_PKA_2 61 67 PF00069 0.623
MOD_PKA_2 71 77 PF00069 0.498
MOD_Plk_1 221 227 PF00069 0.386
MOD_Plk_1 248 254 PF00069 0.445
MOD_Plk_1 68 74 PF00069 0.584
MOD_Plk_4 122 128 PF00069 0.514
MOD_Plk_4 229 235 PF00069 0.375
MOD_ProDKin_1 404 410 PF00069 0.487
MOD_ProDKin_1 542 548 PF00069 0.504
MOD_ProDKin_1 589 595 PF00069 0.498
MOD_ProDKin_1 86 92 PF00069 0.660
MOD_SUMO_rev_2 134 139 PF00179 0.473
MOD_SUMO_rev_2 221 230 PF00179 0.523
MOD_SUMO_rev_2 482 487 PF00179 0.467
TRG_DiLeu_BaEn_2 461 467 PF01217 0.425
TRG_DiLeu_BaLyEn_6 274 279 PF01217 0.489
TRG_ENDOCYTIC_2 162 165 PF00928 0.509
TRG_ENDOCYTIC_2 188 191 PF00928 0.569
TRG_ENDOCYTIC_2 287 290 PF00928 0.437
TRG_ENDOCYTIC_2 394 397 PF00928 0.604
TRG_ENDOCYTIC_2 426 429 PF00928 0.417
TRG_ENDOCYTIC_2 441 444 PF00928 0.303
TRG_ENDOCYTIC_2 447 450 PF00928 0.364
TRG_ER_diArg_1 169 171 PF00400 0.385
TRG_ER_diArg_1 203 205 PF00400 0.495
TRG_ER_diArg_1 216 219 PF00400 0.510
TRG_ER_diArg_1 261 264 PF00400 0.361
TRG_ER_diArg_1 285 287 PF00400 0.581
TRG_ER_diArg_1 454 456 PF00400 0.423
TRG_ER_diArg_1 506 509 PF00400 0.546
TRG_ER_diArg_1 526 528 PF00400 0.390
TRG_ER_diArg_1 594 597 PF00400 0.649
TRG_ER_diArg_1 625 628 PF00400 0.706
TRG_NES_CRM1_1 448 462 PF08389 0.385
TRG_NLS_MonoExtC_3 579 584 PF00514 0.454
TRG_NLS_MonoExtN_4 577 584 PF00514 0.567
TRG_Pf-PMV_PEXEL_1 156 161 PF00026 0.417
TRG_Pf-PMV_PEXEL_1 532 537 PF00026 0.416

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0N9 Leptomonas seymouri 57% 100%
A0A3Q8IQB2 Leishmania donovani 89% 100%
A0A422N6T6 Trypanosoma rangeli 46% 100%
A4HG71 Leishmania braziliensis 77% 100%
A4I3B4 Leishmania infantum 89% 100%
D0A7T3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
Q4Q8P0 Leishmania major 88% 100%
V5BJ07 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS