BTB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZI9_LEIMU

TriTrypDb:

LmxM.28.0280

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0008023	transcription elongation factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0070449	elongin complex	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AZI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZI9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1
GO:0003676	nucleic acid binding	3	1
GO:0003746	translation elongation factor activity	4	1
GO:0005488	binding	1	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0045182	translation regulator activity	1	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	57	59	PF00675	0.490
CLV_PCSK_KEX2_1	59	61	PF00082	0.547
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.547
CLV_PCSK_SKI1_1	162	166	PF00082	0.452
CLV_PCSK_SKI1_1	194	198	PF00082	0.565
CLV_PCSK_SKI1_1	54	58	PF00082	0.591
CLV_Separin_Metazoa	206	210	PF03568	0.502
DEG_APCC_KENBOX_2	116	120	PF00400	0.715
DOC_MAPK_MEF2A_6	156	165	PF00069	0.613
DOC_PP1_RVXF_1	160	166	PF00149	0.512
DOC_PP1_RVXF_1	52	58	PF00149	0.571
DOC_PP4_FxxP_1	197	200	PF00568	0.499
DOC_USP7_MATH_1	175	179	PF00917	0.252
DOC_USP7_MATH_1	33	37	PF00917	0.599
DOC_WW_Pin1_4	47	52	PF00397	0.436
DOC_WW_Pin1_4	82	87	PF00397	0.624
LIG_14-3-3_CanoR_1	189	197	PF00244	0.550
LIG_APCC_ABBA_1	69	74	PF00400	0.401
LIG_BIR_II_1	1	5	PF00653	0.650
LIG_FHA_1	200	206	PF00498	0.533
LIG_FHA_1	63	69	PF00498	0.462
LIG_FHA_2	148	154	PF00498	0.657
LIG_LIR_Apic_2	20	26	PF02991	0.467
LIG_LIR_Apic_2	7	13	PF02991	0.699
LIG_LIR_Gen_1	178	186	PF02991	0.500
LIG_LIR_Gen_1	28	33	PF02991	0.505
LIG_LIR_Gen_1	5	14	PF02991	0.409
LIG_LIR_LC3C_4	66	71	PF02991	0.292
LIG_LIR_Nem_3	178	182	PF02991	0.496
LIG_LIR_Nem_3	28	32	PF02991	0.456
LIG_PDZ_Class_2	211	216	PF00595	0.451
LIG_Pex14_2	6	10	PF04695	0.643
LIG_SH2_CRK	23	27	PF00017	0.576
LIG_SH2_GRB2like	23	26	PF00017	0.655
LIG_SH2_PTP2	29	32	PF00017	0.437
LIG_SH2_STAT5	179	182	PF00017	0.423
LIG_SH2_STAT5	18	21	PF00017	0.625
LIG_SH2_STAT5	29	32	PF00017	0.401
LIG_SH3_3	10	16	PF00018	0.561
LIG_SH3_3	142	148	PF00018	0.780
LIG_SH3_3	160	166	PF00018	0.341
LIG_SUMO_SIM_anti_2	65	72	PF11976	0.295
LIG_SUMO_SIM_par_1	147	154	PF11976	0.676
LIG_TRAF2_1	36	39	PF00917	0.543
LIG_WW_1	15	18	PF00397	0.573
MOD_CDK_SPxxK_3	47	54	PF00069	0.436
MOD_CK1_1	2	8	PF00069	0.423
MOD_CK1_1	84	90	PF00069	0.693
MOD_CK2_1	147	153	PF00069	0.660
MOD_CK2_1	32	38	PF00069	0.591
MOD_GlcNHglycan	1	4	PF01048	0.600
MOD_GlcNHglycan	35	38	PF01048	0.558
MOD_GSK3_1	14	21	PF00069	0.634
MOD_GSK3_1	147	154	PF00069	0.708
MOD_GSK3_1	77	84	PF00069	0.725
MOD_NEK2_1	32	37	PF00069	0.520
MOD_NEK2_2	18	23	PF00069	0.718
MOD_PKA_2	188	194	PF00069	0.542
MOD_Plk_1	157	163	PF00069	0.553
MOD_Plk_4	14	20	PF00069	0.705
MOD_Plk_4	175	181	PF00069	0.468
MOD_Plk_4	64	70	PF00069	0.354
MOD_ProDKin_1	47	53	PF00069	0.433
MOD_ProDKin_1	82	88	PF00069	0.621
TRG_ENDOCYTIC_2	179	182	PF00928	0.548
TRG_ENDOCYTIC_2	29	32	PF00928	0.443
TRG_ER_diArg_1	57	60	PF00400	0.538
TRG_NLS_MonoExtC_3	57	62	PF00514	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P728	Leptomonas seymouri	47%	96%
A0A1X0NVU1	Trypanosomatidae	30%	100%
A0A3Q8IDQ8	Leishmania donovani	83%	100%
A4HG69	Leishmania braziliensis	73%	100%
A4I3B2	Leishmania infantum	83%	100%
Q4Q8P2	Leishmania major	85%	100%