Phosphoadenosine phosphosulfate reductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoadenosine phosphosulfate reductase-like protein

Species:

Leishmania mexicana

UniProt:

E9AZI8_LEIMU

TriTrypDb:

LmxM.28.0270

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

E9AZI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZI8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006747	FAD biosynthetic process	7	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0042726	flavin-containing compound metabolic process	4	1
GO:0042727	flavin-containing compound biosynthetic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046443	FAD metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072387	flavin adenine dinucleotide metabolic process	5	1
GO:0072388	flavin adenine dinucleotide biosynthetic process	6	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0003919	FMN adenylyltransferase activity	6	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0070566	adenylyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.245
CLV_NRD_NRD_1	46	48	PF00675	0.593
CLV_NRD_NRD_1	71	73	PF00675	0.601
CLV_PCSK_KEX2_1	190	192	PF00082	0.592
CLV_PCSK_KEX2_1	21	23	PF00082	0.535
CLV_PCSK_KEX2_1	46	48	PF00082	0.593
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.457
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.535
CLV_PCSK_SKI1_1	111	115	PF00082	0.286
CLV_PCSK_SKI1_1	17	21	PF00082	0.474
CLV_PCSK_SKI1_1	47	51	PF00082	0.602
CLV_Separin_Metazoa	43	47	PF03568	0.610
DOC_MAPK_MEF2A_6	107	114	PF00069	0.478
DOC_PP1_RVXF_1	109	115	PF00149	0.520
DOC_USP7_MATH_1	165	169	PF00917	0.520
DOC_USP7_UBL2_3	103	107	PF12436	0.370
DOC_USP7_UBL2_3	17	21	PF12436	0.339
DOC_WW_Pin1_4	132	137	PF00397	0.539
LIG_14-3-3_CanoR_1	118	122	PF00244	0.400
LIG_14-3-3_CanoR_1	46	52	PF00244	0.604
LIG_14-3-3_CanoR_1	8	16	PF00244	0.565
LIG_14-3-3_CterR_2	212	215	PF00244	0.686
LIG_Actin_WH2_2	97	113	PF00022	0.367
LIG_BIR_II_1	1	5	PF00653	0.544
LIG_FHA_1	48	54	PF00498	0.597
LIG_LIR_Gen_1	171	181	PF02991	0.518
LIG_LIR_Gen_1	66	76	PF02991	0.523
LIG_LIR_Nem_3	135	141	PF02991	0.487
LIG_LIR_Nem_3	171	177	PF02991	0.541
LIG_LIR_Nem_3	18	23	PF02991	0.556
LIG_LIR_Nem_3	66	71	PF02991	0.549
LIG_SH2_CRK	158	162	PF00017	0.449
LIG_SH2_CRK	174	178	PF00017	0.383
LIG_SH2_NCK_1	174	178	PF00017	0.529
LIG_SH2_SRC	23	26	PF00017	0.538
LIG_SH2_STAP1	158	162	PF00017	0.484
LIG_SH2_STAT5	14	17	PF00017	0.442
LIG_SH2_STAT5	158	161	PF00017	0.440
LIG_SH3_1	133	139	PF00018	0.515
LIG_SH3_3	133	139	PF00018	0.526
LIG_SH3_3	46	52	PF00018	0.665
LIG_UBA3_1	15	21	PF00899	0.517
MOD_CK1_1	172	178	PF00069	0.499
MOD_CK1_1	180	186	PF00069	0.551
MOD_CK2_1	165	171	PF00069	0.526
MOD_GlcNHglycan	171	174	PF01048	0.315
MOD_GSK3_1	165	172	PF00069	0.509
MOD_GSK3_1	173	180	PF00069	0.451
MOD_N-GLC_1	9	14	PF02516	0.512
MOD_NEK2_1	114	119	PF00069	0.389
MOD_NEK2_1	148	153	PF00069	0.512
MOD_NEK2_1	169	174	PF00069	0.538
MOD_NEK2_1	97	102	PF00069	0.553
MOD_NEK2_2	165	170	PF00069	0.520
MOD_PIKK_1	91	97	PF00454	0.586
MOD_PKA_2	117	123	PF00069	0.368
MOD_Plk_4	165	171	PF00069	0.520
MOD_Plk_4	35	41	PF00069	0.484
MOD_Plk_4	97	103	PF00069	0.626
MOD_ProDKin_1	132	138	PF00069	0.539
TRG_AP2beta_CARGO_1	66	75	PF09066	0.617
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.596
TRG_ENDOCYTIC_2	158	161	PF00928	0.455
TRG_ENDOCYTIC_2	174	177	PF00928	0.361
TRG_ER_diArg_1	45	47	PF00400	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7C6	Leptomonas seymouri	58%	86%
A0A0S4IUQ2	Bodo saltans	40%	93%
A0A1X0NVD4	Trypanosomatidae	46%	66%
A0A3S7X154	Leishmania donovani	94%	100%
A4HG68	Leishmania braziliensis	87%	100%
A4I3B1	Leishmania infantum	94%	100%
D0A7S9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	67%
O74841	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	81%
P38913	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	70%
Q4Q8P3	Leishmania major	94%	100%
V5B9Z2	Trypanosoma cruzi	44%	67%