NADH-u_ox-rdase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit, putative

Species:

Leishmania mexicana

UniProt:

E9AZI6_LEIMU

TriTrypDb:

LmxM.28.0250

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.440
CLV_NRD_NRD_1	182	184	PF00675	0.403
CLV_NRD_NRD_1	200	202	PF00675	0.364
CLV_NRD_NRD_1	238	240	PF00675	0.525
CLV_NRD_NRD_1	58	60	PF00675	0.477
CLV_PCSK_KEX2_1	195	197	PF00082	0.471
CLV_PCSK_KEX2_1	200	202	PF00082	0.425
CLV_PCSK_KEX2_1	58	60	PF00082	0.477
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.523
CLV_PCSK_PC7_1	196	202	PF00082	0.508
CLV_PCSK_SKI1_1	154	158	PF00082	0.407
CLV_PCSK_SKI1_1	17	21	PF00082	0.483
CLV_PCSK_SKI1_1	64	68	PF00082	0.467
DOC_AGCK_PIF_1	111	116	PF00069	0.292
DOC_CKS1_1	226	231	PF01111	0.533
DOC_CKS1_1	81	86	PF01111	0.274
DOC_PP4_FxxP_1	282	285	PF00568	0.661
DOC_SPAK_OSR1_1	136	140	PF12202	0.344
DOC_USP7_MATH_1	288	292	PF00917	0.621
DOC_USP7_MATH_1	43	47	PF00917	0.442
DOC_USP7_MATH_2	211	217	PF00917	0.425
DOC_WW_Pin1_4	225	230	PF00397	0.522
DOC_WW_Pin1_4	245	250	PF00397	0.378
DOC_WW_Pin1_4	266	271	PF00397	0.658
DOC_WW_Pin1_4	80	85	PF00397	0.492
DOC_WW_Pin1_4	88	93	PF00397	0.297
LIG_14-3-3_CanoR_1	121	127	PF00244	0.298
LIG_14-3-3_CanoR_1	136	142	PF00244	0.319
LIG_14-3-3_CanoR_1	51	55	PF00244	0.469
LIG_Actin_WH2_2	111	129	PF00022	0.344
LIG_BIR_II_1	1	5	PF00653	0.560
LIG_BIR_III_3	1	5	PF00653	0.545
LIG_BRCT_BRCA1_1	133	137	PF00533	0.344
LIG_deltaCOP1_diTrp_1	197	202	PF00928	0.428
LIG_FHA_1	212	218	PF00498	0.495
LIG_FHA_1	258	264	PF00498	0.536
LIG_FHA_1	7	13	PF00498	0.640
LIG_FHA_1	75	81	PF00498	0.566
LIG_FHA_1	89	95	PF00498	0.257
LIG_FHA_2	1	7	PF00498	0.565
LIG_FHA_2	230	236	PF00498	0.467
LIG_FHA_2	30	36	PF00498	0.516
LIG_FHA_2	65	71	PF00498	0.493
LIG_HCF-1_HBM_1	60	63	PF13415	0.489
LIG_IBAR_NPY_1	241	243	PF08397	0.511
LIG_LIR_Apic_2	281	285	PF02991	0.599
LIG_LIR_Gen_1	135	146	PF02991	0.320
LIG_LIR_Gen_1	213	223	PF02991	0.429
LIG_LIR_Gen_1	70	76	PF02991	0.498
LIG_LIR_Nem_3	135	141	PF02991	0.429
LIG_LIR_Nem_3	186	191	PF02991	0.504
LIG_LIR_Nem_3	203	207	PF02991	0.348
LIG_LIR_Nem_3	213	218	PF02991	0.424
LIG_LIR_Nem_3	227	233	PF02991	0.453
LIG_LIR_Nem_3	252	257	PF02991	0.544
LIG_LIR_Nem_3	266	271	PF02991	0.606
LIG_LIR_Nem_3	60	66	PF02991	0.493
LIG_LIR_Nem_3	70	74	PF02991	0.504
LIG_LIR_Nem_3	83	88	PF02991	0.257
LIG_PCNA_PIPBox_1	156	165	PF02747	0.293
LIG_PDZ_Class_1	292	297	PF00595	0.539
LIG_Pex14_1	198	202	PF04695	0.414
LIG_Pex14_1	226	230	PF04695	0.478
LIG_Pex14_2	137	141	PF04695	0.450
LIG_Pex14_2	218	222	PF04695	0.569
LIG_PTB_Apo_2	238	245	PF02174	0.518
LIG_PTB_Apo_2	65	72	PF02174	0.496
LIG_PTB_Phospho_1	65	71	PF10480	0.493
LIG_SH2_CRK	230	234	PF00017	0.591
LIG_SH2_CRK	268	272	PF00017	0.699
LIG_SH2_CRK	63	67	PF00017	0.469
LIG_SH2_GRB2like	71	74	PF00017	0.504
LIG_SH2_SRC	104	107	PF00017	0.274
LIG_SH2_SRC	28	31	PF00017	0.556
LIG_SH2_STAP1	116	120	PF00017	0.348
LIG_SH2_STAP1	257	261	PF00017	0.662
LIG_SH2_STAT5	191	194	PF00017	0.473
LIG_SH2_STAT5	243	246	PF00017	0.518
LIG_SH2_STAT5	280	283	PF00017	0.536
LIG_SH2_STAT5	71	74	PF00017	0.509
LIG_TRAF2_1	37	40	PF00917	0.491
LIG_TYR_ITSM	226	233	PF00017	0.524
LIG_WRC_WIRS_1	138	143	PF05994	0.332
MOD_CDK_SPxK_1	245	251	PF00069	0.503
MOD_CDK_SPxxK_3	266	273	PF00069	0.528
MOD_CK1_1	122	128	PF00069	0.308
MOD_CK1_1	140	146	PF00069	0.308
MOD_CK1_1	216	222	PF00069	0.415
MOD_CK1_1	266	272	PF00069	0.578
MOD_CK1_1	289	295	PF00069	0.528
MOD_CK2_1	29	35	PF00069	0.535
MOD_GlcNHglycan	159	162	PF01048	0.430
MOD_GlcNHglycan	218	221	PF01048	0.405
MOD_GlcNHglycan	245	248	PF01048	0.575
MOD_GlcNHglycan	294	297	PF01048	0.608
MOD_GSK3_1	122	129	PF00069	0.330
MOD_GSK3_1	225	232	PF00069	0.524
MOD_GSK3_1	288	295	PF00069	0.579
MOD_GSK3_1	90	97	PF00069	0.407
MOD_N-GLC_1	278	283	PF02516	0.563
MOD_N-GLC_1	74	79	PF02516	0.547
MOD_NEK2_1	112	117	PF00069	0.394
MOD_NEK2_1	126	131	PF00069	0.314
MOD_NEK2_1	137	142	PF00069	0.303
MOD_NEK2_1	157	162	PF00069	0.360
MOD_NEK2_1	49	54	PF00069	0.471
MOD_NEK2_1	74	79	PF00069	0.547
MOD_NEK2_2	152	157	PF00069	0.317
MOD_PKA_2	126	132	PF00069	0.353
MOD_PKA_2	157	163	PF00069	0.275
MOD_PKA_2	50	56	PF00069	0.469
MOD_Plk_1	23	29	PF00069	0.614
MOD_Plk_1	278	284	PF00069	0.669
MOD_Plk_4	114	120	PF00069	0.437
MOD_Plk_4	140	146	PF00069	0.293
MOD_Plk_4	90	96	PF00069	0.393
MOD_ProDKin_1	225	231	PF00069	0.526
MOD_ProDKin_1	245	251	PF00069	0.378
MOD_ProDKin_1	266	272	PF00069	0.654
MOD_ProDKin_1	80	86	PF00069	0.301
MOD_ProDKin_1	88	94	PF00069	0.297
MOD_SUMO_for_1	264	267	PF00179	0.590
TRG_ENDOCYTIC_2	153	156	PF00928	0.291
TRG_ENDOCYTIC_2	230	233	PF00928	0.571
TRG_ENDOCYTIC_2	268	271	PF00928	0.584
TRG_ENDOCYTIC_2	63	66	PF00928	0.468
TRG_ENDOCYTIC_2	71	74	PF00928	0.486
TRG_ER_diArg_1	200	202	PF00400	0.410
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT8	Leptomonas seymouri	70%	99%
A0A0S4IUG6	Bodo saltans	51%	100%
A0A1X0NVZ8	Trypanosomatidae	64%	100%
A0A3S7X178	Leishmania donovani	99%	100%
A4HG66	Leishmania braziliensis	92%	100%
A4I3A9	Leishmania infantum	99%	100%
D0A7S5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
Q4Q8P5	Leishmania major	97%	100%
V5DAH1	Trypanosoma cruzi	64%	100%