Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZI3_LEIMU

TriTrypDb:

LmxM.28.0220

Length:

356

Annotations

LeishMANIAdb annotations

Related to many other eukaryotic palmitoyltransferases (e.g. mammalian ZDHHC4/9/14/24)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	22
GO:0110165	cellular anatomical entity	1	22
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

E9AZI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZI3

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	1
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	22
GO:0016409	palmitoyltransferase activity	5	22
GO:0016417	S-acyltransferase activity	5	22
GO:0016740	transferase activity	2	22
GO:0016746	acyltransferase activity	3	22
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	22
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	22
GO:0019707	protein-cysteine S-acyltransferase activity	3	22
GO:0140096	catalytic activity, acting on a protein	2	22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	340	344	PF00656	0.536
CLV_NRD_NRD_1	172	174	PF00675	0.235
CLV_NRD_NRD_1	262	264	PF00675	0.526
CLV_NRD_NRD_1	308	310	PF00675	0.236
CLV_NRD_NRD_1	312	314	PF00675	0.238
CLV_NRD_NRD_1	325	327	PF00675	0.329
CLV_NRD_NRD_1	64	66	PF00675	0.401
CLV_NRD_NRD_1	76	78	PF00675	0.327
CLV_PCSK_KEX2_1	172	174	PF00082	0.237
CLV_PCSK_KEX2_1	262	264	PF00082	0.496
CLV_PCSK_KEX2_1	308	310	PF00082	0.234
CLV_PCSK_KEX2_1	325	327	PF00082	0.298
CLV_PCSK_KEX2_1	64	66	PF00082	0.374
CLV_PCSK_KEX2_1	76	78	PF00082	0.339
CLV_PCSK_SKI1_1	207	211	PF00082	0.265
CLV_PCSK_SKI1_1	229	233	PF00082	0.495
CLV_PCSK_SKI1_1	332	336	PF00082	0.373
CLV_PCSK_SKI1_1	69	73	PF00082	0.392
DEG_APCC_DBOX_1	76	84	PF00400	0.494
DEG_SCF_FBW7_1	248	253	PF00400	0.216
DOC_ANK_TNKS_1	15	22	PF00023	0.619
DOC_CKS1_1	251	256	PF01111	0.164
DOC_CYCLIN_RxL_1	226	234	PF00134	0.373
DOC_CYCLIN_RxL_1	46	57	PF00134	0.561
DOC_MAPK_gen_1	204	213	PF00069	0.430
DOC_MAPK_gen_1	313	320	PF00069	0.656
DOC_MAPK_gen_1	76	85	PF00069	0.601
DOC_MAPK_JIP1_4	47	53	PF00069	0.594
DOC_MAPK_MEF2A_6	313	322	PF00069	0.557
DOC_MAPK_MEF2A_6	76	85	PF00069	0.445
DOC_PP1_RVXF_1	202	209	PF00149	0.454
DOC_PP1_RVXF_1	47	54	PF00149	0.694
DOC_PP4_FxxP_1	335	338	PF00568	0.474
DOC_WW_Pin1_4	246	251	PF00397	0.252
DOC_WW_Pin1_4	40	45	PF00397	0.688
LIG_14-3-3_CanoR_1	207	212	PF00244	0.470
LIG_14-3-3_CanoR_1	262	266	PF00244	0.352
LIG_14-3-3_CanoR_1	28	36	PF00244	0.623
LIG_14-3-3_CanoR_1	313	319	PF00244	0.636
LIG_14-3-3_CanoR_1	64	72	PF00244	0.519
LIG_Actin_WH2_2	134	152	PF00022	0.362
LIG_AP2alpha_1	232	236	PF02296	0.227
LIG_BIR_II_1	1	5	PF00653	0.599
LIG_BIR_III_4	18	22	PF00653	0.621
LIG_BRCT_BRCA1_1	87	91	PF00533	0.566
LIG_eIF4E_1	121	127	PF01652	0.376
LIG_eIF4E_1	230	236	PF01652	0.258
LIG_FHA_1	136	142	PF00498	0.389
LIG_FHA_1	208	214	PF00498	0.352
LIG_FHA_1	226	232	PF00498	0.325
LIG_FHA_1	99	105	PF00498	0.290
LIG_FHA_2	137	143	PF00498	0.416
LIG_FHA_2	235	241	PF00498	0.249
LIG_FHA_2	305	311	PF00498	0.450
LIG_GBD_Chelix_1	275	283	PF00786	0.393
LIG_GBD_Chelix_1	286	294	PF00786	0.235
LIG_LIR_Gen_1	120	129	PF02991	0.293
LIG_LIR_Nem_3	120	126	PF02991	0.309
LIG_LIR_Nem_3	228	233	PF02991	0.311
LIG_LIR_Nem_3	50	56	PF02991	0.669
LIG_LIR_Nem_3	74	78	PF02991	0.500
LIG_LYPXL_S_1	145	149	PF13949	0.280
LIG_LYPXL_yS_3	146	149	PF13949	0.484
LIG_LYPXL_yS_3	255	258	PF13949	0.227
LIG_MLH1_MIPbox_1	88	92	PF16413	0.384
LIG_NRBOX	278	284	PF00104	0.392
LIG_NRBOX	317	323	PF00104	0.551
LIG_Pex14_1	208	212	PF04695	0.280
LIG_Pex14_1	226	230	PF04695	0.311
LIG_Pex14_2	132	136	PF04695	0.340
LIG_Pex14_2	232	236	PF04695	0.322
LIG_Pex14_2	331	335	PF04695	0.414
LIG_Pex14_2	87	91	PF04695	0.509
LIG_SH2_CRK	17	21	PF00017	0.572
LIG_SH2_NCK_1	17	21	PF00017	0.572
LIG_SH2_STAT5	121	124	PF00017	0.374
LIG_SH2_STAT5	212	215	PF00017	0.293
LIG_SH2_STAT5	230	233	PF00017	0.341
LIG_SH2_STAT5	298	301	PF00017	0.310
LIG_SH2_STAT5	86	89	PF00017	0.506
LIG_SH3_1	17	23	PF00018	0.573
LIG_SH3_2	23	28	PF14604	0.625
LIG_SH3_3	17	23	PF00018	0.620
LIG_SH3_3	331	337	PF00018	0.538
LIG_SH3_3	36	42	PF00018	0.676
LIG_SUMO_SIM_anti_2	101	107	PF11976	0.323
LIG_SUMO_SIM_par_1	124	131	PF11976	0.393
LIG_UBA3_1	80	84	PF00899	0.497
LIG_WRC_WIRS_1	72	77	PF05994	0.433
LIG_WW_3	173	177	PF00397	0.488
MOD_CDK_SPxxK_3	40	47	PF00069	0.639
MOD_CK1_1	215	221	PF00069	0.323
MOD_CK1_1	24	30	PF00069	0.711
MOD_CK1_1	304	310	PF00069	0.449
MOD_CK2_1	304	310	PF00069	0.437
MOD_CK2_1	64	70	PF00069	0.570
MOD_Cter_Amidation	260	263	PF01082	0.498
MOD_GlcNHglycan	1	4	PF01048	0.518
MOD_GlcNHglycan	29	32	PF01048	0.529
MOD_GSK3_1	127	134	PF00069	0.317
MOD_GSK3_1	212	219	PF00069	0.366
MOD_GSK3_1	246	253	PF00069	0.268
MOD_GSK3_1	299	306	PF00069	0.310
MOD_GSK3_1	337	344	PF00069	0.536
MOD_N-GLC_1	243	248	PF02516	0.474
MOD_N-GLC_1	65	70	PF02516	0.282
MOD_N-GLC_2	184	186	PF02516	0.262
MOD_NEK2_1	127	132	PF00069	0.316
MOD_NEK2_1	136	141	PF00069	0.300
MOD_NEK2_1	290	295	PF00069	0.349
MOD_NEK2_1	301	306	PF00069	0.458
MOD_NEK2_1	98	103	PF00069	0.408
MOD_NEK2_2	71	76	PF00069	0.523
MOD_PKA_1	308	314	PF00069	0.479
MOD_PKA_1	64	70	PF00069	0.469
MOD_PKA_2	261	267	PF00069	0.369
MOD_PKA_2	27	33	PF00069	0.754
MOD_PKA_2	308	314	PF00069	0.470
MOD_PKA_2	64	70	PF00069	0.597
MOD_Plk_1	350	356	PF00069	0.577
MOD_Plk_4	192	198	PF00069	0.502
MOD_Plk_4	217	223	PF00069	0.380
MOD_Plk_4	290	296	PF00069	0.268
MOD_Plk_4	337	343	PF00069	0.505
MOD_ProDKin_1	246	252	PF00069	0.252
MOD_ProDKin_1	40	46	PF00069	0.688
TRG_DiLeu_BaEn_1	351	356	PF01217	0.648
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.469
TRG_ENDOCYTIC_2	146	149	PF00928	0.480
TRG_ENDOCYTIC_2	233	236	PF00928	0.320
TRG_ENDOCYTIC_2	255	258	PF00928	0.348
TRG_ENDOCYTIC_2	298	301	PF00928	0.301
TRG_ER_diArg_1	147	150	PF00400	0.521
TRG_ER_diArg_1	171	173	PF00400	0.435
TRG_ER_diArg_1	324	326	PF00400	0.629
TRG_ER_diArg_1	75	77	PF00400	0.568
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P729	Leptomonas seymouri	33%	100%
A0A0N1HZ19	Leptomonas seymouri	61%	100%
A0A0N1IMN2	Leptomonas seymouri	27%	81%
A0A0S4IT15	Bodo saltans	39%	100%
A0A0S4IXZ6	Bodo saltans	29%	100%
A0A0S4JRL4	Bodo saltans	39%	99%
A0A1X0NX08	Trypanosomatidae	41%	100%
A0A3Q8ICY2	Leishmania donovani	88%	100%
A0A3Q8IIC8	Leishmania donovani	25%	100%
A0A3R7N519	Trypanosoma rangeli	39%	100%
A4HG63	Leishmania braziliensis	70%	100%
A4HMS9	Leishmania braziliensis	27%	100%
A4I395	Leishmania infantum	88%	100%
A4IBG8	Leishmania infantum	25%	100%
B3DN87	Arabidopsis thaliana	26%	100%
D0A7S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A893	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	76%
E9AF82	Leishmania major	28%	100%
E9B6D8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
J9VJ99	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	25%	78%
P0CS68	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	24%	78%
P0CS69	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	24%	78%
Q0WQK2	Arabidopsis thaliana	25%	80%
Q4Q8P8	Leishmania major	88%	100%
Q4Q9K8	Leishmania major	24%	100%
Q5PNZ1	Arabidopsis thaliana	24%	86%
Q5REH2	Pongo abelii	24%	86%
Q8VYS8	Arabidopsis thaliana	23%	87%
Q9CPV7	Mus musculus	24%	86%
Q9FLM3	Arabidopsis thaliana	25%	87%
Q9H6R6	Homo sapiens	24%	86%
Q9NXF8	Homo sapiens	22%	100%
Q9SB58	Arabidopsis thaliana	25%	87%
V5BC02	Trypanosoma cruzi	41%	100%