Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZI3_LEIMU

TriTrypDb:

LmxM.28.0220

Length:

356

Annotations

LeishMANIAdb annotations

Related to many other eukaryotic palmitoyltransferases (e.g. mammalian ZDHHC4/9/14/24)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	22
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	22

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Expansion

Sequence features

E9AZI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZI3

Function

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Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006897	endocytosis	5	1
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	22
GO:0016409	palmitoyltransferase activity	5	22
GO:0016417	S-acyltransferase activity	5	22
GO:0016740	transferase activity	2	22
GO:0016746	acyltransferase activity	3	22
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	22
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	22
GO:0019707	protein-cysteine S-acyltransferase activity	3	22
GO:0140096	catalytic activity, acting on a protein	2	22

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	340	344	PF00656	0.536
CLV_NRD_NRD_1	172	174	PF00675	0.235
CLV_NRD_NRD_1	262	264	PF00675	0.526
CLV_NRD_NRD_1	308	310	PF00675	0.236
CLV_NRD_NRD_1	312	314	PF00675	0.238
CLV_NRD_NRD_1	325	327	PF00675	0.329
CLV_NRD_NRD_1	64	66	PF00675	0.401
CLV_NRD_NRD_1	76	78	PF00675	0.327
CLV_PCSK_KEX2_1	172	174	PF00082	0.237
CLV_PCSK_KEX2_1	262	264	PF00082	0.496

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P729	Leptomonas seymouri	33%	100%
A0A0N1HZ19	Leptomonas seymouri	61%	100%
A0A0N1IMN2	Leptomonas seymouri	27%	81%
A0A0S4IT15	Bodo saltans	39%	100%
A0A0S4IXZ6	Bodo saltans	29%	100%
A0A0S4JRL4	Bodo saltans	39%	99%
A0A1X0NX08	Trypanosomatidae	41%	100%
A0A3Q8ICY2	Leishmania donovani	88%	100%
A0A3Q8IIC8	Leishmania donovani	25%	100%
A0A3R7N519	Trypanosoma rangeli	39%	100%

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