Aminotran_5 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZI1_LEIMU

TriTrypDb:

LmxM.28.0200

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZI1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.653
CLV_NRD_NRD_1	10	12	PF00675	0.397
CLV_NRD_NRD_1	109	111	PF00675	0.741
CLV_NRD_NRD_1	166	168	PF00675	0.421
CLV_NRD_NRD_1	385	387	PF00675	0.377
CLV_NRD_NRD_1	510	512	PF00675	0.413
CLV_NRD_NRD_1	593	595	PF00675	0.437
CLV_PCSK_KEX2_1	10	12	PF00082	0.579
CLV_PCSK_KEX2_1	111	113	PF00082	0.723
CLV_PCSK_KEX2_1	166	168	PF00082	0.421
CLV_PCSK_KEX2_1	510	512	PF00082	0.324
CLV_PCSK_KEX2_1	553	555	PF00082	0.377
CLV_PCSK_KEX2_1	79	81	PF00082	0.374
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.723
CLV_PCSK_PC1ET2_1	553	555	PF00082	0.377
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.415
CLV_PCSK_SKI1_1	249	253	PF00082	0.343
CLV_PCSK_SKI1_1	79	83	PF00082	0.350
CLV_Separin_Metazoa	116	120	PF03568	0.451
DEG_APCC_DBOX_1	248	256	PF00400	0.353
DEG_SPOP_SBC_1	362	366	PF00917	0.366
DOC_CKS1_1	568	573	PF01111	0.386
DOC_CYCLIN_RxL_1	305	316	PF00134	0.213
DOC_CYCLIN_yCln2_LP_2	471	477	PF00134	0.334
DOC_MAPK_gen_1	166	173	PF00069	0.390
DOC_MAPK_gen_1	381	390	PF00069	0.427
DOC_MAPK_gen_1	510	521	PF00069	0.395
DOC_MAPK_MEF2A_6	249	256	PF00069	0.332
DOC_MAPK_NFAT4_5	249	257	PF00069	0.352
DOC_PP1_RVXF_1	306	313	PF00149	0.208
DOC_PP2B_LxvP_1	101	104	PF13499	0.567
DOC_PP2B_LxvP_1	471	474	PF13499	0.334
DOC_PP4_FxxP_1	423	426	PF00568	0.343
DOC_USP7_MATH_1	160	164	PF00917	0.488
DOC_USP7_MATH_1	41	45	PF00917	0.533
DOC_USP7_MATH_1	506	510	PF00917	0.419
DOC_USP7_MATH_1	517	521	PF00917	0.269
DOC_WW_Pin1_4	207	212	PF00397	0.371
DOC_WW_Pin1_4	422	427	PF00397	0.376
DOC_WW_Pin1_4	567	572	PF00397	0.359
DOC_WW_Pin1_4	588	593	PF00397	0.485
LIG_14-3-3_CanoR_1	10	14	PF00244	0.570
LIG_14-3-3_CanoR_1	166	174	PF00244	0.391
LIG_14-3-3_CanoR_1	37	46	PF00244	0.331
LIG_14-3-3_CanoR_1	562	568	PF00244	0.313
LIG_Actin_WH2_2	548	564	PF00022	0.450
LIG_Clathr_ClatBox_1	60	64	PF01394	0.491
LIG_EVH1_2	70	74	PF00568	0.371
LIG_FHA_1	149	155	PF00498	0.676
LIG_FHA_1	278	284	PF00498	0.339
LIG_FHA_1	299	305	PF00498	0.362
LIG_FHA_1	341	347	PF00498	0.357
LIG_FHA_1	353	359	PF00498	0.293
LIG_FHA_1	363	369	PF00498	0.293
LIG_FHA_1	372	378	PF00498	0.238
LIG_FHA_2	134	140	PF00498	0.675
LIG_FHA_2	153	159	PF00498	0.724
LIG_FHA_2	568	574	PF00498	0.381
LIG_LIR_Apic_2	65	71	PF02991	0.460
LIG_LIR_Gen_1	165	176	PF02991	0.573
LIG_LIR_Gen_1	300	310	PF02991	0.343
LIG_LIR_Gen_1	469	477	PF02991	0.413
LIG_LIR_Gen_1	572	582	PF02991	0.346
LIG_LIR_Gen_1	97	108	PF02991	0.458
LIG_LIR_Nem_3	165	171	PF02991	0.693
LIG_LIR_Nem_3	205	209	PF02991	0.211
LIG_LIR_Nem_3	300	306	PF02991	0.343
LIG_LIR_Nem_3	400	406	PF02991	0.425
LIG_LIR_Nem_3	44	49	PF02991	0.479
LIG_LIR_Nem_3	464	470	PF02991	0.348
LIG_LIR_Nem_3	572	577	PF02991	0.348
LIG_LIR_Nem_3	72	77	PF02991	0.427
LIG_LIR_Nem_3	97	103	PF02991	0.529
LIG_NRBOX	26	32	PF00104	0.532
LIG_Pex14_2	173	177	PF04695	0.328
LIG_PTB_Apo_2	275	282	PF02174	0.353
LIG_REV1ctd_RIR_1	429	439	PF16727	0.456
LIG_SH2_GRB2like	206	209	PF00017	0.311
LIG_SH2_NCK_1	568	572	PF00017	0.374
LIG_SH2_PTP2	574	577	PF00017	0.420
LIG_SH2_SRC	235	238	PF00017	0.493
LIG_SH2_STAP1	235	239	PF00017	0.369
LIG_SH2_STAP1	257	261	PF00017	0.364
LIG_SH2_STAT5	100	103	PF00017	0.472
LIG_SH2_STAT5	206	209	PF00017	0.274
LIG_SH2_STAT5	303	306	PF00017	0.363
LIG_SH2_STAT5	361	364	PF00017	0.308
LIG_SH2_STAT5	470	473	PF00017	0.320
LIG_SH2_STAT5	491	494	PF00017	0.399
LIG_SH2_STAT5	537	540	PF00017	0.378
LIG_SH2_STAT5	560	563	PF00017	0.327
LIG_SH2_STAT5	574	577	PF00017	0.299
LIG_SH3_3	519	525	PF00018	0.337
LIG_SH3_3	545	551	PF00018	0.387
LIG_SH3_3	586	592	PF00018	0.544
LIG_SH3_3	89	95	PF00018	0.521
LIG_SUMO_SIM_anti_2	122	128	PF11976	0.528
LIG_SUMO_SIM_par_1	252	258	PF11976	0.321
LIG_SUMO_SIM_par_1	355	360	PF11976	0.326
LIG_SUMO_SIM_par_1	520	526	PF11976	0.381
LIG_SUMO_SIM_par_1	579	586	PF11976	0.490
LIG_TYR_ITIM	204	209	PF00017	0.213
LIG_TYR_ITSM	299	306	PF00017	0.358
LIG_WRC_WIRS_1	49	54	PF05994	0.431
MOD_CDC14_SPxK_1	591	594	PF00782	0.522
MOD_CDK_SPK_2	422	427	PF00069	0.397
MOD_CDK_SPxK_1	588	594	PF00069	0.513
MOD_CDK_SPxxK_3	588	595	PF00069	0.456
MOD_CK1_1	169	175	PF00069	0.558
MOD_CK1_1	410	416	PF00069	0.398
MOD_CK1_1	51	57	PF00069	0.421
MOD_CK1_1	531	537	PF00069	0.518
MOD_CK1_1	604	610	PF00069	0.570
MOD_CK1_1	9	15	PF00069	0.556
MOD_CK2_1	110	116	PF00069	0.651
MOD_CK2_1	122	128	PF00069	0.576
MOD_CK2_1	129	135	PF00069	0.663
MOD_CK2_1	317	323	PF00069	0.377
MOD_CK2_1	517	523	PF00069	0.334
MOD_CK2_1	567	573	PF00069	0.357
MOD_CK2_1	80	86	PF00069	0.414
MOD_GlcNHglycan	143	146	PF01048	0.731
MOD_GlcNHglycan	158	161	PF01048	0.553
MOD_GlcNHglycan	168	171	PF01048	0.643
MOD_GlcNHglycan	177	180	PF01048	0.515
MOD_GlcNHglycan	365	368	PF01048	0.372
MOD_GlcNHglycan	39	42	PF01048	0.441
MOD_GlcNHglycan	497	500	PF01048	0.368
MOD_GlcNHglycan	563	566	PF01048	0.311
MOD_GSK3_1	106	113	PF00069	0.726
MOD_GSK3_1	129	136	PF00069	0.709
MOD_GSK3_1	148	155	PF00069	0.734
MOD_GSK3_1	156	163	PF00069	0.694
MOD_GSK3_1	31	38	PF00069	0.530
MOD_GSK3_1	441	448	PF00069	0.403
MOD_GSK3_1	490	497	PF00069	0.467
MOD_GSK3_1	600	607	PF00069	0.566
MOD_N-GLC_1	207	212	PF02516	0.419
MOD_N-GLC_1	277	282	PF02516	0.339
MOD_N-GLC_1	352	357	PF02516	0.500
MOD_NEK2_1	221	226	PF00069	0.314
MOD_NEK2_1	495	500	PF00069	0.363
MOD_NEK2_1	528	533	PF00069	0.495
MOD_NEK2_1	561	566	PF00069	0.426
MOD_NEK2_2	41	46	PF00069	0.497
MOD_NEK2_2	48	53	PF00069	0.417
MOD_PIKK_1	407	413	PF00454	0.474
MOD_PK_1	17	23	PF00069	0.580
MOD_PK_1	441	447	PF00069	0.534
MOD_PKA_1	110	116	PF00069	0.745
MOD_PKA_1	166	172	PF00069	0.400
MOD_PKA_2	166	172	PF00069	0.610
MOD_PKA_2	561	567	PF00069	0.313
MOD_PKA_2	600	606	PF00069	0.595
MOD_PKA_2	9	15	PF00069	0.375
MOD_Plk_1	277	283	PF00069	0.311
MOD_Plk_1	337	343	PF00069	0.459
MOD_Plk_1	35	41	PF00069	0.533
MOD_Plk_1	352	358	PF00069	0.244
MOD_Plk_1	64	70	PF00069	0.561
MOD_Plk_2-3	122	128	PF00069	0.528
MOD_Plk_4	122	128	PF00069	0.528
MOD_Plk_4	169	175	PF00069	0.371
MOD_Plk_4	221	227	PF00069	0.396
MOD_Plk_4	353	359	PF00069	0.337
MOD_Plk_4	41	47	PF00069	0.576
MOD_Plk_4	410	416	PF00069	0.324
MOD_Plk_4	441	447	PF00069	0.414
MOD_Plk_4	466	472	PF00069	0.418
MOD_Plk_4	517	523	PF00069	0.334
MOD_Plk_4	528	534	PF00069	0.359
MOD_ProDKin_1	207	213	PF00069	0.365
MOD_ProDKin_1	422	428	PF00069	0.384
MOD_ProDKin_1	567	573	PF00069	0.357
MOD_ProDKin_1	588	594	PF00069	0.485
MOD_SUMO_for_1	181	184	PF00179	0.254
MOD_SUMO_rev_2	135	142	PF00179	0.483
MOD_SUMO_rev_2	400	406	PF00179	0.477
TRG_DiLeu_BaEn_2	241	247	PF01217	0.451
TRG_DiLeu_LyEn_5	250	255	PF01217	0.398
TRG_ENDOCYTIC_2	100	103	PF00928	0.472
TRG_ENDOCYTIC_2	206	209	PF00928	0.239
TRG_ENDOCYTIC_2	303	306	PF00928	0.341
TRG_ENDOCYTIC_2	307	310	PF00928	0.328
TRG_ENDOCYTIC_2	470	473	PF00928	0.314
TRG_ENDOCYTIC_2	560	563	PF00928	0.308
TRG_ENDOCYTIC_2	574	577	PF00928	0.343
TRG_ER_diArg_1	166	168	PF00400	0.421
TRG_ER_diArg_1	380	383	PF00400	0.373
TRG_ER_diArg_1	510	512	PF00400	0.324
TRG_NLS_MonoExtC_3	109	114	PF00514	0.745
TRG_NLS_MonoExtN_4	108	115	PF00514	0.732
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.353
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	37	42	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7G6	Leptomonas seymouri	66%	95%
A0A1X0NVS7	Trypanosomatidae	68%	100%
A0A3R7RDE4	Trypanosoma rangeli	65%	100%
A0A3S7X145	Leishmania donovani	88%	100%
A4HG61	Leishmania braziliensis	78%	100%
A7UX13	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	100%
D0A7R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
Q4Q8Q0	Leishmania major	88%	100%
Q5JNT6	Oryza sativa subsp. japonica	27%	100%
Q9LGZ2	Oryza sativa subsp. japonica	26%	100%
V5D807	Trypanosoma cruzi	66%	100%