Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AZI0_LEIMU

TriTrypDb:

LmxM.28.0190

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZI0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.630
CLV_NRD_NRD_1	114	116	PF00675	0.612
CLV_NRD_NRD_1	122	124	PF00675	0.675
CLV_NRD_NRD_1	171	173	PF00675	0.830
CLV_NRD_NRD_1	228	230	PF00675	0.639
CLV_NRD_NRD_1	243	245	PF00675	0.633
CLV_NRD_NRD_1	247	249	PF00675	0.623
CLV_NRD_NRD_1	317	319	PF00675	0.693
CLV_NRD_NRD_1	346	348	PF00675	0.639
CLV_NRD_NRD_1	36	38	PF00675	0.659
CLV_NRD_NRD_1	420	422	PF00675	0.583
CLV_PCSK_KEX2_1	114	116	PF00082	0.612
CLV_PCSK_KEX2_1	171	173	PF00082	0.830
CLV_PCSK_KEX2_1	228	230	PF00082	0.639
CLV_PCSK_KEX2_1	243	245	PF00082	0.633
CLV_PCSK_KEX2_1	317	319	PF00082	0.671
CLV_PCSK_KEX2_1	322	324	PF00082	0.613
CLV_PCSK_KEX2_1	346	348	PF00082	0.639
CLV_PCSK_KEX2_1	357	359	PF00082	0.636
CLV_PCSK_KEX2_1	420	422	PF00082	0.619
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.637
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.738
CLV_PCSK_PC7_1	313	319	PF00082	0.672
CLV_PCSK_SKI1_1	103	107	PF00082	0.522
CLV_PCSK_SKI1_1	133	137	PF00082	0.555
CLV_PCSK_SKI1_1	229	233	PF00082	0.613
CLV_PCSK_SKI1_1	244	248	PF00082	0.637
CLV_PCSK_SKI1_1	285	289	PF00082	0.655
CLV_PCSK_SKI1_1	317	321	PF00082	0.685
CLV_PCSK_SKI1_1	346	350	PF00082	0.738
CLV_PCSK_SKI1_1	496	500	PF00082	0.558
CLV_PCSK_SKI1_1	511	515	PF00082	0.716
CLV_PCSK_SKI1_1	65	69	PF00082	0.582
CLV_PCSK_SKI1_1	82	86	PF00082	0.393
DEG_Nend_Nbox_1	1	3	PF02207	0.671
DEG_ODPH_VHL_1	433	444	PF01847	0.484
DEG_SCF_FBW7_1	230	236	PF00400	0.633
DEG_SPOP_SBC_1	143	147	PF00917	0.644
DEG_SPOP_SBC_1	411	415	PF00917	0.524
DOC_CKS1_1	230	235	PF01111	0.662
DOC_CKS1_1	380	385	PF01111	0.481
DOC_CYCLIN_yCln2_LP_2	302	305	PF00134	0.727
DOC_CYCLIN_yCln2_LP_2	386	392	PF00134	0.678
DOC_MAPK_MEF2A_6	228	237	PF00069	0.678
DOC_PP2B_LxvP_1	302	305	PF13499	0.727
DOC_PP2B_LxvP_1	386	389	PF13499	0.671
DOC_PP4_FxxP_1	432	435	PF00568	0.688
DOC_PP4_MxPP_1	275	278	PF00568	0.494
DOC_USP7_MATH_1	143	147	PF00917	0.620
DOC_USP7_MATH_1	204	208	PF00917	0.721
DOC_USP7_MATH_1	253	257	PF00917	0.637
DOC_USP7_MATH_1	462	466	PF00917	0.571
DOC_USP7_MATH_1	503	507	PF00917	0.541
DOC_USP7_MATH_1	73	77	PF00917	0.373
DOC_WW_Pin1_4	17	22	PF00397	0.620
DOC_WW_Pin1_4	171	176	PF00397	0.638
DOC_WW_Pin1_4	229	234	PF00397	0.661
DOC_WW_Pin1_4	288	293	PF00397	0.683
DOC_WW_Pin1_4	296	301	PF00397	0.730
DOC_WW_Pin1_4	379	384	PF00397	0.522
DOC_WW_Pin1_4	450	455	PF00397	0.711
LIG_14-3-3_CanoR_1	114	118	PF00244	0.664
LIG_14-3-3_CanoR_1	37	42	PF00244	0.733
LIG_14-3-3_CanoR_1	420	428	PF00244	0.708
LIG_14-3-3_CanoR_1	496	505	PF00244	0.719
LIG_BRCT_BRCA1_1	145	149	PF00533	0.616
LIG_BRCT_BRCA1_1	338	342	PF00533	0.615
LIG_BRCT_BRCA1_1	394	398	PF00533	0.724
LIG_BRCT_BRCA1_1	428	432	PF00533	0.696
LIG_BRCT_BRCA1_2	394	400	PF00533	0.726
LIG_DCNL_PONY_1	1	4	PF03556	0.665
LIG_eIF4E_1	225	231	PF01652	0.510
LIG_eIF4E_1	467	473	PF01652	0.599
LIG_EVH1_2	388	392	PF00568	0.696
LIG_FHA_1	230	236	PF00498	0.625
LIG_FHA_1	411	417	PF00498	0.714
LIG_FHA_1	51	57	PF00498	0.732
LIG_FHA_2	264	270	PF00498	0.786
LIG_FHA_2	376	382	PF00498	0.776
LIG_LIR_Apic_2	382	388	PF02991	0.659
LIG_LIR_Apic_2	429	435	PF02991	0.688
LIG_LIR_Gen_1	497	507	PF02991	0.685
LIG_LIR_Nem_3	286	290	PF02991	0.674
LIG_LIR_Nem_3	331	335	PF02991	0.428
LIG_MYND_1	300	304	PF01753	0.723
LIG_MYND_1	431	435	PF01753	0.648
LIG_Pex14_1	428	432	PF04695	0.482
LIG_Pex14_2	149	153	PF04695	0.563
LIG_SH2_CRK	15	19	PF00017	0.787
LIG_SH2_NCK_1	335	339	PF00017	0.423
LIG_SH2_SRC	385	388	PF00017	0.594
LIG_SH2_STAP1	457	461	PF00017	0.811
LIG_SH2_STAP1	95	99	PF00017	0.653
LIG_SH2_STAT3	41	44	PF00017	0.625
LIG_SH2_STAT3	479	482	PF00017	0.609
LIG_SH2_STAT5	385	388	PF00017	0.691
LIG_SH2_STAT5	512	515	PF00017	0.529
LIG_SH2_STAT5	55	58	PF00017	0.708
LIG_SH3_1	172	178	PF00018	0.667
LIG_SH3_2	239	244	PF14604	0.684
LIG_SH3_3	172	178	PF00018	0.667
LIG_SH3_3	198	204	PF00018	0.690
LIG_SH3_3	236	242	PF00018	0.738
LIG_SH3_3	294	300	PF00018	0.670
LIG_SH3_3	305	311	PF00018	0.643
LIG_SH3_3	443	449	PF00018	0.735
LIG_SH3_3	470	476	PF00018	0.765
LIG_SH3_3	478	484	PF00018	0.563
LIG_TRAF2_1	20	23	PF00917	0.696
LIG_TRAF2_1	506	509	PF00917	0.738
LIG_UBA3_1	106	111	PF00899	0.556
LIG_WW_1	454	457	PF00397	0.672
LIG_WW_3	240	244	PF00397	0.684
MOD_CK1_1	129	135	PF00069	0.613
MOD_CK1_1	181	187	PF00069	0.774
MOD_CK1_1	296	302	PF00069	0.730
MOD_CK1_1	331	337	PF00069	0.626
MOD_CK1_1	375	381	PF00069	0.704
MOD_CK1_1	391	397	PF00069	0.717
MOD_CK1_1	494	500	PF00069	0.774
MOD_CK2_1	16	22	PF00069	0.706
MOD_CK2_1	503	509	PF00069	0.752
MOD_CK2_1	73	79	PF00069	0.397
MOD_Cter_Amidation	226	229	PF01082	0.725
MOD_GlcNHglycan	146	149	PF01048	0.627
MOD_GlcNHglycan	167	170	PF01048	0.607
MOD_GlcNHglycan	259	262	PF01048	0.649
MOD_GlcNHglycan	266	269	PF01048	0.607
MOD_GlcNHglycan	85	88	PF01048	0.481
MOD_GSK3_1	113	120	PF00069	0.605
MOD_GSK3_1	129	136	PF00069	0.591
MOD_GSK3_1	167	174	PF00069	0.551
MOD_GSK3_1	177	184	PF00069	0.776
MOD_GSK3_1	229	236	PF00069	0.633
MOD_GSK3_1	253	260	PF00069	0.698
MOD_GSK3_1	279	286	PF00069	0.553
MOD_GSK3_1	333	340	PF00069	0.564
MOD_GSK3_1	342	349	PF00069	0.591
MOD_GSK3_1	368	375	PF00069	0.685
MOD_GSK3_1	388	395	PF00069	0.738
MOD_GSK3_1	497	504	PF00069	0.554
MOD_N-GLC_1	283	288	PF02516	0.691
MOD_N-GLC_1	436	441	PF02516	0.482
MOD_NEK2_1	257	262	PF00069	0.731
MOD_NEK2_1	279	284	PF00069	0.661
MOD_NEK2_1	337	342	PF00069	0.609
MOD_NEK2_1	392	397	PF00069	0.719
MOD_NEK2_2	137	142	PF00069	0.564
MOD_NEK2_2	233	238	PF00069	0.516
MOD_NEK2_2	351	356	PF00069	0.474
MOD_NEK2_2	436	441	PF00069	0.774
MOD_PIKK_1	178	184	PF00454	0.832
MOD_PKA_1	346	352	PF00069	0.739
MOD_PKA_1	37	43	PF00069	0.565
MOD_PKA_1	420	426	PF00069	0.578
MOD_PKA_2	113	119	PF00069	0.654
MOD_PKA_2	346	352	PF00069	0.739
MOD_PKA_2	36	42	PF00069	0.733
MOD_PKA_2	420	426	PF00069	0.624
MOD_PKA_2	74	80	PF00069	0.577
MOD_PKA_2	97	103	PF00069	0.476
MOD_Plk_1	283	289	PF00069	0.568
MOD_Plk_1	436	442	PF00069	0.483
MOD_Plk_1	50	56	PF00069	0.695
MOD_Plk_4	137	143	PF00069	0.572
MOD_Plk_4	253	259	PF00069	0.692
MOD_Plk_4	328	334	PF00069	0.588
MOD_Plk_4	338	344	PF00069	0.520
MOD_Plk_4	375	381	PF00069	0.782
MOD_Plk_4	51	57	PF00069	0.440
MOD_ProDKin_1	17	23	PF00069	0.618
MOD_ProDKin_1	171	177	PF00069	0.637
MOD_ProDKin_1	229	235	PF00069	0.662
MOD_ProDKin_1	288	294	PF00069	0.684
MOD_ProDKin_1	296	302	PF00069	0.734
MOD_ProDKin_1	379	385	PF00069	0.524
MOD_ProDKin_1	450	456	PF00069	0.710
MOD_SUMO_for_1	109	112	PF00179	0.581
MOD_SUMO_for_1	56	59	PF00179	0.739
MOD_SUMO_rev_2	504	513	PF00179	0.627
TRG_DiLeu_BaEn_1	254	259	PF01217	0.511
TRG_DiLeu_BaEn_1	321	326	PF01217	0.647
TRG_DiLeu_BaEn_4	51	57	PF01217	0.732
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.674
TRG_ENDOCYTIC_2	15	18	PF00928	0.787
TRG_ENDOCYTIC_2	490	493	PF00928	0.556
TRG_ER_diArg_1	113	115	PF00400	0.603
TRG_ER_diArg_1	228	230	PF00400	0.643
TRG_ER_diArg_1	242	244	PF00400	0.655
TRG_ER_diArg_1	317	319	PF00400	0.693
TRG_ER_diArg_1	420	422	PF00400	0.486
TRG_NLS_Bipartite_1	346	360	PF00514	0.448
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.732
TRG_Pf-PMV_PEXEL_1	323	328	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	496	501	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P724	Leptomonas seymouri	45%	71%
A0A3S7X148	Leishmania donovani	83%	100%
A4HG60	Leishmania braziliensis	57%	100%
A4I392	Leishmania infantum	82%	100%
Q4Q8Q1	Leishmania major	80%	100%