Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZH9_LEIMU

TriTrypDb:

LmxM.28.0180

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	6
GO:0016020	membrane	2	5

Expansion

Sequence features

E9AZH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZH9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	40	42	PF00675	0.504
CLV_NRD_NRD_1	46	48	PF00675	0.557
CLV_PCSK_KEX2_1	40	42	PF00082	0.507
CLV_PCSK_KEX2_1	46	48	PF00082	0.561
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.631
CLV_PCSK_SKI1_1	13	17	PF00082	0.484
CLV_PCSK_SKI1_1	155	159	PF00082	0.448
CLV_PCSK_SKI1_1	96	100	PF00082	0.403
DEG_APCC_DBOX_1	154	162	PF00400	0.450
DOC_CKS1_1	172	177	PF01111	0.483
DOC_PP2B_LxvP_1	195	198	PF13499	0.450
DOC_USP7_MATH_1	50	54	PF00917	0.544
DOC_WW_Pin1_4	110	115	PF00397	0.297
DOC_WW_Pin1_4	171	176	PF00397	0.490
DOC_WW_Pin1_4	96	101	PF00397	0.478
LIG_14-3-3_CanoR_1	128	134	PF00244	0.496
LIG_14-3-3_CanoR_1	186	191	PF00244	0.529
LIG_Actin_WH2_2	172	188	PF00022	0.365
LIG_BIR_II_1	1	5	PF00653	0.522
LIG_BRCT_BRCA1_1	192	196	PF00533	0.417
LIG_FHA_1	111	117	PF00498	0.334
LIG_FHA_1	97	103	PF00498	0.443
LIG_FHA_2	20	26	PF00498	0.473
LIG_LIR_Gen_1	119	127	PF02991	0.502
LIG_LIR_Gen_1	25	33	PF02991	0.377
LIG_LIR_Nem_3	169	173	PF02991	0.373
LIG_LIR_Nem_3	25	30	PF02991	0.361
LIG_LIR_Nem_3	70	75	PF02991	0.445
LIG_LYPXL_yS_3	164	167	PF13949	0.538
LIG_PCNA_PIPBox_1	68	77	PF02747	0.329
LIG_PCNA_yPIPBox_3	63	75	PF02747	0.347
LIG_PDZ_Class_3	207	212	PF00595	0.512
LIG_Pex14_1	12	16	PF04695	0.453
LIG_Pex14_2	26	30	PF04695	0.319
LIG_Pex14_2	75	79	PF04695	0.480
LIG_SH2_CRK	173	177	PF00017	0.464
LIG_SH2_CRK	181	185	PF00017	0.541
LIG_SH2_GRB2like	120	123	PF00017	0.377
LIG_SH2_STAP1	17	21	PF00017	0.351
LIG_SH2_STAP1	83	87	PF00017	0.503
LIG_SH2_STAT5	120	123	PF00017	0.459
LIG_SH2_STAT5	173	176	PF00017	0.390
LIG_SH3_3	128	134	PF00018	0.330
LIG_SH3_3	169	175	PF00018	0.377
LIG_SUMO_SIM_par_1	113	119	PF11976	0.487
LIG_TYR_ITIM	15	20	PF00017	0.516
LIG_UBA3_1	57	63	PF00899	0.581
MOD_CK1_1	132	138	PF00069	0.584
MOD_CK1_1	19	25	PF00069	0.492
MOD_GlcNHglycan	42	45	PF01048	0.577
MOD_GlcNHglycan	52	55	PF01048	0.383
MOD_GSK3_1	185	192	PF00069	0.497
MOD_GSK3_1	92	99	PF00069	0.469
MOD_N-GLC_1	96	101	PF02516	0.362
MOD_NEK2_1	16	21	PF00069	0.448
MOD_NEK2_1	166	171	PF00069	0.390
MOD_NEK2_1	185	190	PF00069	0.459
MOD_NEK2_2	67	72	PF00069	0.508
MOD_PIKK_1	203	209	PF00454	0.392
MOD_PKA_1	40	46	PF00069	0.587
MOD_PKA_2	185	191	PF00069	0.597
MOD_PKA_2	40	46	PF00069	0.651
MOD_PKA_2	50	56	PF00069	0.416
MOD_Plk_2-3	149	155	PF00069	0.497
MOD_Plk_4	132	138	PF00069	0.556
MOD_Plk_4	16	22	PF00069	0.417
MOD_Plk_4	186	192	PF00069	0.529
MOD_Plk_4	67	73	PF00069	0.445
MOD_ProDKin_1	110	116	PF00069	0.292
MOD_ProDKin_1	171	177	PF00069	0.489
MOD_ProDKin_1	96	102	PF00069	0.481
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.481
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.504
TRG_ENDOCYTIC_2	164	167	PF00928	0.469
TRG_ENDOCYTIC_2	17	20	PF00928	0.508
TRG_ENDOCYTIC_2	173	176	PF00928	0.370
TRG_ENDOCYTIC_2	83	86	PF00928	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Y0	Leptomonas seymouri	76%	100%
A0A1X0NVB8	Trypanosomatidae	42%	98%
A0A3S7X140	Leishmania donovani	91%	100%
A0A422N4D7	Trypanosoma rangeli	43%	100%
A4HG59	Leishmania braziliensis	78%	100%
A4I391	Leishmania infantum	91%	100%
D0A7R7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4Q8Q2	Leishmania major	91%	100%
V5AS20	Trypanosoma cruzi	47%	100%