Putative phopshatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phopshatase, putative

Species:

Leishmania mexicana

UniProt:

E9AZH8_LEIMU

TriTrypDb:

LmxM.28.0170

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AZH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZH8

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016311	dephosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0009966	regulation of signal transduction	4	1
GO:0009968	negative regulation of signal transduction	5	1
GO:0010646	regulation of cell communication	4	1
GO:0010648	negative regulation of cell communication	5	1
GO:0023051	regulation of signaling	3	1
GO:0023057	negative regulation of signaling	4	1
GO:0043408	regulation of MAPK cascade	6	1
GO:0043409	negative regulation of MAPK cascade	7	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0048583	regulation of response to stimulus	3	1
GO:0048585	negative regulation of response to stimulus	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:1902531	regulation of intracellular signal transduction	5	1
GO:1902532	negative regulation of intracellular signal transduction	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004721	phosphoprotein phosphatase activity	3	12
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.487
CLV_NRD_NRD_1	103	105	PF00675	0.486
CLV_NRD_NRD_1	187	189	PF00675	0.478
CLV_NRD_NRD_1	235	237	PF00675	0.580
CLV_NRD_NRD_1	56	58	PF00675	0.687
CLV_PCSK_KEX2_1	187	189	PF00082	0.465
CLV_PCSK_KEX2_1	235	237	PF00082	0.574
CLV_PCSK_KEX2_1	240	242	PF00082	0.324
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.481
CLV_PCSK_PC7_1	236	242	PF00082	0.544
CLV_PCSK_SKI1_1	230	234	PF00082	0.356
CLV_PCSK_SKI1_1	241	245	PF00082	0.384
CLV_PCSK_SKI1_1	355	359	PF00082	0.337
CLV_PCSK_SKI1_1	367	371	PF00082	0.309
CLV_PCSK_SKI1_1	380	384	PF00082	0.328
DOC_CDC14_PxL_1	146	154	PF14671	0.402
DOC_CYCLIN_yClb5_NLxxxL_5	133	142	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	222	228	PF00134	0.454
DOC_MAPK_gen_1	240	246	PF00069	0.428
DOC_MAPK_gen_1	249	258	PF00069	0.447
DOC_MAPK_gen_1	351	359	PF00069	0.372
DOC_MAPK_gen_1	54	64	PF00069	0.627
DOC_MAPK_RevD_3	220	236	PF00069	0.253
DOC_PP2B_LxvP_1	324	327	PF13499	0.340
DOC_PP4_FxxP_1	147	150	PF00568	0.406
DOC_USP7_MATH_1	332	336	PF00917	0.398
DOC_USP7_MATH_1	6	10	PF00917	0.638
DOC_USP7_MATH_1	93	97	PF00917	0.464
DOC_USP7_UBL2_3	54	58	PF12436	0.729
DOC_WW_Pin1_4	31	36	PF00397	0.634
LIG_14-3-3_CanoR_1	104	109	PF00244	0.280
LIG_14-3-3_CanoR_1	235	244	PF00244	0.461
LIG_14-3-3_CanoR_1	290	296	PF00244	0.375
LIG_14-3-3_CanoR_1	57	64	PF00244	0.568
LIG_14-3-3_CanoR_1	79	83	PF00244	0.519
LIG_14-3-3_CanoR_1	90	98	PF00244	0.418
LIG_Actin_WH2_2	277	292	PF00022	0.328
LIG_Actin_WH2_2	366	382	PF00022	0.475
LIG_Actin_WH2_2	91	106	PF00022	0.472
LIG_AP2alpha_1	340	344	PF02296	0.475
LIG_AP2alpha_2	180	182	PF02296	0.494
LIG_APCC_ABBA_1	295	300	PF00400	0.413
LIG_APCC_ABBA_1	337	342	PF00400	0.437
LIG_APCC_ABBA_1	408	413	PF00400	0.262
LIG_BIR_II_1	1	5	PF00653	0.679
LIG_BRCT_BRCA1_1	122	126	PF00533	0.293
LIG_BRCT_BRCA1_1	163	167	PF00533	0.519
LIG_BRCT_BRCA1_1	27	31	PF00533	0.751
LIG_FHA_1	134	140	PF00498	0.486
LIG_FHA_1	292	298	PF00498	0.333
LIG_FHA_1	368	374	PF00498	0.385
LIG_FHA_1	47	53	PF00498	0.710
LIG_FHA_2	381	387	PF00498	0.364
LIG_FHA_2	65	71	PF00498	0.609
LIG_LIR_Apic_2	145	150	PF02991	0.473
LIG_LIR_Gen_1	164	173	PF02991	0.540
LIG_LIR_Gen_1	211	222	PF02991	0.516
LIG_LIR_Gen_1	264	275	PF02991	0.428
LIG_LIR_Gen_1	282	289	PF02991	0.413
LIG_LIR_Gen_1	296	306	PF02991	0.413
LIG_LIR_Gen_1	8	15	PF02991	0.626
LIG_LIR_Nem_3	123	129	PF02991	0.526
LIG_LIR_Nem_3	164	170	PF02991	0.551
LIG_LIR_Nem_3	264	270	PF02991	0.435
LIG_LIR_Nem_3	282	286	PF02991	0.400
LIG_LIR_Nem_3	296	301	PF02991	0.226
LIG_LIR_Nem_3	341	347	PF02991	0.345
LIG_LIR_Nem_3	8	13	PF02991	0.597
LIG_LYPXL_L_2	275	284	PF13949	0.421
LIG_Pex14_2	340	344	PF04695	0.348
LIG_SH2_CRK	228	232	PF00017	0.560
LIG_SH2_SRC	148	151	PF00017	0.442
LIG_SH2_STAP1	228	232	PF00017	0.366
LIG_SH2_STAP1	411	415	PF00017	0.363
LIG_SH2_STAT5	148	151	PF00017	0.512
LIG_SH2_STAT5	283	286	PF00017	0.371
LIG_SH2_STAT5	305	308	PF00017	0.344
LIG_SH2_STAT5	375	378	PF00017	0.328
LIG_SH2_STAT5	39	42	PF00017	0.587
LIG_SH3_3	111	117	PF00018	0.536
LIG_SH3_3	178	184	PF00018	0.484
LIG_SH3_3	313	319	PF00018	0.413
LIG_SH3_3	32	38	PF00018	0.573
LIG_Sin3_3	387	394	PF02671	0.449
LIG_SUMO_SIM_anti_2	312	318	PF11976	0.184
LIG_SUMO_SIM_anti_2	385	392	PF11976	0.449
LIG_SUMO_SIM_par_1	112	118	PF11976	0.467
LIG_SUMO_SIM_par_1	199	205	PF11976	0.505
LIG_TRAF2_1	209	212	PF00917	0.463
LIG_TRAF2_1	67	70	PF00917	0.499
LIG_TYR_ITIM	226	231	PF00017	0.540
LIG_TYR_ITIM	281	286	PF00017	0.521
LIG_UBA3_1	376	380	PF00899	0.449
LIG_WRC_WIRS_1	7	12	PF05994	0.623
MOD_CDK_SPK_2	31	36	PF00069	0.457
MOD_CK1_1	161	167	PF00069	0.499
MOD_CK1_1	23	29	PF00069	0.673
MOD_CK1_1	288	294	PF00069	0.328
MOD_CK1_1	60	66	PF00069	0.610
MOD_CK1_1	78	84	PF00069	0.386
MOD_CK2_1	104	110	PF00069	0.534
MOD_CK2_1	199	205	PF00069	0.505
MOD_CK2_1	206	212	PF00069	0.392
MOD_CK2_1	62	68	PF00069	0.570
MOD_GlcNHglycan	122	125	PF01048	0.549
MOD_GlcNHglycan	19	25	PF01048	0.582
MOD_GlcNHglycan	46	49	PF01048	0.614
MOD_GlcNHglycan	59	62	PF01048	0.689
MOD_GlcNHglycan	86	89	PF01048	0.423
MOD_GlcNHglycan	91	94	PF01048	0.449
MOD_GSK3_1	133	140	PF00069	0.402
MOD_GSK3_1	25	32	PF00069	0.713
MOD_GSK3_1	363	370	PF00069	0.328
MOD_GSK3_1	414	421	PF00069	0.622
MOD_GSK3_1	42	49	PF00069	0.458
MOD_GSK3_1	60	67	PF00069	0.529
MOD_GSK3_1	89	96	PF00069	0.460
MOD_LATS_1	378	384	PF00433	0.410
MOD_LATS_1	416	422	PF00433	0.344
MOD_N-GLC_1	158	163	PF02516	0.442
MOD_N-GLC_1	29	34	PF02516	0.649
MOD_N-GLC_1	84	89	PF02516	0.388
MOD_NEK2_1	120	125	PF00069	0.547
MOD_NEK2_1	138	143	PF00069	0.322
MOD_NEK2_1	285	290	PF00069	0.435
MOD_NEK2_1	365	370	PF00069	0.337
MOD_NEK2_1	414	419	PF00069	0.510
MOD_NEK2_1	89	94	PF00069	0.495
MOD_PKA_1	104	110	PF00069	0.516
MOD_PKA_1	235	241	PF00069	0.481
MOD_PKA_1	57	63	PF00069	0.639
MOD_PKA_2	235	241	PF00069	0.508
MOD_PKA_2	78	84	PF00069	0.506
MOD_PKA_2	89	95	PF00069	0.409
MOD_Plk_1	158	164	PF00069	0.437
MOD_Plk_1	332	338	PF00069	0.475
MOD_Plk_1	75	81	PF00069	0.452
MOD_Plk_1	84	90	PF00069	0.362
MOD_Plk_2-3	15	21	PF00069	0.690
MOD_Plk_4	142	148	PF00069	0.397
MOD_Plk_4	199	205	PF00069	0.505
MOD_Plk_4	293	299	PF00069	0.388
MOD_Plk_4	332	338	PF00069	0.398
MOD_ProDKin_1	31	37	PF00069	0.635
MOD_SUMO_rev_2	9	18	PF00179	0.681
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.256
TRG_ENDOCYTIC_2	228	231	PF00928	0.513
TRG_ENDOCYTIC_2	283	286	PF00928	0.470
TRG_ENDOCYTIC_2	298	301	PF00928	0.186
TRG_ENDOCYTIC_2	411	414	PF00928	0.449
TRG_ER_diArg_1	186	188	PF00400	0.506
TRG_ER_diArg_1	234	236	PF00400	0.534
TRG_ER_diArg_1	249	252	PF00400	0.452
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE85	Leptomonas seymouri	66%	100%
A0A0S4IVI6	Bodo saltans	32%	100%
A0A1X0NVC7	Trypanosomatidae	47%	100%
A0A3Q8IEF5	Leishmania donovani	93%	100%
A0A3R7KS85	Trypanosoma rangeli	47%	100%
A4HG58	Leishmania braziliensis	81%	100%
A4I390	Leishmania infantum	93%	100%
D0A7R6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q4Q8Q3	Leishmania major	92%	100%
V5B7J4	Trypanosoma cruzi	48%	100%