Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9AZH7_LEIMU

TriTrypDb:

LmxM.28.0160

Length:

196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZH7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.519
CLV_NRD_NRD_1	17	19	PF00675	0.501
CLV_NRD_NRD_1	190	192	PF00675	0.587
CLV_NRD_NRD_1	6	8	PF00675	0.552
CLV_NRD_NRD_1	78	80	PF00675	0.502
CLV_PCSK_KEX2_1	10	12	PF00082	0.539
CLV_PCSK_KEX2_1	17	19	PF00082	0.503
CLV_PCSK_KEX2_1	189	191	PF00082	0.595
CLV_PCSK_KEX2_1	82	84	PF00082	0.450
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.549
CLV_PCSK_PC7_1	7	13	PF00082	0.568
CLV_PCSK_SKI1_1	85	89	PF00082	0.423
CLV_PCSK_SKI1_1	99	103	PF00082	0.577
DOC_MAPK_gen_1	79	89	PF00069	0.455
DOC_MAPK_MEF2A_6	142	150	PF00069	0.435
DOC_USP7_UBL2_3	138	142	PF12436	0.558
DOC_WW_Pin1_4	44	49	PF00397	0.570
LIG_14-3-3_CanoR_1	83	88	PF00244	0.428
LIG_FHA_1	124	130	PF00498	0.583
LIG_FHA_1	84	90	PF00498	0.412
LIG_FHA_2	105	111	PF00498	0.508
LIG_FHA_2	180	186	PF00498	0.374
LIG_FHA_2	4	10	PF00498	0.612
LIG_FHA_2	45	51	PF00498	0.693
LIG_PCNA_yPIPBox_3	138	147	PF02747	0.335
LIG_SH2_STAP1	118	122	PF00017	0.591
LIG_SH2_STAT3	118	121	PF00017	0.640
LIG_SH2_STAT5	147	150	PF00017	0.492
LIG_SH3_3	56	62	PF00018	0.653
LIG_SUMO_SIM_par_1	106	112	PF11976	0.516
LIG_SUMO_SIM_par_1	55	61	PF11976	0.483
MOD_CK1_1	28	34	PF00069	0.586
MOD_CK1_1	94	100	PF00069	0.497
MOD_CK2_1	179	185	PF00069	0.594
MOD_CK2_1	3	9	PF00069	0.576
MOD_GlcNHglycan	93	96	PF01048	0.512
MOD_GSK3_1	21	28	PF00069	0.560
MOD_NEK2_1	104	109	PF00069	0.456
MOD_NEK2_1	146	151	PF00069	0.433
MOD_PIKK_1	179	185	PF00454	0.448
MOD_PKB_1	10	18	PF00069	0.601
MOD_Plk_4	104	110	PF00069	0.447
MOD_Plk_4	71	77	PF00069	0.540
MOD_ProDKin_1	44	50	PF00069	0.574
MOD_SUMO_rev_2	55	64	PF00179	0.674
TRG_DiLeu_BaEn_4	130	136	PF01217	0.544
TRG_ENDOCYTIC_2	147	150	PF00928	0.495
TRG_ER_diArg_1	10	12	PF00400	0.534
TRG_ER_diArg_1	17	19	PF00400	0.510
TRG_ER_diArg_1	188	191	PF00400	0.587
TRG_Pf-PMV_PEXEL_1	17	22	PF00026	0.568

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEM8	Leishmania donovani	93%	100%
A0A422N4H9	Trypanosoma rangeli	43%	70%
A4HG57	Leishmania braziliensis	76%	100%
A4I389	Leishmania infantum	92%	100%
D0A7R5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	67%
Q4Q8Q4	Leishmania major	88%	100%
V5BGL1	Trypanosoma cruzi	44%	70%