MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania mexicana

UniProt:

E9AZH6_LEIMU

TriTrypDb:

LmxM.28.0150

Length:

528

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AZH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZH6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0022857	transmembrane transporter activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.542
CLV_NRD_NRD_1	106	108	PF00675	0.269
CLV_PCSK_KEX2_1	106	108	PF00082	0.269
CLV_PCSK_KEX2_1	467	469	PF00082	0.303
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.370
CLV_PCSK_SKI1_1	107	111	PF00082	0.193
CLV_PCSK_SKI1_1	139	143	PF00082	0.292
CLV_PCSK_SKI1_1	159	163	PF00082	0.110
CLV_PCSK_SKI1_1	282	286	PF00082	0.465
DEG_COP1_1	481	489	PF00400	0.681
DOC_CYCLIN_RxL_1	295	306	PF00134	0.327
DOC_CYCLIN_yCln2_LP_2	187	193	PF00134	0.350
DOC_CYCLIN_yCln2_LP_2	254	260	PF00134	0.501
DOC_MAPK_gen_1	106	112	PF00069	0.469
DOC_MAPK_gen_1	159	169	PF00069	0.440
DOC_MAPK_MEF2A_6	162	171	PF00069	0.440
DOC_MAPK_MEF2A_6	229	236	PF00069	0.346
DOC_PP1_RVXF_1	137	143	PF00149	0.308
DOC_PP1_RVXF_1	296	303	PF00149	0.310
DOC_PP2B_LxvP_1	187	190	PF13499	0.435
DOC_PP2B_LxvP_1	254	257	PF13499	0.501
DOC_USP7_MATH_1	2	6	PF00917	0.692
DOC_USP7_MATH_1	201	205	PF00917	0.435
DOC_USP7_MATH_1	317	321	PF00917	0.435
DOC_USP7_MATH_1	374	378	PF00917	0.542
DOC_USP7_MATH_1	386	390	PF00917	0.378
DOC_USP7_UBL2_3	66	70	PF12436	0.301
DOC_WW_Pin1_4	308	313	PF00397	0.292
LIG_14-3-3_CanoR_1	229	235	PF00244	0.542
LIG_14-3-3_CanoR_1	298	303	PF00244	0.413
LIG_14-3-3_CanoR_1	304	313	PF00244	0.160
LIG_14-3-3_CanoR_1	323	327	PF00244	0.451
LIG_14-3-3_CanoR_1	523	528	PF00244	0.558
LIG_Actin_WH2_2	90	108	PF00022	0.378
LIG_APCC_Cbox_1	100	106	PF00515	0.346
LIG_BIR_II_1	1	5	PF00653	0.693
LIG_BIR_III_2	514	518	PF00653	0.714
LIG_BRCT_BRCA1_1	119	123	PF00533	0.298
LIG_BRCT_BRCA1_1	182	186	PF00533	0.292
LIG_EH1_1	435	443	PF00400	0.360
LIG_FHA_1	116	122	PF00498	0.304
LIG_FHA_1	129	135	PF00498	0.294
LIG_FHA_1	270	276	PF00498	0.262
LIG_FHA_1	304	310	PF00498	0.381
LIG_FHA_1	323	329	PF00498	0.440
LIG_FHA_1	359	365	PF00498	0.407
LIG_FHA_1	414	420	PF00498	0.520
LIG_FHA_1	430	436	PF00498	0.265
LIG_FHA_1	447	453	PF00498	0.327
LIG_FHA_1	455	461	PF00498	0.604
LIG_FHA_1	502	508	PF00498	0.732
LIG_FHA_2	241	247	PF00498	0.527
LIG_FXI_DFP_1	46	50	PF00024	0.356
LIG_GBD_Chelix_1	206	214	PF00786	0.426
LIG_GBD_Chelix_1	437	445	PF00786	0.435
LIG_LIR_Apic_2	370	376	PF02991	0.378
LIG_LIR_Apic_2	82	87	PF02991	0.292
LIG_LIR_Gen_1	130	141	PF02991	0.349
LIG_LIR_Gen_1	15	25	PF02991	0.655
LIG_LIR_Gen_1	182	192	PF02991	0.301
LIG_LIR_Gen_1	325	335	PF02991	0.293
LIG_LIR_Nem_3	100	105	PF02991	0.451
LIG_LIR_Nem_3	130	136	PF02991	0.318
LIG_LIR_Nem_3	15	21	PF02991	0.631
LIG_LIR_Nem_3	174	180	PF02991	0.292
LIG_LIR_Nem_3	182	187	PF02991	0.292
LIG_LIR_Nem_3	27	33	PF02991	0.447
LIG_LIR_Nem_3	301	305	PF02991	0.324
LIG_LIR_Nem_3	325	330	PF02991	0.293
LIG_LIR_Nem_3	333	338	PF02991	0.259
LIG_LIR_Nem_3	365	371	PF02991	0.286
LIG_LIR_Nem_3	40	44	PF02991	0.268
LIG_LIR_Nem_3	481	485	PF02991	0.652
LIG_MYND_3	423	427	PF01753	0.390
LIG_MYND_3	486	490	PF01753	0.720
LIG_OCRL_FandH_1	334	346	PF00620	0.327
LIG_PCNA_PIPBox_1	353	362	PF02747	0.413
LIG_Pex14_2	156	160	PF04695	0.501
LIG_Pex14_2	184	188	PF04695	0.292
LIG_REV1ctd_RIR_1	282	292	PF16727	0.251
LIG_SH2_CRK	271	275	PF00017	0.292
LIG_SH2_CRK	360	364	PF00017	0.292
LIG_SH2_CRK	47	51	PF00017	0.324
LIG_SH2_PTP2	124	127	PF00017	0.285
LIG_SH2_PTP2	31	34	PF00017	0.285
LIG_SH2_SRC	79	82	PF00017	0.413
LIG_SH2_STAP1	271	275	PF00017	0.292
LIG_SH2_STAP1	360	364	PF00017	0.292
LIG_SH2_STAP1	72	76	PF00017	0.251
LIG_SH2_STAT5	102	105	PF00017	0.451
LIG_SH2_STAT5	124	127	PF00017	0.182
LIG_SH2_STAT5	231	234	PF00017	0.440
LIG_SH2_STAT5	271	274	PF00017	0.327
LIG_SH2_STAT5	291	294	PF00017	0.110
LIG_SH2_STAT5	31	34	PF00017	0.338
LIG_SH2_STAT5	360	363	PF00017	0.444
LIG_SH2_STAT5	45	48	PF00017	0.228
LIG_SH2_STAT5	72	75	PF00017	0.269
LIG_SH2_STAT5	79	82	PF00017	0.295
LIG_SH3_3	306	312	PF00018	0.413
LIG_SH3_3	366	372	PF00018	0.292
LIG_SH3_3	500	506	PF00018	0.770
LIG_SUMO_SIM_anti_2	113	118	PF11976	0.378
LIG_SUMO_SIM_anti_2	447	454	PF11976	0.320
LIG_SUMO_SIM_anti_2	89	95	PF11976	0.382
LIG_SUMO_SIM_par_1	113	118	PF11976	0.436
LIG_SUMO_SIM_par_1	447	454	PF11976	0.174
LIG_TYR_ITIM	122	127	PF00017	0.285
LIG_TYR_ITIM	258	263	PF00017	0.435
LIG_Vh1_VBS_1	329	347	PF01044	0.160
LIG_WRC_WIRS_1	359	364	PF05994	0.327
LIG_WRC_WIRS_1	38	43	PF05994	0.292
MOD_CK1_1	16	22	PF00069	0.671
MOD_CK1_1	240	246	PF00069	0.544
MOD_CK1_1	248	254	PF00069	0.414
MOD_CK1_1	462	468	PF00069	0.589
MOD_CK1_1	52	58	PF00069	0.308
MOD_CK1_1	82	88	PF00069	0.160
MOD_CK2_1	412	418	PF00069	0.460
MOD_GlcNHglycan	153	156	PF01048	0.308
MOD_GlcNHglycan	177	180	PF01048	0.160
MOD_GlcNHglycan	203	206	PF01048	0.435
MOD_GlcNHglycan	306	309	PF01048	0.293
MOD_GlcNHglycan	364	367	PF01048	0.279
MOD_GlcNHglycan	438	441	PF01048	0.327
MOD_GlcNHglycan	461	464	PF01048	0.352
MOD_GlcNHglycan	54	57	PF01048	0.541
MOD_GSK3_1	12	19	PF00069	0.687
MOD_GSK3_1	145	152	PF00069	0.313
MOD_GSK3_1	171	178	PF00069	0.308
MOD_GSK3_1	304	311	PF00069	0.293
MOD_GSK3_1	358	365	PF00069	0.281
MOD_GSK3_1	413	420	PF00069	0.451
MOD_GSK3_1	501	508	PF00069	0.754
MOD_GSK3_1	519	526	PF00069	0.744
MOD_GSK3_1	82	89	PF00069	0.160
MOD_LATS_1	68	74	PF00433	0.301
MOD_N-GLC_1	413	418	PF02516	0.635
MOD_NEK2_1	110	115	PF00069	0.267
MOD_NEK2_1	117	122	PF00069	0.320
MOD_NEK2_1	149	154	PF00069	0.354
MOD_NEK2_1	171	176	PF00069	0.300
MOD_NEK2_1	269	274	PF00069	0.311
MOD_NEK2_1	330	335	PF00069	0.313
MOD_NEK2_1	342	347	PF00069	0.231
MOD_NEK2_1	362	367	PF00069	0.343
MOD_NEK2_1	436	441	PF00069	0.304
MOD_NEK2_1	444	449	PF00069	0.268
MOD_NEK2_1	461	466	PF00069	0.484
MOD_NEK2_1	507	512	PF00069	0.700
MOD_NEK2_2	79	84	PF00069	0.413
MOD_PIKK_1	149	155	PF00454	0.378
MOD_PIKK_1	417	423	PF00454	0.491
MOD_PIKK_1	496	502	PF00454	0.571
MOD_PK_1	245	251	PF00069	0.346
MOD_PKA_2	303	309	PF00069	0.160
MOD_PKA_2	322	328	PF00069	0.440
MOD_Plk_1	245	251	PF00069	0.457
MOD_Plk_4	117	123	PF00069	0.369
MOD_Plk_4	128	134	PF00069	0.420
MOD_Plk_4	13	19	PF00069	0.618
MOD_Plk_4	298	304	PF00069	0.382
MOD_Plk_4	322	328	PF00069	0.434
MOD_Plk_4	342	348	PF00069	0.110
MOD_Plk_4	358	364	PF00069	0.286
MOD_Plk_4	375	381	PF00069	0.453
MOD_Plk_4	40	46	PF00069	0.292
MOD_Plk_4	446	452	PF00069	0.190
MOD_Plk_4	79	85	PF00069	0.286
MOD_Plk_4	86	92	PF00069	0.291
MOD_ProDKin_1	308	314	PF00069	0.292
TRG_DiLeu_BaEn_1	433	438	PF01217	0.382
TRG_DiLeu_BaEn_4	23	29	PF01217	0.576
TRG_ENDOCYTIC_2	102	105	PF00928	0.451
TRG_ENDOCYTIC_2	124	127	PF00928	0.287
TRG_ENDOCYTIC_2	132	135	PF00928	0.243
TRG_ENDOCYTIC_2	231	234	PF00928	0.527
TRG_ENDOCYTIC_2	260	263	PF00928	0.343
TRG_ENDOCYTIC_2	271	274	PF00928	0.232
TRG_ENDOCYTIC_2	31	34	PF00928	0.366
TRG_ENDOCYTIC_2	360	363	PF00928	0.292
TRG_ENDOCYTIC_2	384	387	PF00928	0.440
TRG_ER_diArg_1	105	107	PF00400	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7C2	Leptomonas seymouri	67%	94%
A0A0S4IUS4	Bodo saltans	55%	100%
A0A1X0NVY8	Trypanosomatidae	55%	100%
A0A3R7NBY9	Trypanosoma rangeli	53%	100%
A0A3S7X168	Leishmania donovani	91%	100%
A4I388	Leishmania infantum	91%	100%
D0A7R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
Q1JQC1	Bos taurus	32%	100%
Q32LQ6	Danio rerio	36%	100%
Q4Q8Q5	Leishmania major	89%	100%
Q5R8G5	Pongo abelii	32%	100%
Q5ZIT9	Gallus gallus	29%	100%
Q9DC37	Mus musculus	32%	100%
Q9H3U5	Homo sapiens	32%	100%
V5BBZ8	Trypanosoma cruzi	56%	100%