Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZH4_LEIMU

TriTrypDb:

LmxM.28.0130

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19

Expansion

Sequence features

E9AZH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZH4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	173	175	PF00082	0.493
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.497
CLV_PCSK_SKI1_1	111	115	PF00082	0.491
DOC_MAPK_gen_1	38	47	PF00069	0.392
DOC_MAPK_gen_1	76	86	PF00069	0.483
DOC_MAPK_MEF2A_6	79	88	PF00069	0.487
DOC_USP7_MATH_1	156	160	PF00917	0.697
LIG_14-3-3_CanoR_1	32	40	PF00244	0.268
LIG_14-3-3_CanoR_1	5	9	PF00244	0.593
LIG_Actin_WH2_2	26	43	PF00022	0.324
LIG_Actin_WH2_2	95	113	PF00022	0.369
LIG_EH1_1	15	23	PF00400	0.393
LIG_FHA_1	162	168	PF00498	0.592
LIG_FHA_1	72	78	PF00498	0.586
LIG_FHA_1	99	105	PF00498	0.324
LIG_FHA_2	94	100	PF00498	0.169
LIG_GBD_Chelix_1	85	93	PF00786	0.445
LIG_LIR_Gen_1	101	110	PF02991	0.389
LIG_LIR_Gen_1	133	142	PF02991	0.493
LIG_LIR_Gen_1	42	50	PF02991	0.328
LIG_LIR_Nem_3	101	106	PF02991	0.343
LIG_LIR_Nem_3	133	137	PF02991	0.370
LIG_LIR_Nem_3	23	27	PF02991	0.375
LIG_LIR_Nem_3	42	47	PF02991	0.328
LIG_PCNA_PIPBox_1	138	147	PF02747	0.621
LIG_PDZ_Class_3	177	182	PF00595	0.648
LIG_Pex14_2	131	135	PF04695	0.377
LIG_Pex14_2	144	148	PF04695	0.584
LIG_SH2_CRK	137	141	PF00017	0.640
LIG_SH2_CRK	15	19	PF00017	0.438
LIG_SH2_STAP1	65	69	PF00017	0.528
LIG_SH2_STAT5	27	30	PF00017	0.384
LIG_SH2_STAT5	44	47	PF00017	0.150
LIG_SUMO_SIM_par_1	17	23	PF11976	0.357
LIG_TYR_ITIM	13	18	PF00017	0.435
LIG_WRC_WIRS_1	103	108	PF05994	0.475
LIG_WRC_WIRS_1	21	26	PF05994	0.458
MOD_CK2_1	93	99	PF00069	0.169
MOD_GSK3_1	89	96	PF00069	0.322
MOD_GSK3_1	98	105	PF00069	0.344
MOD_NEK2_1	114	119	PF00069	0.293
MOD_NEK2_1	33	38	PF00069	0.315
MOD_NEK2_1	4	9	PF00069	0.544
MOD_NEK2_1	63	68	PF00069	0.472
MOD_NEK2_1	89	94	PF00069	0.408
MOD_PIKK_1	172	178	PF00454	0.704
MOD_PKA_2	4	10	PF00069	0.629
MOD_Plk_1	98	104	PF00069	0.238
MOD_Plk_4	114	120	PF00069	0.311
MOD_Plk_4	93	99	PF00069	0.294
TRG_DiLeu_BaEn_2	98	104	PF01217	0.310
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.575
TRG_ENDOCYTIC_2	137	140	PF00928	0.551
TRG_ENDOCYTIC_2	15	18	PF00928	0.443
TRG_ENDOCYTIC_2	27	30	PF00928	0.467
TRG_ENDOCYTIC_2	44	47	PF00928	0.300
TRG_NES_CRM1_1	99	109	PF08389	0.236
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT5	Leptomonas seymouri	62%	100%
A0A0N1PC80	Leptomonas seymouri	25%	99%
A0A0S4IY98	Bodo saltans	37%	100%
A0A0S4J4Y6	Bodo saltans	25%	100%
A0A0S4JQJ3	Bodo saltans	24%	100%
A0A1X0NX01	Trypanosomatidae	41%	99%
A0A1X0NXC4	Trypanosomatidae	32%	100%
A0A3Q8IF10	Leishmania donovani	25%	99%
A0A3Q8IQ96	Leishmania donovani	87%	100%
A0A3R7JVT6	Trypanosoma rangeli	42%	99%
A4HBK6	Leishmania braziliensis	26%	100%
A4HG55	Leishmania braziliensis	69%	100%
A4HZL0	Leishmania infantum	25%	99%
A4I386	Leishmania infantum	87%	100%
E9AUX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4Q8Q7	Leishmania major	87%	100%
Q4QCK7	Leishmania major	25%	100%
V5B3X7	Trypanosoma cruzi	27%	73%
V5BC06	Trypanosoma cruzi	35%	99%