ATP pyrophosphate-lyase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxygen-sensing adenylate cyclase

Species:

Leishmania mexicana

UniProt:

E9AZH0_LEIMU

TriTrypDb:

LmxM.28.0090

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AZH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZH0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006163	purine nucleotide metabolic process	5	7
GO:0006164	purine nucleotide biosynthetic process	6	7
GO:0006171	cAMP biosynthetic process	8	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006753	nucleoside phosphate metabolic process	4	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0007165	signal transduction	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009117	nucleotide metabolic process	5	7
GO:0009150	purine ribonucleotide metabolic process	6	7
GO:0009152	purine ribonucleotide biosynthetic process	7	7
GO:0009165	nucleotide biosynthetic process	6	7
GO:0009187	cyclic nucleotide metabolic process	6	7
GO:0009190	cyclic nucleotide biosynthetic process	7	7
GO:0009259	ribonucleotide metabolic process	5	7
GO:0009260	ribonucleotide biosynthetic process	6	7
GO:0009987	cellular process	1	7
GO:0018130	heterocycle biosynthetic process	4	7
GO:0019438	aromatic compound biosynthetic process	4	7
GO:0019637	organophosphate metabolic process	3	7
GO:0019693	ribose phosphate metabolic process	4	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034654	nucleobase-containing compound biosynthetic process	4	7
GO:0035556	intracellular signal transduction	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0044281	small molecule metabolic process	2	7
GO:0046058	cAMP metabolic process	7	7
GO:0046390	ribose phosphate biosynthetic process	5	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0052652	cyclic purine nucleotide metabolic process	6	7
GO:0055086	nucleobase-containing small molecule metabolic process	3	7
GO:0065007	biological regulation	1	7
GO:0071704	organic substance metabolic process	2	7
GO:0072521	purine-containing compound metabolic process	4	7
GO:0072522	purine-containing compound biosynthetic process	5	7
GO:0090407	organophosphate biosynthetic process	4	7
GO:1901135	carbohydrate derivative metabolic process	3	7
GO:1901137	carbohydrate derivative biosynthetic process	4	7
GO:1901293	nucleoside phosphate biosynthetic process	5	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901362	organic cyclic compound biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7
GO:0000302	response to reactive oxygen species	4	1
GO:0001666	response to hypoxia	3	1
GO:0003032	detection of oxygen	4	1
GO:0006810	transport	3	1
GO:0006950	response to stress	2	1
GO:0006979	response to oxidative stress	3	1
GO:0009593	detection of chemical stimulus	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0015669	gas transport	4	1
GO:0015671	oxygen transport	5	1
GO:0031279	regulation of cyclase activity	4	1
GO:0036293	response to decreased oxygen levels	4	1
GO:0042221	response to chemical	2	1
GO:0045761	regulation of adenylate cyclase activity	5	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050896	response to stimulus	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051339	regulation of lyase activity	4	1
GO:0051606	detection of stimulus	2	1
GO:0065009	regulation of molecular function	2	1
GO:0070482	response to oxygen levels	3	1
GO:0070483	detection of hypoxia	4	1
GO:1901700	response to oxygen-containing compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	7
GO:0016829	lyase activity	2	5
GO:0019825	oxygen binding	3	7
GO:0020037	heme binding	4	7
GO:0036094	small molecule binding	2	7
GO:0046906	tetrapyrrole binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004016	adenylate cyclase activity	3	1
GO:0005344	oxygen carrier activity	2	1
GO:0009975	cyclase activity	2	1
GO:0016849	phosphorus-oxygen lyase activity	3	1
GO:0019826	oxygen sensor activity	2	1
GO:0070025	carbon monoxide binding	2	1
GO:0140104	molecular carrier activity	1	1
GO:0140299	small molecule sensor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	489	493	PF00656	0.335
CLV_C14_Caspase3-7	526	530	PF00656	0.191
CLV_C14_Caspase3-7	67	71	PF00656	0.616
CLV_C14_Caspase3-7	79	83	PF00656	0.580
CLV_NRD_NRD_1	176	178	PF00675	0.288
CLV_NRD_NRD_1	311	313	PF00675	0.383
CLV_NRD_NRD_1	476	478	PF00675	0.339
CLV_NRD_NRD_1	566	568	PF00675	0.392
CLV_NRD_NRD_1	58	60	PF00675	0.589
CLV_NRD_NRD_1	68	70	PF00675	0.599
CLV_NRD_NRD_1	9	11	PF00675	0.626
CLV_PCSK_FUR_1	174	178	PF00082	0.285
CLV_PCSK_KEX2_1	141	143	PF00082	0.558
CLV_PCSK_KEX2_1	176	178	PF00082	0.288
CLV_PCSK_KEX2_1	311	313	PF00082	0.351
CLV_PCSK_KEX2_1	476	478	PF00082	0.329
CLV_PCSK_KEX2_1	566	568	PF00082	0.392
CLV_PCSK_KEX2_1	58	60	PF00082	0.617
CLV_PCSK_KEX2_1	68	70	PF00082	0.664
CLV_PCSK_KEX2_1	9	11	PF00082	0.604
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.558
CLV_PCSK_PC7_1	137	143	PF00082	0.407
CLV_PCSK_SKI1_1	137	141	PF00082	0.441
CLV_PCSK_SKI1_1	192	196	PF00082	0.329
CLV_PCSK_SKI1_1	236	240	PF00082	0.283
CLV_PCSK_SKI1_1	264	268	PF00082	0.346
CLV_PCSK_SKI1_1	289	293	PF00082	0.469
CLV_PCSK_SKI1_1	358	362	PF00082	0.454
CLV_PCSK_SKI1_1	394	398	PF00082	0.329
CLV_PCSK_SKI1_1	499	503	PF00082	0.301
CLV_Separin_Metazoa	514	518	PF03568	0.277
CLV_Separin_Metazoa	651	655	PF03568	0.414
DOC_CKS1_1	620	625	PF01111	0.505
DOC_MAPK_gen_1	174	182	PF00069	0.416
DOC_MAPK_gen_1	261	271	PF00069	0.331
DOC_MAPK_gen_1	311	317	PF00069	0.307
DOC_MAPK_gen_1	459	468	PF00069	0.254
DOC_MAPK_gen_1	543	551	PF00069	0.339
DOC_MAPK_HePTP_8	456	468	PF00069	0.329
DOC_MAPK_HePTP_8	503	515	PF00069	0.335
DOC_MAPK_MEF2A_6	174	182	PF00069	0.416
DOC_MAPK_MEF2A_6	207	214	PF00069	0.335
DOC_MAPK_MEF2A_6	264	271	PF00069	0.398
DOC_MAPK_MEF2A_6	459	468	PF00069	0.329
DOC_MAPK_MEF2A_6	499	507	PF00069	0.335
DOC_MAPK_MEF2A_6	543	551	PF00069	0.283
DOC_MAPK_NFAT4_5	264	272	PF00069	0.382
DOC_PP1_RVXF_1	177	183	PF00149	0.421
DOC_PP2B_LxvP_1	434	437	PF13499	0.430
DOC_PP4_FxxP_1	385	388	PF00568	0.335
DOC_USP7_MATH_1	3	7	PF00917	0.553
DOC_USP7_MATH_1	404	408	PF00917	0.379
DOC_USP7_MATH_1	437	441	PF00917	0.437
DOC_USP7_MATH_1	467	471	PF00917	0.329
DOC_USP7_UBL2_3	289	293	PF12436	0.345
DOC_WW_Pin1_4	273	278	PF00397	0.380
DOC_WW_Pin1_4	619	624	PF00397	0.509
LIG_14-3-3_CanoR_1	312	318	PF00244	0.290
LIG_14-3-3_CanoR_1	339	345	PF00244	0.354
LIG_14-3-3_CanoR_1	371	379	PF00244	0.335
LIG_14-3-3_CanoR_1	654	659	PF00244	0.435
LIG_APCC_ABBA_1	323	328	PF00400	0.422
LIG_BRCT_BRCA1_1	439	443	PF00533	0.388
LIG_BRCT_BRCA1_1	611	615	PF00533	0.299
LIG_BRCT_BRCA1_1	70	74	PF00533	0.615
LIG_CaM_IQ_9	291	307	PF13499	0.401
LIG_deltaCOP1_diTrp_1	256	263	PF00928	0.277
LIG_eIF4E_1	265	271	PF01652	0.372
LIG_FHA_1	128	134	PF00498	0.501
LIG_FHA_1	148	154	PF00498	0.247
LIG_FHA_1	340	346	PF00498	0.191
LIG_FHA_1	496	502	PF00498	0.335
LIG_FHA_1	542	548	PF00498	0.335
LIG_FHA_2	31	37	PF00498	0.522
LIG_FHA_2	446	452	PF00498	0.277
LIG_FHA_2	487	493	PF00498	0.335
LIG_FHA_2	65	71	PF00498	0.643
LIG_LIR_Gen_1	230	240	PF02991	0.295
LIG_LIR_Gen_1	256	267	PF02991	0.255
LIG_LIR_Gen_1	330	340	PF02991	0.448
LIG_LIR_Gen_1	347	355	PF02991	0.335
LIG_LIR_Gen_1	406	417	PF02991	0.357
LIG_LIR_Gen_1	558	568	PF02991	0.277
LIG_LIR_Gen_1	595	604	PF02991	0.339
LIG_LIR_Gen_1	633	643	PF02991	0.399
LIG_LIR_Gen_1	670	677	PF02991	0.606
LIG_LIR_Nem_3	148	154	PF02991	0.364
LIG_LIR_Nem_3	256	262	PF02991	0.495
LIG_LIR_Nem_3	280	285	PF02991	0.422
LIG_LIR_Nem_3	297	301	PF02991	0.282
LIG_LIR_Nem_3	330	335	PF02991	0.477
LIG_LIR_Nem_3	347	351	PF02991	0.456
LIG_LIR_Nem_3	406	412	PF02991	0.359
LIG_LIR_Nem_3	440	446	PF02991	0.335
LIG_LIR_Nem_3	481	485	PF02991	0.352
LIG_LIR_Nem_3	558	564	PF02991	0.332
LIG_LIR_Nem_3	595	600	PF02991	0.339
LIG_LIR_Nem_3	612	618	PF02991	0.389
LIG_LIR_Nem_3	633	638	PF02991	0.375
LIG_LIR_Nem_3	645	649	PF02991	0.317
LIG_LIR_Nem_3	670	675	PF02991	0.585
LIG_Pex14_1	411	415	PF04695	0.375
LIG_Pex14_2	239	243	PF04695	0.335
LIG_Pex14_2	385	389	PF04695	0.335
LIG_Pex14_2	409	413	PF04695	0.399
LIG_Pex14_2	443	447	PF04695	0.335
LIG_Pex14_2	668	672	PF04695	0.427
LIG_SH2_CRK	205	209	PF00017	0.329
LIG_SH2_CRK	282	286	PF00017	0.412
LIG_SH2_CRK	561	565	PF00017	0.277
LIG_SH2_STAP1	168	172	PF00017	0.361
LIG_SH2_STAT5	265	268	PF00017	0.329
LIG_SH2_STAT5	613	616	PF00017	0.394
LIG_SH3_1	517	523	PF00018	0.335
LIG_SH3_3	517	523	PF00018	0.335
LIG_SH3_3	617	623	PF00018	0.344
LIG_SUMO_SIM_anti_2	124	130	PF11976	0.494
LIG_SUMO_SIM_anti_2	347	353	PF11976	0.293
LIG_SUMO_SIM_par_1	124	130	PF11976	0.494
LIG_SUMO_SIM_par_1	24	33	PF11976	0.529
LIG_TRAF2_1	254	257	PF00917	0.335
LIG_UBA3_1	290	299	PF00899	0.393
LIG_WRC_WIRS_1	345	350	PF05994	0.210
LIG_WRC_WIRS_1	643	648	PF05994	0.417
MOD_CDK_SPxxK_3	619	626	PF00069	0.515
MOD_CK1_1	143	149	PF00069	0.466
MOD_CK1_1	458	464	PF00069	0.329
MOD_CK1_1	46	52	PF00069	0.592
MOD_CK1_1	593	599	PF00069	0.293
MOD_CK1_1	64	70	PF00069	0.467
MOD_CK2_1	116	122	PF00069	0.530
MOD_CK2_1	30	36	PF00069	0.521
MOD_CK2_1	327	333	PF00069	0.439
MOD_CK2_1	445	451	PF00069	0.277
MOD_CK2_1	599	605	PF00069	0.409
MOD_GlcNHglycan	101	104	PF01048	0.491
MOD_GlcNHglycan	420	423	PF01048	0.380
MOD_GlcNHglycan	45	48	PF01048	0.564
MOD_GlcNHglycan	582	585	PF01048	0.331
MOD_GSK3_1	143	150	PF00069	0.457
MOD_GSK3_1	423	430	PF00069	0.479
MOD_GSK3_1	43	50	PF00069	0.528
MOD_GSK3_1	435	442	PF00069	0.337
MOD_GSK3_1	445	452	PF00069	0.335
MOD_GSK3_1	458	465	PF00069	0.292
MOD_GSK3_1	486	493	PF00069	0.394
MOD_GSK3_1	64	71	PF00069	0.627
MOD_N-GLC_1	114	119	PF02516	0.521
MOD_N-GLC_1	375	380	PF02516	0.335
MOD_N-GLC_1	43	48	PF02516	0.701
MOD_N-GLC_2	306	308	PF02516	0.435
MOD_N-GLC_2	576	578	PF02516	0.335
MOD_NEK2_1	197	202	PF00069	0.315
MOD_NEK2_1	338	343	PF00069	0.439
MOD_NEK2_1	389	394	PF00069	0.335
MOD_NEK2_1	96	101	PF00069	0.497
MOD_NEK2_2	642	647	PF00069	0.407
MOD_NMyristoyl	1	7	PF02799	0.584
MOD_PKA_1	68	74	PF00069	0.596
MOD_PKA_2	111	117	PF00069	0.559
MOD_PKA_2	338	344	PF00069	0.359
MOD_PKA_2	370	376	PF00069	0.335
MOD_PKA_2	593	599	PF00069	0.335
MOD_PKA_2	68	74	PF00069	0.618
MOD_Plk_1	114	120	PF00069	0.492
MOD_Plk_1	143	149	PF00069	0.460
MOD_Plk_1	375	381	PF00069	0.335
MOD_Plk_1	541	547	PF00069	0.379
MOD_Plk_2-3	486	492	PF00069	0.335
MOD_Plk_4	190	196	PF00069	0.335
MOD_Plk_4	313	319	PF00069	0.374
MOD_Plk_4	344	350	PF00069	0.293
MOD_Plk_4	427	433	PF00069	0.517
MOD_Plk_4	490	496	PF00069	0.335
MOD_Plk_4	609	615	PF00069	0.359
MOD_Plk_4	654	660	PF00069	0.367
MOD_Plk_4	96	102	PF00069	0.531
MOD_ProDKin_1	273	279	PF00069	0.377
MOD_ProDKin_1	619	625	PF00069	0.509
MOD_SUMO_rev_2	458	464	PF00179	0.254
MOD_SUMO_rev_2	481	490	PF00179	0.304
MOD_SUMO_rev_2	64	74	PF00179	0.486
TRG_DiLeu_BaEn_1	651	656	PF01217	0.520
TRG_DiLeu_BaLyEn_6	474	479	PF01217	0.329
TRG_ENDOCYTIC_2	168	171	PF00928	0.399
TRG_ENDOCYTIC_2	282	285	PF00928	0.457
TRG_ENDOCYTIC_2	561	564	PF00928	0.335
TRG_ER_diArg_1	107	110	PF00400	0.518
TRG_ER_diArg_1	174	177	PF00400	0.449
TRG_ER_diArg_1	310	312	PF00400	0.358
TRG_ER_diArg_1	475	477	PF00400	0.329
TRG_ER_diArg_1	545	548	PF00400	0.281
TRG_ER_diArg_1	566	568	PF00400	0.389
TRG_ER_diArg_1	9	11	PF00400	0.569
TRG_NES_CRM1_1	288	303	PF08389	0.398
TRG_NES_CRM1_1	500	514	PF08389	0.335
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.353
TRG_Pf-PMV_PEXEL_1	476	481	PF00026	0.277

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A1	Leptomonas seymouri	34%	71%
A0A0N0P721	Leptomonas seymouri	67%	98%
A0A3S7X137	Leishmania donovani	94%	100%
A4I382	Leishmania infantum	94%	100%
Q4Q8R1	Leishmania major	90%	100%