VWFA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZG8_LEIMU

TriTrypDb:

LmxM.28.0070

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZG8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.333
CLV_NRD_NRD_1	10	12	PF00675	0.671
CLV_NRD_NRD_1	124	126	PF00675	0.497
CLV_NRD_NRD_1	344	346	PF00675	0.531
CLV_NRD_NRD_1	452	454	PF00675	0.448
CLV_PCSK_FUR_1	385	389	PF00082	0.361
CLV_PCSK_FUR_1	450	454	PF00082	0.381
CLV_PCSK_KEX2_1	10	12	PF00082	0.671
CLV_PCSK_KEX2_1	124	126	PF00082	0.538
CLV_PCSK_KEX2_1	263	265	PF00082	0.410
CLV_PCSK_KEX2_1	387	389	PF00082	0.369
CLV_PCSK_KEX2_1	452	454	PF00082	0.448
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.441
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.369
CLV_PCSK_PC7_1	6	12	PF00082	0.550
CLV_PCSK_SKI1_1	124	128	PF00082	0.576
CLV_PCSK_SKI1_1	254	258	PF00082	0.405
CLV_PCSK_SKI1_1	264	268	PF00082	0.294
CLV_PCSK_SKI1_1	341	345	PF00082	0.451
CLV_PCSK_SKI1_1	424	428	PF00082	0.285
DEG_APCC_DBOX_1	263	271	PF00400	0.376
DEG_APCC_KENBOX_2	326	330	PF00400	0.477
DEG_SPOP_SBC_1	307	311	PF00917	0.483
DOC_MAPK_DCC_7	176	186	PF00069	0.413
DOC_MAPK_gen_1	235	243	PF00069	0.534
DOC_MAPK_gen_1	263	269	PF00069	0.425
DOC_MAPK_gen_1	448	456	PF00069	0.354
DOC_MAPK_MEF2A_6	28	35	PF00069	0.490
DOC_PP2B_LxvP_1	481	484	PF13499	0.432
DOC_PP4_FxxP_1	353	356	PF00568	0.287
DOC_PP4_MxPP_1	256	259	PF00568	0.294
DOC_USP7_MATH_1	153	157	PF00917	0.363
DOC_USP7_MATH_1	222	226	PF00917	0.567
DOC_USP7_MATH_1	307	311	PF00917	0.558
DOC_USP7_MATH_1	464	468	PF00917	0.618
DOC_USP7_MATH_1	495	499	PF00917	0.671
DOC_USP7_MATH_1	80	84	PF00917	0.520
DOC_USP7_MATH_1	98	102	PF00917	0.611
DOC_USP7_UBL2_3	223	227	PF12436	0.597
DOC_WW_Pin1_4	19	24	PF00397	0.536
DOC_WW_Pin1_4	308	313	PF00397	0.540
DOC_WW_Pin1_4	476	481	PF00397	0.697
LIG_14-3-3_CanoR_1	10	20	PF00244	0.657
LIG_14-3-3_CanoR_1	117	123	PF00244	0.403
LIG_14-3-3_CanoR_1	144	153	PF00244	0.417
LIG_14-3-3_CanoR_1	193	202	PF00244	0.354
LIG_14-3-3_CanoR_1	345	350	PF00244	0.468
LIG_14-3-3_CanoR_1	388	396	PF00244	0.509
LIG_14-3-3_CanoR_1	54	58	PF00244	0.486
LIG_Actin_WH2_2	329	347	PF00022	0.418
LIG_BIR_II_1	1	5	PF00653	0.557
LIG_BRCT_BRCA1_1	46	50	PF00533	0.569
LIG_CSL_BTD_1	20	23	PF09270	0.621
LIG_eIF4E_1	145	151	PF01652	0.450
LIG_FHA_1	100	106	PF00498	0.588
LIG_FHA_1	111	117	PF00498	0.313
LIG_FHA_1	160	166	PF00498	0.439
LIG_FHA_1	317	323	PF00498	0.490
LIG_FHA_1	391	397	PF00498	0.429
LIG_FHA_1	40	46	PF00498	0.585
LIG_FHA_1	449	455	PF00498	0.448
LIG_FHA_1	74	80	PF00498	0.671
LIG_FHA_2	3	9	PF00498	0.636
LIG_FHA_2	408	414	PF00498	0.566
LIG_FHA_2	86	92	PF00498	0.565
LIG_LIR_Apic_2	352	356	PF02991	0.294
LIG_LIR_Apic_2	474	480	PF02991	0.531
LIG_LIR_Apic_2	66	71	PF02991	0.569
LIG_LIR_Gen_1	113	122	PF02991	0.301
LIG_LIR_Gen_1	146	154	PF02991	0.437
LIG_LIR_Gen_1	164	171	PF02991	0.327
LIG_LIR_Gen_1	192	202	PF02991	0.588
LIG_LIR_Gen_1	294	304	PF02991	0.548
LIG_LIR_Gen_1	428	436	PF02991	0.371
LIG_LIR_Nem_3	113	118	PF02991	0.490
LIG_LIR_Nem_3	146	150	PF02991	0.335
LIG_LIR_Nem_3	164	170	PF02991	0.433
LIG_LIR_Nem_3	178	183	PF02991	0.445
LIG_LIR_Nem_3	192	198	PF02991	0.468
LIG_LIR_Nem_3	294	299	PF02991	0.551
LIG_LIR_Nem_3	47	53	PF02991	0.565
LIG_PDZ_Class_3	516	521	PF00595	0.658
LIG_Pex14_2	299	303	PF04695	0.551
LIG_Pex14_2	425	429	PF04695	0.315
LIG_RPA_C_Fungi	204	216	PF08784	0.275
LIG_SH2_CRK	199	203	PF00017	0.460
LIG_SH2_STAP1	379	383	PF00017	0.425
LIG_SH2_STAP1	473	477	PF00017	0.547
LIG_SH2_STAP1	51	55	PF00017	0.562
LIG_SH2_STAT5	185	188	PF00017	0.395
LIG_SH2_STAT5	285	288	PF00017	0.466
LIG_SH2_STAT5	357	360	PF00017	0.388
LIG_SH2_STAT5	477	480	PF00017	0.608
LIG_SH2_STAT5	514	517	PF00017	0.602
LIG_SH3_1	477	483	PF00018	0.653
LIG_SH3_3	397	403	PF00018	0.539
LIG_SH3_3	477	483	PF00018	0.653
LIG_SH3_3	55	61	PF00018	0.543
LIG_SUMO_SIM_anti_2	244	252	PF11976	0.473
LIG_SUMO_SIM_par_1	41	47	PF11976	0.602
LIG_UBA3_1	249	254	PF00899	0.556
LIG_UBA3_1	35	41	PF00899	0.427
LIG_WW_2	483	486	PF00397	0.438
MOD_CDC14_SPxK_1	311	314	PF00782	0.505
MOD_CDK_SPxK_1	308	314	PF00069	0.496
MOD_CK1_1	12	18	PF00069	0.530
MOD_CK1_1	120	126	PF00069	0.558
MOD_CK1_1	175	181	PF00069	0.609
MOD_CK1_1	2	8	PF00069	0.564
MOD_CK1_1	230	236	PF00069	0.578
MOD_CK1_1	252	258	PF00069	0.247
MOD_CK1_1	390	396	PF00069	0.422
MOD_CK1_1	512	518	PF00069	0.476
MOD_CK2_1	19	25	PF00069	0.521
MOD_CK2_1	2	8	PF00069	0.641
MOD_CK2_1	317	323	PF00069	0.530
MOD_CK2_1	359	365	PF00069	0.569
MOD_CK2_1	407	413	PF00069	0.570
MOD_CK2_1	85	91	PF00069	0.473
MOD_GlcNHglycan	11	14	PF01048	0.611
MOD_GlcNHglycan	130	134	PF01048	0.467
MOD_GlcNHglycan	177	180	PF01048	0.542
MOD_GlcNHglycan	195	198	PF01048	0.484
MOD_GlcNHglycan	224	227	PF01048	0.620
MOD_GlcNHglycan	319	322	PF01048	0.627
MOD_GlcNHglycan	396	399	PF01048	0.531
MOD_GlcNHglycan	46	49	PF01048	0.457
MOD_GSK3_1	11	18	PF00069	0.641
MOD_GSK3_1	116	123	PF00069	0.523
MOD_GSK3_1	227	234	PF00069	0.572
MOD_GSK3_1	390	397	PF00069	0.490
MOD_GSK3_1	407	414	PF00069	0.505
MOD_N-GLC_2	500	502	PF02516	0.402
MOD_NEK2_1	1	6	PF00069	0.737
MOD_NEK2_1	116	121	PF00069	0.452
MOD_NEK2_1	143	148	PF00069	0.376
MOD_NEK2_1	344	349	PF00069	0.540
MOD_NEK2_1	427	432	PF00069	0.501
MOD_NEK2_1	457	462	PF00069	0.445
MOD_NEK2_1	53	58	PF00069	0.612
MOD_NEK2_1	85	90	PF00069	0.429
MOD_NEK2_1	9	14	PF00069	0.656
MOD_NEK2_2	216	221	PF00069	0.485
MOD_NEK2_2	285	290	PF00069	0.420
MOD_PIKK_1	493	499	PF00454	0.416
MOD_PKA_1	345	351	PF00069	0.509
MOD_PKA_1	387	393	PF00069	0.378
MOD_PKA_2	116	122	PF00069	0.440
MOD_PKA_2	143	149	PF00069	0.344
MOD_PKA_2	175	181	PF00069	0.470
MOD_PKA_2	344	350	PF00069	0.513
MOD_PKA_2	387	393	PF00069	0.548
MOD_PKA_2	53	59	PF00069	0.465
MOD_PKA_2	9	15	PF00069	0.691
MOD_Plk_1	291	297	PF00069	0.487
MOD_Plk_1	390	396	PF00069	0.448
MOD_Plk_1	509	515	PF00069	0.749
MOD_Plk_2-3	487	493	PF00069	0.550
MOD_Plk_4	111	117	PF00069	0.507
MOD_Plk_4	135	141	PF00069	0.403
MOD_Plk_4	161	167	PF00069	0.421
MOD_Plk_4	201	207	PF00069	0.375
MOD_Plk_4	252	258	PF00069	0.489
MOD_Plk_4	371	377	PF00069	0.441
MOD_Plk_4	390	396	PF00069	0.263
MOD_Plk_4	457	463	PF00069	0.485
MOD_Plk_4	53	59	PF00069	0.484
MOD_ProDKin_1	19	25	PF00069	0.534
MOD_ProDKin_1	308	314	PF00069	0.548
MOD_ProDKin_1	476	482	PF00069	0.701
MOD_SUMO_for_1	289	292	PF00179	0.622
TRG_DiLeu_BaEn_1	391	396	PF01217	0.487
TRG_DiLeu_BaEn_1	74	79	PF01217	0.616
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.419
TRG_ENDOCYTIC_2	185	188	PF00928	0.398
TRG_ENDOCYTIC_2	199	202	PF00928	0.510
TRG_ENDOCYTIC_2	296	299	PF00928	0.547
TRG_ENDOCYTIC_2	379	382	PF00928	0.391
TRG_ER_diArg_1	124	126	PF00400	0.494
TRG_ER_diArg_1	450	453	PF00400	0.441
TRG_ER_diArg_1	9	11	PF00400	0.678
TRG_NES_CRM1_1	34	46	PF08389	0.526
TRG_Pf-PMV_PEXEL_1	387	391	PF00026	0.253

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ13	Leptomonas seymouri	53%	100%
A0A1X0NVA2	Trypanosomatidae	26%	96%
A0A3R7L246	Trypanosoma rangeli	24%	100%
A0A3S7X131	Leishmania donovani	86%	99%
A4HG50	Leishmania braziliensis	71%	100%
A4I380	Leishmania infantum	86%	99%
Q4Q8R3	Leishmania major	86%	100%
V5BGK7	Trypanosoma cruzi	24%	100%