FIST_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZG7_LEIMU

TriTrypDb:

LmxM.28.0060

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZG7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.637
CLV_NRD_NRD_1	2	4	PF00675	0.560
CLV_NRD_NRD_1	400	402	PF00675	0.537
CLV_NRD_NRD_1	45	47	PF00675	0.574
CLV_NRD_NRD_1	52	54	PF00675	0.580
CLV_NRD_NRD_1	6	8	PF00675	0.561
CLV_PCSK_KEX2_1	18	20	PF00082	0.622
CLV_PCSK_KEX2_1	2	4	PF00082	0.562
CLV_PCSK_KEX2_1	382	384	PF00082	0.578
CLV_PCSK_KEX2_1	400	402	PF00082	0.566
CLV_PCSK_KEX2_1	45	47	PF00082	0.607
CLV_PCSK_KEX2_1	6	8	PF00082	0.558
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.578
CLV_PCSK_PC7_1	2	8	PF00082	0.659
CLV_PCSK_SKI1_1	259	263	PF00082	0.613
CLV_PCSK_SKI1_1	297	301	PF00082	0.415
CLV_PCSK_SKI1_1	318	322	PF00082	0.403
CLV_PCSK_SKI1_1	33	37	PF00082	0.643
CLV_PCSK_SKI1_1	54	58	PF00082	0.584
CLV_PCSK_SKI1_1	7	11	PF00082	0.585
DEG_APCC_DBOX_1	5	13	PF00400	0.617
DEG_Nend_UBRbox_1	1	4	PF02207	0.540
DEG_ODPH_VHL_1	384	395	PF01847	0.544
DEG_SPOP_SBC_1	404	408	PF00917	0.600
DEG_SPOP_SBC_1	473	477	PF00917	0.431
DOC_CDC14_PxL_1	148	156	PF14671	0.490
DOC_CKS1_1	26	31	PF01111	0.602
DOC_CYCLIN_RxL_1	30	40	PF00134	0.581
DOC_MAPK_DCC_7	423	431	PF00069	0.665
DOC_MAPK_gen_1	315	323	PF00069	0.466
DOC_MAPK_gen_1	382	389	PF00069	0.583
DOC_MAPK_gen_1	6	14	PF00069	0.679
DOC_MAPK_MEF2A_6	175	182	PF00069	0.571
DOC_MAPK_MEF2A_6	315	323	PF00069	0.403
DOC_MAPK_MEF2A_6	324	332	PF00069	0.418
DOC_MAPK_MEF2A_6	423	431	PF00069	0.552
DOC_PP1_RVXF_1	51	58	PF00149	0.507
DOC_PP2B_LxvP_1	218	221	PF13499	0.666
DOC_PP4_FxxP_1	345	348	PF00568	0.400
DOC_PP4_FxxP_1	456	459	PF00568	0.507
DOC_USP7_MATH_1	221	225	PF00917	0.747
DOC_USP7_MATH_1	427	431	PF00917	0.661
DOC_USP7_MATH_1	473	477	PF00917	0.431
DOC_USP7_MATH_1	59	63	PF00917	0.550
DOC_WW_Pin1_4	115	120	PF00397	0.535
DOC_WW_Pin1_4	25	30	PF00397	0.517
DOC_WW_Pin1_4	455	460	PF00397	0.616
LIG_14-3-3_CanoR_1	297	306	PF00244	0.395
LIG_14-3-3_CanoR_1	474	479	PF00244	0.433
LIG_14-3-3_CanoR_1	6	14	PF00244	0.639
LIG_BIR_III_2	162	166	PF00653	0.539
LIG_BRCT_BRCA1_1	157	161	PF00533	0.572
LIG_BRCT_BRCA1_1	237	241	PF00533	0.492
LIG_BRCT_BRCA1_1	316	320	PF00533	0.438
LIG_Clathr_ClatBox_1	377	381	PF01394	0.546
LIG_EVH1_1	82	86	PF00568	0.537
LIG_FHA_1	263	269	PF00498	0.567
LIG_FHA_1	298	304	PF00498	0.377
LIG_FHA_1	8	14	PF00498	0.402
LIG_HP1_1	427	431	PF01393	0.429
LIG_LIR_Apic_2	305	310	PF02991	0.518
LIG_LIR_Apic_2	342	348	PF02991	0.408
LIG_LIR_Gen_1	158	165	PF02991	0.559
LIG_LIR_Gen_1	475	485	PF02991	0.453
LIG_LIR_Gen_1	94	104	PF02991	0.551
LIG_LIR_Nem_3	158	164	PF02991	0.564
LIG_LIR_Nem_3	317	323	PF02991	0.402
LIG_LIR_Nem_3	475	481	PF02991	0.332
LIG_LYPXL_S_1	218	222	PF13949	0.581
LIG_LYPXL_yS_3	219	222	PF13949	0.587
LIG_MLH1_MIPbox_1	237	241	PF16413	0.510
LIG_SH2_CRK	478	482	PF00017	0.406
LIG_SH2_CRK	90	94	PF00017	0.584
LIG_SH2_GRB2like	90	93	PF00017	0.562
LIG_SH2_NCK_1	307	311	PF00017	0.580
LIG_SH2_STAP1	193	197	PF00017	0.455
LIG_SH2_STAP1	97	101	PF00017	0.488
LIG_SH2_STAT5	478	481	PF00017	0.455
LIG_SH3_3	23	29	PF00018	0.469
LIG_SH3_3	325	331	PF00018	0.485
LIG_SH3_3	332	338	PF00018	0.475
LIG_SH3_3	421	427	PF00018	0.611
LIG_SH3_3	80	86	PF00018	0.515
LIG_SH3_3	98	104	PF00018	0.498
LIG_SUMO_SIM_par_1	427	433	PF11976	0.470
LIG_TRFH_1	345	349	PF08558	0.524
LIG_TYR_ITIM	191	196	PF00017	0.489
LIG_UBA3_1	376	382	PF00899	0.466
LIG_WRC_WIRS_1	156	161	PF05994	0.424
MOD_CK1_1	202	208	PF00069	0.516
MOD_CK1_1	273	279	PF00069	0.429
MOD_CK1_1	430	436	PF00069	0.670
MOD_CK2_1	305	311	PF00069	0.573
MOD_GlcNHglycan	197	200	PF01048	0.497
MOD_GlcNHglycan	230	234	PF01048	0.757
MOD_GlcNHglycan	249	252	PF01048	0.453
MOD_GlcNHglycan	275	278	PF01048	0.453
MOD_GlcNHglycan	432	435	PF01048	0.593
MOD_GlcNHglycan	61	64	PF01048	0.474
MOD_GSK3_1	195	202	PF00069	0.585
MOD_GSK3_1	264	271	PF00069	0.469
MOD_GSK3_1	273	280	PF00069	0.354
MOD_GSK3_1	349	356	PF00069	0.520
MOD_GSK3_1	372	379	PF00069	0.584
MOD_GSK3_1	55	62	PF00069	0.574
MOD_N-GLC_1	91	96	PF02516	0.510
MOD_N-GLC_2	110	112	PF02516	0.458
MOD_N-GLC_2	87	89	PF02516	0.477
MOD_NEK2_1	184	189	PF00069	0.577
MOD_NEK2_1	204	209	PF00069	0.538
MOD_NEK2_1	343	348	PF00069	0.396
MOD_NEK2_1	372	377	PF00069	0.635
MOD_NEK2_1	411	416	PF00069	0.491
MOD_NEK2_2	287	292	PF00069	0.453
MOD_OFUCOSY	446	451	PF10250	0.652
MOD_PIKK_1	20	26	PF00454	0.582
MOD_PKA_2	247	253	PF00069	0.518
MOD_PKA_2	473	479	PF00069	0.433
MOD_PKA_2	5	11	PF00069	0.590
MOD_Plk_1	235	241	PF00069	0.554
MOD_Plk_1	341	347	PF00069	0.505
MOD_Plk_1	466	472	PF00069	0.560
MOD_Plk_1	91	97	PF00069	0.486
MOD_Plk_2-3	157	163	PF00069	0.544
MOD_Plk_2-3	305	311	PF00069	0.554
MOD_Plk_4	235	241	PF00069	0.545
MOD_Plk_4	264	270	PF00069	0.487
MOD_Plk_4	330	336	PF00069	0.412
MOD_Plk_4	372	378	PF00069	0.510
MOD_Plk_4	438	444	PF00069	0.481
MOD_Plk_4	467	473	PF00069	0.470
MOD_Plk_4	8	14	PF00069	0.474
MOD_ProDKin_1	115	121	PF00069	0.540
MOD_ProDKin_1	25	31	PF00069	0.512
MOD_ProDKin_1	455	461	PF00069	0.611
MOD_SUMO_for_1	422	425	PF00179	0.552
TRG_ENDOCYTIC_2	193	196	PF00928	0.486
TRG_ENDOCYTIC_2	219	222	PF00928	0.636
TRG_ENDOCYTIC_2	478	481	PF00928	0.504
TRG_ENDOCYTIC_2	90	93	PF00928	0.476
TRG_ENDOCYTIC_2	97	100	PF00928	0.455
TRG_ER_diArg_1	1	3	PF00400	0.543
TRG_ER_diArg_1	18	20	PF00400	0.451
TRG_ER_diArg_1	66	69	PF00400	0.460
TRG_NES_CRM1_1	367	381	PF08389	0.558
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.675
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCN6	Leptomonas seymouri	76%	99%
A0A0S4J200	Bodo saltans	41%	95%
A0A1X0NVX9	Trypanosomatidae	56%	98%
A0A3Q8IDL9	Leishmania donovani	92%	100%
A0A3R7NQD0	Trypanosoma rangeli	51%	96%
A4HG49	Leishmania braziliensis	84%	100%
A4I379	Leishmania infantum	92%	100%
D0A7Q8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	98%
Q4Q8R4	Leishmania major	94%	100%