NYD-SP28 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nexin-dynein regulatory complex 2

Species:

Leishmania mexicana

UniProt:

E9AZG6_LEIMU

TriTrypDb:

LmxM.28.0050

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005858	axonemal dynein complex	4	12
GO:0005875	microtubule associated complex	2	12
GO:0030286	dynein complex	3	12
GO:0032991	protein-containing complex	1	12
GO:1902494	catalytic complex	2	12
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	3
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	3
GO:0031514	motile cilium	5	2

Expansion

Sequence features

E9AZG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZG6

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0070286	axonemal dynein complex assembly	6	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0001539	cilium or flagellum-dependent cell motility	3	1
GO:0003352	regulation of cilium movement	6	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0048870	cell motility	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0060285	cilium-dependent cell motility	4	1
GO:0060632	regulation of microtubule-based movement	5	1
GO:0065007	biological regulation	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	398	402	PF00656	0.692
CLV_NRD_NRD_1	12	14	PF00675	0.720
CLV_NRD_NRD_1	162	164	PF00675	0.326
CLV_NRD_NRD_1	263	265	PF00675	0.560
CLV_NRD_NRD_1	32	34	PF00675	0.271
CLV_NRD_NRD_1	382	384	PF00675	0.681
CLV_NRD_NRD_1	86	88	PF00675	0.310
CLV_NRD_NRD_1	94	96	PF00675	0.306
CLV_PCSK_KEX2_1	32	34	PF00082	0.283
CLV_PCSK_KEX2_1	342	344	PF00082	0.566
CLV_PCSK_KEX2_1	381	383	PF00082	0.559
CLV_PCSK_KEX2_1	86	88	PF00082	0.318
CLV_PCSK_KEX2_1	9	11	PF00082	0.567
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.566
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.559
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.567
CLV_PCSK_SKI1_1	14	18	PF00082	0.637
CLV_PCSK_SKI1_1	173	177	PF00082	0.480
CLV_PCSK_SKI1_1	298	302	PF00082	0.445
CLV_PCSK_SKI1_1	303	307	PF00082	0.454
CLV_PCSK_SKI1_1	422	426	PF00082	0.435
CLV_PCSK_SKI1_1	434	438	PF00082	0.441
DEG_APCC_DBOX_1	172	180	PF00400	0.591
DOC_CYCLIN_RxL_1	32	42	PF00134	0.571
DOC_CYCLIN_RxL_1	342	352	PF00134	0.438
DOC_CYCLIN_RxL_1	431	440	PF00134	0.567
DOC_MAPK_gen_1	13	22	PF00069	0.670
DOC_MAPK_gen_1	32	40	PF00069	0.482
DOC_MAPK_gen_1	342	353	PF00069	0.465
DOC_PP1_RVXF_1	63	70	PF00149	0.460
DOC_SPAK_OSR1_1	415	419	PF12202	0.528
DOC_USP7_MATH_1	117	121	PF00917	0.524
DOC_USP7_MATH_1	27	31	PF00917	0.474
DOC_USP7_MATH_1	385	389	PF00917	0.618
DOC_USP7_MATH_1	482	486	PF00917	0.665
DOC_USP7_MATH_1	61	65	PF00917	0.473
DOC_USP7_UBL2_3	307	311	PF12436	0.513
DOC_USP7_UBL2_3	5	9	PF12436	0.590
LIG_14-3-3_CanoR_1	463	469	PF00244	0.666
LIG_14-3-3_CanoR_1	86	90	PF00244	0.554
LIG_Actin_WH2_2	202	219	PF00022	0.634
LIG_BIR_III_2	401	405	PF00653	0.625
LIG_deltaCOP1_diTrp_1	408	417	PF00928	0.474
LIG_deltaCOP1_diTrp_1	63	69	PF00928	0.481
LIG_FHA_1	254	260	PF00498	0.593
LIG_FHA_1	465	471	PF00498	0.565
LIG_FHA_1	99	105	PF00498	0.536
LIG_FHA_2	100	106	PF00498	0.595
LIG_FHA_2	198	204	PF00498	0.600
LIG_FHA_2	357	363	PF00498	0.466
LIG_LIR_Gen_1	408	418	PF02991	0.566
LIG_LIR_Gen_1	63	70	PF02991	0.481
LIG_LIR_Nem_3	228	234	PF02991	0.517
LIG_LIR_Nem_3	408	413	PF02991	0.564
LIG_LIR_Nem_3	63	69	PF02991	0.481
LIG_PCNA_PIPBox_1	445	454	PF02747	0.469
LIG_PCNA_yPIPBox_3	35	48	PF02747	0.464
LIG_PCNA_yPIPBox_3	434	448	PF02747	0.466
LIG_SH2_NCK_1	156	160	PF00017	0.578
LIG_SH2_NCK_1	493	497	PF00017	0.705
LIG_SH2_STAT5	245	248	PF00017	0.629
LIG_SH2_STAT5	451	454	PF00017	0.463
LIG_SUMO_SIM_anti_2	81	86	PF11976	0.492
LIG_SUMO_SIM_par_1	465	471	PF11976	0.551
LIG_TRAF2_1	332	335	PF00917	0.596
MOD_CK1_1	272	278	PF00069	0.446
MOD_CK2_1	15	21	PF00069	0.544
MOD_CK2_1	197	203	PF00069	0.597
MOD_CK2_1	356	362	PF00069	0.479
MOD_CK2_1	99	105	PF00069	0.557
MOD_Cter_Amidation	11	14	PF01082	0.543
MOD_GlcNHglycan	372	375	PF01048	0.662
MOD_GlcNHglycan	387	391	PF01048	0.770
MOD_GlcNHglycan	397	400	PF01048	0.727
MOD_GlcNHglycan	58	61	PF01048	0.378
MOD_GSK3_1	271	278	PF00069	0.487
MOD_GSK3_1	464	471	PF00069	0.613
MOD_GSK3_1	52	59	PF00069	0.488
MOD_GSK3_1	85	92	PF00069	0.554
MOD_N-GLC_1	330	335	PF02516	0.569
MOD_N-GLC_1	369	374	PF02516	0.605
MOD_N-GLC_1	482	487	PF02516	0.679
MOD_NEK2_1	234	239	PF00069	0.482
MOD_NEK2_1	269	274	PF00069	0.454
MOD_NEK2_1	337	342	PF00069	0.503
MOD_NEK2_1	39	44	PF00069	0.566
MOD_NEK2_1	462	467	PF00069	0.551
MOD_NEK2_1	468	473	PF00069	0.545
MOD_NEK2_1	99	104	PF00069	0.524
MOD_PIKK_1	428	434	PF00454	0.451
MOD_PIKK_1	468	474	PF00454	0.611
MOD_PKA_1	5	11	PF00069	0.675
MOD_PKA_2	462	468	PF00069	0.644
MOD_PKA_2	85	91	PF00069	0.554
MOD_Plk_1	105	111	PF00069	0.539
MOD_Plk_1	298	304	PF00069	0.483
MOD_Plk_1	453	459	PF00069	0.512
MOD_Plk_1	89	95	PF00069	0.552
MOD_Plk_2-3	105	111	PF00069	0.571
MOD_Plk_2-3	453	459	PF00069	0.544
MOD_Plk_4	124	130	PF00069	0.592
MOD_Plk_4	464	470	PF00069	0.573
MOD_Plk_4	99	105	PF00069	0.531
MOD_SUMO_rev_2	157	166	PF00179	0.532
MOD_SUMO_rev_2	182	190	PF00179	0.484
MOD_SUMO_rev_2	46	54	PF00179	0.527
TRG_DiLeu_BaEn_2	496	502	PF01217	0.643
TRG_DiLeu_BaEn_4	439	445	PF01217	0.450
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.563
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.563
TRG_ENDOCYTIC_2	231	234	PF00928	0.520
TRG_ENDOCYTIC_2	493	496	PF00928	0.606
TRG_ER_diArg_1	32	35	PF00400	0.479
TRG_ER_diArg_1	382	384	PF00400	0.678
TRG_ER_diArg_1	85	87	PF00400	0.492
TRG_NLS_MonoExtN_4	10	17	PF00514	0.535
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	355	360	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.341
TRG_Pf-PMV_PEXEL_1	76	81	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5X5	Leptomonas seymouri	74%	100%
A0A0S4J2B0	Bodo saltans	47%	99%
A0A1X0NVC5	Trypanosomatidae	53%	100%
A0A3Q8IHV5	Leishmania donovani	93%	100%
A0A3R7MHP0	Trypanosoma rangeli	52%	100%
A4HG48	Leishmania braziliensis	81%	100%
A4I378	Leishmania infantum	93%	100%
A8JB22	Chlamydomonas reinhardtii	28%	89%
D0A7Q6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q2TA16	Bos taurus	29%	100%
Q4Q8R5	Leishmania major	93%	100%
Q4R7G7	Macaca fascicularis	29%	100%
Q5XIJ8	Rattus norvegicus	29%	100%
Q6DHI2	Danio rerio	26%	100%
Q8IXS2	Homo sapiens	29%	100%
Q8VHI7	Mus musculus	28%	100%
V5AS08	Trypanosoma cruzi	52%	100%