TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZG5_LEIMU

TriTrypDb:

LmxM.28.0040

Length:

916

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.705
CLV_C14_Caspase3-7	370	374	PF00656	0.267
CLV_NRD_NRD_1	208	210	PF00675	0.759
CLV_NRD_NRD_1	277	279	PF00675	0.584
CLV_NRD_NRD_1	331	333	PF00675	0.493
CLV_NRD_NRD_1	368	370	PF00675	0.493
CLV_NRD_NRD_1	385	387	PF00675	0.373
CLV_NRD_NRD_1	467	469	PF00675	0.514
CLV_NRD_NRD_1	502	504	PF00675	0.467
CLV_NRD_NRD_1	621	623	PF00675	0.421
CLV_NRD_NRD_1	774	776	PF00675	0.553
CLV_NRD_NRD_1	911	913	PF00675	0.601
CLV_PCSK_KEX2_1	277	279	PF00082	0.591
CLV_PCSK_KEX2_1	368	370	PF00082	0.489
CLV_PCSK_KEX2_1	502	504	PF00082	0.450
CLV_PCSK_KEX2_1	52	54	PF00082	0.653
CLV_PCSK_KEX2_1	71	73	PF00082	0.743
CLV_PCSK_KEX2_1	774	776	PF00082	0.541
CLV_PCSK_KEX2_1	911	913	PF00082	0.593
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.643
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.743
CLV_PCSK_PC1ET2_1	911	913	PF00082	0.593
CLV_PCSK_PC7_1	364	370	PF00082	0.588
CLV_PCSK_PC7_1	498	504	PF00082	0.592
CLV_PCSK_SKI1_1	128	132	PF00082	0.595
CLV_PCSK_SKI1_1	17	21	PF00082	0.523
CLV_PCSK_SKI1_1	173	177	PF00082	0.627
CLV_PCSK_SKI1_1	277	281	PF00082	0.627
CLV_PCSK_SKI1_1	316	320	PF00082	0.550
CLV_PCSK_SKI1_1	369	373	PF00082	0.446
CLV_PCSK_SKI1_1	436	440	PF00082	0.454
CLV_PCSK_SKI1_1	477	481	PF00082	0.488
CLV_PCSK_SKI1_1	503	507	PF00082	0.494
CLV_PCSK_SKI1_1	587	591	PF00082	0.552
CLV_PCSK_SKI1_1	622	626	PF00082	0.411
CLV_PCSK_SKI1_1	715	719	PF00082	0.501
CLV_PCSK_SKI1_1	774	778	PF00082	0.547
CLV_PCSK_SKI1_1	819	823	PF00082	0.480
CLV_Separin_Metazoa	600	604	PF03568	0.533
DEG_APCC_DBOX_1	368	376	PF00400	0.536
DEG_APCC_DBOX_1	502	510	PF00400	0.484
DEG_APCC_DBOX_1	621	629	PF00400	0.414
DEG_APCC_DBOX_1	669	677	PF00400	0.591
DEG_SCF_FBW7_2	159	166	PF00400	0.680
DEG_SPOP_SBC_1	778	782	PF00917	0.328
DOC_CKS1_1	181	186	PF01111	0.502
DOC_CKS1_1	73	78	PF01111	0.727
DOC_CYCLIN_RxL_1	14	22	PF00134	0.510
DOC_CYCLIN_RxL_1	313	323	PF00134	0.521
DOC_CYCLIN_RxL_1	498	510	PF00134	0.554
DOC_CYCLIN_RxL_1	712	722	PF00134	0.533
DOC_MAPK_gen_1	115	123	PF00069	0.729
DOC_MAPK_gen_1	209	219	PF00069	0.609
DOC_MAPK_gen_1	386	392	PF00069	0.521
DOC_MAPK_gen_1	410	419	PF00069	0.522
DOC_MAPK_gen_1	792	802	PF00069	0.247
DOC_MAPK_gen_1	91	98	PF00069	0.663
DOC_MAPK_MEF2A_6	115	123	PF00069	0.710
DOC_MAPK_MEF2A_6	209	217	PF00069	0.608
DOC_MAPK_MEF2A_6	91	98	PF00069	0.615
DOC_PP1_RVXF_1	15	21	PF00149	0.524
DOC_PP1_RVXF_1	299	305	PF00149	0.700
DOC_PP1_RVXF_1	654	661	PF00149	0.516
DOC_PP2B_LxvP_1	121	124	PF13499	0.756
DOC_PP4_MxPP_1	1	4	PF00568	0.798
DOC_USP7_MATH_1	153	157	PF00917	0.694
DOC_USP7_MATH_1	235	239	PF00917	0.721
DOC_USP7_MATH_1	320	324	PF00917	0.546
DOC_USP7_MATH_1	339	343	PF00917	0.353
DOC_USP7_MATH_1	438	442	PF00917	0.547
DOC_USP7_MATH_1	473	477	PF00917	0.468
DOC_USP7_MATH_1	559	563	PF00917	0.526
DOC_USP7_MATH_1	692	696	PF00917	0.669
DOC_USP7_MATH_1	741	745	PF00917	0.559
DOC_USP7_UBL2_3	907	911	PF12436	0.477
DOC_WW_Pin1_4	159	164	PF00397	0.669
DOC_WW_Pin1_4	180	185	PF00397	0.646
DOC_WW_Pin1_4	615	620	PF00397	0.453
DOC_WW_Pin1_4	690	695	PF00397	0.580
DOC_WW_Pin1_4	72	77	PF00397	0.720
LIG_14-3-3_CanoR_1	277	282	PF00244	0.623
LIG_14-3-3_CanoR_1	297	301	PF00244	0.494
LIG_14-3-3_CanoR_1	340	346	PF00244	0.577
LIG_14-3-3_CanoR_1	477	485	PF00244	0.532
LIG_14-3-3_CanoR_1	502	506	PF00244	0.529
LIG_14-3-3_CanoR_1	507	515	PF00244	0.550
LIG_14-3-3_CanoR_1	587	592	PF00244	0.452
LIG_14-3-3_CanoR_1	677	683	PF00244	0.552
LIG_Actin_WH2_2	588	605	PF00022	0.496
LIG_Actin_WH2_2	651	669	PF00022	0.528
LIG_APCC_ABBA_1	867	872	PF00400	0.473
LIG_BIR_III_4	373	377	PF00653	0.280
LIG_CtBP_PxDLS_1	124	128	PF00389	0.775
LIG_deltaCOP1_diTrp_1	862	870	PF00928	0.510
LIG_FHA_1	192	198	PF00498	0.764
LIG_FHA_1	297	303	PF00498	0.657
LIG_FHA_1	394	400	PF00498	0.558
LIG_FHA_1	530	536	PF00498	0.527
LIG_FHA_1	590	596	PF00498	0.509
LIG_FHA_1	700	706	PF00498	0.584
LIG_FHA_1	771	777	PF00498	0.408
LIG_FHA_1	778	784	PF00498	0.377
LIG_FHA_1	803	809	PF00498	0.487
LIG_FHA_1	813	819	PF00498	0.346
LIG_FHA_1	864	870	PF00498	0.423
LIG_FHA_1	885	891	PF00498	0.493
LIG_FHA_1	897	903	PF00498	0.401
LIG_FHA_2	111	117	PF00498	0.709
LIG_FHA_2	160	166	PF00498	0.630
LIG_FHA_2	223	229	PF00498	0.638
LIG_FHA_2	404	410	PF00498	0.470
LIG_FHA_2	695	701	PF00498	0.670
LIG_FHA_2	761	767	PF00498	0.486
LIG_IRF3_LxIS_1	851	856	PF10401	0.495
LIG_LIR_Gen_1	517	525	PF02991	0.413
LIG_LIR_Gen_1	680	691	PF02991	0.690
LIG_LIR_Gen_1	766	776	PF02991	0.458
LIG_LIR_Nem_3	517	523	PF02991	0.412
LIG_LIR_Nem_3	567	572	PF02991	0.504
LIG_PCNA_yPIPBox_3	570	582	PF02747	0.483
LIG_Pex14_2	398	402	PF04695	0.507
LIG_PROFILIN_1	143	149	PF00235	0.495
LIG_SH2_CRK	573	577	PF00017	0.255
LIG_SH2_STAP1	39	43	PF00017	0.566
LIG_SH2_STAP1	520	524	PF00017	0.409
LIG_SH2_STAP1	699	703	PF00017	0.532
LIG_SH2_STAT3	39	42	PF00017	0.564
LIG_SH2_STAT5	816	819	PF00017	0.489
LIG_SH3_2	80	85	PF14604	0.769
LIG_SH3_2	99	104	PF14604	0.686
LIG_SH3_3	137	143	PF00018	0.666
LIG_SH3_3	2	8	PF00018	0.741
LIG_SH3_3	70	76	PF00018	0.752
LIG_SH3_3	755	761	PF00018	0.509
LIG_SH3_3	77	83	PF00018	0.774
LIG_SH3_3	841	847	PF00018	0.576
LIG_SH3_3	96	102	PF00018	0.673
LIG_Sin3_3	489	496	PF02671	0.456
LIG_SUMO_SIM_anti_2	453	458	PF11976	0.503
LIG_SUMO_SIM_anti_2	744	750	PF11976	0.442
LIG_SUMO_SIM_par_1	449	455	PF11976	0.558
LIG_SUMO_SIM_par_1	94	100	PF11976	0.697
LIG_TRAF2_1	163	166	PF00917	0.748
LIG_TRAF2_1	597	600	PF00917	0.568
LIG_WRC_WIRS_1	328	333	PF05994	0.441
MOD_CDK_SPxxK_3	615	622	PF00069	0.275
MOD_CK1_1	126	132	PF00069	0.678
MOD_CK1_1	138	144	PF00069	0.673
MOD_CK1_1	195	201	PF00069	0.757
MOD_CK1_1	355	361	PF00069	0.590
MOD_CK1_1	393	399	PF00069	0.491
MOD_CK1_1	527	533	PF00069	0.358
MOD_CK1_1	684	690	PF00069	0.657
MOD_CK1_1	693	699	PF00069	0.623
MOD_CK1_1	710	716	PF00069	0.442
MOD_CK1_1	744	750	PF00069	0.463
MOD_CK1_1	788	794	PF00069	0.449
MOD_CK1_1	856	862	PF00069	0.469
MOD_CK1_1	876	882	PF00069	0.442
MOD_CK1_1	884	890	PF00069	0.505
MOD_CK2_1	110	116	PF00069	0.729
MOD_CK2_1	159	165	PF00069	0.645
MOD_CK2_1	222	228	PF00069	0.540
MOD_CK2_1	32	38	PF00069	0.691
MOD_CK2_1	403	409	PF00069	0.499
MOD_CK2_1	444	450	PF00069	0.557
MOD_CK2_1	475	481	PF00069	0.487
MOD_CK2_1	527	533	PF00069	0.389
MOD_CK2_1	640	646	PF00069	0.567
MOD_CK2_1	694	700	PF00069	0.674
MOD_DYRK1A_RPxSP_1	72	76	PF00069	0.619
MOD_GlcNHglycan	140	143	PF01048	0.731
MOD_GlcNHglycan	155	158	PF01048	0.691
MOD_GlcNHglycan	197	200	PF01048	0.608
MOD_GlcNHglycan	21	24	PF01048	0.477
MOD_GlcNHglycan	237	240	PF01048	0.712
MOD_GlcNHglycan	322	325	PF01048	0.536
MOD_GlcNHglycan	341	344	PF01048	0.342
MOD_GlcNHglycan	357	360	PF01048	0.462
MOD_GlcNHglycan	392	395	PF01048	0.473
MOD_GlcNHglycan	446	449	PF01048	0.574
MOD_GlcNHglycan	481	484	PF01048	0.579
MOD_GlcNHglycan	494	497	PF01048	0.543
MOD_GlcNHglycan	708	712	PF01048	0.553
MOD_GlcNHglycan	742	746	PF01048	0.471
MOD_GlcNHglycan	80	83	PF01048	0.789
MOD_GlcNHglycan	858	861	PF01048	0.470
MOD_GlcNHglycan	878	881	PF01048	0.261
MOD_GlcNHglycan	9	12	PF01048	0.617
MOD_GSK3_1	110	117	PF00069	0.745
MOD_GSK3_1	126	133	PF00069	0.699
MOD_GSK3_1	147	154	PF00069	0.696
MOD_GSK3_1	191	198	PF00069	0.725
MOD_GSK3_1	222	229	PF00069	0.525
MOD_GSK3_1	296	303	PF00069	0.581
MOD_GSK3_1	348	355	PF00069	0.526
MOD_GSK3_1	440	447	PF00069	0.591
MOD_GSK3_1	473	480	PF00069	0.443
MOD_GSK3_1	497	504	PF00069	0.546
MOD_GSK3_1	690	697	PF00069	0.473
MOD_GSK3_1	778	785	PF00069	0.446
MOD_GSK3_1	786	793	PF00069	0.357
MOD_GSK3_1	849	856	PF00069	0.427
MOD_LATS_1	585	591	PF00433	0.532
MOD_N-GLC_1	778	783	PF02516	0.404
MOD_N-GLC_1	812	817	PF02516	0.516
MOD_NEK2_1	130	135	PF00069	0.722
MOD_NEK2_1	19	24	PF00069	0.539
MOD_NEK2_1	296	301	PF00069	0.639
MOD_NEK2_1	32	37	PF00069	0.624
MOD_NEK2_1	390	395	PF00069	0.449
MOD_NEK2_1	457	462	PF00069	0.480
MOD_NEK2_1	479	484	PF00069	0.542
MOD_NEK2_1	640	645	PF00069	0.557
MOD_NEK2_1	770	775	PF00069	0.483
MOD_NEK2_1	790	795	PF00069	0.419
MOD_NEK2_1	802	807	PF00069	0.530
MOD_NEK2_1	853	858	PF00069	0.421
MOD_NEK2_1	873	878	PF00069	0.372
MOD_NEK2_2	327	332	PF00069	0.472
MOD_NEK2_2	694	699	PF00069	0.435
MOD_NEK2_2	863	868	PF00069	0.469
MOD_PIKK_1	457	463	PF00454	0.561
MOD_PIKK_1	527	533	PF00454	0.503
MOD_PIKK_1	884	890	PF00454	0.449
MOD_PKA_1	277	283	PF00069	0.672
MOD_PKA_2	114	120	PF00069	0.676
MOD_PKA_2	277	283	PF00069	0.600
MOD_PKA_2	296	302	PF00069	0.500
MOD_PKA_2	339	345	PF00069	0.564
MOD_PKA_2	457	463	PF00069	0.512
MOD_PKA_2	497	503	PF00069	0.548
MOD_PKA_2	676	682	PF00069	0.561
MOD_PKA_2	684	690	PF00069	0.636
MOD_Plk_1	452	458	PF00069	0.476
MOD_Plk_1	515	521	PF00069	0.540
MOD_Plk_1	778	784	PF00069	0.486
MOD_Plk_1	803	809	PF00069	0.523
MOD_Plk_1	812	818	PF00069	0.444
MOD_Plk_4	192	198	PF00069	0.660
MOD_Plk_4	222	228	PF00069	0.662
MOD_Plk_4	452	458	PF00069	0.453
MOD_Plk_4	515	521	PF00069	0.540
MOD_Plk_4	694	700	PF00069	0.433
MOD_Plk_4	701	707	PF00069	0.657
MOD_Plk_4	734	740	PF00069	0.542
MOD_Plk_4	744	750	PF00069	0.419
MOD_Plk_4	782	788	PF00069	0.413
MOD_Plk_4	812	818	PF00069	0.407
MOD_Plk_4	881	887	PF00069	0.526
MOD_ProDKin_1	159	165	PF00069	0.670
MOD_ProDKin_1	180	186	PF00069	0.644
MOD_ProDKin_1	615	621	PF00069	0.447
MOD_ProDKin_1	690	696	PF00069	0.575
MOD_ProDKin_1	72	78	PF00069	0.724
MOD_SUMO_for_1	739	742	PF00179	0.541
MOD_SUMO_for_1	903	906	PF00179	0.601
MOD_SUMO_rev_2	165	175	PF00179	0.690
TRG_DiLeu_BaEn_4	274	280	PF01217	0.567
TRG_DiLeu_BaEn_4	432	438	PF01217	0.508
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.633
TRG_ENDOCYTIC_2	520	523	PF00928	0.412
TRG_ENDOCYTIC_2	573	576	PF00928	0.244
TRG_ENDOCYTIC_2	768	771	PF00928	0.420
TRG_ER_diArg_1	277	279	PF00400	0.648
TRG_ER_diArg_1	367	369	PF00400	0.496
TRG_ER_diArg_1	501	503	PF00400	0.472
TRG_ER_diArg_1	774	776	PF00400	0.577
TRG_ER_diLys_1	911	916	PF00400	0.536
TRG_NES_CRM1_1	708	722	PF08389	0.544
TRG_NLS_MonoCore_2	208	213	PF00514	0.457
TRG_NLS_MonoCore_2	910	915	PF00514	0.561
TRG_NLS_MonoExtC_3	208	213	PF00514	0.720
TRG_NLS_MonoExtC_3	910	915	PF00514	0.561
TRG_NLS_MonoExtN_4	911	916	PF00514	0.582
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	477	481	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	503	508	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	542	547	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF72	Leptomonas seymouri	60%	99%
A0A0S4J1J7	Bodo saltans	29%	86%
A0A1X0NWQ3	Trypanosomatidae	36%	97%
A0A3Q8ICX2	Leishmania donovani	90%	100%
A0A3R7LZ16	Trypanosoma rangeli	36%	96%
A4HG47	Leishmania braziliensis	75%	100%
A4I377	Leishmania infantum	89%	100%
D0A7Q3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	97%
Q4Q8R6	Leishmania major	90%	100%
V5BBZ0	Trypanosoma cruzi	35%	97%