LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase, putative
Species:
Leishmania mexicana
UniProt:
E9AZF6_LEIMU
TriTrypDb:
LmxM.27.2470
Length:
545

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 6
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 21
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 15
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 35
NetGPI no yes: 0, no: 35
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 3
GO:0031974 membrane-enclosed lumen 2 2
GO:0031981 nuclear lumen 5 2
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 2
GO:0043233 organelle lumen 3 2
GO:0070013 intracellular organelle lumen 4 2
GO:0097014 ciliary plasm 5 2
GO:0099568 cytoplasmic region 3 2
GO:0110165 cellular anatomical entity 1 4
GO:0005930 axoneme 2 1
GO:0005952 cAMP-dependent protein kinase complex 3 1
GO:0032991 protein-containing complex 1 1
GO:0061695 transferase complex, transferring phosphorus-containing groups 4 1
GO:0140535 intracellular protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1902554 serine/threonine protein kinase complex 6 1
GO:1902911 protein kinase complex 5 1
GO:1990234 transferase complex 3 1
GO:0016020 membrane 2 1
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

E9AZF6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZF6

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 36
GO:0006793 phosphorus metabolic process 3 36
GO:0006796 phosphate-containing compound metabolic process 4 36
GO:0006807 nitrogen compound metabolic process 2 36
GO:0008152 metabolic process 1 36
GO:0009987 cellular process 1 36
GO:0016310 phosphorylation 5 36
GO:0019538 protein metabolic process 3 36
GO:0036211 protein modification process 4 36
GO:0043170 macromolecule metabolic process 3 36
GO:0043412 macromolecule modification 4 36
GO:0044237 cellular metabolic process 2 36
GO:0044238 primary metabolic process 2 36
GO:0071704 organic substance metabolic process 2 36
GO:1901564 organonitrogen compound metabolic process 3 36
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0018105 peptidyl-serine phosphorylation 6 3
GO:0018193 peptidyl-amino acid modification 5 3
GO:0018209 peptidyl-serine modification 6 3
GO:0022402 cell cycle process 2 1
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:1903047 mitotic cell cycle process 3 1
GO:0007165 signal transduction 2 3
GO:0035556 intracellular signal transduction 3 2
GO:0050789 regulation of biological process 2 3
GO:0050794 regulation of cellular process 3 3
GO:0065007 biological regulation 1 3
GO:0046777 protein autophosphorylation 6 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 36
GO:0003824 catalytic activity 1 36
GO:0004672 protein kinase activity 3 36
GO:0005488 binding 1 36
GO:0005524 ATP binding 5 36
GO:0016301 kinase activity 4 36
GO:0016740 transferase activity 2 36
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 36
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 36
GO:0017076 purine nucleotide binding 4 36
GO:0030554 adenyl nucleotide binding 5 36
GO:0032553 ribonucleotide binding 3 36
GO:0032555 purine ribonucleotide binding 4 36
GO:0032559 adenyl ribonucleotide binding 5 36
GO:0035639 purine ribonucleoside triphosphate binding 4 36
GO:0036094 small molecule binding 2 36
GO:0043167 ion binding 2 36
GO:0043168 anion binding 3 36
GO:0097159 organic cyclic compound binding 2 36
GO:0097367 carbohydrate derivative binding 2 36
GO:0140096 catalytic activity, acting on a protein 2 36
GO:1901265 nucleoside phosphate binding 3 36
GO:1901363 heterocyclic compound binding 2 36
GO:0004674 protein serine/threonine kinase activity 4 28
GO:0008270 zinc ion binding 6 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1
GO:0046914 transition metal ion binding 5 1
GO:0004690 cyclic nucleotide-dependent protein kinase activity 5 1
GO:0004691 cAMP-dependent protein kinase activity 6 1
GO:0004683 calmodulin-dependent protein kinase activity 5 1
GO:0005515 protein binding 2 1
GO:0005516 calmodulin binding 3 1
GO:0009931 calcium-dependent protein serine/threonine kinase activity 5 1
GO:0010857 calcium-dependent protein kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 202 204 PF00675 0.333
CLV_NRD_NRD_1 436 438 PF00675 0.397
CLV_NRD_NRD_1 52 54 PF00675 0.239
CLV_NRD_NRD_1 534 536 PF00675 0.489
CLV_PCSK_KEX2_1 404 406 PF00082 0.456
CLV_PCSK_KEX2_1 438 440 PF00082 0.390
CLV_PCSK_KEX2_1 52 54 PF00082 0.477
CLV_PCSK_PC1ET2_1 404 406 PF00082 0.473
CLV_PCSK_PC1ET2_1 438 440 PF00082 0.390
CLV_PCSK_PC1ET2_1 52 54 PF00082 0.477
CLV_PCSK_SKI1_1 124 128 PF00082 0.242
CLV_PCSK_SKI1_1 141 145 PF00082 0.320
CLV_PCSK_SKI1_1 305 309 PF00082 0.448
CLV_PCSK_SKI1_1 310 314 PF00082 0.544
CLV_PCSK_SKI1_1 520 524 PF00082 0.572
DEG_APCC_DBOX_1 123 131 PF00400 0.293
DEG_APCC_DBOX_1 436 444 PF00400 0.394
DEG_SCF_FBW7_1 525 531 PF00400 0.501
DEG_SPOP_SBC_1 178 182 PF00917 0.328
DEG_SPOP_SBC_1 528 532 PF00917 0.512
DOC_CKS1_1 525 530 PF01111 0.489
DOC_MAPK_gen_1 141 150 PF00069 0.314
DOC_MAPK_gen_1 309 318 PF00069 0.496
DOC_MAPK_gen_1 39 49 PF00069 0.224
DOC_MAPK_JIP1_4 144 150 PF00069 0.291
DOC_MAPK_MEF2A_6 90 98 PF00069 0.259
DOC_USP7_MATH_1 423 427 PF00917 0.501
DOC_USP7_UBL2_3 309 313 PF12436 0.403
DOC_USP7_UBL2_3 48 52 PF12436 0.328
DOC_USP7_UBL2_3 507 511 PF12436 0.662
DOC_USP7_UBL2_3 536 540 PF12436 0.521
DOC_USP7_UBL2_3 54 58 PF12436 0.332
DOC_WW_Pin1_4 152 157 PF00397 0.215
DOC_WW_Pin1_4 183 188 PF00397 0.306
DOC_WW_Pin1_4 255 260 PF00397 0.292
DOC_WW_Pin1_4 329 334 PF00397 0.462
DOC_WW_Pin1_4 512 517 PF00397 0.622
DOC_WW_Pin1_4 524 529 PF00397 0.618
LIG_14-3-3_CanoR_1 16 22 PF00244 0.308
LIG_14-3-3_CanoR_1 246 250 PF00244 0.391
LIG_14-3-3_CanoR_1 340 348 PF00244 0.587
LIG_14-3-3_CanoR_1 359 364 PF00244 0.419
LIG_14-3-3_CanoR_1 475 479 PF00244 0.583
LIG_Actin_WH2_2 136 153 PF00022 0.244
LIG_APCC_ABBA_1 409 414 PF00400 0.564
LIG_APCC_ABBAyCdc20_2 136 142 PF00400 0.242
LIG_deltaCOP1_diTrp_1 330 338 PF00928 0.547
LIG_EH1_1 92 100 PF00400 0.211
LIG_eIF4E_1 93 99 PF01652 0.223
LIG_FHA_1 218 224 PF00498 0.290
LIG_FHA_1 236 242 PF00498 0.223
LIG_FHA_1 320 326 PF00498 0.412
LIG_FHA_1 39 45 PF00498 0.317
LIG_FHA_1 62 68 PF00498 0.203
LIG_FHA_2 200 206 PF00498 0.241
LIG_FHA_2 276 282 PF00498 0.416
LIG_FHA_2 35 41 PF00498 0.217
LIG_FHA_2 489 495 PF00498 0.602
LIG_LIR_Apic_2 186 192 PF02991 0.314
LIG_LIR_Apic_2 330 334 PF02991 0.544
LIG_LIR_Gen_1 220 229 PF02991 0.230
LIG_LIR_Gen_1 237 243 PF02991 0.291
LIG_LIR_Gen_1 252 261 PF02991 0.172
LIG_LIR_Gen_1 332 339 PF02991 0.600
LIG_LIR_Gen_1 342 349 PF02991 0.592
LIG_LIR_Gen_1 398 407 PF02991 0.467
LIG_LIR_LC3C_4 238 243 PF02991 0.174
LIG_LIR_Nem_3 220 224 PF02991 0.261
LIG_LIR_Nem_3 237 242 PF02991 0.348
LIG_LIR_Nem_3 252 257 PF02991 0.201
LIG_LIR_Nem_3 270 274 PF02991 0.172
LIG_LIR_Nem_3 332 338 PF02991 0.494
LIG_LIR_Nem_3 342 348 PF02991 0.516
LIG_LIR_Nem_3 398 402 PF02991 0.441
LIG_LIR_Nem_3 408 413 PF02991 0.447
LIG_LIR_Nem_3 477 482 PF02991 0.565
LIG_LIR_Nem_3 89 95 PF02991 0.371
LIG_LYPXL_S_1 409 413 PF13949 0.432
LIG_LYPXL_yS_3 410 413 PF13949 0.434
LIG_PCNA_PIPBox_1 280 289 PF02747 0.159
LIG_PCNA_yPIPBox_3 276 287 PF02747 0.177
LIG_Pex14_1 331 335 PF04695 0.547
LIG_Pex14_2 235 239 PF04695 0.334
LIG_SH2_CRK 30 34 PF00017 0.269
LIG_SH2_NCK_1 271 275 PF00017 0.191
LIG_SH2_NCK_1 30 34 PF00017 0.223
LIG_SH2_PTP2 189 192 PF00017 0.281
LIG_SH2_PTP2 221 224 PF00017 0.301
LIG_SH2_PTP2 93 96 PF00017 0.412
LIG_SH2_SRC 177 180 PF00017 0.328
LIG_SH2_SRC 271 274 PF00017 0.191
LIG_SH2_STAP1 30 34 PF00017 0.223
LIG_SH2_STAP1 45 49 PF00017 0.344
LIG_SH2_STAT5 177 180 PF00017 0.328
LIG_SH2_STAT5 189 192 PF00017 0.315
LIG_SH2_STAT5 221 224 PF00017 0.303
LIG_SH2_STAT5 399 402 PF00017 0.434
LIG_SH2_STAT5 445 448 PF00017 0.380
LIG_SH2_STAT5 85 88 PF00017 0.302
LIG_SH2_STAT5 93 96 PF00017 0.341
LIG_SH3_3 271 277 PF00018 0.327
LIG_SH3_3 510 516 PF00018 0.581
LIG_SH3_3 522 528 PF00018 0.484
LIG_SUMO_SIM_anti_2 66 71 PF11976 0.250
LIG_SUMO_SIM_par_1 94 100 PF11976 0.366
LIG_TRAF2_1 278 281 PF00917 0.177
LIG_TYR_ITIM 219 224 PF00017 0.343
LIG_TYR_ITIM 269 274 PF00017 0.191
LIG_UBA3_1 104 112 PF00899 0.301
MOD_CDK_SPxxK_3 255 262 PF00069 0.293
MOD_CK1_1 117 123 PF00069 0.233
MOD_CK1_1 155 161 PF00069 0.230
MOD_CK1_1 162 168 PF00069 0.216
MOD_CK1_1 300 306 PF00069 0.420
MOD_CK1_1 474 480 PF00069 0.521
MOD_CK1_1 515 521 PF00069 0.500
MOD_CK1_1 530 536 PF00069 0.557
MOD_CK1_1 539 545 PF00069 0.586
MOD_CK2_1 199 205 PF00069 0.241
MOD_CK2_1 231 237 PF00069 0.272
MOD_CK2_1 275 281 PF00069 0.201
MOD_CK2_1 34 40 PF00069 0.216
MOD_CK2_1 488 494 PF00069 0.581
MOD_Cter_Amidation 402 405 PF01082 0.454
MOD_GlcNHglycan 127 130 PF01048 0.305
MOD_GlcNHglycan 224 227 PF01048 0.242
MOD_GlcNHglycan 99 102 PF01048 0.298
MOD_GSK3_1 152 159 PF00069 0.272
MOD_GSK3_1 179 186 PF00069 0.362
MOD_GSK3_1 231 238 PF00069 0.251
MOD_GSK3_1 241 248 PF00069 0.325
MOD_GSK3_1 339 346 PF00069 0.574
MOD_GSK3_1 34 41 PF00069 0.206
MOD_GSK3_1 359 366 PF00069 0.700
MOD_GSK3_1 484 491 PF00069 0.527
MOD_GSK3_1 524 531 PF00069 0.731
MOD_GSK3_1 535 542 PF00069 0.641
MOD_N-GLC_1 117 122 PF02516 0.191
MOD_N-GLC_1 162 167 PF02516 0.365
MOD_NEK2_1 241 246 PF00069 0.253
MOD_NEK2_1 319 324 PF00069 0.453
MOD_NEK2_1 34 39 PF00069 0.253
MOD_NEK2_1 471 476 PF00069 0.476
MOD_NEK2_1 482 487 PF00069 0.493
MOD_PIKK_1 319 325 PF00454 0.558
MOD_PIKK_1 350 356 PF00454 0.456
MOD_PKA_1 535 541 PF00069 0.490
MOD_PKA_2 245 251 PF00069 0.375
MOD_PKA_2 275 281 PF00069 0.249
MOD_PKA_2 339 345 PF00069 0.618
MOD_PKA_2 34 40 PF00069 0.279
MOD_PKA_2 474 480 PF00069 0.594
MOD_Plk_1 117 123 PF00069 0.305
MOD_Plk_1 423 429 PF00069 0.434
MOD_Plk_4 117 123 PF00069 0.214
MOD_Plk_4 185 191 PF00069 0.258
MOD_Plk_4 321 327 PF00069 0.435
MOD_Plk_4 344 350 PF00069 0.424
MOD_Plk_4 474 480 PF00069 0.539
MOD_ProDKin_1 152 158 PF00069 0.215
MOD_ProDKin_1 183 189 PF00069 0.306
MOD_ProDKin_1 255 261 PF00069 0.292
MOD_ProDKin_1 329 335 PF00069 0.463
MOD_ProDKin_1 512 518 PF00069 0.625
MOD_ProDKin_1 524 530 PF00069 0.617
MOD_SUMO_for_1 143 146 PF00179 0.332
TRG_DiLeu_BaEn_1 237 242 PF01217 0.191
TRG_DiLeu_BaEn_2 407 413 PF01217 0.552
TRG_ENDOCYTIC_2 221 224 PF00928 0.316
TRG_ENDOCYTIC_2 271 274 PF00928 0.194
TRG_ENDOCYTIC_2 30 33 PF00928 0.284
TRG_ENDOCYTIC_2 399 402 PF00928 0.421
TRG_ENDOCYTIC_2 410 413 PF00928 0.434
TRG_ENDOCYTIC_2 93 96 PF00928 0.332
TRG_ER_diArg_1 200 203 PF00400 0.397
TRG_ER_diArg_1 437 440 PF00400 0.390
TRG_NLS_MonoExtC_3 308 313 PF00514 0.372
TRG_NLS_MonoExtN_4 309 314 PF00514 0.396
TRG_Pf-PMV_PEXEL_1 141 146 PF00026 0.314

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PE80 Leptomonas seymouri 71% 97%
A0A0S4J7K4 Bodo saltans 59% 100%
A0A1X0NJV4 Trypanosomatidae 60% 100%
A0A1X0P1A2 Trypanosomatidae 60% 100%
A0A3Q8IC87 Leishmania donovani 32% 100%
A0A3Q8IDK8 Leishmania donovani 95% 97%
A0A3Q8IFK8 Leishmania donovani 27% 100%
A0A3Q8INQ4 Leishmania donovani 30% 100%
A0A3Q8IVR8 Leishmania donovani 25% 100%
A0A3R7RIN5 Trypanosoma rangeli 27% 100%
A0A3S5H5G0 Leishmania donovani 28% 100%
A0A3S5H5U5 Leishmania donovani 22% 100%
A0A3S5H789 Leishmania donovani 27% 100%
A0A3S7WTN9 Leishmania donovani 25% 100%
A0A3S7X9R4 Leishmania donovani 29% 100%
A4H436 Leishmania braziliensis 24% 100%
A4H459 Leishmania braziliensis 29% 100%
A4H4S9 Leishmania braziliensis 24% 100%
A4HCD7 Leishmania braziliensis 33% 100%
A4HED7 Leishmania braziliensis 29% 100%
A4HG27 Leishmania braziliensis 83% 100%
A4HJT5 Leishmania braziliensis 27% 100%
A4HN71 Leishmania braziliensis 29% 100%
A4HNT2 Leishmania braziliensis 24% 100%
A4HP12 Leishmania braziliensis 27% 100%
A4HSE2 Leishmania infantum 28% 100%
A4HWP5 Leishmania infantum 25% 100%
A4HYX6 Leishmania infantum 27% 100%
A4HZV1 Leishmania infantum 32% 100%
A4I1T4 Leishmania infantum 30% 100%
A4I349 Leishmania infantum 95% 97%
A4I7A1 Leishmania infantum 27% 100%
A4IBT4 Leishmania infantum 29% 100%
A4IBT9 Leishmania infantum 29% 100%
A4ICR2 Leishmania infantum 25% 100%
C9ZK98 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZN29 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9ACW7 Leishmania major 91% 100%
E9AG71 Leishmania infantum 22% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AKZ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AUS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
Q4Q204 Leishmania major 25% 100%
Q4Q5W2 Leishmania major 27% 100%
Q4Q9K2 Leishmania major 31% 100%
Q4QBR6 Leishmania major 32% 100%
Q4QCR3 Leishmania major 26% 100%
Q4QIV8 Leishmania major 25% 100%
Q4QJJ0 Leishmania major 28% 100%
Q6C7U0 Yarrowia lipolytica (strain CLIB 122 / E 150) 26% 77%
Q9GNR4 Leishmania major 29% 100%
Q9SUL7 Arabidopsis thaliana 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS