Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZF4_LEIMU

TriTrypDb:

LmxM.27.2450

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZF4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	194	198	PF00656	0.590
CLV_NRD_NRD_1	115	117	PF00675	0.591
CLV_NRD_NRD_1	131	133	PF00675	0.357
CLV_NRD_NRD_1	192	194	PF00675	0.774
CLV_NRD_NRD_1	260	262	PF00675	0.554
CLV_NRD_NRD_1	318	320	PF00675	0.528
CLV_NRD_NRD_1	378	380	PF00675	0.585
CLV_PCSK_KEX2_1	115	117	PF00082	0.496
CLV_PCSK_KEX2_1	192	194	PF00082	0.634
CLV_PCSK_KEX2_1	260	262	PF00082	0.504
CLV_PCSK_KEX2_1	318	320	PF00082	0.559
CLV_PCSK_KEX2_1	378	380	PF00082	0.591
CLV_PCSK_PC7_1	314	320	PF00082	0.457
CLV_PCSK_SKI1_1	292	296	PF00082	0.458
CLV_PCSK_SKI1_1	72	76	PF00082	0.407
DEG_APCC_DBOX_1	343	351	PF00400	0.500
DEG_COP1_1	387	397	PF00400	0.462
DEG_Nend_UBRbox_3	1	3	PF02207	0.646
DEG_SCF_FBW7_1	405	412	PF00400	0.452
DEG_SPOP_SBC_1	388	392	PF00917	0.511
DOC_MAPK_gen_1	113	123	PF00069	0.319
DOC_MAPK_MEF2A_6	202	209	PF00069	0.626
DOC_PP4_FxxP_1	228	231	PF00568	0.551
DOC_USP7_MATH_1	108	112	PF00917	0.577
DOC_USP7_MATH_1	187	191	PF00917	0.664
DOC_USP7_MATH_1	213	217	PF00917	0.436
DOC_USP7_MATH_1	242	246	PF00917	0.767
DOC_USP7_MATH_1	249	253	PF00917	0.712
DOC_USP7_MATH_1	388	392	PF00917	0.760
DOC_USP7_MATH_1	398	402	PF00917	0.766
DOC_USP7_MATH_1	420	424	PF00917	0.698
DOC_USP7_MATH_1	429	433	PF00917	0.765
DOC_USP7_UBL2_3	113	117	PF12436	0.455
DOC_WW_Pin1_4	227	232	PF00397	0.683
DOC_WW_Pin1_4	238	243	PF00397	0.645
DOC_WW_Pin1_4	393	398	PF00397	0.734
DOC_WW_Pin1_4	405	410	PF00397	0.707
LIG_14-3-3_CanoR_1	115	123	PF00244	0.611
LIG_14-3-3_CanoR_1	260	270	PF00244	0.617
LIG_14-3-3_CanoR_1	318	325	PF00244	0.603
LIG_14-3-3_CanoR_1	341	351	PF00244	0.483
LIG_14-3-3_CanoR_1	410	419	PF00244	0.615
LIG_14-3-3_CanoR_1	85	91	PF00244	0.503
LIG_BIR_III_4	212	216	PF00653	0.438
LIG_BRCT_BRCA1_1	275	279	PF00533	0.632
LIG_deltaCOP1_diTrp_1	439	443	PF00928	0.633
LIG_EH_1	354	358	PF12763	0.350
LIG_FHA_1	137	143	PF00498	0.299
LIG_FHA_1	239	245	PF00498	0.586
LIG_FHA_1	253	259	PF00498	0.431
LIG_FHA_1	406	412	PF00498	0.547
LIG_FHA_1	85	91	PF00498	0.407
LIG_FHA_2	168	174	PF00498	0.634
LIG_FHA_2	368	374	PF00498	0.527
LIG_FHA_2	434	440	PF00498	0.585
LIG_LIR_Apic_2	227	231	PF02991	0.553
LIG_LIR_Gen_1	106	114	PF02991	0.335
LIG_LIR_Gen_1	223	233	PF02991	0.489
LIG_LIR_Gen_1	276	285	PF02991	0.595
LIG_LIR_Gen_1	415	426	PF02991	0.616
LIG_LIR_Gen_1	438	447	PF02991	0.580
LIG_LIR_Nem_3	223	228	PF02991	0.524
LIG_LIR_Nem_3	239	243	PF02991	0.560
LIG_LIR_Nem_3	276	282	PF02991	0.618
LIG_LIR_Nem_3	415	421	PF02991	0.613
LIG_PCNA_PIPBox_1	340	349	PF02747	0.442
LIG_PCNA_yPIPBox_3	28	38	PF02747	0.496
LIG_SH2_PTP2	281	284	PF00017	0.452
LIG_SH2_PTP2	418	421	PF00017	0.614
LIG_SH2_SRC	281	284	PF00017	0.452
LIG_SH2_SRC	91	94	PF00017	0.423
LIG_SH2_STAP1	137	141	PF00017	0.463
LIG_SH2_STAP1	225	229	PF00017	0.500
LIG_SH2_STAP1	38	42	PF00017	0.446
LIG_SH2_STAT5	109	112	PF00017	0.356
LIG_SH2_STAT5	143	146	PF00017	0.396
LIG_SH2_STAT5	281	284	PF00017	0.452
LIG_SH2_STAT5	418	421	PF00017	0.678
LIG_SH3_3	226	232	PF00018	0.471
LIG_SH3_3	391	397	PF00018	0.527
LIG_SH3_3	416	422	PF00018	0.568
LIG_SUMO_SIM_anti_2	172	179	PF11976	0.490
LIG_SUMO_SIM_anti_2	362	370	PF11976	0.312
LIG_SUMO_SIM_anti_2	54	59	PF11976	0.564
LIG_TRAF2_1	170	173	PF00917	0.634
LIG_TRAF2_1	251	254	PF00917	0.476
LIG_TRAF2_1	284	287	PF00917	0.547
LIG_TYR_ITIM	416	421	PF00017	0.568
LIG_UBA3_1	66	75	PF00899	0.457
LIG_WRC_WIRS_1	225	230	PF05994	0.495
LIG_WW_2	232	235	PF00397	0.413
MOD_CDK_SPK_2	405	410	PF00069	0.511
MOD_CK1_1	159	165	PF00069	0.540
MOD_CK1_1	227	233	PF00069	0.727
MOD_CK1_1	252	258	PF00069	0.599
MOD_CK1_1	412	418	PF00069	0.580
MOD_CK1_1	424	430	PF00069	0.550
MOD_CK1_1	73	79	PF00069	0.452
MOD_CK2_1	108	114	PF00069	0.313
MOD_CK2_1	167	173	PF00069	0.453
MOD_CK2_1	213	219	PF00069	0.605
MOD_CK2_1	248	254	PF00069	0.488
MOD_CK2_1	367	373	PF00069	0.465
MOD_CK2_1	433	439	PF00069	0.587
MOD_GlcNHglycan	185	188	PF01048	0.579
MOD_GlcNHglycan	211	216	PF01048	0.597
MOD_GlcNHglycan	40	43	PF01048	0.568
MOD_GlcNHglycan	402	405	PF01048	0.586
MOD_GlcNHglycan	431	434	PF01048	0.563
MOD_GSK3_1	183	190	PF00069	0.669
MOD_GSK3_1	220	227	PF00069	0.632
MOD_GSK3_1	238	245	PF00069	0.486
MOD_GSK3_1	248	255	PF00069	0.673
MOD_GSK3_1	296	303	PF00069	0.545
MOD_GSK3_1	317	324	PF00069	0.430
MOD_GSK3_1	363	370	PF00069	0.462
MOD_GSK3_1	384	391	PF00069	0.620
MOD_GSK3_1	405	412	PF00069	0.763
MOD_GSK3_1	420	427	PF00069	0.461
MOD_GSK3_1	429	436	PF00069	0.536
MOD_N-GLC_1	249	254	PF02516	0.564
MOD_N-GLC_1	30	35	PF02516	0.497
MOD_NEK2_1	243	248	PF00069	0.457
MOD_NEK2_1	270	275	PF00069	0.644
MOD_NEK2_1	30	35	PF00069	0.515
MOD_NEK2_1	350	355	PF00069	0.530
MOD_NEK2_1	367	372	PF00069	0.397
MOD_NEK2_1	411	416	PF00069	0.498
MOD_NEK2_1	70	75	PF00069	0.425
MOD_NEK2_2	108	113	PF00069	0.337
MOD_NEK2_2	329	334	PF00069	0.351
MOD_PIKK_1	149	155	PF00454	0.487
MOD_PIKK_1	159	165	PF00454	0.489
MOD_PIKK_1	270	276	PF00454	0.574
MOD_PIKK_1	317	323	PF00454	0.449
MOD_PIKK_1	350	356	PF00454	0.456
MOD_PIKK_1	398	404	PF00454	0.597
MOD_PIKK_1	65	71	PF00454	0.530
MOD_PIKK_1	93	99	PF00454	0.506
MOD_PKA_1	115	121	PF00069	0.438
MOD_PKA_2	115	121	PF00069	0.528
MOD_PKA_2	191	197	PF00069	0.727
MOD_PKA_2	317	323	PF00069	0.592
MOD_PKA_2	409	415	PF00069	0.508
MOD_PKA_2	424	430	PF00069	0.463
MOD_PKA_2	84	90	PF00069	0.526
MOD_Plk_1	149	155	PF00069	0.605
MOD_Plk_1	18	24	PF00069	0.525
MOD_Plk_1	30	36	PF00069	0.511
MOD_Plk_4	18	24	PF00069	0.525
MOD_Plk_4	224	230	PF00069	0.690
MOD_Plk_4	300	306	PF00069	0.560
MOD_Plk_4	363	369	PF00069	0.400
MOD_Plk_4	414	420	PF00069	0.677
MOD_Plk_4	51	57	PF00069	0.482
MOD_Plk_4	62	68	PF00069	0.342
MOD_ProDKin_1	227	233	PF00069	0.682
MOD_ProDKin_1	238	244	PF00069	0.645
MOD_ProDKin_1	393	399	PF00069	0.734
MOD_ProDKin_1	405	411	PF00069	0.705
TRG_DiLeu_BaEn_1	286	291	PF01217	0.539
TRG_DiLeu_BaEn_1	363	368	PF01217	0.307
TRG_DiLeu_BaEn_1	52	57	PF01217	0.578
TRG_DiLeu_BaEn_3	203	209	PF01217	0.455
TRG_DiLeu_BaEn_4	286	292	PF01217	0.545
TRG_ENDOCYTIC_2	109	112	PF00928	0.410
TRG_ENDOCYTIC_2	225	228	PF00928	0.501
TRG_ENDOCYTIC_2	418	421	PF00928	0.614
TRG_ER_diArg_1	192	195	PF00400	0.728
TRG_ER_diArg_1	260	262	PF00400	0.621
TRG_ER_diArg_1	378	380	PF00400	0.527
TRG_NES_CRM1_1	362	375	PF08389	0.441
TRG_Pf-PMV_PEXEL_1	124	129	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB83	Leptomonas seymouri	48%	100%
A0A1X0NF90	Trypanosomatidae	27%	100%
A0A3R7KL96	Trypanosoma rangeli	26%	100%
A0A3S7X122	Leishmania donovani	88%	100%
A4HG25	Leishmania braziliensis	72%	99%
A4I346	Leishmania infantum	88%	100%
C9ZJL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ACW5	Leishmania major	88%	100%
V5BB13	Trypanosoma cruzi	26%	100%