PHD-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZF2_LEIMU

TriTrypDb:

LmxM.27.2430

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZF2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	147	149	PF00675	0.618
CLV_NRD_NRD_1	186	188	PF00675	0.736
CLV_NRD_NRD_1	206	208	PF00675	0.419
CLV_NRD_NRD_1	403	405	PF00675	0.789
CLV_NRD_NRD_1	555	557	PF00675	0.847
CLV_NRD_NRD_1	60	62	PF00675	0.693
CLV_PCSK_KEX2_1	146	148	PF00082	0.613
CLV_PCSK_KEX2_1	186	188	PF00082	0.736
CLV_PCSK_KEX2_1	206	208	PF00082	0.419
CLV_PCSK_KEX2_1	379	381	PF00082	0.759
CLV_PCSK_KEX2_1	555	557	PF00082	0.847
CLV_PCSK_KEX2_1	60	62	PF00082	0.693
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.759
CLV_PCSK_SKI1_1	355	359	PF00082	0.789
CLV_PCSK_SKI1_1	95	99	PF00082	0.688
DEG_SIAH_1	318	326	PF03145	0.759
DEG_SPOP_SBC_1	560	564	PF00917	0.835
DOC_CKS1_1	192	197	PF01111	0.572
DOC_CKS1_1	463	468	PF01111	0.736
DOC_CYCLIN_yClb3_PxF_3	507	513	PF00134	0.711
DOC_PP2B_LxvP_1	506	509	PF13499	0.725
DOC_PP4_FxxP_1	535	538	PF00568	0.659
DOC_USP7_MATH_1	109	113	PF00917	0.736
DOC_USP7_MATH_1	257	261	PF00917	0.796
DOC_USP7_MATH_1	280	284	PF00917	0.764
DOC_USP7_MATH_1	313	317	PF00917	0.750
DOC_USP7_MATH_1	326	330	PF00917	0.621
DOC_USP7_MATH_1	426	430	PF00917	0.859
DOC_USP7_MATH_1	497	501	PF00917	0.843
DOC_USP7_MATH_1	5	9	PF00917	0.574
DOC_USP7_MATH_1	72	76	PF00917	0.643
DOC_WW_Pin1_4	123	128	PF00397	0.731
DOC_WW_Pin1_4	178	183	PF00397	0.729
DOC_WW_Pin1_4	191	196	PF00397	0.450
DOC_WW_Pin1_4	248	253	PF00397	0.646
DOC_WW_Pin1_4	315	320	PF00397	0.826
DOC_WW_Pin1_4	321	326	PF00397	0.735
DOC_WW_Pin1_4	327	332	PF00397	0.636
DOC_WW_Pin1_4	407	412	PF00397	0.832
DOC_WW_Pin1_4	418	423	PF00397	0.674
DOC_WW_Pin1_4	439	444	PF00397	0.836
DOC_WW_Pin1_4	448	453	PF00397	0.705
DOC_WW_Pin1_4	456	461	PF00397	0.576
DOC_WW_Pin1_4	462	467	PF00397	0.596
DOC_WW_Pin1_4	484	489	PF00397	0.699
LIG_14-3-3_CanoR_1	25	29	PF00244	0.610
LIG_14-3-3_CanoR_1	343	349	PF00244	0.833
LIG_14-3-3_CanoR_1	434	443	PF00244	0.636
LIG_14-3-3_CanoR_1	54	62	PF00244	0.687
LIG_14-3-3_CanoR_1	68	76	PF00244	0.532
LIG_BIR_II_1	1	5	PF00653	0.629
LIG_EVH1_1	506	510	PF00568	0.723
LIG_EVH1_2	509	513	PF00568	0.793
LIG_FHA_1	47	53	PF00498	0.669
LIG_FHA_1	96	102	PF00498	0.670
LIG_FHA_2	137	143	PF00498	0.663
LIG_FHA_2	32	38	PF00498	0.667
LIG_FHA_2	384	390	PF00498	0.766
LIG_FHA_2	561	567	PF00498	0.830
LIG_LIR_Apic_2	478	484	PF02991	0.612
LIG_LIR_Gen_1	151	160	PF02991	0.600
LIG_LIR_Gen_1	19	28	PF02991	0.669
LIG_LIR_Nem_3	19	24	PF02991	0.661
LIG_PROFILIN_1	466	472	PF00235	0.729
LIG_PROFILIN_1	488	494	PF00235	0.700
LIG_PTAP_UEV_1	242	247	PF05743	0.702
LIG_RPA_C_Fungi	369	381	PF08784	0.644
LIG_SH2_CRK	481	485	PF00017	0.744
LIG_SH2_NCK_1	481	485	PF00017	0.744
LIG_SH2_SRC	481	484	PF00017	0.645
LIG_SH2_STAP1	199	203	PF00017	0.672
LIG_SH2_STAT5	152	155	PF00017	0.673
LIG_SH3_1	449	455	PF00018	0.672
LIG_SH3_2	243	248	PF14604	0.700
LIG_SH3_2	341	346	PF14604	0.623
LIG_SH3_2	551	556	PF14604	0.842
LIG_SH3_3	162	168	PF00018	0.733
LIG_SH3_3	240	246	PF00018	0.763
LIG_SH3_3	258	264	PF00018	0.560
LIG_SH3_3	282	288	PF00018	0.586
LIG_SH3_3	338	344	PF00018	0.568
LIG_SH3_3	406	412	PF00018	0.748
LIG_SH3_3	440	446	PF00018	0.616
LIG_SH3_3	449	455	PF00018	0.736
LIG_SH3_3	457	463	PF00018	0.654
LIG_SH3_3	464	470	PF00018	0.653
LIG_SH3_3	482	488	PF00018	0.547
LIG_SH3_3	489	495	PF00018	0.686
LIG_SH3_3	504	510	PF00018	0.584
LIG_SH3_3	548	554	PF00018	0.655
LIG_TRAF2_1	112	115	PF00917	0.700
LIG_WW_3	421	425	PF00397	0.816
MOD_CDC14_SPxK_1	421	424	PF00782	0.775
MOD_CDK_SPxK_1	418	424	PF00069	0.816
MOD_CDK_SPxxK_3	321	328	PF00069	0.765
MOD_CDK_SPxxK_3	442	449	PF00069	0.625
MOD_CK1_1	121	127	PF00069	0.808
MOD_CK1_1	134	140	PF00069	0.562
MOD_CK1_1	251	257	PF00069	0.712
MOD_CK1_1	3	9	PF00069	0.640
MOD_CK1_1	307	313	PF00069	0.837
MOD_CK1_1	315	321	PF00069	0.684
MOD_CK1_1	360	366	PF00069	0.832
MOD_CK1_1	369	375	PF00069	0.692
MOD_CK1_1	384	390	PF00069	0.604
MOD_CK1_1	393	399	PF00069	0.691
MOD_CK1_1	427	433	PF00069	0.754
MOD_CK1_1	437	443	PF00069	0.690
MOD_CK1_1	454	460	PF00069	0.558
MOD_CK1_1	475	481	PF00069	0.554
MOD_CK1_1	55	61	PF00069	0.687
MOD_CK1_1	562	568	PF00069	0.827
MOD_CK2_1	109	115	PF00069	0.742
MOD_CK2_1	136	142	PF00069	0.676
MOD_CK2_1	156	162	PF00069	0.595
MOD_CK2_1	31	37	PF00069	0.540
MOD_GlcNHglycan	230	233	PF01048	0.585
MOD_GlcNHglycan	243	246	PF01048	0.781
MOD_GlcNHglycan	253	256	PF01048	0.673
MOD_GlcNHglycan	311	314	PF01048	0.723
MOD_GlcNHglycan	315	318	PF01048	0.747
MOD_GlcNHglycan	319	322	PF01048	0.691
MOD_GlcNHglycan	34	37	PF01048	0.552
MOD_GlcNHglycan	346	349	PF01048	0.830
MOD_GlcNHglycan	371	374	PF01048	0.843
MOD_GlcNHglycan	399	402	PF01048	0.609
MOD_GlcNHglycan	426	429	PF01048	0.821
MOD_GlcNHglycan	436	439	PF01048	0.724
MOD_GlcNHglycan	474	477	PF01048	0.769
MOD_GlcNHglycan	499	502	PF01048	0.770
MOD_GlcNHglycan	535	538	PF01048	0.606
MOD_GlcNHglycan	539	542	PF01048	0.750
MOD_GlcNHglycan	54	57	PF01048	0.468
MOD_GlcNHglycan	7	10	PF01048	0.520
MOD_GSK3_1	117	124	PF00069	0.740
MOD_GSK3_1	130	137	PF00069	0.588
MOD_GSK3_1	237	244	PF00069	0.771
MOD_GSK3_1	304	311	PF00069	0.733
MOD_GSK3_1	313	320	PF00069	0.678
MOD_GSK3_1	327	334	PF00069	0.589
MOD_GSK3_1	357	364	PF00069	0.832
MOD_GSK3_1	381	388	PF00069	0.763
MOD_GSK3_1	389	396	PF00069	0.712
MOD_GSK3_1	426	433	PF00069	0.815
MOD_GSK3_1	471	478	PF00069	0.545
MOD_GSK3_1	533	540	PF00069	0.780
MOD_GSK3_1	63	70	PF00069	0.551
MOD_N-GLC_1	257	262	PF02516	0.542
MOD_NEK2_1	131	136	PF00069	0.728
MOD_NEK2_1	24	29	PF00069	0.572
MOD_NEK2_1	305	310	PF00069	0.834
MOD_NEK2_1	333	338	PF00069	0.568
MOD_NEK2_1	357	362	PF00069	0.832
MOD_NEK2_1	415	420	PF00069	0.800
MOD_NEK2_1	514	519	PF00069	0.839
MOD_PIKK_1	63	69	PF00454	0.677
MOD_PIKK_1	84	90	PF00454	0.649
MOD_PKA_2	24	30	PF00069	0.606
MOD_PKA_2	430	436	PF00069	0.631
MOD_PKA_2	67	73	PF00069	0.667
MOD_Plk_1	257	263	PF00069	0.538
MOD_Plk_1	3	9	PF00069	0.635
MOD_Plk_2-3	110	116	PF00069	0.553
MOD_ProDKin_1	123	129	PF00069	0.731
MOD_ProDKin_1	178	184	PF00069	0.728
MOD_ProDKin_1	191	197	PF00069	0.441
MOD_ProDKin_1	248	254	PF00069	0.650
MOD_ProDKin_1	315	321	PF00069	0.829
MOD_ProDKin_1	327	333	PF00069	0.637
MOD_ProDKin_1	407	413	PF00069	0.831
MOD_ProDKin_1	418	424	PF00069	0.677
MOD_ProDKin_1	439	445	PF00069	0.837
MOD_ProDKin_1	448	454	PF00069	0.708
MOD_ProDKin_1	456	462	PF00069	0.571
MOD_ProDKin_1	484	490	PF00069	0.697
MOD_SUMO_for_1	297	300	PF00179	0.742
TRG_DiLeu_BaEn_4	12	18	PF01217	0.712
TRG_ENDOCYTIC_2	152	155	PF00928	0.595
TRG_ER_diArg_1	145	148	PF00400	0.614
TRG_ER_diArg_1	186	188	PF00400	0.736
TRG_ER_diArg_1	217	220	PF00400	0.544
TRG_ER_diArg_1	554	556	PF00400	0.840
TRG_ER_diArg_1	60	62	PF00400	0.693
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X110	Leishmania donovani	87%	100%
A4HG23	Leishmania braziliensis	72%	100%
A4I344	Leishmania infantum	87%	100%
E9ACW3	Leishmania major	87%	100%