Putative TPR-repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR-repeat protein, putative

Species:

Leishmania mexicana

UniProt:

E9AZE8_LEIMU

TriTrypDb:

LmxM.27.2390

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0101031	protein folding chaperone complex	3	1
GO:0140535	intracellular protein-containing complex	2	1

Expansion

Sequence features

E9AZE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.661
CLV_NRD_NRD_1	170	172	PF00675	0.282
CLV_NRD_NRD_1	174	176	PF00675	0.282
CLV_NRD_NRD_1	278	280	PF00675	0.530
CLV_NRD_NRD_1	283	285	PF00675	0.511
CLV_NRD_NRD_1	307	309	PF00675	0.629
CLV_NRD_NRD_1	390	392	PF00675	0.331
CLV_NRD_NRD_1	40	42	PF00675	0.578
CLV_NRD_NRD_1	492	494	PF00675	0.504
CLV_PCSK_FUR_1	305	309	PF00082	0.595
CLV_PCSK_KEX2_1	170	172	PF00082	0.282
CLV_PCSK_KEX2_1	215	217	PF00082	0.600
CLV_PCSK_KEX2_1	235	237	PF00082	0.418
CLV_PCSK_KEX2_1	278	280	PF00082	0.535
CLV_PCSK_KEX2_1	304	306	PF00082	0.599
CLV_PCSK_KEX2_1	307	309	PF00082	0.587
CLV_PCSK_KEX2_1	390	392	PF00082	0.331
CLV_PCSK_KEX2_1	40	42	PF00082	0.443
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.600
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.418
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.589
CLV_PCSK_SKI1_1	152	156	PF00082	0.459
CLV_PCSK_SKI1_1	493	497	PF00082	0.458
DEG_APCC_DBOX_1	16	24	PF00400	0.584
DEG_APCC_DBOX_1	174	182	PF00400	0.290
DEG_APCC_DBOX_1	184	192	PF00400	0.269
DEG_Nend_UBRbox_2	1	3	PF02207	0.558
DEG_SPOP_SBC_1	222	226	PF00917	0.532
DEG_SPOP_SBC_1	345	349	PF00917	0.721
DEG_SPOP_SBC_1	352	356	PF00917	0.766
DOC_CKS1_1	379	384	PF01111	0.517
DOC_CKS1_1	481	486	PF01111	0.519
DOC_MAPK_gen_1	304	314	PF00069	0.556
DOC_MAPK_MEF2A_6	152	160	PF00069	0.248
DOC_MAPK_MEF2A_6	307	316	PF00069	0.410
DOC_MAPK_MEF2A_6	454	462	PF00069	0.464
DOC_USP7_MATH_1	333	337	PF00917	0.647
DOC_USP7_MATH_1	352	356	PF00917	0.702
DOC_USP7_MATH_1	370	374	PF00917	0.566
DOC_USP7_MATH_1	375	379	PF00917	0.653
DOC_USP7_MATH_1	79	83	PF00917	0.659
DOC_USP7_UBL2_3	176	180	PF12436	0.373
DOC_USP7_UBL2_3	96	100	PF12436	0.381
DOC_WW_Pin1_4	226	231	PF00397	0.456
DOC_WW_Pin1_4	319	324	PF00397	0.711
DOC_WW_Pin1_4	329	334	PF00397	0.639
DOC_WW_Pin1_4	347	352	PF00397	0.651
DOC_WW_Pin1_4	353	358	PF00397	0.736
DOC_WW_Pin1_4	378	383	PF00397	0.436
DOC_WW_Pin1_4	420	425	PF00397	0.448
DOC_WW_Pin1_4	480	485	PF00397	0.537
LIG_14-3-3_CanoR_1	260	268	PF00244	0.508
LIG_FHA_1	116	122	PF00498	0.458
LIG_FHA_1	127	133	PF00498	0.469
LIG_FHA_1	153	159	PF00498	0.456
LIG_FHA_1	207	213	PF00498	0.408
LIG_FHA_1	341	347	PF00498	0.706
LIG_FHA_1	434	440	PF00498	0.480
LIG_FHA_2	146	152	PF00498	0.499
LIG_FHA_2	261	267	PF00498	0.655
LIG_LIR_Gen_1	384	392	PF02991	0.437
LIG_LIR_Nem_3	384	388	PF02991	0.437
LIG_LIR_Nem_3	389	395	PF02991	0.435
LIG_PCNA_PIPBox_1	398	407	PF02747	0.534
LIG_Pex14_2	388	392	PF04695	0.448
LIG_SH2_GRB2like	134	137	PF00017	0.415
LIG_SH2_NCK_1	164	168	PF00017	0.400
LIG_SH2_STAP1	134	138	PF00017	0.416
LIG_SH2_STAP1	164	168	PF00017	0.400
LIG_SH2_STAT3	405	408	PF00017	0.397
LIG_SH2_STAT5	117	120	PF00017	0.462
LIG_SH2_STAT5	141	144	PF00017	0.388
LIG_SH2_STAT5	405	408	PF00017	0.448
LIG_SH3_1	478	484	PF00018	0.573
LIG_SH3_2	481	486	PF14604	0.589
LIG_SH3_3	478	484	PF00018	0.593
LIG_SUMO_SIM_anti_2	310	320	PF11976	0.654
LIG_SUMO_SIM_anti_2	472	479	PF11976	0.447
LIG_TRAF2_1	201	204	PF00917	0.528
LIG_TRAF2_1	262	265	PF00917	0.648
LIG_TRAF2_1	286	289	PF00917	0.604
LIG_UBA3_1	426	435	PF00899	0.436
LIG_WRC_WIRS_1	434	439	PF05994	0.534
MOD_CDK_SPK_2	378	383	PF00069	0.470
MOD_CDK_SPxK_1	480	486	PF00069	0.540
MOD_CK1_1	127	133	PF00069	0.469
MOD_CK1_1	259	265	PF00069	0.652
MOD_CK1_1	332	338	PF00069	0.661
MOD_CK1_1	347	353	PF00069	0.643
MOD_CK1_1	355	361	PF00069	0.652
MOD_CK1_1	378	384	PF00069	0.462
MOD_CK1_1	420	426	PF00069	0.501
MOD_CK2_1	1	7	PF00069	0.622
MOD_CK2_1	145	151	PF00069	0.446
MOD_CK2_1	259	265	PF00069	0.575
MOD_CK2_1	381	387	PF00069	0.284
MOD_CK2_1	450	456	PF00069	0.484
MOD_CK2_1	58	64	PF00069	0.536
MOD_GlcNHglycan	106	109	PF01048	0.539
MOD_GlcNHglycan	126	129	PF01048	0.356
MOD_GlcNHglycan	198	202	PF01048	0.415
MOD_GlcNHglycan	335	338	PF01048	0.654
MOD_GlcNHglycan	360	363	PF01048	0.710
MOD_GlcNHglycan	46	49	PF01048	0.719
MOD_GlcNHglycan	478	481	PF01048	0.528
MOD_GlcNHglycan	81	84	PF01048	0.592
MOD_GSK3_1	220	227	PF00069	0.680
MOD_GSK3_1	256	263	PF00069	0.567
MOD_GSK3_1	329	336	PF00069	0.645
MOD_GSK3_1	340	347	PF00069	0.596
MOD_GSK3_1	351	358	PF00069	0.694
MOD_GSK3_1	377	384	PF00069	0.497
MOD_GSK3_1	433	440	PF00069	0.506
MOD_GSK3_1	476	483	PF00069	0.398
MOD_N-GLC_1	420	425	PF02516	0.248
MOD_N-GLC_1	437	442	PF02516	0.248
MOD_NEK2_1	1	6	PF00069	0.625
MOD_NEK2_1	104	109	PF00069	0.488
MOD_NEK2_1	346	351	PF00069	0.570
MOD_NEK2_1	417	422	PF00069	0.482
MOD_NEK2_1	437	442	PF00069	0.339
MOD_NEK2_1	476	481	PF00069	0.455
MOD_PKA_2	259	265	PF00069	0.406
MOD_PKA_2	370	376	PF00069	0.530
MOD_PKA_2	55	61	PF00069	0.544
MOD_Plk_1	1	7	PF00069	0.622
MOD_Plk_1	152	158	PF00069	0.291
MOD_Plk_1	340	346	PF00069	0.481
MOD_Plk_2-3	241	247	PF00069	0.706
MOD_ProDKin_1	226	232	PF00069	0.453
MOD_ProDKin_1	319	325	PF00069	0.714
MOD_ProDKin_1	329	335	PF00069	0.640
MOD_ProDKin_1	347	353	PF00069	0.653
MOD_ProDKin_1	355	361	PF00069	0.730
MOD_ProDKin_1	378	384	PF00069	0.434
MOD_ProDKin_1	420	426	PF00069	0.448
MOD_ProDKin_1	480	486	PF00069	0.540
MOD_SUMO_rev_2	13	23	PF00179	0.480
MOD_SUMO_rev_2	320	330	PF00179	0.707
MOD_SUMO_rev_2	487	495	PF00179	0.543
TRG_ENDOCYTIC_2	141	144	PF00928	0.412
TRG_ER_diArg_1	169	171	PF00400	0.282
TRG_ER_diArg_1	277	279	PF00400	0.602
TRG_ER_diArg_1	305	308	PF00400	0.575
TRG_ER_diArg_1	368	371	PF00400	0.714
TRG_ER_diArg_1	390	392	PF00400	0.531
TRG_ER_diLys_1	494	498	PF00400	0.557
TRG_NLS_MonoExtC_3	303	308	PF00514	0.556
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF88	Leptomonas seymouri	58%	100%
A0A0S4J9Z5	Bodo saltans	38%	100%
A0A1X0NH58	Trypanosomatidae	39%	100%
A0A3Q8IHU4	Leishmania donovani	88%	100%
A0A3R7KY85	Trypanosoma rangeli	39%	100%
A4HG19	Leishmania braziliensis	76%	98%
A4I340	Leishmania infantum	88%	100%
C9ZJL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ACV9	Leishmania major	84%	98%
Q28IV3	Xenopus tropicalis	25%	76%
Q5ZKQ3	Gallus gallus	23%	75%
Q6NU95	Xenopus laevis	25%	75%
V5AR46	Trypanosoma cruzi	38%	100%