CPL domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZE5_LEIMU

TriTrypDb:

LmxM.27.2360

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZE5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.533
CLV_NRD_NRD_1	305	307	PF00675	0.487
CLV_PCSK_KEX2_1	329	331	PF00082	0.610
CLV_PCSK_KEX2_1	337	339	PF00082	0.559
CLV_PCSK_KEX2_1	381	383	PF00082	0.643
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.557
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.486
CLV_PCSK_PC1ET2_1	381	383	PF00082	0.643
CLV_PCSK_SKI1_1	107	111	PF00082	0.542
CLV_PCSK_SKI1_1	139	143	PF00082	0.469
CLV_PCSK_SKI1_1	158	162	PF00082	0.280
CLV_PCSK_SKI1_1	198	202	PF00082	0.471
CLV_PCSK_SKI1_1	230	234	PF00082	0.279
DEG_APCC_DBOX_1	229	237	PF00400	0.250
DEG_SPOP_SBC_1	369	373	PF00917	0.434
DOC_CYCLIN_RxL_1	106	118	PF00134	0.239
DOC_CYCLIN_RxL_1	195	202	PF00134	0.461
DOC_MAPK_gen_1	337	344	PF00069	0.292
DOC_MAPK_MEF2A_6	337	346	PF00069	0.294
DOC_PP1_RVXF_1	341	347	PF00149	0.553
DOC_PP4_FxxP_1	151	154	PF00568	0.476
DOC_PP4_FxxP_1	201	204	PF00568	0.522
DOC_USP7_MATH_1	318	322	PF00917	0.514
DOC_USP7_MATH_1	349	353	PF00917	0.629
DOC_USP7_MATH_1	53	57	PF00917	0.528
DOC_USP7_UBL2_3	107	111	PF12436	0.556
DOC_USP7_UBL2_3	139	143	PF12436	0.553
DOC_USP7_UBL2_3	178	182	PF12436	0.380
DOC_USP7_UBL2_3	222	226	PF12436	0.565
LIG_14-3-3_CanoR_1	330	339	PF00244	0.558
LIG_14-3-3_CanoR_1	77	87	PF00244	0.538
LIG_BRCT_BRCA1_1	147	151	PF00533	0.262
LIG_CaM_NSCaTE_8	14	21	PF13499	0.511
LIG_deltaCOP1_diTrp_1	95	101	PF00928	0.529
LIG_EH1_1	269	277	PF00400	0.523
LIG_FHA_1	108	114	PF00498	0.529
LIG_FHA_1	13	19	PF00498	0.491
LIG_FHA_1	154	160	PF00498	0.389
LIG_FHA_1	298	304	PF00498	0.403
LIG_FHA_1	334	340	PF00498	0.529
LIG_FHA_1	39	45	PF00498	0.536
LIG_FHA_1	4	10	PF00498	0.553
LIG_FHA_1	71	77	PF00498	0.381
LIG_FHA_1	79	85	PF00498	0.371
LIG_FHA_2	197	203	PF00498	0.420
LIG_FHA_2	256	262	PF00498	0.558
LIG_FHA_2	90	96	PF00498	0.455
LIG_IRF3_LxIS_1	327	334	PF10401	0.295
LIG_LIR_Apic_2	148	154	PF02991	0.497
LIG_LIR_Apic_2	199	204	PF02991	0.279
LIG_LIR_Gen_1	266	276	PF02991	0.399
LIG_LIR_Gen_1	96	105	PF02991	0.381
LIG_LIR_Nem_3	211	217	PF02991	0.423
LIG_LIR_Nem_3	266	271	PF02991	0.408
LIG_LIR_Nem_3	96	102	PF02991	0.554
LIG_NRBOX	112	118	PF00104	0.480
LIG_PAM2_1	5	17	PF00658	0.528
LIG_PCNA_yPIPBox_3	283	293	PF02747	0.541
LIG_SH2_SRC	268	271	PF00017	0.518
LIG_SH2_STAP1	268	272	PF00017	0.403
LIG_SH2_STAP1	323	327	PF00017	0.514
LIG_SH3_3	41	47	PF00018	0.557
LIG_SH3_3	99	105	PF00018	0.475
LIG_SUMO_SIM_par_1	5	10	PF11976	0.480
LIG_TRAF2_1	192	195	PF00917	0.511
LIG_UBA3_1	134	143	PF00899	0.437
LIG_UBA3_1	313	320	PF00899	0.431
LIG_UBA3_1	361	367	PF00899	0.557
LIG_WRC_WIRS_1	98	103	PF05994	0.521
MOD_CK1_1	145	151	PF00069	0.512
MOD_CK1_1	28	34	PF00069	0.408
MOD_CK1_1	3	9	PF00069	0.582
MOD_CK1_1	352	358	PF00069	0.654
MOD_CK1_1	370	376	PF00069	0.656
MOD_CK1_1	40	46	PF00069	0.474
MOD_CK1_1	70	76	PF00069	0.397
MOD_CK1_1	89	95	PF00069	0.390
MOD_CK2_1	169	175	PF00069	0.519
MOD_CK2_1	196	202	PF00069	0.353
MOD_CK2_1	255	261	PF00069	0.537
MOD_GlcNHglycan	2	5	PF01048	0.671
MOD_GlcNHglycan	27	30	PF01048	0.407
MOD_GlcNHglycan	375	378	PF01048	0.502
MOD_GSK3_1	107	114	PF00069	0.523
MOD_GSK3_1	142	149	PF00069	0.426
MOD_GSK3_1	319	326	PF00069	0.510
MOD_GSK3_1	349	356	PF00069	0.632
MOD_GSK3_1	367	374	PF00069	0.571
MOD_N-GLC_1	347	352	PF02516	0.531
MOD_NEK2_1	146	151	PF00069	0.389
MOD_NEK2_1	180	185	PF00069	0.464
MOD_NEK2_1	196	201	PF00069	0.310
MOD_NEK2_1	217	222	PF00069	0.462
MOD_NEK2_1	331	336	PF00069	0.547
MOD_PIKK_1	291	297	PF00454	0.450
MOD_PIKK_1	331	337	PF00454	0.552
MOD_PIKK_1	347	353	PF00454	0.481
MOD_PIKK_1	354	360	PF00454	0.609
MOD_PKA_1	12	18	PF00069	0.359
MOD_PKA_1	142	148	PF00069	0.503
MOD_PKA_2	264	270	PF00069	0.448
MOD_Plk_4	111	117	PF00069	0.285
MOD_Plk_4	142	148	PF00069	0.403
MOD_Plk_4	67	73	PF00069	0.410
MOD_SUMO_for_1	105	108	PF00179	0.538
MOD_SUMO_rev_2	220	227	PF00179	0.526
TRG_ENDOCYTIC_2	268	271	PF00928	0.387
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1A8	Leptomonas seymouri	65%	100%
A0A0S4J8X0	Bodo saltans	27%	100%
A0A1X0NG17	Trypanosomatidae	34%	99%
A0A3S7X117	Leishmania donovani	92%	100%
A0A422NDW9	Trypanosoma rangeli	35%	99%
A4HG16	Leishmania braziliensis	83%	100%
A4I338	Leishmania infantum	91%	100%
C9ZJL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	99%
E9ACV6	Leishmania major	90%	100%
V5BB08	Trypanosoma cruzi	35%	99%