Vesicle-associated membrane protein (Vamp),putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vesicle-associated membrane protein 7

Species:

Leishmania mexicana

UniProt:

E9AZE4_LEIMU

TriTrypDb:

LmxM.27.2350

Length:

220

Annotations

LeishMANIAdb annotations

Homologous to animal VAMP7 proteins. Likely involved in vesicular transport.. Localization: Vesicular (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0000331	contractile vacuole	6	1
GO:0005773	vacuole	5	1
GO:0005886	plasma membrane	3	1
GO:0020016	ciliary pocket	2	1
GO:0020022	acidocalcisome	5	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

E9AZE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZE4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0016192	vesicle-mediated transport	4	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0006950	response to stress	2	1
GO:0006970	response to osmotic stress	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0033554	cellular response to stress	3	1
GO:0042221	response to chemical	2	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0062197	cellular response to chemical stress	4	1
GO:0070887	cellular response to chemical stimulus	3	1
GO:0071214	cellular response to abiotic stimulus	3	1
GO:0071470	cellular response to osmotic stress	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0104004	cellular response to environmental stimulus	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.407
CLV_PCSK_SKI1_1	12	16	PF00082	0.391
CLV_PCSK_SKI1_1	180	184	PF00082	0.221
CLV_PCSK_SKI1_1	72	76	PF00082	0.232
CLV_PCSK_SKI1_1	82	86	PF00082	0.233
DEG_SPOP_SBC_1	62	66	PF00917	0.484
DOC_MAPK_HePTP_8	187	199	PF00069	0.435
DOC_MAPK_MEF2A_6	190	199	PF00069	0.511
DOC_MAPK_RevD_3	205	219	PF00069	0.273
DOC_PP1_RVXF_1	70	76	PF00149	0.489
DOC_USP7_MATH_1	40	44	PF00917	0.510
DOC_USP7_UBL2_3	82	86	PF12436	0.484
DOC_WW_Pin1_4	100	105	PF00397	0.452
DOC_WW_Pin1_4	121	126	PF00397	0.546
DOC_WW_Pin1_4	18	23	PF00397	0.550
LIG_14-3-3_CanoR_1	118	122	PF00244	0.587
LIG_BIR_II_1	1	5	PF00653	0.455
LIG_Clathr_ClatBox_1	7	11	PF01394	0.514
LIG_EH1_1	188	196	PF00400	0.522
LIG_FHA_1	138	144	PF00498	0.484
LIG_FHA_1	163	169	PF00498	0.396
LIG_FHA_2	118	124	PF00498	0.551
LIG_FHA_2	158	164	PF00498	0.522
LIG_Integrin_RGD_1	154	156	PF01839	0.322
LIG_LIR_Gen_1	49	59	PF02991	0.453
LIG_LIR_Nem_3	49	54	PF02991	0.453
LIG_PCNA_yPIPBox_3	71	82	PF02747	0.460
LIG_Pex14_2	85	89	PF04695	0.421
LIG_Rb_LxCxE_1	163	181	PF01857	0.343
LIG_SH2_GRB2like	69	72	PF00017	0.463
LIG_SH2_STAP1	69	73	PF00017	0.522
LIG_SUMO_SIM_par_1	202	208	PF11976	0.150
LIG_TRAF2_1	124	127	PF00917	0.574
LIG_UBA3_1	78	86	PF00899	0.520
MOD_CK1_1	117	123	PF00069	0.599
MOD_CK1_1	2	8	PF00069	0.463
MOD_CK2_1	117	123	PF00069	0.523
MOD_GlcNHglycan	65	68	PF01048	0.248
MOD_GSK3_1	109	116	PF00069	0.541
MOD_GSK3_1	117	124	PF00069	0.506
MOD_GSK3_1	174	181	PF00069	0.479
MOD_N-GLC_1	121	126	PF02516	0.419
MOD_N-GLC_1	137	142	PF02516	0.358
MOD_N-GLC_1	18	23	PF02516	0.287
MOD_N-GLC_1	3	8	PF02516	0.287
MOD_NEK2_1	110	115	PF00069	0.502
MOD_NEK2_1	85	90	PF00069	0.424
MOD_PKA_2	117	123	PF00069	0.479
MOD_Plk_1	3	9	PF00069	0.487
MOD_Plk_4	3	9	PF00069	0.451
MOD_ProDKin_1	100	106	PF00069	0.452
MOD_ProDKin_1	121	127	PF00069	0.553
MOD_ProDKin_1	18	24	PF00069	0.548
TRG_NES_CRM1_1	45	58	PF08389	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I418	Leptomonas seymouri	27%	100%
A0A0N1IMB1	Leptomonas seymouri	69%	100%
A0A0S4IUW0	Bodo saltans	25%	100%
A0A0S4JCC4	Bodo saltans	45%	94%
A0A0S4JL59	Bodo saltans	22%	98%
A0A0S4JYF9	Bodo saltans	27%	100%
A0A1X0NF95	Trypanosomatidae	51%	99%
A0A1X0NQE9	Trypanosomatidae	25%	100%
A0A1X0NYJ8	Trypanosomatidae	23%	88%
A0A3S7WQ28	Leishmania donovani	27%	100%
A0A3S7X115	Leishmania donovani	88%	100%
A0A422N7W7	Trypanosoma rangeli	26%	100%
A0A422NDY3	Trypanosoma rangeli	50%	99%
A4H570	Leishmania braziliensis	26%	93%
A4HG15	Leishmania braziliensis	72%	100%
A4HTF3	Leishmania infantum	27%	100%
A4I337	Leishmania infantum	88%	100%
C9ZJK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZPM9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ACV5	Leishmania major	85%	100%
E9AM81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	93%
O23429	Arabidopsis thaliana	24%	99%
O48850	Arabidopsis thaliana	27%	77%
O49377	Arabidopsis thaliana	28%	100%
P47192	Arabidopsis thaliana	27%	100%
P51809	Homo sapiens	29%	100%
P70280	Mus musculus	29%	100%
Q17QI5	Bos taurus	29%	100%
Q4QIG6	Leishmania major	27%	94%
Q54NW7	Dictyostelium discoideum	24%	100%
Q5RF94	Pongo abelii	29%	100%
Q5ZL74	Gallus gallus	28%	100%
Q6C537	Yarrowia lipolytica (strain CLIB 122 / E 150)	23%	100%
Q6CJA0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	21%	100%
Q86AQ7	Dictyostelium discoideum	25%	85%
Q9FMR5	Arabidopsis thaliana	25%	100%
Q9JHW5	Rattus norvegicus	28%	100%
Q9LFP1	Arabidopsis thaliana	26%	100%
Q9M376	Arabidopsis thaliana	22%	92%
Q9MAS5	Arabidopsis thaliana	27%	100%
Q9SIQ9	Arabidopsis thaliana	30%	100%
Q9Y7L0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q9ZTW3	Arabidopsis thaliana	25%	100%
V5BFM1	Trypanosoma cruzi	50%	99%