TROVE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AZE2_LEIMU

TriTrypDb:

LmxM.27.2337

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZE2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	153	155	PF00675	0.579
CLV_NRD_NRD_1	204	206	PF00675	0.524
CLV_NRD_NRD_1	214	216	PF00675	0.447
CLV_NRD_NRD_1	253	255	PF00675	0.506
CLV_NRD_NRD_1	264	266	PF00675	0.447
CLV_NRD_NRD_1	332	334	PF00675	0.525
CLV_NRD_NRD_1	42	44	PF00675	0.397
CLV_NRD_NRD_1	69	71	PF00675	0.597
CLV_NRD_NRD_1	86	88	PF00675	0.406
CLV_PCSK_FUR_1	99	103	PF00082	0.549
CLV_PCSK_KEX2_1	101	103	PF00082	0.534
CLV_PCSK_KEX2_1	204	206	PF00082	0.519
CLV_PCSK_KEX2_1	214	216	PF00082	0.445
CLV_PCSK_KEX2_1	252	254	PF00082	0.499
CLV_PCSK_KEX2_1	264	266	PF00082	0.444
CLV_PCSK_KEX2_1	332	334	PF00082	0.499
CLV_PCSK_KEX2_1	42	44	PF00082	0.398
CLV_PCSK_KEX2_1	69	71	PF00082	0.597
CLV_PCSK_KEX2_1	86	88	PF00082	0.406
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.381
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.519
CLV_PCSK_SKI1_1	101	105	PF00082	0.554
CLV_PCSK_SKI1_1	20	24	PF00082	0.466
CLV_PCSK_SKI1_1	205	209	PF00082	0.421
CLV_PCSK_SKI1_1	245	249	PF00082	0.461
CLV_PCSK_SKI1_1	254	258	PF00082	0.458
CLV_PCSK_SKI1_1	341	345	PF00082	0.656
CLV_PCSK_SKI1_1	48	52	PF00082	0.396
DEG_APCC_DBOX_1	86	94	PF00400	0.378
DEG_Nend_UBRbox_2	1	3	PF02207	0.578
DOC_CKS1_1	176	181	PF01111	0.486
DOC_CYCLIN_RxL_1	252	260	PF00134	0.510
DOC_CYCLIN_RxL_1	99	107	PF00134	0.563
DOC_MAPK_DCC_7	99	108	PF00069	0.526
DOC_MAPK_gen_1	252	259	PF00069	0.510
DOC_MAPK_gen_1	261	269	PF00069	0.446
DOC_MAPK_gen_1	45	55	PF00069	0.413
DOC_MAPK_gen_1	99	108	PF00069	0.570
DOC_MAPK_MEF2A_6	174	183	PF00069	0.491
DOC_MAPK_MEF2A_6	99	108	PF00069	0.570
DOC_MAPK_NFAT4_5	101	109	PF00069	0.583
DOC_PP1_RVXF_1	252	259	PF00149	0.495
DOC_PP1_RVXF_1	270	277	PF00149	0.467
DOC_PP1_RVXF_1	90	96	PF00149	0.545
DOC_SPAK_OSR1_1	112	116	PF12202	0.596
DOC_USP7_MATH_1	291	295	PF00917	0.560
DOC_USP7_MATH_1	324	328	PF00917	0.592
DOC_USP7_MATH_1	60	64	PF00917	0.514
DOC_USP7_UBL2_3	151	155	PF12436	0.612
DOC_WW_Pin1_4	175	180	PF00397	0.494
LIG_14-3-3_CanoR_1	20	30	PF00244	0.583
LIG_14-3-3_CanoR_1	264	268	PF00244	0.556
LIG_14-3-3_CanoR_1	275	279	PF00244	0.428
LIG_14-3-3_CanoR_1	295	299	PF00244	0.383
LIG_14-3-3_CanoR_1	332	337	PF00244	0.746
LIG_14-3-3_CanoR_1	369	373	PF00244	0.564
LIG_14-3-3_CanoR_1	42	52	PF00244	0.525
LIG_Actin_WH2_2	232	250	PF00022	0.528
LIG_APCC_ABBAyCdc20_2	254	260	PF00400	0.425
LIG_BRCT_BRCA1_1	119	123	PF00533	0.469
LIG_BRCT_BRCA1_1	26	30	PF00533	0.531
LIG_CaM_IQ_9	196	211	PF13499	0.478
LIG_CtBP_PxDLS_1	105	109	PF00389	0.569
LIG_deltaCOP1_diTrp_1	284	288	PF00928	0.531
LIG_FHA_1	1	7	PF00498	0.516
LIG_FHA_1	141	147	PF00498	0.522
LIG_FHA_1	176	182	PF00498	0.601
LIG_FHA_1	264	270	PF00498	0.380
LIG_FHA_1	310	316	PF00498	0.483
LIG_FHA_1	326	332	PF00498	0.558
LIG_FHA_1	47	53	PF00498	0.540
LIG_FHA_1	98	104	PF00498	0.407
LIG_FHA_2	27	33	PF00498	0.481
LIG_FHA_2	275	281	PF00498	0.547
LIG_FHA_2	357	363	PF00498	0.547
LIG_FHA_2	66	72	PF00498	0.585
LIG_LIR_Gen_1	10	19	PF02991	0.451
LIG_LIR_Gen_1	120	129	PF02991	0.512
LIG_LIR_Gen_1	180	189	PF02991	0.445
LIG_LIR_Gen_1	273	282	PF02991	0.495
LIG_LIR_Gen_1	283	293	PF02991	0.512
LIG_LIR_Nem_3	10	15	PF02991	0.435
LIG_LIR_Nem_3	120	126	PF02991	0.509
LIG_LIR_Nem_3	180	186	PF02991	0.443
LIG_LIR_Nem_3	273	279	PF02991	0.488
LIG_LIR_Nem_3	283	288	PF02991	0.517
LIG_LIR_Nem_3	334	339	PF02991	0.616
LIG_NRBOX	180	186	PF00104	0.443
LIG_NRBOX	372	378	PF00104	0.447
LIG_NRBOX	78	84	PF00104	0.514
LIG_PCNA_yPIPBox_3	369	377	PF02747	0.376
LIG_Pex14_2	37	41	PF04695	0.476
LIG_Rb_LxCxE_1	182	202	PF01857	0.413
LIG_REV1ctd_RIR_1	205	213	PF16727	0.387
LIG_REV1ctd_RIR_1	285	292	PF16727	0.586
LIG_SH2_CRK	336	340	PF00017	0.617
LIG_SH2_STAP1	166	170	PF00017	0.649
LIG_SH2_STAP1	398	402	PF00017	0.501
LIG_SH3_3	336	342	PF00018	0.665
LIG_SUMO_SIM_anti_2	2	11	PF11976	0.358
LIG_SUMO_SIM_par_1	2	11	PF11976	0.528
LIG_SUMO_SIM_par_1	265	271	PF11976	0.378
LIG_TYR_ITIM	59	64	PF00017	0.506
LIG_UBA3_1	286	292	PF00899	0.420
LIG_UBA3_1	52	57	PF00899	0.550
LIG_WRC_WIRS_1	34	39	PF05994	0.520
LIG_WRC_WIRS_1	9	14	PF05994	0.436
MOD_CK1_1	124	130	PF00069	0.659
MOD_CK1_1	144	150	PF00069	0.582
MOD_CK1_1	24	30	PF00069	0.592
MOD_CK1_1	270	276	PF00069	0.573
MOD_CK1_1	294	300	PF00069	0.550
MOD_CK1_1	327	333	PF00069	0.656
MOD_CK1_1	335	341	PF00069	0.569
MOD_CK1_1	401	407	PF00069	0.437
MOD_CK1_1	46	52	PF00069	0.476
MOD_CK2_1	274	280	PF00069	0.551
MOD_CK2_1	356	362	PF00069	0.426
MOD_CK2_1	41	47	PF00069	0.573
MOD_CK2_1	65	71	PF00069	0.522
MOD_CMANNOS	298	301	PF00535	0.593
MOD_Cter_Amidation	262	265	PF01082	0.527
MOD_GlcNHglycan	166	169	PF01048	0.602
MOD_GlcNHglycan	23	26	PF01048	0.406
MOD_GlcNHglycan	231	234	PF01048	0.486
MOD_GSK3_1	117	124	PF00069	0.640
MOD_GSK3_1	140	147	PF00069	0.606
MOD_GSK3_1	263	270	PF00069	0.557
MOD_GSK3_1	327	334	PF00069	0.624
MOD_GSK3_1	397	404	PF00069	0.569
MOD_N-GLC_1	280	285	PF02516	0.516
MOD_NEK2_1	146	151	PF00069	0.662
MOD_NEK2_1	207	212	PF00069	0.386
MOD_NEK2_1	229	234	PF00069	0.484
MOD_NEK2_1	247	252	PF00069	0.357
MOD_NEK2_1	274	279	PF00069	0.549
MOD_NEK2_1	309	314	PF00069	0.437
MOD_NEK2_1	368	373	PF00069	0.508
MOD_NEK2_1	7	12	PF00069	0.488
MOD_NEK2_1	73	78	PF00069	0.529
MOD_NEK2_2	398	403	PF00069	0.506
MOD_PIKK_1	196	202	PF00454	0.463
MOD_PIKK_1	302	308	PF00454	0.514
MOD_PKA_1	332	338	PF00069	0.523
MOD_PKA_2	117	123	PF00069	0.642
MOD_PKA_2	263	269	PF00069	0.562
MOD_PKA_2	274	280	PF00069	0.438
MOD_PKA_2	294	300	PF00069	0.383
MOD_PKA_2	324	330	PF00069	0.660
MOD_PKA_2	331	337	PF00069	0.597
MOD_PKA_2	368	374	PF00069	0.504
MOD_PKA_2	41	47	PF00069	0.398
MOD_Plk_1	270	276	PF00069	0.573
MOD_Plk_1	398	404	PF00069	0.505
MOD_Plk_2-3	26	32	PF00069	0.500
MOD_Plk_4	141	147	PF00069	0.522
MOD_Plk_4	33	39	PF00069	0.484
MOD_Plk_4	368	374	PF00069	0.504
MOD_Plk_4	48	54	PF00069	0.458
MOD_Plk_4	73	79	PF00069	0.513
MOD_ProDKin_1	175	181	PF00069	0.489
MOD_SUMO_rev_2	187	194	PF00179	0.588
TRG_DiLeu_BaEn_1	180	185	PF01217	0.500
TRG_DiLeu_BaEn_2	361	367	PF01217	0.376
TRG_DiLeu_BaEn_2	389	395	PF01217	0.438
TRG_ENDOCYTIC_2	336	339	PF00928	0.616
TRG_ENDOCYTIC_2	61	64	PF00928	0.525
TRG_ER_diArg_1	14	17	PF00400	0.435
TRG_ER_diArg_1	213	215	PF00400	0.522
TRG_ER_diArg_1	251	254	PF00400	0.484
TRG_ER_diArg_1	315	318	PF00400	0.530
TRG_ER_diArg_1	331	333	PF00400	0.511
TRG_ER_diArg_1	41	43	PF00400	0.394
TRG_NES_CRM1_1	72	85	PF08389	0.550
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.558
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T5	Leptomonas seymouri	28%	99%
A0A3Q8IEE0	Leishmania donovani	83%	100%
A4HG13	Leishmania braziliensis	63%	100%
E9ACV3	Leishmania major	84%	100%
E9AHG2	Leishmania infantum	83%	100%