Protein phosphatase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase-like protein

Species:

Leishmania mexicana

UniProt:

E9AZD9_LEIMU

TriTrypDb:

LmxM.27.2320

Length:

314

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

E9AZD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZD9

Function

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Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	13
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016311	dephosphorylation	5	13
GO:0019538	protein metabolic process	3	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004721	phosphoprotein phosphatase activity	3	13
GO:0004722	protein serine/threonine phosphatase activity	4	13
GO:0016787	hydrolase activity	2	13
GO:0016788	hydrolase activity, acting on ester bonds	3	13
GO:0016791	phosphatase activity	5	13
GO:0017018	myosin phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	13
GO:0140096	catalytic activity, acting on a protein	2	13

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	97	101	PF00656	0.394
CLV_PCSK_SKI1_1	109	113	PF00082	0.327
CLV_PCSK_SKI1_1	154	158	PF00082	0.268
CLV_PCSK_SKI1_1	180	184	PF00082	0.312
CLV_PCSK_SKI1_1	300	304	PF00082	0.397
DEG_SCF_FBW7_2	231	236	PF00400	0.275
DOC_CYCLIN_RxL_1	297	308	PF00134	0.478
DOC_MAPK_MEF2A_6	214	222	PF00069	0.394
DOC_MAPK_RevD_3	292	306	PF00069	0.450
DOC_PP1_RVXF_1	251	258	PF00149	0.346

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5C7	Leptomonas seymouri	38%	79%
A0A0N0P8F8	Leptomonas seymouri	88%	100%
A0A0N1I0H9	Leptomonas seymouri	41%	100%
A0A0N1I8W9	Leptomonas seymouri	29%	72%
A0A0N1IHU6	Leptomonas seymouri	30%	77%
A0A0N1PAL8	Leptomonas seymouri	32%	82%
A0A0N1PEL9	Leptomonas seymouri	32%	84%
A0A0S4IY95	Bodo saltans	51%	87%
A0A0S4J0A6	Bodo saltans	30%	77%
A0A0S4JHB4	Bodo saltans	28%	82%

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