Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZD8_LEIMU

TriTrypDb:

LmxM.27.2310

Length:

247

Annotations

LeishMANIAdb annotations

A conserved but unique protein in Kinetoplastids (can also be organellar)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AZD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZD8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.539
CLV_NRD_NRD_1	66	68	PF00675	0.467
CLV_NRD_NRD_1	76	78	PF00675	0.454
CLV_PCSK_KEX2_1	17	19	PF00082	0.545
CLV_PCSK_KEX2_1	187	189	PF00082	0.392
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.545
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.451
CLV_PCSK_SKI1_1	77	81	PF00082	0.509
DEG_Nend_UBRbox_2	1	3	PF02207	0.756
DOC_CYCLIN_yCln2_LP_2	131	137	PF00134	0.699
DOC_MAPK_gen_1	118	127	PF00069	0.699
DOC_MAPK_gen_1	234	243	PF00069	0.671
DOC_MAPK_gen_1	77	84	PF00069	0.715
DOC_MAPK_HePTP_8	184	201	PF00069	0.380
DOC_MAPK_RevD_3	172	188	PF00069	0.344
DOC_PP2B_LxvP_1	131	134	PF13499	0.673
DOC_PP2B_LxvP_1	84	87	PF13499	0.690
DOC_PP4_FxxP_1	139	142	PF00568	0.401
DOC_PP4_FxxP_1	209	212	PF00568	0.511
DOC_USP7_MATH_1	212	216	PF00917	0.401
LIG_14-3-3_CanoR_1	188	197	PF00244	0.475
LIG_14-3-3_CanoR_1	234	243	PF00244	0.618
LIG_BRCT_BRCA1_1	142	146	PF00533	0.408
LIG_Clathr_ClatBox_1	100	104	PF01394	0.764
LIG_CtBP_PxDLS_1	73	77	PF00389	0.702
LIG_deltaCOP1_diTrp_1	8	15	PF00928	0.741
LIG_FHA_1	192	198	PF00498	0.444
LIG_FHA_1	224	230	PF00498	0.432
LIG_FHA_1	27	33	PF00498	0.729
LIG_LIR_Gen_1	238	246	PF02991	0.663
LIG_LIR_Gen_1	7	15	PF02991	0.688
LIG_LIR_Nem_3	238	243	PF02991	0.632
LIG_LIR_Nem_3	39	45	PF02991	0.736
LIG_LIR_Nem_3	7	12	PF02991	0.674
LIG_NRP_CendR_1	245	247	PF00754	0.496
LIG_Pex14_2	209	213	PF04695	0.439
LIG_PTAP_UEV_1	108	113	PF05743	0.583
LIG_SH2_CRK	42	46	PF00017	0.534
LIG_SH2_SRC	42	45	PF00017	0.585
LIG_SH2_STAP1	191	195	PF00017	0.429
LIG_SH2_STAT5	231	234	PF00017	0.532
LIG_SH3_1	18	24	PF00018	0.708
LIG_SH3_3	100	106	PF00018	0.661
LIG_SH3_3	171	177	PF00018	0.387
LIG_SH3_3	18	24	PF00018	0.780
LIG_SH3_3	83	89	PF00018	0.748
LIG_SUMO_SIM_anti_2	149	154	PF11976	0.444
LIG_SUMO_SIM_par_1	123	129	PF11976	0.697
LIG_SUMO_SIM_par_1	151	156	PF11976	0.402
LIG_SUMO_SIM_par_1	172	178	PF11976	0.364
LIG_SUMO_SIM_par_1	43	49	PF11976	0.665
LIG_UBA3_1	182	187	PF00899	0.485
LIG_WRC_WIRS_1	12	17	PF05994	0.743
LIG_WRC_WIRS_1	240	245	PF05994	0.675
LIG_WW_3	85	89	PF00397	0.737
MOD_CAAXbox	244	247	PF01239	0.721
MOD_CK1_1	110	116	PF00069	0.776
MOD_CK1_1	156	162	PF00069	0.430
MOD_GlcNHglycan	109	112	PF01048	0.475
MOD_GlcNHglycan	142	145	PF01048	0.478
MOD_GlcNHglycan	191	194	PF01048	0.260
MOD_GSK3_1	212	219	PF00069	0.194
MOD_GSK3_1	235	242	PF00069	0.598
MOD_GSK3_1	34	41	PF00069	0.731
MOD_N-GLC_2	33	35	PF02516	0.362
MOD_NEK2_1	153	158	PF00069	0.463
MOD_NEK2_1	216	221	PF00069	0.373
MOD_NEK2_1	222	227	PF00069	0.366
MOD_NEK2_1	38	43	PF00069	0.596
MOD_PKA_2	235	241	PF00069	0.609
MOD_PKB_1	234	242	PF00069	0.579
MOD_Plk_1	38	44	PF00069	0.648
MOD_Plk_4	126	132	PF00069	0.668
MOD_Plk_4	212	218	PF00069	0.401
MOD_Plk_4	223	229	PF00069	0.372
MOD_Plk_4	236	242	PF00069	0.557
TRG_DiLeu_BaEn_2	97	103	PF01217	0.698
TRG_ENDOCYTIC_2	240	243	PF00928	0.669
TRG_ENDOCYTIC_2	42	45	PF00928	0.735
TRG_ER_diArg_1	15	18	PF00400	0.747
TRG_ER_diArg_1	233	236	PF00400	0.612
TRG_NLS_Bipartite_1	67	81	PF00514	0.721
TRG_NLS_MonoExtN_4	74	81	PF00514	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMI2	Leptomonas seymouri	65%	100%
A0A1X0NSH8	Trypanosomatidae	36%	100%
A0A3Q8IAR5	Leishmania donovani	94%	100%
A0A3R7NGU7	Trypanosoma rangeli	33%	100%
A4HG09	Leishmania braziliensis	83%	100%
A4I328	Leishmania infantum	94%	100%
E9ACU9	Leishmania major	92%	100%
V5B3U0	Trypanosoma cruzi	35%	100%