Transcription elongation regulator-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription elongation regulator-like protein

Species:

Leishmania mexicana

UniProt:

E9AZD6_LEIMU

TriTrypDb:

LmxM.27.2300

Length:

702

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0008023	transcription elongation factor complex	3	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032044	DSIF complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AZD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZD6

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	12
GO:0006357	regulation of transcription by RNA polymerase II	7	12
GO:0009889	regulation of biosynthetic process	4	12
GO:0010468	regulation of gene expression	5	12
GO:0010556	regulation of macromolecule biosynthetic process	5	12
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031326	regulation of cellular biosynthetic process	5	12
GO:0032784	regulation of DNA-templated transcription elongation	7	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051252	regulation of RNA metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0080090	regulation of primary metabolic process	4	12
GO:1903506	regulation of nucleic acid-templated transcription	7	12
GO:2001141	regulation of RNA biosynthetic process	6	12
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006354	DNA-templated transcription elongation	6	1
GO:0006368	transcription elongation by RNA polymerase II	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0032774	RNA biosynthetic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	410	414	PF00656	0.530
CLV_C14_Caspase3-7	84	88	PF00656	0.660
CLV_C14_Caspase3-7	93	97	PF00656	0.640
CLV_NRD_NRD_1	161	163	PF00675	0.585
CLV_NRD_NRD_1	207	209	PF00675	0.263
CLV_NRD_NRD_1	233	235	PF00675	0.282
CLV_NRD_NRD_1	37	39	PF00675	0.617
CLV_NRD_NRD_1	47	49	PF00675	0.577
CLV_NRD_NRD_1	50	52	PF00675	0.573
CLV_NRD_NRD_1	648	650	PF00675	0.631
CLV_NRD_NRD_1	653	655	PF00675	0.671
CLV_PCSK_FUR_1	48	52	PF00082	0.504
CLV_PCSK_KEX2_1	161	163	PF00082	0.570
CLV_PCSK_KEX2_1	235	237	PF00082	0.405
CLV_PCSK_KEX2_1	324	326	PF00082	0.503
CLV_PCSK_KEX2_1	47	49	PF00082	0.580
CLV_PCSK_KEX2_1	50	52	PF00082	0.616
CLV_PCSK_KEX2_1	53	55	PF00082	0.655
CLV_PCSK_KEX2_1	57	59	PF00082	0.692
CLV_PCSK_KEX2_1	653	655	PF00082	0.682
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.405
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.503
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.654
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.673
CLV_PCSK_PC7_1	649	655	PF00082	0.680
CLV_PCSK_SKI1_1	116	120	PF00082	0.647
CLV_PCSK_SKI1_1	259	263	PF00082	0.405
CLV_PCSK_SKI1_1	329	333	PF00082	0.503
CLV_PCSK_SKI1_1	395	399	PF00082	0.529
CLV_PCSK_SKI1_1	620	624	PF00082	0.368
CLV_PCSK_SKI1_1	77	81	PF00082	0.717
CLV_Separin_Metazoa	151	155	PF03568	0.404
DEG_APCC_DBOX_1	287	295	PF00400	0.368
DOC_CKS1_1	330	335	PF01111	0.482
DOC_CKS1_1	601	606	PF01111	0.463
DOC_CYCLIN_RxL_1	113	123	PF00134	0.554
DOC_MAPK_gen_1	182	190	PF00069	0.282
DOC_MAPK_gen_1	208	215	PF00069	0.267
DOC_MAPK_gen_1	273	282	PF00069	0.377
DOC_MAPK_gen_1	548	556	PF00069	0.393
DOC_MAPK_MEF2A_6	208	215	PF00069	0.279
DOC_MAPK_MEF2A_6	448	456	PF00069	0.415
DOC_MAPK_MEF2A_6	487	496	PF00069	0.499
DOC_PP2B_PxIxI_1	406	412	PF00149	0.458
DOC_PP4_FxxP_1	330	333	PF00568	0.399
DOC_SPAK_OSR1_1	250	254	PF12202	0.405
DOC_USP7_MATH_1	183	187	PF00917	0.405
DOC_USP7_MATH_1	19	23	PF00917	0.617
DOC_USP7_MATH_1	479	483	PF00917	0.423
DOC_USP7_MATH_1	66	70	PF00917	0.697
DOC_USP7_MATH_1	679	683	PF00917	0.633
DOC_USP7_MATH_1	82	86	PF00917	0.479
DOC_USP7_UBL2_3	317	321	PF12436	0.407
DOC_USP7_UBL2_3	41	45	PF12436	0.600
DOC_USP7_UBL2_3	53	57	PF12436	0.542
DOC_WW_Pin1_4	329	334	PF00397	0.483
DOC_WW_Pin1_4	600	605	PF00397	0.442
DOC_WW_Pin1_4	626	631	PF00397	0.520
LIG_14-3-3_CanoR_1	161	169	PF00244	0.458
LIG_14-3-3_CanoR_1	268	276	PF00244	0.556
LIG_14-3-3_CanoR_1	416	422	PF00244	0.498
LIG_14-3-3_CanoR_1	564	569	PF00244	0.438
LIG_14-3-3_CanoR_1	649	657	PF00244	0.608
LIG_Actin_WH2_2	408	425	PF00022	0.471
LIG_APCC_ABBA_1	493	498	PF00400	0.368
LIG_APCC_ABBAyCdc20_2	225	231	PF00400	0.267
LIG_CSL_BTD_1	601	604	PF09270	0.517
LIG_FHA_1	189	195	PF00498	0.405
LIG_FHA_1	269	275	PF00498	0.594
LIG_FHA_1	303	309	PF00498	0.342
LIG_FHA_1	321	327	PF00498	0.431
LIG_FHA_1	363	369	PF00498	0.464
LIG_FHA_1	377	383	PF00498	0.494
LIG_FHA_1	417	423	PF00498	0.455
LIG_FHA_1	436	442	PF00498	0.232
LIG_FHA_1	609	615	PF00498	0.365
LIG_FHA_1	619	625	PF00498	0.341
LIG_FHA_1	656	662	PF00498	0.470
LIG_FHA_2	125	131	PF00498	0.475
LIG_FHA_2	293	299	PF00498	0.242
LIG_Integrin_RGD_1	288	290	PF01839	0.496
LIG_KLC1_Yacidic_2	226	231	PF13176	0.267
LIG_LIR_Apic_2	327	333	PF02991	0.549
LIG_LIR_Gen_1	226	232	PF02991	0.268
LIG_LIR_Gen_1	278	287	PF02991	0.337
LIG_LIR_Gen_1	4	15	PF02991	0.678
LIG_LIR_Gen_1	565	574	PF02991	0.525
LIG_LIR_Nem_3	226	230	PF02991	0.268
LIG_LIR_Nem_3	278	282	PF02991	0.318
LIG_LIR_Nem_3	345	351	PF02991	0.461
LIG_LIR_Nem_3	4	10	PF02991	0.673
LIG_LIR_Nem_3	488	492	PF02991	0.505
LIG_LIR_Nem_3	565	571	PF02991	0.518
LIG_NRBOX	9	15	PF00104	0.560
LIG_PTB_Apo_2	192	199	PF02174	0.267
LIG_PTB_Phospho_1	192	198	PF10480	0.267
LIG_SH2_CRK	568	572	PF00017	0.527
LIG_SH2_NCK_1	135	139	PF00017	0.596
LIG_SH2_NCK_1	568	572	PF00017	0.491
LIG_SH2_NCK_1	670	674	PF00017	0.653
LIG_SH2_PTP2	227	230	PF00017	0.267
LIG_SH2_PTP2	279	282	PF00017	0.412
LIG_SH2_SRC	135	138	PF00017	0.594
LIG_SH2_SRC	227	230	PF00017	0.267
LIG_SH2_STAP1	198	202	PF00017	0.282
LIG_SH2_STAP1	670	674	PF00017	0.653
LIG_SH2_STAP1	7	11	PF00017	0.672
LIG_SH2_STAT3	386	389	PF00017	0.499
LIG_SH2_STAT5	117	120	PF00017	0.576
LIG_SH2_STAT5	227	230	PF00017	0.267
LIG_SH2_STAT5	279	282	PF00017	0.412
LIG_SH2_STAT5	346	349	PF00017	0.376
LIG_SH2_STAT5	358	361	PF00017	0.307
LIG_SH2_STAT5	78	81	PF00017	0.596
LIG_SH3_3	252	258	PF00018	0.405
LIG_SH3_3	312	318	PF00018	0.454
LIG_SH3_3	598	604	PF00018	0.444
LIG_SH3_4	317	324	PF00018	0.468
LIG_SUMO_SIM_anti_2	491	496	PF11976	0.483
LIG_SUMO_SIM_anti_2	553	559	PF11976	0.435
LIG_SUMO_SIM_anti_2	641	647	PF11976	0.414
LIG_SUMO_SIM_par_1	533	539	PF11976	0.369
LIG_TRAF2_1	127	130	PF00917	0.459
LIG_TRAF2_1	378	381	PF00917	0.400
LIG_TRAF2_1	657	660	PF00917	0.680
LIG_TYR_ITIM	5	10	PF00017	0.668
LIG_TYR_ITIM	566	571	PF00017	0.516
MOD_CDK_SPK_2	329	334	PF00069	0.483
MOD_CK1_1	156	162	PF00069	0.590
MOD_CK1_1	459	465	PF00069	0.436
MOD_CK1_1	488	494	PF00069	0.494
MOD_CK1_1	522	528	PF00069	0.519
MOD_CK1_1	682	688	PF00069	0.686
MOD_CK1_1	85	91	PF00069	0.588
MOD_CK2_1	124	130	PF00069	0.471
MOD_CK2_1	375	381	PF00069	0.410
MOD_CK2_1	533	539	PF00069	0.472
MOD_CK2_1	66	72	PF00069	0.781
MOD_CK2_1	85	91	PF00069	0.503
MOD_Cter_Amidation	647	650	PF01082	0.626
MOD_GlcNHglycan	369	372	PF01048	0.437
MOD_GlcNHglycan	457	461	PF01048	0.541
MOD_GlcNHglycan	481	484	PF01048	0.405
MOD_GlcNHglycan	665	668	PF01048	0.695
MOD_GlcNHglycan	677	680	PF01048	0.692
MOD_GlcNHglycan	698	701	PF01048	0.551
MOD_GlcNHglycan	84	87	PF01048	0.590
MOD_GSK3_1	153	160	PF00069	0.646
MOD_GSK3_1	264	271	PF00069	0.615
MOD_GSK3_1	407	414	PF00069	0.527
MOD_GSK3_1	431	438	PF00069	0.428
MOD_GSK3_1	459	466	PF00069	0.479
MOD_GSK3_1	481	488	PF00069	0.433
MOD_GSK3_1	513	520	PF00069	0.524
MOD_GSK3_1	575	582	PF00069	0.547
MOD_GSK3_1	675	682	PF00069	0.674
MOD_N-GLC_1	696	701	PF02516	0.674
MOD_N-GLC_2	195	197	PF02516	0.267
MOD_N-GLC_2	511	513	PF02516	0.489
MOD_NEK2_1	359	364	PF00069	0.261
MOD_NEK2_1	367	372	PF00069	0.414
MOD_NEK2_1	422	427	PF00069	0.403
MOD_NEK2_1	433	438	PF00069	0.425
MOD_NEK2_1	441	446	PF00069	0.408
MOD_NEK2_1	618	623	PF00069	0.343
MOD_NEK2_2	214	219	PF00069	0.267
MOD_NEK2_2	519	524	PF00069	0.579
MOD_PIKK_1	162	168	PF00454	0.626
MOD_PIKK_1	268	274	PF00454	0.607
MOD_PIKK_1	655	661	PF00454	0.644
MOD_PK_1	517	523	PF00069	0.624
MOD_PKA_1	649	655	PF00069	0.645
MOD_PKA_2	153	159	PF00069	0.447
MOD_PKA_2	183	189	PF00069	0.376
MOD_PKA_2	267	273	PF00069	0.564
MOD_PKA_2	415	421	PF00069	0.453
MOD_PKA_2	422	428	PF00069	0.373
MOD_PKA_2	575	581	PF00069	0.458
MOD_PKA_2	648	654	PF00069	0.560
MOD_PKA_2	675	681	PF00069	0.642
MOD_PKA_2	682	688	PF00069	0.573
MOD_PKB_1	340	348	PF00069	0.259
MOD_Plk_1	342	348	PF00069	0.462
MOD_Plk_1	585	591	PF00069	0.545
MOD_Plk_1	688	694	PF00069	0.641
MOD_Plk_2-3	124	130	PF00069	0.602
MOD_Plk_2-3	533	539	PF00069	0.437
MOD_Plk_2-3	689	695	PF00069	0.678
MOD_Plk_2-3	87	93	PF00069	0.632
MOD_Plk_4	342	348	PF00069	0.515
MOD_Plk_4	481	487	PF00069	0.379
MOD_Plk_4	488	494	PF00069	0.356
MOD_Plk_4	689	695	PF00069	0.678
MOD_ProDKin_1	329	335	PF00069	0.484
MOD_ProDKin_1	600	606	PF00069	0.444
MOD_ProDKin_1	626	632	PF00069	0.520
MOD_SUMO_for_1	506	509	PF00179	0.519
MOD_SUMO_for_1	638	641	PF00179	0.427
MOD_SUMO_rev_2	121	128	PF00179	0.580
MOD_SUMO_rev_2	171	177	PF00179	0.415
MOD_SUMO_rev_2	49	59	PF00179	0.485
TRG_DiLeu_BaEn_1	641	646	PF01217	0.427
TRG_DiLeu_BaEn_1	9	14	PF01217	0.560
TRG_ENDOCYTIC_2	227	230	PF00928	0.267
TRG_ENDOCYTIC_2	279	282	PF00928	0.412
TRG_ENDOCYTIC_2	568	571	PF00928	0.524
TRG_ENDOCYTIC_2	7	10	PF00928	0.673
TRG_ER_diArg_1	161	163	PF00400	0.616
TRG_ER_diArg_1	182	185	PF00400	0.282
TRG_ER_diArg_1	234	237	PF00400	0.405
TRG_ER_diArg_1	280	283	PF00400	0.342
TRG_ER_diArg_1	624	627	PF00400	0.342
TRG_NES_CRM1_1	212	222	PF08389	0.282
TRG_NLS_Bipartite_1	41	61	PF00514	0.683
TRG_NLS_MonoCore_2	56	61	PF00514	0.691
TRG_NLS_MonoExtC_3	233	239	PF00514	0.405
TRG_NLS_MonoExtC_3	37	42	PF00514	0.619
TRG_NLS_MonoExtC_3	56	62	PF00514	0.488
TRG_NLS_MonoExtN_4	36	42	PF00514	0.620
TRG_NLS_MonoExtN_4	54	61	PF00514	0.502
TRG_Pf-PMV_PEXEL_1	116	121	PF00026	0.666
TRG_Pf-PMV_PEXEL_1	161	166	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9I1	Leptomonas seymouri	80%	100%
A0A0S4IUW1	Bodo saltans	42%	96%
A0A1X0NRB9	Trypanosomatidae	51%	96%
A0A3Q8IDN1	Leishmania donovani	93%	100%
A0A422NAL6	Trypanosoma rangeli	52%	99%
A4HG07	Leishmania braziliensis	89%	99%
A4I326	Leishmania infantum	93%	100%
C9ZJK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	98%
E9ACU7	Leishmania major	95%	100%
O13936	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	71%
O80770	Arabidopsis thaliana	24%	71%
Q2UGU3	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	26%	68%
Q4I5I4	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	26%	67%
Q4PIC4	Ustilago maydis (strain 521 / FGSC 9021)	24%	74%
Q4WP96	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	26%	66%
Q5ALX3	Candida albicans (strain SC5314 / ATCC MYA-2876)	28%	73%
Q5BCN2	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	69%
Q6BZG0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	25%	73%
Q6CC84	Yarrowia lipolytica (strain CLIB 122 / E 150)	28%	72%
Q6CWW9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	68%
Q6FRZ5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	26%	70%
Q7S3C4	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	67%
Q9STN3	Arabidopsis thaliana	26%	67%
V5D465	Trypanosoma cruzi	52%	98%