ACOX domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyl-CoA oxidase, putative

Species:

Leishmania mexicana

UniProt:

E9AZD5_LEIMU

TriTrypDb:

LmxM.27.2290

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	11
GO:0042579	microbody	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AZD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZD5

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	11
GO:0006629	lipid metabolic process	3	11
GO:0006631	fatty acid metabolic process	4	11
GO:0006635	fatty acid beta-oxidation	6	10
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	10
GO:0009062	fatty acid catabolic process	5	10
GO:0009987	cellular process	1	11
GO:0016042	lipid catabolic process	4	10
GO:0016054	organic acid catabolic process	4	10
GO:0019395	fatty acid oxidation	5	10
GO:0019752	carboxylic acid metabolic process	5	11
GO:0030258	lipid modification	4	10
GO:0032787	monocarboxylic acid metabolic process	6	11
GO:0034440	lipid oxidation	5	10
GO:0043436	oxoacid metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044242	cellular lipid catabolic process	4	10
GO:0044248	cellular catabolic process	3	10
GO:0044255	cellular lipid metabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044282	small molecule catabolic process	3	10
GO:0046395	carboxylic acid catabolic process	5	10
GO:0071704	organic substance metabolic process	2	11
GO:0072329	monocarboxylic acid catabolic process	6	10
GO:1901575	organic substance catabolic process	3	10
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	7	1
GO:0042592	homeostatic process	3	1
GO:0048878	chemical homeostasis	4	1
GO:0055088	lipid homeostasis	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0003997	acyl-CoA oxidase activity	5	11
GO:0005488	binding	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	11
GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0050660	flavin adenine dinucleotide binding	4	11
GO:0071949	FAD binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0005504	fatty acid binding	3	1
GO:0008289	lipid binding	2	1
GO:0031406	carboxylic acid binding	4	1
GO:0033293	monocarboxylic acid binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.437
CLV_C14_Caspase3-7	429	433	PF00656	0.532
CLV_C14_Caspase3-7	612	616	PF00656	0.355
CLV_NRD_NRD_1	111	113	PF00675	0.458
CLV_NRD_NRD_1	12	14	PF00675	0.707
CLV_NRD_NRD_1	246	248	PF00675	0.529
CLV_NRD_NRD_1	313	315	PF00675	0.426
CLV_NRD_NRD_1	347	349	PF00675	0.501
CLV_NRD_NRD_1	525	527	PF00675	0.321
CLV_NRD_NRD_1	573	575	PF00675	0.312
CLV_NRD_NRD_1	681	683	PF00675	0.697
CLV_NRD_NRD_1	715	717	PF00675	0.702
CLV_PCSK_FUR_1	310	314	PF00082	0.495
CLV_PCSK_KEX2_1	111	113	PF00082	0.425
CLV_PCSK_KEX2_1	12	14	PF00082	0.705
CLV_PCSK_KEX2_1	246	248	PF00082	0.507
CLV_PCSK_KEX2_1	312	314	PF00082	0.420
CLV_PCSK_KEX2_1	347	349	PF00082	0.486
CLV_PCSK_KEX2_1	515	517	PF00082	0.415
CLV_PCSK_KEX2_1	525	527	PF00082	0.298
CLV_PCSK_KEX2_1	681	683	PF00082	0.692
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.425
CLV_PCSK_PC7_1	107	113	PF00082	0.367
CLV_PCSK_PC7_1	521	527	PF00082	0.312
CLV_PCSK_SKI1_1	252	256	PF00082	0.567
CLV_PCSK_SKI1_1	314	318	PF00082	0.351
CLV_PCSK_SKI1_1	326	330	PF00082	0.312
CLV_PCSK_SKI1_1	485	489	PF00082	0.495
CLV_PCSK_SKI1_1	574	578	PF00082	0.332
CLV_PCSK_SKI1_1	60	64	PF00082	0.391
CLV_PCSK_SKI1_1	643	647	PF00082	0.598
CLV_Separin_Metazoa	307	311	PF03568	0.517
DEG_APCC_DBOX_1	573	581	PF00400	0.332
DEG_APCC_DBOX_1	59	67	PF00400	0.420
DEG_ODPH_VHL_1	621	634	PF01847	0.355
DOC_CYCLIN_RxL_1	495	507	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	281	287	PF00134	0.463
DOC_CYCLIN_yCln2_LP_2	475	481	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	66	69	PF00134	0.325
DOC_MAPK_gen_1	347	355	PF00069	0.536
DOC_MAPK_MEF2A_6	347	355	PF00069	0.545
DOC_PP1_RVXF_1	450	457	PF00149	0.368
DOC_PP1_RVXF_1	499	506	PF00149	0.371
DOC_PP1_RVXF_1	576	583	PF00149	0.355
DOC_PP1_RVXF_1	590	596	PF00149	0.355
DOC_PP2B_LxvP_1	66	69	PF13499	0.495
DOC_PP2B_LxvP_1	83	86	PF13499	0.600
DOC_PP4_FxxP_1	15	18	PF00568	0.448
DOC_PP4_FxxP_1	383	386	PF00568	0.481
DOC_PP4_FxxP_1	39	42	PF00568	0.420
DOC_USP7_MATH_1	145	149	PF00917	0.501
DOC_USP7_MATH_1	210	214	PF00917	0.428
DOC_USP7_MATH_1	361	365	PF00917	0.454
DOC_USP7_MATH_1	455	459	PF00917	0.373
DOC_USP7_MATH_1	641	645	PF00917	0.576
DOC_USP7_MATH_1	675	679	PF00917	0.700
DOC_USP7_UBL2_3	563	567	PF12436	0.405
DOC_WW_Pin1_4	106	111	PF00397	0.389
DOC_WW_Pin1_4	173	178	PF00397	0.547
DOC_WW_Pin1_4	357	362	PF00397	0.365
DOC_WW_Pin1_4	386	391	PF00397	0.537
DOC_WW_Pin1_4	490	495	PF00397	0.536
DOC_WW_Pin1_4	600	605	PF00397	0.314
DOC_WW_Pin1_4	694	699	PF00397	0.670
LIG_14-3-3_CanoR_1	111	117	PF00244	0.370
LIG_14-3-3_CanoR_1	246	252	PF00244	0.505
LIG_14-3-3_CanoR_1	4	11	PF00244	0.699
LIG_14-3-3_CanoR_1	541	546	PF00244	0.424
LIG_14-3-3_CanoR_1	643	648	PF00244	0.558
LIG_14-3-3_CanoR_1	666	670	PF00244	0.675
LIG_Actin_WH2_2	700	718	PF00022	0.392
LIG_ActinCP_TwfCPI_2	15	22	PF01115	0.450
LIG_APCC_ABBA_1	380	385	PF00400	0.468
LIG_deltaCOP1_diTrp_1	531	540	PF00928	0.312
LIG_eIF4E_1	135	141	PF01652	0.436
LIG_EVH1_1	67	71	PF00568	0.460
LIG_EVH1_2	70	74	PF00568	0.482
LIG_FHA_1	213	219	PF00498	0.391
LIG_FHA_1	304	310	PF00498	0.504
LIG_FHA_1	315	321	PF00498	0.288
LIG_FHA_1	328	334	PF00498	0.310
LIG_FHA_1	417	423	PF00498	0.523
LIG_FHA_1	445	451	PF00498	0.489
LIG_FHA_1	458	464	PF00498	0.341
LIG_FHA_1	471	477	PF00498	0.517
LIG_FHA_2	35	41	PF00498	0.556
LIG_FHA_2	412	418	PF00498	0.498
LIG_FHA_2	427	433	PF00498	0.302
LIG_FHA_2	644	650	PF00498	0.614
LIG_FHA_2	657	663	PF00498	0.570
LIG_FHA_2	666	672	PF00498	0.670
LIG_FHA_2	73	79	PF00498	0.675
LIG_HP1_1	361	365	PF01393	0.454
LIG_Integrin_RGD_1	663	665	PF01839	0.609
LIG_KLC1_Yacidic_2	554	559	PF13176	0.424
LIG_LIR_Apic_2	36	42	PF02991	0.435
LIG_LIR_Apic_2	649	655	PF02991	0.630
LIG_LIR_Gen_1	102	110	PF02991	0.398
LIG_LIR_Gen_1	115	125	PF02991	0.337
LIG_LIR_Gen_1	369	375	PF02991	0.358
LIG_LIR_Gen_1	453	463	PF02991	0.295
LIG_LIR_Gen_1	533	540	PF02991	0.324
LIG_LIR_Gen_1	550	560	PF02991	0.267
LIG_LIR_Gen_1	699	708	PF02991	0.522
LIG_LIR_Nem_3	102	106	PF02991	0.380
LIG_LIR_Nem_3	115	120	PF02991	0.299
LIG_LIR_Nem_3	136	140	PF02991	0.408
LIG_LIR_Nem_3	196	202	PF02991	0.374
LIG_LIR_Nem_3	369	373	PF02991	0.365
LIG_LIR_Nem_3	41	47	PF02991	0.390
LIG_LIR_Nem_3	453	459	PF02991	0.364
LIG_LIR_Nem_3	533	538	PF02991	0.324
LIG_LIR_Nem_3	550	555	PF02991	0.267
LIG_LIR_Nem_3	649	654	PF02991	0.495
LIG_LIR_Nem_3	699	704	PF02991	0.543
LIG_LYPXL_yS_3	350	353	PF13949	0.524
LIG_NRBOX	471	477	PF00104	0.546
LIG_NRBOX	592	598	PF00104	0.456
LIG_OCRL_FandH_1	505	517	PF00620	0.481
LIG_PCNA_yPIPBox_3	359	368	PF02747	0.451
LIG_PTB_Apo_2	486	493	PF02174	0.514
LIG_PTB_Phospho_1	486	492	PF10480	0.513
LIG_REV1ctd_RIR_1	503	513	PF16727	0.364
LIG_RPA_C_Fungi	308	320	PF08784	0.474
LIG_SH2_PTP2	321	324	PF00017	0.411
LIG_SH2_PTP2	370	373	PF00017	0.364
LIG_SH2_SRC	392	395	PF00017	0.504
LIG_SH2_SRC	557	560	PF00017	0.424
LIG_SH2_STAP1	117	121	PF00017	0.373
LIG_SH2_STAP1	392	396	PF00017	0.436
LIG_SH2_STAP1	535	539	PF00017	0.332
LIG_SH2_STAT5	135	138	PF00017	0.442
LIG_SH2_STAT5	285	288	PF00017	0.496
LIG_SH2_STAT5	295	298	PF00017	0.593
LIG_SH2_STAT5	321	324	PF00017	0.370
LIG_SH2_STAT5	33	36	PF00017	0.649
LIG_SH2_STAT5	335	338	PF00017	0.376
LIG_SH2_STAT5	370	373	PF00017	0.341
LIG_SH2_STAT5	557	560	PF00017	0.424
LIG_SH3_1	65	71	PF00018	0.586
LIG_SH3_3	15	21	PF00018	0.566
LIG_SH3_3	271	277	PF00018	0.440
LIG_SH3_3	338	344	PF00018	0.493
LIG_SH3_3	475	481	PF00018	0.524
LIG_SH3_3	617	623	PF00018	0.312
LIG_SH3_3	65	71	PF00018	0.523
LIG_SUMO_SIM_par_1	407	414	PF11976	0.467
LIG_TRAF2_1	167	170	PF00917	0.479
LIG_TRAF2_1	297	300	PF00917	0.613
LIG_TRAF2_1	38	41	PF00917	0.418
LIG_TRAF2_1	689	692	PF00917	0.607
LIG_TRAF2_1	697	700	PF00917	0.561
LIG_TYR_ITIM	555	560	PF00017	0.394
LIG_WRC_WIRS_1	100	105	PF05994	0.407
LIG_WRC_WIRS_1	412	417	PF05994	0.435
MOD_CDC14_SPxK_1	603	606	PF00782	0.338
MOD_CDK_SPK_2	106	111	PF00069	0.474
MOD_CDK_SPK_2	490	495	PF00069	0.536
MOD_CDK_SPxK_1	106	112	PF00069	0.488
MOD_CDK_SPxK_1	600	606	PF00069	0.314
MOD_CK1_1	159	165	PF00069	0.466
MOD_CK1_1	425	431	PF00069	0.418
MOD_CK1_1	72	78	PF00069	0.652
MOD_CK2_1	112	118	PF00069	0.408
MOD_CK2_1	34	40	PF00069	0.516
MOD_CK2_1	527	533	PF00069	0.394
MOD_CK2_1	643	649	PF00069	0.602
MOD_CK2_1	656	662	PF00069	0.554
MOD_CK2_1	694	700	PF00069	0.599
MOD_CK2_1	72	78	PF00069	0.666
MOD_CMANNOS	468	471	PF00535	0.496
MOD_CMANNOS	534	537	PF00535	0.312
MOD_Cter_Amidation	572	575	PF01082	0.355
MOD_Cter_Amidation	679	682	PF01082	0.697
MOD_GlcNHglycan	158	161	PF01048	0.487
MOD_GlcNHglycan	212	215	PF01048	0.409
MOD_GlcNHglycan	239	242	PF01048	0.634
MOD_GlcNHglycan	385	389	PF01048	0.600
MOD_GlcNHglycan	446	450	PF01048	0.484
MOD_GlcNHglycan	5	8	PF01048	0.669
MOD_GlcNHglycan	643	646	PF01048	0.614
MOD_GSK3_1	173	180	PF00069	0.516
MOD_GSK3_1	210	217	PF00069	0.341
MOD_GSK3_1	252	259	PF00069	0.531
MOD_GSK3_1	327	334	PF00069	0.372
MOD_GSK3_1	357	364	PF00069	0.468
MOD_GSK3_1	384	391	PF00069	0.584
MOD_GSK3_1	422	429	PF00069	0.464
MOD_GSK3_1	562	569	PF00069	0.332
MOD_GSK3_1	596	603	PF00069	0.372
MOD_GSK3_1	650	657	PF00069	0.505
MOD_GSK3_1	670	677	PF00069	0.414
MOD_N-GLC_1	223	228	PF02516	0.487
MOD_N-GLC_1	257	262	PF02516	0.544
MOD_N-GLC_1	673	678	PF02516	0.664
MOD_N-GLC_1	72	77	PF02516	0.595
MOD_NEK2_1	140	145	PF00069	0.426
MOD_NEK2_1	193	198	PF00069	0.412
MOD_NEK2_1	239	244	PF00069	0.573
MOD_NEK2_1	366	371	PF00069	0.209
MOD_NEK2_1	398	403	PF00069	0.345
MOD_NEK2_1	422	427	PF00069	0.489
MOD_NEK2_1	445	450	PF00069	0.488
MOD_NEK2_1	595	600	PF00069	0.405
MOD_NEK2_2	145	150	PF00069	0.501
MOD_PIKK_1	298	304	PF00454	0.604
MOD_PIKK_1	72	78	PF00454	0.623
MOD_PK_1	247	253	PF00069	0.484
MOD_PKA_2	16	22	PF00069	0.659
MOD_PKA_2	193	199	PF00069	0.414
MOD_PKA_2	3	9	PF00069	0.719
MOD_PKA_2	665	671	PF00069	0.672
MOD_PKB_1	312	320	PF00069	0.418
MOD_Plk_1	256	262	PF00069	0.573
MOD_Plk_1	416	422	PF00069	0.530
MOD_Plk_1	445	451	PF00069	0.377
MOD_Plk_2-3	411	417	PF00069	0.476
MOD_Plk_2-3	665	671	PF00069	0.701
MOD_Plk_4	112	118	PF00069	0.389
MOD_Plk_4	361	367	PF00069	0.366
MOD_Plk_4	433	439	PF00069	0.423
MOD_Plk_4	471	477	PF00069	0.540
MOD_Plk_4	616	622	PF00069	0.305
MOD_Plk_4	643	649	PF00069	0.528
MOD_ProDKin_1	106	112	PF00069	0.389
MOD_ProDKin_1	173	179	PF00069	0.545
MOD_ProDKin_1	357	363	PF00069	0.359
MOD_ProDKin_1	386	392	PF00069	0.532
MOD_ProDKin_1	490	496	PF00069	0.532
MOD_ProDKin_1	600	606	PF00069	0.314
MOD_ProDKin_1	694	700	PF00069	0.670
MOD_SUMO_rev_2	289	293	PF00179	0.551
TRG_DiLeu_BaEn_4	78	84	PF01217	0.677
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.456
TRG_ENDOCYTIC_2	116	119	PF00928	0.430
TRG_ENDOCYTIC_2	321	324	PF00928	0.431
TRG_ENDOCYTIC_2	350	353	PF00928	0.432
TRG_ENDOCYTIC_2	370	373	PF00928	0.136
TRG_ENDOCYTIC_2	535	538	PF00928	0.314
TRG_ENDOCYTIC_2	557	560	PF00928	0.349
TRG_ENDOCYTIC_2	651	654	PF00928	0.487
TRG_ER_diArg_1	11	13	PF00400	0.706
TRG_ER_diArg_1	110	112	PF00400	0.484
TRG_ER_diArg_1	245	247	PF00400	0.512
TRG_ER_diArg_1	309	312	PF00400	0.476
TRG_ER_diArg_1	313	315	PF00400	0.420
TRG_ER_diArg_1	346	348	PF00400	0.581
TRG_ER_diArg_1	540	543	PF00400	0.385
TRG_ER_diArg_1	571	574	PF00400	0.312
TRG_NES_CRM1_1	608	624	PF08389	0.415
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	93	98	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2V2	Leptomonas seymouri	75%	92%
A0A0S4IUE9	Bodo saltans	47%	99%
A0A1X0NR05	Trypanosomatidae	55%	99%
A0A3S7X102	Leishmania donovani	95%	100%
A4HG06	Leishmania braziliensis	89%	100%
A4I325	Leishmania infantum	95%	100%
C9ZJJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	99%
E9ACU6	Leishmania major	95%	100%
O64894	Cucurbita maxima	23%	100%
O65201	Arabidopsis thaliana	23%	100%
V5ANG8	Trypanosoma cruzi	59%	98%