PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Meiotic cell cortex C-terminal pleckstrin homology, putative

Species:

Leishmania mexicana

UniProt:

E9AZD4_LEIMU

TriTrypDb:

LmxM.27.2280

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	5
GO:0005938	cell cortex	3	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AZD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZD4

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	5
GO:0032065	maintenance of protein location in cell cortex	4	5
GO:0032507	maintenance of protein location in cell	3	5
GO:0045185	maintenance of protein location	3	5
GO:0051179	localization	1	5
GO:0051235	maintenance of location	2	5
GO:0051651	maintenance of location in cell	2	5

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0005543	phospholipid binding	3	5
GO:0008289	lipid binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.316
CLV_NRD_NRD_1	146	148	PF00675	0.366
CLV_NRD_NRD_1	20	22	PF00675	0.714
CLV_NRD_NRD_1	45	47	PF00675	0.503
CLV_NRD_NRD_1	86	88	PF00675	0.366
CLV_PCSK_KEX2_1	148	150	PF00082	0.366
CLV_PCSK_KEX2_1	20	22	PF00082	0.714
CLV_PCSK_KEX2_1	86	88	PF00082	0.366
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.366
CLV_PCSK_SKI1_1	148	152	PF00082	0.366
CLV_PCSK_SKI1_1	182	186	PF00082	0.567
DOC_CYCLIN_RxL_1	146	156	PF00134	0.364
DOC_MAPK_gen_1	147	153	PF00069	0.361
DOC_MAPK_gen_1	46	52	PF00069	0.498
DOC_PP2B_LxvP_1	50	53	PF13499	0.553
DOC_USP7_MATH_1	10	14	PF00917	0.619
DOC_USP7_UBL2_3	76	80	PF12436	0.366
DOC_WW_Pin1_4	31	36	PF00397	0.653
DOC_WW_Pin1_4	37	42	PF00397	0.587
DOC_WW_Pin1_4	8	13	PF00397	0.579
LIG_14-3-3_CanoR_1	23	31	PF00244	0.678
LIG_14-3-3_CanoR_1	62	66	PF00244	0.457
LIG_deltaCOP1_diTrp_1	72	77	PF00928	0.366
LIG_FHA_1	136	142	PF00498	0.366
LIG_FHA_1	38	44	PF00498	0.508
LIG_FHA_1	47	53	PF00498	0.535
LIG_FHA_1	56	62	PF00498	0.491
LIG_FHA_2	121	127	PF00498	0.449
LIG_FHA_2	161	167	PF00498	0.316
LIG_FHA_2	61	67	PF00498	0.422
LIG_LIR_Gen_1	138	144	PF02991	0.366
LIG_LIR_Gen_1	162	172	PF02991	0.366
LIG_LIR_Gen_1	93	103	PF02991	0.366
LIG_LIR_Nem_3	101	106	PF02991	0.299
LIG_LIR_Nem_3	138	142	PF02991	0.366
LIG_LIR_Nem_3	162	168	PF02991	0.366
LIG_LIR_Nem_3	93	99	PF02991	0.366
LIG_PALB2_WD40_1	160	168	PF16756	0.366
LIG_PTB_Apo_2	104	111	PF02174	0.283
LIG_SH2_CRK	139	143	PF00017	0.233
LIG_SH2_STAT5	96	99	PF00017	0.366
LIG_SH3_3	6	12	PF00018	0.646
LIG_SUMO_SIM_par_1	140	146	PF11976	0.402
LIG_SUMO_SIM_par_1	57	64	PF11976	0.357
MOD_CDK_SPK_2	31	36	PF00069	0.520
MOD_CK1_1	102	108	PF00069	0.233
MOD_CK1_1	11	17	PF00069	0.587
MOD_CK1_1	19	25	PF00069	0.549
MOD_CK1_1	64	70	PF00069	0.366
MOD_CK2_1	126	132	PF00069	0.408
MOD_CK2_1	160	166	PF00069	0.391
MOD_CK2_1	60	66	PF00069	0.432
MOD_CK2_1	98	104	PF00069	0.383
MOD_GlcNHglycan	2	5	PF01048	0.638
MOD_GlcNHglycan	25	28	PF01048	0.547
MOD_GSK3_1	11	18	PF00069	0.626
MOD_GSK3_1	121	128	PF00069	0.332
MOD_GSK3_1	19	26	PF00069	0.650
MOD_GSK3_1	31	38	PF00069	0.652
MOD_GSK3_1	60	67	PF00069	0.551
MOD_GSK3_1	76	83	PF00069	0.259
MOD_GSK3_1	98	105	PF00069	0.499
MOD_NEK2_1	143	148	PF00069	0.366
MOD_NEK2_1	98	103	PF00069	0.366
MOD_NMyristoyl	1	7	PF02799	0.551
MOD_PIKK_1	11	17	PF00454	0.550
MOD_PK_1	80	86	PF00069	0.366
MOD_PKA_1	46	52	PF00069	0.498
MOD_PKA_2	19	25	PF00069	0.649
MOD_PKA_2	35	41	PF00069	0.517
MOD_PKA_2	61	67	PF00069	0.455
MOD_PKB_1	21	29	PF00069	0.544
MOD_Plk_1	125	131	PF00069	0.332
MOD_Plk_2-3	126	132	PF00069	0.366
MOD_Plk_4	160	166	PF00069	0.316
MOD_Plk_4	92	98	PF00069	0.316
MOD_ProDKin_1	31	37	PF00069	0.652
MOD_ProDKin_1	8	14	PF00069	0.580
TRG_ENDOCYTIC_2	139	142	PF00928	0.366
TRG_ENDOCYTIC_2	96	99	PF00928	0.366
TRG_ER_diArg_1	147	150	PF00400	0.366
TRG_ER_diArg_1	20	23	PF00400	0.663
TRG_ER_diArg_1	86	88	PF00400	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HG05	Leishmania braziliensis	85%	100%
A4I324	Leishmania infantum	95%	100%
E9ACU5	Leishmania major	92%	100%