Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZD0_LEIMU

TriTrypDb:

LmxM.27.2240

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000323	lytic vacuole	6	1
GO:0005768	endosome	7	1
GO:0005773	vacuole	5	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZD0

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0035493	SNARE complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.513
CLV_C14_Caspase3-7	492	496	PF00656	0.589
CLV_NRD_NRD_1	324	326	PF00675	0.585
CLV_NRD_NRD_1	496	498	PF00675	0.505
CLV_NRD_NRD_1	535	537	PF00675	0.533
CLV_PCSK_FUR_1	322	326	PF00082	0.560
CLV_PCSK_KEX2_1	324	326	PF00082	0.585
CLV_PCSK_KEX2_1	535	537	PF00082	0.533
CLV_PCSK_SKI1_1	247	251	PF00082	0.627
CLV_PCSK_SKI1_1	410	414	PF00082	0.521
CLV_PCSK_SKI1_1	535	539	PF00082	0.610
DEG_APCC_DBOX_1	146	154	PF00400	0.598
DEG_Nend_UBRbox_2	1	3	PF02207	0.702
DEG_SPOP_SBC_1	73	77	PF00917	0.567
DOC_CKS1_1	200	205	PF01111	0.490
DOC_CYCLIN_RxL_1	374	386	PF00134	0.540
DOC_CYCLIN_yCln2_LP_2	462	468	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	487	493	PF00134	0.679
DOC_MAPK_FxFP_2	185	188	PF00069	0.496
DOC_MAPK_gen_1	374	383	PF00069	0.483
DOC_MAPK_MEF2A_6	128	137	PF00069	0.596
DOC_MAPK_MEF2A_6	290	298	PF00069	0.504
DOC_MAPK_MEF2A_6	410	417	PF00069	0.588
DOC_MAPK_MEF2A_6	543	552	PF00069	0.443
DOC_PP1_RVXF_1	130	137	PF00149	0.633
DOC_PP2B_LxvP_1	487	490	PF13499	0.672
DOC_PP4_FxxP_1	172	175	PF00568	0.741
DOC_PP4_FxxP_1	185	188	PF00568	0.528
DOC_USP7_MATH_1	22	26	PF00917	0.673
DOC_USP7_MATH_1	66	70	PF00917	0.705
DOC_USP7_UBL2_3	528	532	PF12436	0.525
DOC_WW_Pin1_4	171	176	PF00397	0.584
DOC_WW_Pin1_4	199	204	PF00397	0.727
DOC_WW_Pin1_4	342	347	PF00397	0.605
DOC_WW_Pin1_4	475	480	PF00397	0.487
DOC_WW_Pin1_4	69	74	PF00397	0.754
DOC_WW_Pin1_4	9	14	PF00397	0.671
LIG_14-3-3_CanoR_1	138	146	PF00244	0.482
LIG_14-3-3_CanoR_1	168	173	PF00244	0.744
LIG_14-3-3_CanoR_1	219	225	PF00244	0.761
LIG_14-3-3_CanoR_1	23	28	PF00244	0.633
LIG_14-3-3_CanoR_1	295	305	PF00244	0.493
LIG_14-3-3_CanoR_1	535	544	PF00244	0.315
LIG_BRCT_BRCA1_1	112	116	PF00533	0.566
LIG_FHA_1	129	135	PF00498	0.633
LIG_FHA_1	138	144	PF00498	0.540
LIG_FHA_1	156	162	PF00498	0.618
LIG_FHA_1	16	22	PF00498	0.559
LIG_FHA_1	307	313	PF00498	0.545
LIG_FHA_1	384	390	PF00498	0.584
LIG_FHA_1	73	79	PF00498	0.680
LIG_FHA_1	9	15	PF00498	0.512
LIG_FHA_2	102	108	PF00498	0.483
LIG_FHA_2	175	181	PF00498	0.792
LIG_FHA_2	240	246	PF00498	0.637
LIG_FHA_2	353	359	PF00498	0.610
LIG_FHA_2	43	49	PF00498	0.541
LIG_FHA_2	431	437	PF00498	0.612
LIG_FHA_2	490	496	PF00498	0.576
LIG_FHA_2	74	80	PF00498	0.570
LIG_LIR_Apic_2	169	175	PF02991	0.797
LIG_LIR_Apic_2	184	188	PF02991	0.499
LIG_LIR_Apic_2	223	229	PF02991	0.724
LIG_LIR_Gen_1	253	262	PF02991	0.542
LIG_LIR_Nem_3	253	259	PF02991	0.556
LIG_LIR_Nem_3	338	342	PF02991	0.648
LIG_LYPXL_yS_3	464	467	PF13949	0.488
LIG_NRBOX	543	549	PF00104	0.411
LIG_PCNA_yPIPBox_3	90	99	PF02747	0.625
LIG_RPA_C_Fungi	360	372	PF08784	0.629
LIG_SH2_GRB2like	393	396	PF00017	0.729
LIG_SH2_STAP1	17	21	PF00017	0.548
LIG_SH2_STAP1	385	389	PF00017	0.527
LIG_SH2_STAP1	393	397	PF00017	0.680
LIG_SH2_STAP1	458	462	PF00017	0.512
LIG_SH2_STAT5	139	142	PF00017	0.549
LIG_SH2_STAT5	17	20	PF00017	0.516
LIG_SH2_STAT5	342	345	PF00017	0.665
LIG_SH2_STAT5	385	388	PF00017	0.572
LIG_SH2_STAT5	491	494	PF00017	0.601
LIG_SH2_STAT5	53	56	PF00017	0.513
LIG_SH3_3	140	146	PF00018	0.482
LIG_SH3_3	7	13	PF00018	0.630
LIG_SH3_CIN85_PxpxPR_1	230	235	PF14604	0.696
LIG_Sin3_3	157	164	PF02671	0.481
LIG_SUMO_SIM_par_1	308	313	PF11976	0.491
LIG_SUMO_SIM_par_1	385	391	PF11976	0.569
LIG_SUMO_SIM_par_1	449	455	PF11976	0.432
LIG_SUMO_SIM_par_1	464	470	PF11976	0.456
LIG_TRAF2_1	104	107	PF00917	0.590
LIG_TRAF2_1	211	214	PF00917	0.777
LIG_TRAF2_1	356	359	PF00917	0.517
LIG_TYR_ITIM	462	467	PF00017	0.491
LIG_Vh1_VBS_1	537	555	PF01044	0.512
MOD_CK1_1	151	157	PF00069	0.568
MOD_CK1_1	174	180	PF00069	0.503
MOD_CK1_1	199	205	PF00069	0.567
MOD_CK1_1	352	358	PF00069	0.541
MOD_CK1_1	470	476	PF00069	0.520
MOD_CK1_1	69	75	PF00069	0.718
MOD_CK2_1	100	106	PF00069	0.584
MOD_CK2_1	174	180	PF00069	0.789
MOD_CK2_1	305	311	PF00069	0.494
MOD_CK2_1	352	358	PF00069	0.604
MOD_CK2_1	42	48	PF00069	0.554
MOD_CK2_1	429	435	PF00069	0.633
MOD_GlcNHglycan	152	156	PF01048	0.581
MOD_GlcNHglycan	30	33	PF01048	0.608
MOD_GlcNHglycan	424	427	PF01048	0.447
MOD_GlcNHglycan	469	472	PF01048	0.521
MOD_GlcNHglycan	481	484	PF01048	0.537
MOD_GlcNHglycan	66	69	PF01048	0.698
MOD_GSK3_1	124	131	PF00069	0.684
MOD_GSK3_1	151	158	PF00069	0.611
MOD_GSK3_1	183	190	PF00069	0.750
MOD_GSK3_1	195	202	PF00069	0.685
MOD_GSK3_1	215	222	PF00069	0.644
MOD_GSK3_1	383	390	PF00069	0.479
MOD_GSK3_1	452	459	PF00069	0.465
MOD_GSK3_1	475	482	PF00069	0.484
MOD_GSK3_1	5	12	PF00069	0.705
MOD_GSK3_1	56	63	PF00069	0.552
MOD_GSK3_1	64	71	PF00069	0.609
MOD_N-GLC_1	479	484	PF02516	0.649
MOD_N-GLC_2	409	411	PF02516	0.589
MOD_NEK2_1	239	244	PF00069	0.762
MOD_NEK2_1	305	310	PF00069	0.540
MOD_NEK2_1	370	375	PF00069	0.567
MOD_NEK2_1	429	434	PF00069	0.680
MOD_NEK2_1	51	56	PF00069	0.525
MOD_NEK2_1	64	69	PF00069	0.676
MOD_PIKK_1	388	394	PF00454	0.561
MOD_PIKK_1	42	48	PF00454	0.572
MOD_PKA_2	137	143	PF00069	0.533
MOD_PKA_2	22	28	PF00069	0.589
MOD_PKA_2	239	245	PF00069	0.744
MOD_Plk_1	108	114	PF00069	0.631
MOD_Plk_4	196	202	PF00069	0.665
MOD_Plk_4	452	458	PF00069	0.413
MOD_Plk_4	5	11	PF00069	0.693
MOD_Plk_4	60	66	PF00069	0.688
MOD_ProDKin_1	171	177	PF00069	0.582
MOD_ProDKin_1	199	205	PF00069	0.728
MOD_ProDKin_1	342	348	PF00069	0.603
MOD_ProDKin_1	475	481	PF00069	0.487
MOD_ProDKin_1	69	75	PF00069	0.755
MOD_ProDKin_1	9	15	PF00069	0.662
TRG_DiLeu_BaEn_4	439	445	PF01217	0.513
TRG_ENDOCYTIC_2	464	467	PF00928	0.488
TRG_ER_diArg_1	322	325	PF00400	0.586
TRG_ER_diArg_1	363	366	PF00400	0.611
TRG_ER_diArg_1	535	537	PF00400	0.549
TRG_NES_CRM1_1	380	392	PF08389	0.551
TRG_NES_CRM1_1	542	556	PF08389	0.513
TRG_Pf-PMV_PEXEL_1	324	329	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG49	Leptomonas seymouri	57%	72%
A0A3S7X103	Leishmania donovani	94%	100%
A0A422NAK9	Trypanosoma rangeli	28%	100%
A4HG01	Leishmania braziliensis	84%	100%
A4I320	Leishmania infantum	94%	100%
C9ZJJ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	97%
E9ACU1	Leishmania major	92%	100%