Putative dual specificity protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dual specificity protein phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AZC7_LEIMU

TriTrypDb:

LmxM.27.2210

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZC7

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016311	dephosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:0007165	signal transduction	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004721	phosphoprotein phosphatase activity	3	11
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0004725	protein tyrosine phosphatase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.472
CLV_NRD_NRD_1	11	13	PF00675	0.758
CLV_NRD_NRD_1	115	117	PF00675	0.570
CLV_NRD_NRD_1	286	288	PF00675	0.384
CLV_NRD_NRD_1	334	336	PF00675	0.529
CLV_NRD_NRD_1	350	352	PF00675	0.372
CLV_NRD_NRD_1	67	69	PF00675	0.654
CLV_PCSK_KEX2_1	208	210	PF00082	0.348
CLV_PCSK_KEX2_1	334	336	PF00082	0.529
CLV_PCSK_KEX2_1	350	352	PF00082	0.372
CLV_PCSK_KEX2_1	67	69	PF00082	0.768
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.292
CLV_PCSK_PC7_1	204	210	PF00082	0.292
CLV_PCSK_SKI1_1	142	146	PF00082	0.613
DEG_Nend_UBRbox_3	1	3	PF02207	0.501
DOC_CKS1_1	219	224	PF01111	0.292
DOC_CKS1_1	85	90	PF01111	0.431
DOC_CYCLIN_RxL_1	137	148	PF00134	0.502
DOC_CYCLIN_RxL_1	26	35	PF00134	0.474
DOC_CYCLIN_RxL_1	284	294	PF00134	0.349
DOC_MAPK_gen_1	137	145	PF00069	0.429
DOC_PP1_RVXF_1	27	34	PF00149	0.473
DOC_USP7_MATH_1	161	165	PF00917	0.736
DOC_USP7_MATH_1	171	175	PF00917	0.564
DOC_USP7_MATH_1	338	342	PF00917	0.503
DOC_USP7_MATH_1	53	57	PF00917	0.568
DOC_WW_Pin1_4	218	223	PF00397	0.292
DOC_WW_Pin1_4	242	247	PF00397	0.410
DOC_WW_Pin1_4	305	310	PF00397	0.271
DOC_WW_Pin1_4	57	62	PF00397	0.750
DOC_WW_Pin1_4	6	11	PF00397	0.553
DOC_WW_Pin1_4	84	89	PF00397	0.624
LIG_14-3-3_CanoR_1	116	120	PF00244	0.563
LIG_14-3-3_CanoR_1	12	17	PF00244	0.655
LIG_14-3-3_CanoR_1	142	152	PF00244	0.398
LIG_14-3-3_CanoR_1	209	219	PF00244	0.300
LIG_14-3-3_CanoR_1	233	240	PF00244	0.171
LIG_14-3-3_CanoR_1	290	300	PF00244	0.314
LIG_14-3-3_CanoR_1	32	40	PF00244	0.430
LIG_14-3-3_CanoR_1	323	331	PF00244	0.295
LIG_14-3-3_CanoR_1	57	61	PF00244	0.768
LIG_FHA_1	134	140	PF00498	0.581
LIG_FHA_1	45	51	PF00498	0.728
LIG_FHA_1	85	91	PF00498	0.607
LIG_FHA_2	116	122	PF00498	0.422
LIG_FHA_2	200	206	PF00498	0.226
LIG_LIR_Gen_1	228	236	PF02991	0.282
LIG_LIR_Gen_1	251	260	PF02991	0.337
LIG_LIR_Nem_3	228	234	PF02991	0.281
LIG_LIR_Nem_3	251	255	PF02991	0.337
LIG_Pex14_1	194	198	PF04695	0.335
LIG_Pex14_2	225	229	PF04695	0.285
LIG_Pex14_2	248	252	PF04695	0.349
LIG_PTAP_UEV_1	60	65	PF05743	0.605
LIG_REV1ctd_RIR_1	25	33	PF16727	0.478
LIG_RPA_C_Fungi	111	123	PF08784	0.491
LIG_SH2_CRK	231	235	PF00017	0.284
LIG_SH2_SRC	318	321	PF00017	0.292
LIG_SH2_STAT3	298	301	PF00017	0.171
LIG_SH2_STAT5	284	287	PF00017	0.271
LIG_SH2_STAT5	298	301	PF00017	0.271
LIG_SH3_3	220	226	PF00018	0.319
LIG_SH3_3	58	64	PF00018	0.798
LIG_SH3_3	82	88	PF00018	0.481
LIG_TRAF2_1	94	97	PF00917	0.498
LIG_UBA3_1	122	129	PF00899	0.456
LIG_WRC_WIRS_1	175	180	PF05994	0.579
MOD_CDC14_SPxK_1	9	12	PF00782	0.491
MOD_CDK_SPxK_1	6	12	PF00069	0.492
MOD_CDK_SPxxK_3	6	13	PF00069	0.492
MOD_CK1_1	156	162	PF00069	0.655
MOD_CK1_1	174	180	PF00069	0.337
MOD_CK1_1	308	314	PF00069	0.292
MOD_CK1_1	55	61	PF00069	0.698
MOD_CK2_1	115	121	PF00069	0.470
MOD_CK2_1	199	205	PF00069	0.320
MOD_DYRK1A_RPxSP_1	57	61	PF00069	0.491
MOD_DYRK1A_RPxSP_1	84	88	PF00069	0.320
MOD_GlcNHglycan	158	161	PF01048	0.620
MOD_GlcNHglycan	164	167	PF01048	0.548
MOD_GlcNHglycan	234	237	PF01048	0.404
MOD_GlcNHglycan	281	284	PF01048	0.464
MOD_GlcNHglycan	293	296	PF01048	0.339
MOD_GlcNHglycan	34	37	PF01048	0.417
MOD_GlcNHglycan	61	64	PF01048	0.741
MOD_GSK3_1	152	159	PF00069	0.681
MOD_GSK3_1	272	279	PF00069	0.271
MOD_GSK3_1	52	59	PF00069	0.648
MOD_GSK3_1	70	77	PF00069	0.799
MOD_N-GLC_1	153	158	PF02516	0.574
MOD_N-GLC_1	77	82	PF02516	0.519
MOD_NEK2_1	100	105	PF00069	0.415
MOD_NEK2_1	152	157	PF00069	0.574
MOD_NEK2_1	162	167	PF00069	0.682
MOD_NEK2_1	291	296	PF00069	0.296
MOD_PIKK_1	70	76	PF00454	0.691
MOD_PKA_1	12	18	PF00069	0.719
MOD_PKA_2	115	121	PF00069	0.470
MOD_PKA_2	232	238	PF00069	0.171
MOD_PKA_2	56	62	PF00069	0.590
MOD_Plk_1	77	83	PF00069	0.450
MOD_Plk_4	276	282	PF00069	0.384
MOD_Plk_4	338	344	PF00069	0.346
MOD_ProDKin_1	218	224	PF00069	0.292
MOD_ProDKin_1	242	248	PF00069	0.410
MOD_ProDKin_1	305	311	PF00069	0.271
MOD_ProDKin_1	57	63	PF00069	0.749
MOD_ProDKin_1	6	12	PF00069	0.554
MOD_ProDKin_1	84	90	PF00069	0.623
MOD_SUMO_rev_2	224	232	PF00179	0.171
TRG_ENDOCYTIC_2	231	234	PF00928	0.285
TRG_ER_diArg_1	139	142	PF00400	0.311
TRG_ER_diArg_1	349	351	PF00400	0.450
TRG_Pf-PMV_PEXEL_1	142	147	PF00026	0.353
TRG_Pf-PMV_PEXEL_1	335	340	PF00026	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDK0	Leptomonas seymouri	43%	100%
A0A1X0NRN9	Trypanosomatidae	38%	100%
A0A3S7X0Z1	Leishmania donovani	89%	100%
A0A422N807	Trypanosoma rangeli	39%	100%
A4HFZ8	Leishmania braziliensis	70%	99%
A4I317	Leishmania infantum	89%	100%
C9ZJI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9ACT8	Leishmania major	88%	100%
V5BIV4	Trypanosoma cruzi	39%	100%