LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AZC2_LEIMU
TriTrypDb:
LmxM.27.2160
Length:
376

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZC2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZC2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 2 4 PF00675 0.688
CLV_NRD_NRD_1 23 25 PF00675 0.605
CLV_NRD_NRD_1 346 348 PF00675 0.499
CLV_PCSK_KEX2_1 2 4 PF00082 0.688
CLV_PCSK_KEX2_1 346 348 PF00082 0.499
CLV_PCSK_SKI1_1 27 31 PF00082 0.568
CLV_PCSK_SKI1_1 76 80 PF00082 0.369
DEG_COP1_1 238 246 PF00400 0.384
DEG_Nend_UBRbox_1 1 4 PF02207 0.670
DOC_CKS1_1 150 155 PF01111 0.438
DOC_CKS1_1 299 304 PF01111 0.364
DOC_CYCLIN_yCln2_LP_2 317 323 PF00134 0.491
DOC_MAPK_gen_1 235 243 PF00069 0.444
DOC_PP2B_LxvP_1 283 286 PF13499 0.463
DOC_USP7_MATH_1 236 240 PF00917 0.534
DOC_WW_Pin1_4 149 154 PF00397 0.330
DOC_WW_Pin1_4 298 303 PF00397 0.361
DOC_WW_Pin1_4 84 89 PF00397 0.391
LIG_14-3-3_CanoR_1 127 133 PF00244 0.339
LIG_14-3-3_CanoR_1 142 147 PF00244 0.342
LIG_14-3-3_CanoR_1 2 11 PF00244 0.646
LIG_14-3-3_CanoR_1 27 36 PF00244 0.631
LIG_Actin_RPEL_3 66 85 PF02755 0.355
LIG_Actin_WH2_2 59 75 PF00022 0.376
LIG_APCC_ABBA_1 16 21 PF00400 0.576
LIG_BIR_III_2 251 255 PF00653 0.349
LIG_BRCT_BRCA1_1 106 110 PF00533 0.443
LIG_BRCT_BRCA1_1 89 93 PF00533 0.445
LIG_DLG_GKlike_1 142 150 PF00625 0.382
LIG_FHA_1 150 156 PF00498 0.346
LIG_FHA_1 61 67 PF00498 0.495
LIG_FHA_1 84 90 PF00498 0.449
LIG_FHA_2 261 267 PF00498 0.483
LIG_LIR_Apic_2 101 106 PF02991 0.483
LIG_LIR_Gen_1 90 99 PF02991 0.322
LIG_LIR_Nem_3 148 154 PF02991 0.336
LIG_LIR_Nem_3 203 209 PF02991 0.321
LIG_LIR_Nem_3 266 270 PF02991 0.484
LIG_LIR_Nem_3 90 96 PF02991 0.320
LIG_MYND_1 244 248 PF01753 0.326
LIG_MYND_3 253 257 PF01753 0.404
LIG_Pex14_2 201 205 PF04695 0.458
LIG_Pex14_2 348 352 PF04695 0.471
LIG_REV1ctd_RIR_1 203 211 PF16727 0.449
LIG_REV1ctd_RIR_1 231 241 PF16727 0.428
LIG_REV1ctd_RIR_1 285 294 PF16727 0.496
LIG_REV1ctd_RIR_1 326 335 PF16727 0.365
LIG_SH2_CRK 103 107 PF00017 0.516
LIG_SH2_CRK 57 61 PF00017 0.489
LIG_SH2_NCK_1 103 107 PF00017 0.516
LIG_SH2_NCK_1 270 274 PF00017 0.318
LIG_SH2_STAP1 270 274 PF00017 0.318
LIG_SH2_STAT5 151 154 PF00017 0.331
LIG_SH2_STAT5 157 160 PF00017 0.307
LIG_SH2_STAT5 186 189 PF00017 0.418
LIG_SH2_STAT5 242 245 PF00017 0.529
LIG_SH2_STAT5 270 273 PF00017 0.365
LIG_SH2_STAT5 344 347 PF00017 0.374
LIG_SH3_3 147 153 PF00018 0.461
LIG_SH3_3 74 80 PF00018 0.492
LIG_SUMO_SIM_par_1 335 341 PF11976 0.391
LIG_TRAF2_1 145 148 PF00917 0.390
MOD_CDK_SPxxK_3 298 305 PF00069 0.369
MOD_CK1_1 128 134 PF00069 0.429
MOD_CK1_1 149 155 PF00069 0.325
MOD_CK1_1 87 93 PF00069 0.396
MOD_CK2_1 142 148 PF00069 0.378
MOD_CK2_1 260 266 PF00069 0.464
MOD_GlcNHglycan 127 130 PF01048 0.447
MOD_GlcNHglycan 177 182 PF01048 0.494
MOD_GlcNHglycan 89 92 PF01048 0.448
MOD_GSK3_1 138 145 PF00069 0.380
MOD_GSK3_1 185 192 PF00069 0.430
MOD_GSK3_1 2 9 PF00069 0.536
MOD_GSK3_1 268 275 PF00069 0.424
MOD_GSK3_1 27 34 PF00069 0.619
MOD_GSK3_1 83 90 PF00069 0.332
MOD_N-GLC_1 43 48 PF02516 0.391
MOD_NEK2_1 1 6 PF00069 0.643
MOD_NEK2_1 125 130 PF00069 0.408
MOD_NEK2_1 146 151 PF00069 0.379
MOD_NEK2_1 159 164 PF00069 0.323
MOD_NEK2_1 62 67 PF00069 0.552
MOD_NEK2_1 72 77 PF00069 0.429
MOD_PIKK_1 2 8 PF00454 0.536
MOD_PIKK_1 213 219 PF00454 0.465
MOD_PKA_1 2 8 PF00069 0.536
MOD_PKA_1 38 44 PF00069 0.436
MOD_PKA_2 1 7 PF00069 0.656
MOD_PKA_2 19 25 PF00069 0.421
MOD_PKA_2 72 78 PF00069 0.447
MOD_Plk_1 146 152 PF00069 0.371
MOD_Plk_4 146 152 PF00069 0.464
MOD_Plk_4 242 248 PF00069 0.352
MOD_Plk_4 260 266 PF00069 0.369
MOD_Plk_4 31 37 PF00069 0.432
MOD_ProDKin_1 149 155 PF00069 0.328
MOD_ProDKin_1 298 304 PF00069 0.365
MOD_ProDKin_1 84 90 PF00069 0.398
TRG_DiLeu_BaEn_1 366 371 PF01217 0.528
TRG_DiLeu_BaEn_2 120 126 PF01217 0.394
TRG_DiLeu_BaEn_4 178 184 PF01217 0.574
TRG_DiLeu_LyEn_5 366 371 PF01217 0.614
TRG_ENDOCYTIC_2 270 273 PF00928 0.507
TRG_ENDOCYTIC_2 57 60 PF00928 0.479
TRG_ER_diArg_1 1 3 PF00400 0.693
TRG_ER_diArg_1 345 347 PF00400 0.478
TRG_NLS_MonoCore_2 23 28 PF00514 0.580
TRG_Pf-PMV_PEXEL_1 369 374 PF00026 0.582

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2W1 Leptomonas seymouri 75% 100%
A0A0S4ISK5 Bodo saltans 46% 100%
A0A1X0NRI0 Trypanosomatidae 53% 100%
A0A3Q8ICV5 Leishmania donovani 96% 100%
A4HFZ3 Leishmania braziliensis 89% 100%
A4I312 Leishmania infantum 96% 100%
C9ZJH9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
E9ADJ6 Leishmania major 95% 100%
V5BNB6 Trypanosoma cruzi 59% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS