LeishMANIAdb
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Signal peptidase II

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Signal peptidase II
Gene product:
hypothetical protein, unknown function
Species:
Leishmania mexicana
UniProt:
E9AZC1_LEIMU
TriTrypDb:
LmxM.27.2150
Length:
53

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZC1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZC1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 47 51 PF00082 0.609
DEG_Nend_UBRbox_1 1 4 PF02207 0.653
DOC_USP7_MATH_1 33 37 PF00917 0.322
LIG_14-3-3_CanoR_1 2 7 PF00244 0.642
LIG_BRCT_BRCA1_1 4 8 PF00533 0.523
LIG_deltaCOP1_diTrp_1 35 39 PF00928 0.512
LIG_LIR_Gen_1 35 44 PF02991 0.465
LIG_LIR_Nem_3 5 11 PF02991 0.582
LIG_SH2_CRK 13 17 PF00017 0.382
LIG_SUMO_SIM_anti_2 22 29 PF11976 0.382
MOD_CK2_1 29 35 PF00069 0.458
MOD_GlcNHglycan 31 34 PF01048 0.517
MOD_GSK3_1 29 36 PF00069 0.409
MOD_Plk_4 19 25 PF00069 0.478
TRG_ENDOCYTIC_2 13 16 PF00928 0.382
TRG_ER_diLys_1 50 53 PF00400 0.465

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7X0Y7 Leishmania donovani 94% 100%
A4HFZ2 Leishmania braziliensis 85% 100%
A4I311 Leishmania infantum 94% 100%
E9ADJ5 Leishmania major 94% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS