PI3K/PI4K catalytic domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol 3- and 4-kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AZC0_LEIMU

TriTrypDb:

LmxM.27.2140

Length:

1017

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZC0

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.506
CLV_C14_Caspase3-7	412	416	PF00656	0.326
CLV_C14_Caspase3-7	849	853	PF00656	0.636
CLV_NRD_NRD_1	242	244	PF00675	0.633
CLV_NRD_NRD_1	260	262	PF00675	0.526
CLV_NRD_NRD_1	326	328	PF00675	0.759
CLV_NRD_NRD_1	456	458	PF00675	0.310
CLV_NRD_NRD_1	49	51	PF00675	0.745
CLV_NRD_NRD_1	615	617	PF00675	0.434
CLV_NRD_NRD_1	621	623	PF00675	0.259
CLV_NRD_NRD_1	813	815	PF00675	0.489
CLV_NRD_NRD_1	845	847	PF00675	0.513
CLV_NRD_NRD_1	971	973	PF00675	0.414
CLV_PCSK_FUR_1	324	328	PF00082	0.618
CLV_PCSK_FUR_1	47	51	PF00082	0.651
CLV_PCSK_KEX2_1	242	244	PF00082	0.659
CLV_PCSK_KEX2_1	326	328	PF00082	0.759
CLV_PCSK_KEX2_1	456	458	PF00082	0.310
CLV_PCSK_KEX2_1	49	51	PF00082	0.767
CLV_PCSK_KEX2_1	615	617	PF00082	0.418
CLV_PCSK_KEX2_1	621	623	PF00082	0.300
CLV_PCSK_KEX2_1	813	815	PF00082	0.517
CLV_PCSK_KEX2_1	971	973	PF00082	0.414
CLV_PCSK_PC7_1	322	328	PF00082	0.606
CLV_PCSK_SKI1_1	236	240	PF00082	0.542
CLV_PCSK_SKI1_1	367	371	PF00082	0.424
CLV_PCSK_SKI1_1	457	461	PF00082	0.310
CLV_PCSK_SKI1_1	719	723	PF00082	0.305
CLV_Separin_Metazoa	247	251	PF03568	0.646
CLV_Separin_Metazoa	716	720	PF03568	0.310
CLV_Separin_Metazoa	943	947	PF03568	0.305
DEG_APCC_DBOX_1	1005	1013	PF00400	0.430
DEG_APCC_DBOX_1	456	464	PF00400	0.333
DEG_Nend_UBRbox_1	1	4	PF02207	0.549
DEG_SCF_FBW7_2	134	141	PF00400	0.623
DEG_SPOP_SBC_1	34	38	PF00917	0.621
DEG_SPOP_SBC_1	828	832	PF00917	0.619
DEG_SPOP_SBC_1	907	911	PF00917	0.677
DOC_CKS1_1	162	167	PF01111	0.558
DOC_CYCLIN_yCln2_LP_2	72	78	PF00134	0.627
DOC_MAPK_MEF2A_6	556	564	PF00069	0.333
DOC_PP2B_LxvP_1	562	565	PF13499	0.383
DOC_PP4_FxxP_1	4	7	PF00568	0.481
DOC_PP4_MxPP_1	221	224	PF00568	0.668
DOC_USP7_MATH_1	214	218	PF00917	0.570
DOC_USP7_MATH_1	398	402	PF00917	0.604
DOC_USP7_MATH_1	411	415	PF00917	0.389
DOC_USP7_MATH_1	502	506	PF00917	0.223
DOC_USP7_MATH_1	631	635	PF00917	0.369
DOC_USP7_MATH_1	647	651	PF00917	0.231
DOC_USP7_MATH_1	652	656	PF00917	0.320
DOC_USP7_MATH_1	724	728	PF00917	0.466
DOC_USP7_MATH_1	755	759	PF00917	0.680
DOC_USP7_MATH_1	789	793	PF00917	0.609
DOC_USP7_MATH_1	805	809	PF00917	0.713
DOC_USP7_MATH_1	829	833	PF00917	0.661
DOC_USP7_MATH_1	907	911	PF00917	0.670
DOC_USP7_MATH_1	95	99	PF00917	0.514
DOC_WW_Pin1_4	122	127	PF00397	0.703
DOC_WW_Pin1_4	134	139	PF00397	0.624
DOC_WW_Pin1_4	161	166	PF00397	0.555
DOC_WW_Pin1_4	205	210	PF00397	0.622
DOC_WW_Pin1_4	219	224	PF00397	0.627
DOC_WW_Pin1_4	22	27	PF00397	0.681
DOC_WW_Pin1_4	242	247	PF00397	0.663
DOC_WW_Pin1_4	283	288	PF00397	0.677
DOC_WW_Pin1_4	399	404	PF00397	0.563
DOC_WW_Pin1_4	624	629	PF00397	0.287
DOC_WW_Pin1_4	637	642	PF00397	0.457
DOC_WW_Pin1_4	648	653	PF00397	0.346
DOC_WW_Pin1_4	67	72	PF00397	0.661
DOC_WW_Pin1_4	747	752	PF00397	0.501
DOC_WW_Pin1_4	776	781	PF00397	0.486
DOC_WW_Pin1_4	813	818	PF00397	0.581
DOC_WW_Pin1_4	910	915	PF00397	0.692
LIG_14-3-3_CanoR_1	169	174	PF00244	0.679
LIG_14-3-3_CanoR_1	185	194	PF00244	0.560
LIG_14-3-3_CanoR_1	236	242	PF00244	0.626
LIG_14-3-3_CanoR_1	441	449	PF00244	0.208
LIG_14-3-3_CanoR_1	725	733	PF00244	0.465
LIG_14-3-3_CanoR_1	737	745	PF00244	0.583
LIG_14-3-3_CanoR_1	924	933	PF00244	0.507
LIG_14-3-3_CanoR_1	946	954	PF00244	0.350
LIG_14-3-3_CanoR_1	972	981	PF00244	0.448
LIG_Actin_WH2_2	342	357	PF00022	0.327
LIG_Actin_WH2_2	542	558	PF00022	0.333
LIG_ActinCP_TwfCPI_2	4	14	PF01115	0.476
LIG_APCC_ABBA_1	136	141	PF00400	0.621
LIG_Clathr_ClatBox_1	379	383	PF01394	0.460
LIG_Clathr_ClatBox_1	668	672	PF01394	0.310
LIG_deltaCOP1_diTrp_1	685	691	PF00928	0.310
LIG_deltaCOP1_diTrp_1	990	1001	PF00928	0.435
LIG_FHA_1	110	116	PF00498	0.612
LIG_FHA_1	135	141	PF00498	0.497
LIG_FHA_1	165	171	PF00498	0.631
LIG_FHA_1	174	180	PF00498	0.594
LIG_FHA_1	254	260	PF00498	0.567
LIG_FHA_1	276	282	PF00498	0.622
LIG_FHA_1	291	297	PF00498	0.699
LIG_FHA_1	390	396	PF00498	0.420
LIG_FHA_1	473	479	PF00498	0.317
LIG_FHA_1	6	12	PF00498	0.581
LIG_FHA_1	67	73	PF00498	0.628
LIG_FHA_1	728	734	PF00498	0.565
LIG_FHA_1	829	835	PF00498	0.569
LIG_FHA_1	867	873	PF00498	0.549
LIG_FHA_1	911	917	PF00498	0.644
LIG_FHA_1	946	952	PF00498	0.392
LIG_FHA_2	173	179	PF00498	0.640
LIG_FHA_2	410	416	PF00498	0.326
LIG_FHA_2	630	636	PF00498	0.208
LIG_FHA_2	658	664	PF00498	0.270
LIG_FHA_2	758	764	PF00498	0.640
LIG_FHA_2	938	944	PF00498	0.392
LIG_FHA_2	960	966	PF00498	0.366
LIG_HCF-1_HBM_1	672	675	PF13415	0.310
LIG_Integrin_RGD_1	880	882	PF01839	0.604
LIG_IRF3_LxIS_1	165	171	PF10401	0.629
LIG_LIR_Apic_2	672	678	PF02991	0.310
LIG_LIR_Apic_2	679	684	PF02991	0.310
LIG_LIR_Gen_1	191	200	PF02991	0.618
LIG_LIR_Gen_1	683	692	PF02991	0.310
LIG_LIR_Gen_1	995	1005	PF02991	0.390
LIG_LIR_Nem_3	191	197	PF02991	0.617
LIG_LIR_Nem_3	45	51	PF02991	0.629
LIG_LIR_Nem_3	480	486	PF02991	0.320
LIG_LIR_Nem_3	532	537	PF02991	0.270
LIG_LIR_Nem_3	683	689	PF02991	0.310
LIG_LIR_Nem_3	991	997	PF02991	0.448
LIG_LIR_Nem_3	999	1004	PF02991	0.400
LIG_MYND_1	666	670	PF01753	0.310
LIG_NRBOX	459	465	PF00104	0.333
LIG_SH2_NCK_1	681	685	PF00017	0.310
LIG_SH2_PTP2	675	678	PF00017	0.310
LIG_SH2_SRC	681	684	PF00017	0.310
LIG_SH2_SRC	964	967	PF00017	0.368
LIG_SH2_STAP1	933	937	PF00017	0.510
LIG_SH2_STAT5	263	266	PF00017	0.504
LIG_SH2_STAT5	300	303	PF00017	0.579
LIG_SH2_STAT5	462	465	PF00017	0.333
LIG_SH2_STAT5	675	678	PF00017	0.310
LIG_SH2_STAT5	705	708	PF00017	0.310
LIG_SH2_STAT5	90	93	PF00017	0.649
LIG_SH3_3	221	227	PF00018	0.544
LIG_SH3_3	23	29	PF00018	0.611
LIG_SH3_3	397	403	PF00018	0.457
LIG_SH3_3	420	426	PF00018	0.311
LIG_SH3_3	638	644	PF00018	0.390
LIG_SH3_3	774	780	PF00018	0.480
LIG_SUMO_SIM_anti_2	16	22	PF11976	0.512
LIG_SUMO_SIM_anti_2	808	813	PF11976	0.477
LIG_SUMO_SIM_par_1	130	137	PF11976	0.626
LIG_SUMO_SIM_par_1	474	480	PF11976	0.310
LIG_TRAF2_1	200	203	PF00917	0.655
MOD_CK1_1	102	108	PF00069	0.636
MOD_CK1_1	109	115	PF00069	0.652
MOD_CK1_1	128	134	PF00069	0.613
MOD_CK1_1	186	192	PF00069	0.683
MOD_CK1_1	228	234	PF00069	0.646
MOD_CK1_1	27	33	PF00069	0.679
MOD_CK1_1	308	314	PF00069	0.580
MOD_CK1_1	333	339	PF00069	0.517
MOD_CK1_1	401	407	PF00069	0.644
MOD_CK1_1	5	11	PF00069	0.689
MOD_CK1_1	505	511	PF00069	0.308
MOD_CK1_1	639	645	PF00069	0.349
MOD_CK1_1	70	76	PF00069	0.600
MOD_CK1_1	726	732	PF00069	0.527
MOD_CK1_1	859	865	PF00069	0.500
MOD_CK1_1	906	912	PF00069	0.646
MOD_CK2_1	241	247	PF00069	0.703
MOD_CK2_1	35	41	PF00069	0.634
MOD_CK2_1	452	458	PF00069	0.351
MOD_CK2_1	647	653	PF00069	0.239
MOD_CK2_1	657	663	PF00069	0.258
MOD_CK2_1	834	840	PF00069	0.584
MOD_CK2_1	937	943	PF00069	0.397
MOD_CK2_1	959	965	PF00069	0.370
MOD_CK2_1	976	982	PF00069	0.406
MOD_CMANNOS	688	691	PF00535	0.310
MOD_Cter_Amidation	613	616	PF01082	0.383
MOD_DYRK1A_RPxSP_1	122	126	PF00069	0.517
MOD_DYRK1A_RPxSP_1	399	403	PF00069	0.534
MOD_GlcNHglycan	1014	1017	PF01048	0.564
MOD_GlcNHglycan	122	125	PF01048	0.671
MOD_GlcNHglycan	141	144	PF01048	0.616
MOD_GlcNHglycan	307	310	PF01048	0.550
MOD_GlcNHglycan	346	349	PF01048	0.459
MOD_GlcNHglycan	355	358	PF01048	0.598
MOD_GlcNHglycan	359	362	PF01048	0.583
MOD_GlcNHglycan	387	390	PF01048	0.490
MOD_GlcNHglycan	452	455	PF01048	0.312
MOD_GlcNHglycan	479	482	PF01048	0.208
MOD_GlcNHglycan	653	657	PF01048	0.306
MOD_GlcNHglycan	678	681	PF01048	0.350
MOD_GlcNHglycan	698	701	PF01048	0.350
MOD_GlcNHglycan	719	722	PF01048	0.331
MOD_GlcNHglycan	786	789	PF01048	0.654
MOD_GlcNHglycan	821	824	PF01048	0.588
MOD_GlcNHglycan	831	834	PF01048	0.607
MOD_GlcNHglycan	848	851	PF01048	0.723
MOD_GlcNHglycan	905	908	PF01048	0.639
MOD_GSK3_1	105	112	PF00069	0.673
MOD_GSK3_1	160	167	PF00069	0.647
MOD_GSK3_1	168	175	PF00069	0.612
MOD_GSK3_1	177	184	PF00069	0.567
MOD_GSK3_1	186	193	PF00069	0.587
MOD_GSK3_1	210	217	PF00069	0.655
MOD_GSK3_1	228	235	PF00069	0.536
MOD_GSK3_1	237	244	PF00069	0.592
MOD_GSK3_1	24	31	PF00069	0.722
MOD_GSK3_1	253	260	PF00069	0.490
MOD_GSK3_1	281	288	PF00069	0.765
MOD_GSK3_1	329	336	PF00069	0.570
MOD_GSK3_1	353	360	PF00069	0.534
MOD_GSK3_1	385	392	PF00069	0.481
MOD_GSK3_1	398	405	PF00069	0.577
MOD_GSK3_1	409	416	PF00069	0.285
MOD_GSK3_1	486	493	PF00069	0.345
MOD_GSK3_1	498	505	PF00069	0.331
MOD_GSK3_1	62	69	PF00069	0.655
MOD_GSK3_1	639	646	PF00069	0.449
MOD_GSK3_1	648	655	PF00069	0.348
MOD_GSK3_1	687	694	PF00069	0.376
MOD_GSK3_1	723	730	PF00069	0.557
MOD_GSK3_1	732	739	PF00069	0.549
MOD_GSK3_1	813	820	PF00069	0.549
MOD_GSK3_1	859	866	PF00069	0.535
MOD_GSK3_1	899	906	PF00069	0.619
MOD_GSK3_1	908	915	PF00069	0.625
MOD_GSK3_1	95	102	PF00069	0.728
MOD_LATS_1	554	560	PF00433	0.333
MOD_N-GLC_1	109	114	PF02516	0.774
MOD_N-GLC_1	128	133	PF02516	0.565
MOD_N-GLC_1	187	192	PF02516	0.626
MOD_N-GLC_1	629	634	PF02516	0.208
MOD_N-GLC_1	88	93	PF02516	0.660
MOD_NEK2_1	1012	1017	PF00069	0.493
MOD_NEK2_1	160	165	PF00069	0.651
MOD_NEK2_1	168	173	PF00069	0.687
MOD_NEK2_1	264	269	PF00069	0.489
MOD_NEK2_1	32	37	PF00069	0.571
MOD_NEK2_1	353	358	PF00069	0.469
MOD_NEK2_1	375	380	PF00069	0.521
MOD_NEK2_1	524	529	PF00069	0.333
MOD_NEK2_1	66	71	PF00069	0.501
MOD_NEK2_1	717	722	PF00069	0.383
MOD_NEK2_1	723	728	PF00069	0.460
MOD_NEK2_1	736	741	PF00069	0.564
MOD_NEK2_1	945	950	PF00069	0.340
MOD_NEK2_1	959	964	PF00069	0.377
MOD_NEK2_2	237	242	PF00069	0.531
MOD_NEK2_2	317	322	PF00069	0.617
MOD_NEK2_2	502	507	PF00069	0.214
MOD_OFUCOSY	328	334	PF10250	0.600
MOD_PIKK_1	973	979	PF00454	0.454
MOD_PKA_1	846	852	PF00069	0.636
MOD_PKA_2	149	155	PF00069	0.750
MOD_PKA_2	168	174	PF00069	0.496
MOD_PKA_2	184	190	PF00069	0.554
MOD_PKA_2	241	247	PF00069	0.643
MOD_PKA_2	275	281	PF00069	0.723
MOD_PKA_2	344	350	PF00069	0.425
MOD_PKA_2	398	404	PF00069	0.605
MOD_PKA_2	440	446	PF00069	0.408
MOD_PKA_2	524	530	PF00069	0.303
MOD_PKA_2	724	730	PF00069	0.486
MOD_PKA_2	736	742	PF00069	0.564
MOD_PKA_2	898	904	PF00069	0.523
MOD_PKA_2	925	931	PF00069	0.528
MOD_PKA_2	945	951	PF00069	0.318
MOD_PKA_2	973	979	PF00069	0.459
MOD_PKB_1	327	335	PF00069	0.714
MOD_PKB_1	897	905	PF00069	0.561
MOD_Plk_1	128	134	PF00069	0.719
MOD_Plk_1	317	323	PF00069	0.657
MOD_Plk_1	502	508	PF00069	0.208
MOD_Plk_1	541	547	PF00069	0.255
MOD_Plk_1	652	658	PF00069	0.476
MOD_Plk_1	671	677	PF00069	0.255
MOD_Plk_1	731	737	PF00069	0.507
MOD_Plk_1	882	888	PF00069	0.519
MOD_Plk_1	990	996	PF00069	0.448
MOD_Plk_2-3	882	888	PF00069	0.485
MOD_Plk_2-3	990	996	PF00069	0.448
MOD_Plk_4	296	302	PF00069	0.580
MOD_Plk_4	375	381	PF00069	0.490
MOD_Plk_4	389	395	PF00069	0.368
MOD_Plk_4	62	68	PF00069	0.512
MOD_Plk_4	671	677	PF00069	0.299
MOD_Plk_4	976	982	PF00069	0.439
MOD_ProDKin_1	122	128	PF00069	0.700
MOD_ProDKin_1	134	140	PF00069	0.623
MOD_ProDKin_1	161	167	PF00069	0.557
MOD_ProDKin_1	205	211	PF00069	0.624
MOD_ProDKin_1	219	225	PF00069	0.629
MOD_ProDKin_1	22	28	PF00069	0.682
MOD_ProDKin_1	242	248	PF00069	0.665
MOD_ProDKin_1	283	289	PF00069	0.677
MOD_ProDKin_1	399	405	PF00069	0.567
MOD_ProDKin_1	624	630	PF00069	0.287
MOD_ProDKin_1	637	643	PF00069	0.457
MOD_ProDKin_1	648	654	PF00069	0.346
MOD_ProDKin_1	67	73	PF00069	0.662
MOD_ProDKin_1	747	753	PF00069	0.504
MOD_ProDKin_1	776	782	PF00069	0.486
MOD_ProDKin_1	813	819	PF00069	0.582
MOD_ProDKin_1	910	916	PF00069	0.693
MOD_SUMO_for_1	13	16	PF00179	0.455
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.628
TRG_DiLeu_BaLyEn_6	947	952	PF01217	0.346
TRG_ENDOCYTIC_2	194	197	PF00928	0.623
TRG_ENDOCYTIC_2	686	689	PF00928	0.310
TRG_ER_diArg_1	1005	1008	PF00400	0.419
TRG_ER_diArg_1	241	243	PF00400	0.686
TRG_ER_diArg_1	321	324	PF00400	0.757
TRG_ER_diArg_1	325	327	PF00400	0.747
TRG_ER_diArg_1	48	50	PF00400	0.611
TRG_ER_diArg_1	615	617	PF00400	0.379
TRG_ER_diArg_1	621	624	PF00400	0.300
TRG_ER_diArg_1	812	814	PF00400	0.485
TRG_ER_diArg_1	921	924	PF00400	0.518
TRG_ER_diArg_1	971	974	PF00400	0.422
TRG_Pf-PMV_PEXEL_1	592	597	PF00026	0.310
TRG_Pf-PMV_PEXEL_1	793	797	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD91	Leptomonas seymouri	45%	100%
A0A3Q8IEF4	Leishmania donovani	81%	100%
A4HFZ1	Leishmania braziliensis	60%	100%
A4I310	Leishmania infantum	81%	91%
E9ADJ4	Leishmania major	81%	99%