Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Lipase (class 3), putative

Species:

Leishmania mexicana

UniProt:

E9AZB7_LEIMU

TriTrypDb:

LmxM.27.2110

Length:

791

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZB7

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	6
GO:0008152	metabolic process	1	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:0009056	catabolic process	2	1
GO:0016042	lipid catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016298	lipase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	462	466	PF00656	0.675
CLV_C14_Caspase3-7	672	676	PF00656	0.524
CLV_C14_Caspase3-7	690	694	PF00656	0.755
CLV_NRD_NRD_1	254	256	PF00675	0.583
CLV_NRD_NRD_1	377	379	PF00675	0.683
CLV_NRD_NRD_1	403	405	PF00675	0.687
CLV_NRD_NRD_1	514	516	PF00675	0.233
CLV_NRD_NRD_1	711	713	PF00675	0.734
CLV_NRD_NRD_1	783	785	PF00675	0.537
CLV_PCSK_KEX2_1	109	111	PF00082	0.638
CLV_PCSK_KEX2_1	254	256	PF00082	0.583
CLV_PCSK_KEX2_1	271	273	PF00082	0.478
CLV_PCSK_KEX2_1	377	379	PF00082	0.436
CLV_PCSK_KEX2_1	403	405	PF00082	0.699
CLV_PCSK_KEX2_1	418	420	PF00082	0.626
CLV_PCSK_KEX2_1	514	516	PF00082	0.483
CLV_PCSK_KEX2_1	783	785	PF00082	0.534
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.638
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.653
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.436
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.704
CLV_PCSK_PC7_1	373	379	PF00082	0.430
CLV_PCSK_SKI1_1	176	180	PF00082	0.715
CLV_PCSK_SKI1_1	192	196	PF00082	0.522
CLV_PCSK_SKI1_1	243	247	PF00082	0.508
CLV_PCSK_SKI1_1	60	64	PF00082	0.632
CLV_PCSK_SKI1_1	728	732	PF00082	0.568
CLV_PCSK_SKI1_1	82	86	PF00082	0.608
DEG_Nend_UBRbox_1	1	4	PF02207	0.580
DEG_ODPH_VHL_1	10	21	PF01847	0.509
DEG_SCF_FBW7_1	439	445	PF00400	0.542
DOC_CDC14_PxL_1	572	580	PF14671	0.483
DOC_CDC14_PxL_1	96	104	PF14671	0.535
DOC_CKS1_1	439	444	PF01111	0.544
DOC_CKS1_1	461	466	PF01111	0.675
DOC_CKS1_1	644	649	PF01111	0.634
DOC_CYCLIN_RxL_1	724	734	PF00134	0.575
DOC_MAPK_DCC_7	98	107	PF00069	0.544
DOC_MAPK_gen_1	514	521	PF00069	0.483
DOC_MAPK_MEF2A_6	446	453	PF00069	0.706
DOC_PP1_RVXF_1	137	144	PF00149	0.615
DOC_PP1_RVXF_1	145	151	PF00149	0.621
DOC_PP2B_LxvP_1	290	293	PF13499	0.568
DOC_PP2B_LxvP_1	527	530	PF13499	0.483
DOC_PP4_FxxP_1	19	22	PF00568	0.515
DOC_PP4_FxxP_1	195	198	PF00568	0.747
DOC_USP7_MATH_1	275	279	PF00917	0.533
DOC_USP7_MATH_1	285	289	PF00917	0.437
DOC_USP7_MATH_1	29	33	PF00917	0.705
DOC_USP7_MATH_1	340	344	PF00917	0.508
DOC_USP7_MATH_1	413	417	PF00917	0.620
DOC_USP7_MATH_1	425	429	PF00917	0.600
DOC_USP7_MATH_1	431	435	PF00917	0.620
DOC_USP7_MATH_1	530	534	PF00917	0.483
DOC_USP7_MATH_1	553	557	PF00917	0.416
DOC_USP7_MATH_1	599	603	PF00917	0.714
DOC_USP7_MATH_1	679	683	PF00917	0.672
DOC_USP7_MATH_1	706	710	PF00917	0.817
DOC_WW_Pin1_4	100	105	PF00397	0.623
DOC_WW_Pin1_4	160	165	PF00397	0.735
DOC_WW_Pin1_4	194	199	PF00397	0.750
DOC_WW_Pin1_4	25	30	PF00397	0.616
DOC_WW_Pin1_4	391	396	PF00397	0.679
DOC_WW_Pin1_4	409	414	PF00397	0.665
DOC_WW_Pin1_4	438	443	PF00397	0.561
DOC_WW_Pin1_4	460	465	PF00397	0.716
DOC_WW_Pin1_4	643	648	PF00397	0.634
DOC_WW_Pin1_4	731	736	PF00397	0.601
LIG_14-3-3_CanoR_1	110	117	PF00244	0.607
LIG_14-3-3_CanoR_1	139	144	PF00244	0.562
LIG_14-3-3_CanoR_1	243	252	PF00244	0.517
LIG_14-3-3_CanoR_1	255	264	PF00244	0.445
LIG_14-3-3_CanoR_1	301	309	PF00244	0.521
LIG_14-3-3_CanoR_1	321	327	PF00244	0.268
LIG_14-3-3_CanoR_1	403	408	PF00244	0.594
LIG_Actin_WH2_2	282	300	PF00022	0.500
LIG_BIR_III_2	392	396	PF00653	0.681
LIG_BIR_III_4	695	699	PF00653	0.537
LIG_BRCT_BRCA1_1	190	194	PF00533	0.633
LIG_BRCT_BRCA1_1	195	199	PF00533	0.674
LIG_BRCT_BRCA1_1	342	346	PF00533	0.508
LIG_BRCT_BRCA1_1	50	54	PF00533	0.677
LIG_EH1_1	231	239	PF00400	0.518
LIG_EH1_1	756	764	PF00400	0.605
LIG_eIF4E_1	232	238	PF01652	0.574
LIG_FHA_1	21	27	PF00498	0.695
LIG_FHA_1	224	230	PF00498	0.742
LIG_FHA_1	259	265	PF00498	0.578
LIG_FHA_1	285	291	PF00498	0.596
LIG_FHA_1	330	336	PF00498	0.602
LIG_FHA_1	434	440	PF00498	0.804
LIG_FHA_1	524	530	PF00498	0.483
LIG_FHA_1	738	744	PF00498	0.537
LIG_FHA_2	359	365	PF00498	0.581
LIG_FHA_2	383	389	PF00498	0.620
LIG_FHA_2	394	400	PF00498	0.589
LIG_FHA_2	430	436	PF00498	0.726
LIG_FHA_2	649	655	PF00498	0.692
LIG_FHA_2	665	671	PF00498	0.675
LIG_FHA_2	688	694	PF00498	0.754
LIG_FHA_2	783	789	PF00498	0.538
LIG_LIR_Gen_1	140	148	PF02991	0.663
LIG_LIR_Gen_1	163	174	PF02991	0.719
LIG_LIR_Gen_1	308	319	PF02991	0.543
LIG_LIR_Gen_1	332	341	PF02991	0.622
LIG_LIR_Gen_1	480	485	PF02991	0.499
LIG_LIR_Gen_1	533	543	PF02991	0.416
LIG_LIR_Nem_3	140	146	PF02991	0.656
LIG_LIR_Nem_3	163	169	PF02991	0.659
LIG_LIR_Nem_3	246	252	PF02991	0.520
LIG_LIR_Nem_3	308	314	PF02991	0.534
LIG_LIR_Nem_3	480	484	PF02991	0.499
LIG_LIR_Nem_3	533	538	PF02991	0.483
LIG_LYPXL_yS_3	99	102	PF13949	0.597
LIG_MYND_1	100	104	PF01753	0.549
LIG_Pex14_2	195	199	PF04695	0.749
LIG_PTB_Apo_2	357	364	PF02174	0.573
LIG_Rb_pABgroove_1	357	365	PF01858	0.577
LIG_SH2_CRK	311	315	PF00017	0.447
LIG_SH2_CRK	504	508	PF00017	0.233
LIG_SH2_SRC	66	69	PF00017	0.599
LIG_SH2_STAP1	125	129	PF00017	0.556
LIG_SH2_STAP1	244	248	PF00017	0.504
LIG_SH2_STAP1	311	315	PF00017	0.447
LIG_SH2_STAP1	504	508	PF00017	0.483
LIG_SH2_STAP1	771	775	PF00017	0.598
LIG_SH2_STAT3	232	235	PF00017	0.590
LIG_SH2_STAT3	350	353	PF00017	0.487
LIG_SH2_STAT3	456	459	PF00017	0.683
LIG_SH2_STAT5	481	484	PF00017	0.261
LIG_SH2_STAT5	66	69	PF00017	0.665
LIG_SH3_2	644	649	PF14604	0.729
LIG_SH3_3	339	345	PF00018	0.555
LIG_SH3_3	504	510	PF00018	0.429
LIG_SH3_3	6	12	PF00018	0.750
LIG_SH3_3	638	644	PF00018	0.734
LIG_SH3_3	741	747	PF00018	0.610
LIG_SUMO_SIM_anti_2	263	269	PF11976	0.588
LIG_SUMO_SIM_anti_2	480	486	PF11976	0.233
LIG_SUMO_SIM_par_1	449	454	PF11976	0.621
LIG_SUMO_SIM_par_1	480	486	PF11976	0.233
LIG_SUMO_SIM_par_1	728	734	PF11976	0.573
LIG_TRAF2_1	278	281	PF00917	0.555
LIG_TRAF2_1	774	777	PF00917	0.412
LIG_TRAF2_1	786	789	PF00917	0.770
LIG_TRFH_1	456	460	PF08558	0.687
LIG_TYR_ITIM	502	507	PF00017	0.416
LIG_UBA3_1	266	271	PF00899	0.612
LIG_UBA3_1	756	760	PF00899	0.599
LIG_WRC_WIRS_1	323	328	PF05994	0.508
LIG_WRC_WIRS_1	330	335	PF05994	0.504
MOD_CDK_SPxK_1	643	649	PF00069	0.550
MOD_CK1_1	20	26	PF00069	0.723
MOD_CK1_1	257	263	PF00069	0.624
MOD_CK1_1	27	33	PF00069	0.694
MOD_CK1_1	284	290	PF00069	0.532
MOD_CK1_1	304	310	PF00069	0.371
MOD_CK1_1	48	54	PF00069	0.568
MOD_CK1_1	704	710	PF00069	0.649
MOD_CK2_1	139	145	PF00069	0.667
MOD_CK2_1	174	180	PF00069	0.561
MOD_CK2_1	275	281	PF00069	0.585
MOD_CK2_1	285	291	PF00069	0.382
MOD_CK2_1	382	388	PF00069	0.610
MOD_CK2_1	393	399	PF00069	0.534
MOD_CK2_1	429	435	PF00069	0.756
MOD_CK2_1	648	654	PF00069	0.658
MOD_CK2_1	704	710	PF00069	0.753
MOD_CK2_1	771	777	PF00069	0.615
MOD_CK2_1	782	788	PF00069	0.547
MOD_GlcNHglycan	111	114	PF01048	0.441
MOD_GlcNHglycan	23	26	PF01048	0.763
MOD_GlcNHglycan	283	286	PF01048	0.463
MOD_GlcNHglycan	29	32	PF01048	0.672
MOD_GlcNHglycan	294	297	PF01048	0.459
MOD_GlcNHglycan	36	39	PF01048	0.592
MOD_GlcNHglycan	415	418	PF01048	0.584
MOD_GlcNHglycan	429	432	PF01048	0.699
MOD_GlcNHglycan	50	53	PF01048	0.458
MOD_GlcNHglycan	555	558	PF01048	0.449
MOD_GlcNHglycan	597	600	PF01048	0.712
MOD_GlcNHglycan	602	605	PF01048	0.665
MOD_GlcNHglycan	690	693	PF01048	0.690
MOD_GlcNHglycan	771	774	PF01048	0.600
MOD_GSK3_1	133	140	PF00069	0.541
MOD_GSK3_1	156	163	PF00069	0.733
MOD_GSK3_1	17	24	PF00069	0.751
MOD_GSK3_1	25	32	PF00069	0.633
MOD_GSK3_1	254	261	PF00069	0.599
MOD_GSK3_1	281	288	PF00069	0.418
MOD_GSK3_1	297	304	PF00069	0.408
MOD_GSK3_1	322	329	PF00069	0.500
MOD_GSK3_1	39	46	PF00069	0.558
MOD_GSK3_1	409	416	PF00069	0.624
MOD_GSK3_1	425	432	PF00069	0.655
MOD_GSK3_1	438	445	PF00069	0.579
MOD_GSK3_1	48	55	PF00069	0.593
MOD_GSK3_1	595	602	PF00069	0.693
MOD_GSK3_1	649	656	PF00069	0.603
MOD_GSK3_1	697	704	PF00069	0.744
MOD_GSK3_1	767	774	PF00069	0.529
MOD_N-GLC_1	281	286	PF02516	0.537
MOD_NEK2_1	137	142	PF00069	0.589
MOD_NEK2_1	182	187	PF00069	0.731
MOD_NEK2_1	258	263	PF00069	0.631
MOD_NEK2_1	266	271	PF00069	0.565
MOD_NEK2_1	297	302	PF00069	0.558
MOD_NEK2_1	326	331	PF00069	0.550
MOD_NEK2_1	429	434	PF00069	0.704
MOD_NEK2_1	497	502	PF00069	0.483
MOD_NEK2_1	730	735	PF00069	0.590
MOD_NEK2_1	758	763	PF00069	0.614
MOD_NEK2_1	767	772	PF00069	0.456
MOD_NEK2_1	91	96	PF00069	0.520
MOD_NEK2_2	530	535	PF00069	0.483
MOD_OFUCOSY	534	540	PF10250	0.416
MOD_PIKK_1	203	209	PF00454	0.519
MOD_PIKK_1	301	307	PF00454	0.595
MOD_PIKK_1	340	346	PF00454	0.575
MOD_PIKK_1	679	685	PF00454	0.508
MOD_PK_1	403	409	PF00069	0.524
MOD_PKA_1	109	115	PF00069	0.624
MOD_PKA_1	254	260	PF00069	0.594
MOD_PKA_1	403	409	PF00069	0.517
MOD_PKA_1	783	789	PF00069	0.550
MOD_PKA_2	109	115	PF00069	0.624
MOD_PKA_2	254	260	PF00069	0.594
MOD_PKA_2	297	303	PF00069	0.495
MOD_PKA_2	326	332	PF00069	0.562
MOD_PKA_2	365	371	PF00069	0.642
MOD_PKA_2	403	409	PF00069	0.587
MOD_PKA_2	622	628	PF00069	0.585
MOD_PKA_2	782	788	PF00069	0.538
MOD_Plk_1	133	139	PF00069	0.629
MOD_Plk_1	174	180	PF00069	0.645
MOD_Plk_1	281	287	PF00069	0.534
MOD_Plk_1	653	659	PF00069	0.648
MOD_Plk_1	669	675	PF00069	0.713
MOD_Plk_4	103	109	PF00069	0.510
MOD_Plk_4	133	139	PF00069	0.415
MOD_Plk_4	174	180	PF00069	0.668
MOD_Plk_4	285	291	PF00069	0.594
MOD_Plk_4	358	364	PF00069	0.573
MOD_Plk_4	477	483	PF00069	0.458
MOD_Plk_4	758	764	PF00069	0.615
MOD_Plk_4	91	97	PF00069	0.553
MOD_ProDKin_1	100	106	PF00069	0.620
MOD_ProDKin_1	160	166	PF00069	0.733
MOD_ProDKin_1	194	200	PF00069	0.750
MOD_ProDKin_1	25	31	PF00069	0.617
MOD_ProDKin_1	391	397	PF00069	0.682
MOD_ProDKin_1	409	415	PF00069	0.660
MOD_ProDKin_1	438	444	PF00069	0.558
MOD_ProDKin_1	460	466	PF00069	0.701
MOD_ProDKin_1	643	649	PF00069	0.638
MOD_ProDKin_1	731	737	PF00069	0.609
TRG_DiLeu_BaLyEn_6	582	587	PF01217	0.570
TRG_ENDOCYTIC_2	111	114	PF00928	0.455
TRG_ENDOCYTIC_2	249	252	PF00928	0.531
TRG_ENDOCYTIC_2	311	314	PF00928	0.515
TRG_ENDOCYTIC_2	481	484	PF00928	0.483
TRG_ENDOCYTIC_2	504	507	PF00928	0.416
TRG_ENDOCYTIC_2	89	92	PF00928	0.552
TRG_ENDOCYTIC_2	99	102	PF00928	0.489
TRG_ER_diArg_1	253	255	PF00400	0.578
TRG_ER_diArg_1	403	405	PF00400	0.687
TRG_ER_diArg_1	513	515	PF00400	0.266
TRG_ER_diArg_1	782	784	PF00400	0.518
TRG_NES_CRM1_1	755	765	PF08389	0.600
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.709
TRG_Pf-PMV_PEXEL_1	585	589	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	65	70	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	717	722	PF00026	0.708

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7I3	Leishmania donovani	88%	100%
A4HFY8	Leishmania braziliensis	67%	100%
A4I2Y1	Leishmania infantum	89%	72%
E9ADJ1	Leishmania major	86%	98%