Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9AZB6_LEIMU

TriTrypDb:

LmxM.27.2100

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016604	nuclear body	2	1
GO:0016607	nuclear speck	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AZB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZB6

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0005488	binding	1	9
GO:0008270	zinc ion binding	6	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.639
CLV_C14_Caspase3-7	99	103	PF00656	0.657
CLV_NRD_NRD_1	127	129	PF00675	0.622
CLV_NRD_NRD_1	219	221	PF00675	0.745
CLV_NRD_NRD_1	224	226	PF00675	0.794
CLV_NRD_NRD_1	237	239	PF00675	0.423
CLV_NRD_NRD_1	318	320	PF00675	0.502
CLV_NRD_NRD_1	348	350	PF00675	0.662
CLV_NRD_NRD_1	363	365	PF00675	0.653
CLV_NRD_NRD_1	373	375	PF00675	0.735
CLV_NRD_NRD_1	395	397	PF00675	0.662
CLV_NRD_NRD_1	407	409	PF00675	0.517
CLV_PCSK_FUR_1	344	348	PF00082	0.629
CLV_PCSK_FUR_1	357	361	PF00082	0.674
CLV_PCSK_FUR_1	370	374	PF00082	0.737
CLV_PCSK_FUR_1	392	396	PF00082	0.557
CLV_PCSK_FUR_1	405	409	PF00082	0.760
CLV_PCSK_KEX2_1	127	129	PF00082	0.580
CLV_PCSK_KEX2_1	219	221	PF00082	0.660
CLV_PCSK_KEX2_1	224	226	PF00082	0.732
CLV_PCSK_KEX2_1	237	239	PF00082	0.423
CLV_PCSK_KEX2_1	292	294	PF00082	0.390
CLV_PCSK_KEX2_1	318	320	PF00082	0.502
CLV_PCSK_KEX2_1	344	346	PF00082	0.634
CLV_PCSK_KEX2_1	347	349	PF00082	0.646
CLV_PCSK_KEX2_1	359	361	PF00082	0.656
CLV_PCSK_KEX2_1	362	364	PF00082	0.671
CLV_PCSK_KEX2_1	372	374	PF00082	0.626
CLV_PCSK_KEX2_1	394	396	PF00082	0.665
CLV_PCSK_KEX2_1	405	407	PF00082	0.567
CLV_PCSK_KEX2_1	421	423	PF00082	0.642
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.291
CLV_PCSK_PC7_1	220	226	PF00082	0.601
CLV_PCSK_PC7_1	340	346	PF00082	0.612
CLV_PCSK_PC7_1	357	363	PF00082	0.712
CLV_PCSK_PC7_1	390	396	PF00082	0.649
CLV_PCSK_PC7_1	401	407	PF00082	0.633
CLV_PCSK_PC7_1	417	423	PF00082	0.610
CLV_PCSK_SKI1_1	155	159	PF00082	0.298
CLV_PCSK_SKI1_1	188	192	PF00082	0.341
CLV_PCSK_SKI1_1	255	259	PF00082	0.244
DEG_APCC_DBOX_1	150	158	PF00400	0.459
DOC_CYCLIN_RxL_1	185	195	PF00134	0.514
DOC_MAPK_gen_1	134	142	PF00069	0.478
DOC_MAPK_gen_1	237	244	PF00069	0.520
DOC_MAPK_gen_1	306	315	PF00069	0.676
DOC_MAPK_MEF2A_6	237	246	PF00069	0.502
DOC_MAPK_MEF2A_6	275	282	PF00069	0.514
DOC_PP2B_PxIxI_1	275	281	PF00149	0.491
DOC_PP4_FxxP_1	261	264	PF00568	0.514
DOC_PP4_FxxP_1	273	276	PF00568	0.514
DOC_PP4_FxxP_1	54	57	PF00568	0.514
DOC_USP7_MATH_1	284	288	PF00917	0.474
DOC_WW_Pin1_4	156	161	PF00397	0.459
DOC_WW_Pin1_4	260	265	PF00397	0.491
DOC_WW_Pin1_4	399	404	PF00397	0.585
DOC_WW_Pin1_4	409	414	PF00397	0.597
DOC_WW_Pin1_4	415	420	PF00397	0.588
LIG_BIR_II_1	1	5	PF00653	0.532
LIG_BIR_III_4	102	106	PF00653	0.673
LIG_FHA_1	3	9	PF00498	0.276
LIG_FHA_2	14	20	PF00498	0.449
LIG_FHA_2	179	185	PF00498	0.496
LIG_FHA_2	284	290	PF00498	0.534
LIG_FHA_2	97	103	PF00498	0.654
LIG_LIR_Apic_2	270	276	PF02991	0.514
LIG_LIR_Apic_2	51	57	PF02991	0.491
LIG_LIR_Gen_1	166	175	PF02991	0.525
LIG_LIR_Gen_1	18	27	PF02991	0.460
LIG_LIR_Nem_3	166	170	PF02991	0.580
LIG_LIR_Nem_3	18	24	PF02991	0.460
LIG_MAD2	139	147	PF02301	0.374
LIG_NRP_CendR_1	421	423	PF00754	0.678
LIG_REV1ctd_RIR_1	21	30	PF16727	0.447
LIG_SH2_STAP1	186	190	PF00017	0.378
LIG_SH2_STAT5	180	183	PF00017	0.528
LIG_SH2_STAT5	7	10	PF00017	0.449
LIG_SH2_STAT5	78	81	PF00017	0.480
LIG_SH3_3	154	160	PF00018	0.459
LIG_SH3_3	203	209	PF00018	0.518
LIG_SH3_3	30	36	PF00018	0.514
LIG_TRAF2_1	181	184	PF00917	0.459
LIG_TRFH_1	167	171	PF08558	0.454
LIG_WW_3	207	211	PF00397	0.598
LIG_WW_3	402	406	PF00397	0.743
LIG_WW_3	412	416	PF00397	0.686
LIG_WW_3	418	422	PF00397	0.651
MOD_CDC14_SPxK_1	402	405	PF00782	0.583
MOD_CDC14_SPxK_1	412	415	PF00782	0.591
MOD_CDC14_SPxK_1	418	421	PF00782	0.580
MOD_CDK_SPxK_1	399	405	PF00069	0.586
MOD_CDK_SPxK_1	409	415	PF00069	0.599
MOD_CDK_SPxxK_3	399	406	PF00069	0.636
MOD_CDK_SPxxK_3	415	422	PF00069	0.612
MOD_CK1_1	2	8	PF00069	0.488
MOD_CK1_1	251	257	PF00069	0.560
MOD_CK1_1	334	340	PF00069	0.623
MOD_CK1_1	350	356	PF00069	0.617
MOD_CK1_1	62	68	PF00069	0.510
MOD_CK2_1	11	17	PF00069	0.517
MOD_CK2_1	178	184	PF00069	0.460
MOD_CK2_1	283	289	PF00069	0.527
MOD_DYRK1A_RPxSP_1	399	403	PF00069	0.587
MOD_DYRK1A_RPxSP_1	415	419	PF00069	0.598
MOD_GlcNHglycan	1	4	PF01048	0.551
MOD_GlcNHglycan	116	119	PF01048	0.659
MOD_GlcNHglycan	128	131	PF01048	0.714
MOD_GlcNHglycan	13	16	PF01048	0.319
MOD_GlcNHglycan	232	235	PF01048	0.638
MOD_GlcNHglycan	286	289	PF01048	0.276
MOD_GlcNHglycan	297	300	PF01048	0.262
MOD_GlcNHglycan	354	357	PF01048	0.465
MOD_GlcNHglycan	36	39	PF01048	0.273
MOD_GlcNHglycan	43	46	PF01048	0.387
MOD_GlcNHglycan	61	64	PF01048	0.195
MOD_GlcNHglycan	66	69	PF01048	0.521
MOD_GlcNHglycan	79	82	PF01048	0.491
MOD_GSK3_1	104	111	PF00069	0.578
MOD_GSK3_1	2	9	PF00069	0.489
MOD_GSK3_1	334	341	PF00069	0.600
MOD_GSK3_1	347	354	PF00069	0.449
MOD_GSK3_1	395	402	PF00069	0.660
MOD_GSK3_1	409	416	PF00069	0.639
MOD_GSK3_1	62	69	PF00069	0.514
MOD_GSK3_1	82	89	PF00069	0.414
MOD_LATS_1	393	399	PF00433	0.625
MOD_NEK2_1	192	197	PF00069	0.452
MOD_NEK2_1	302	307	PF00069	0.538
MOD_PKA_1	347	353	PF00069	0.543
MOD_PKA_1	362	368	PF00069	0.666
MOD_PKA_1	372	378	PF00069	0.620
MOD_PKA_1	395	401	PF00069	0.654
MOD_PKA_1	407	413	PF00069	0.527
MOD_PKA_2	126	132	PF00069	0.669
MOD_PKA_2	347	353	PF00069	0.692
MOD_PKA_2	362	368	PF00069	0.666
MOD_PKA_2	372	378	PF00069	0.620
MOD_PKA_2	395	401	PF00069	0.654
MOD_PKA_2	407	413	PF00069	0.527
MOD_PKB_1	345	353	PF00069	0.620
MOD_PKB_1	360	368	PF00069	0.667
MOD_PKB_1	370	378	PF00069	0.452
MOD_PKB_1	380	388	PF00069	0.763
MOD_PKB_1	405	413	PF00069	0.651
MOD_Plk_4	141	147	PF00069	0.491
MOD_Plk_4	192	198	PF00069	0.413
MOD_Plk_4	2	8	PF00069	0.488
MOD_ProDKin_1	156	162	PF00069	0.459
MOD_ProDKin_1	260	266	PF00069	0.491
MOD_ProDKin_1	399	405	PF00069	0.586
MOD_ProDKin_1	409	415	PF00069	0.599
MOD_SUMO_for_1	274	277	PF00179	0.514
MOD_SUMO_for_1	307	310	PF00179	0.404
TRG_DiLeu_BaLyEn_6	311	316	PF01217	0.521
TRG_ER_diArg_1	126	128	PF00400	0.624
TRG_ER_diArg_1	223	225	PF00400	0.491
TRG_ER_diArg_1	344	347	PF00400	0.697
TRG_ER_diArg_1	359	362	PF00400	0.794
TRG_ER_diArg_1	372	374	PF00400	0.615
TRG_ER_diArg_1	392	395	PF00400	0.590
TRG_ER_diArg_1	404	407	PF00400	0.708
TRG_ER_diArg_1	414	417	PF00400	0.519
TRG_ER_diArg_1	420	423	PF00400	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMB5	Leptomonas seymouri	50%	100%
A0A3R7LQ31	Trypanosoma rangeli	32%	97%
A0A3S7X0Y2	Leishmania donovani	94%	93%
A4HFY7	Leishmania braziliensis	80%	100%
A4I2Y0	Leishmania infantum	94%	94%
C9ZJH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	96%
E9ADJ0	Leishmania major	94%	100%