Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZB3_LEIMU

TriTrypDb:

LmxM.27.2070

Length:

852

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AZB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZB3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	460	464	PF00656	0.813
CLV_C14_Caspase3-7	614	618	PF00656	0.655
CLV_NRD_NRD_1	153	155	PF00675	0.401
CLV_NRD_NRD_1	24	26	PF00675	0.437
CLV_NRD_NRD_1	289	291	PF00675	0.696
CLV_NRD_NRD_1	465	467	PF00675	0.456
CLV_NRD_NRD_1	498	500	PF00675	0.623
CLV_NRD_NRD_1	665	667	PF00675	0.617
CLV_NRD_NRD_1	720	722	PF00675	0.586
CLV_PCSK_FUR_1	663	667	PF00082	0.616
CLV_PCSK_KEX2_1	153	155	PF00082	0.401
CLV_PCSK_KEX2_1	24	26	PF00082	0.437
CLV_PCSK_KEX2_1	289	291	PF00082	0.696
CLV_PCSK_KEX2_1	465	467	PF00082	0.456
CLV_PCSK_KEX2_1	497	499	PF00082	0.629
CLV_PCSK_KEX2_1	665	667	PF00082	0.617
CLV_PCSK_KEX2_1	710	712	PF00082	0.560
CLV_PCSK_PC1ET2_1	710	712	PF00082	0.560
CLV_PCSK_SKI1_1	101	105	PF00082	0.610
CLV_PCSK_SKI1_1	769	773	PF00082	0.641
CLV_PCSK_SKI1_1	799	803	PF00082	0.766
DEG_APCC_DBOX_1	798	806	PF00400	0.567
DEG_SPOP_SBC_1	456	460	PF00917	0.787
DEG_SPOP_SBC_1	478	482	PF00917	0.635
DEG_SPOP_SBC_1	518	522	PF00917	0.751
DOC_CDC14_PxL_1	78	86	PF14671	0.626
DOC_CYCLIN_RxL_1	721	734	PF00134	0.767
DOC_MAPK_DCC_7	154	164	PF00069	0.536
DOC_MAPK_gen_1	196	205	PF00069	0.681
DOC_MAPK_gen_1	319	329	PF00069	0.635
DOC_MAPK_HePTP_8	205	217	PF00069	0.635
DOC_MAPK_MEF2A_6	208	217	PF00069	0.529
DOC_MAPK_MEF2A_6	322	331	PF00069	0.635
DOC_PP1_RVXF_1	724	731	PF00149	0.768
DOC_PP2B_LxvP_1	139	142	PF13499	0.780
DOC_PP2B_LxvP_1	581	584	PF13499	0.801
DOC_PP4_FxxP_1	772	775	PF00568	0.483
DOC_SPAK_OSR1_1	208	212	PF12202	0.529
DOC_USP7_MATH_1	121	125	PF00917	0.635
DOC_USP7_MATH_1	152	156	PF00917	0.762
DOC_USP7_MATH_1	320	324	PF00917	0.697
DOC_USP7_MATH_1	483	487	PF00917	0.709
DOC_USP7_MATH_1	491	495	PF00917	0.842
DOC_USP7_MATH_1	50	54	PF00917	0.748
DOC_USP7_MATH_1	514	518	PF00917	0.762
DOC_USP7_MATH_1	530	534	PF00917	0.662
DOC_USP7_MATH_1	558	562	PF00917	0.656
DOC_USP7_MATH_1	67	71	PF00917	0.711
DOC_USP7_MATH_1	784	788	PF00917	0.534
DOC_USP7_MATH_1	809	813	PF00917	0.577
DOC_USP7_UBL2_3	722	726	PF12436	0.774
DOC_WW_Pin1_4	108	113	PF00397	0.707
DOC_WW_Pin1_4	174	179	PF00397	0.500
DOC_WW_Pin1_4	562	567	PF00397	0.781
DOC_WW_Pin1_4	788	793	PF00397	0.526
DOC_WW_Pin1_4	805	810	PF00397	0.416
DOC_WW_Pin1_4	831	836	PF00397	0.525
DOC_WW_Pin1_4	84	89	PF00397	0.792
LIG_14-3-3_CanoR_1	101	110	PF00244	0.807
LIG_14-3-3_CanoR_1	153	163	PF00244	0.598
LIG_14-3-3_CanoR_1	168	174	PF00244	0.688
LIG_14-3-3_CanoR_1	181	189	PF00244	0.554
LIG_14-3-3_CanoR_1	254	262	PF00244	0.468
LIG_14-3-3_CanoR_1	355	363	PF00244	0.480
LIG_14-3-3_CanoR_1	404	411	PF00244	0.716
LIG_14-3-3_CanoR_1	417	427	PF00244	0.589
LIG_14-3-3_CanoR_1	447	455	PF00244	0.739
LIG_14-3-3_CanoR_1	465	473	PF00244	0.681
LIG_14-3-3_CanoR_1	516	525	PF00244	0.751
LIG_14-3-3_CanoR_1	646	651	PF00244	0.806
LIG_14-3-3_CanoR_1	670	674	PF00244	0.688
LIG_Actin_WH2_2	300	317	PF00022	0.240
LIG_APCC_ABBA_1	192	197	PF00400	0.684
LIG_APCC_ABBA_1	327	332	PF00400	0.467
LIG_BIR_III_4	442	446	PF00653	0.770
LIG_BRCT_BRCA1_1	283	287	PF00533	0.482
LIG_Clathr_ClatBox_1	328	332	PF01394	0.529
LIG_EH1_1	208	216	PF00400	0.529
LIG_FHA_1	229	235	PF00498	0.561
LIG_FHA_1	295	301	PF00498	0.519
LIG_FHA_1	341	347	PF00498	0.393
LIG_FHA_1	349	355	PF00498	0.329
LIG_FHA_1	434	440	PF00498	0.754
LIG_FHA_1	457	463	PF00498	0.810
LIG_FHA_1	751	757	PF00498	0.616
LIG_FHA_2	143	149	PF00498	0.780
LIG_FHA_2	404	410	PF00498	0.553
LIG_FHA_2	585	591	PF00498	0.793
LIG_FHA_2	739	745	PF00498	0.529
LIG_FHA_2	838	844	PF00498	0.601
LIG_GBD_Chelix_1	341	349	PF00786	0.256
LIG_Integrin_RGD_1	499	501	PF01839	0.547
LIG_Integrin_RGD_1	64	66	PF01839	0.533
LIG_LIR_Gen_1	197	206	PF02991	0.679
LIG_LIR_Gen_1	220	228	PF02991	0.500
LIG_LIR_Gen_1	230	241	PF02991	0.329
LIG_LIR_Gen_1	268	275	PF02991	0.482
LIG_LIR_Nem_3	190	195	PF02991	0.660
LIG_LIR_Nem_3	197	203	PF02991	0.575
LIG_LIR_Nem_3	220	225	PF02991	0.500
LIG_LIR_Nem_3	230	236	PF02991	0.313
LIG_LIR_Nem_3	240	245	PF02991	0.335
LIG_LIR_Nem_3	268	272	PF02991	0.479
LIG_LIR_Nem_3	579	583	PF02991	0.808
LIG_LIR_Nem_3	590	596	PF02991	0.704
LIG_LIR_Nem_3	761	767	PF02991	0.487
LIG_NRBOX	387	393	PF00104	0.240
LIG_Pex14_2	287	291	PF04695	0.486
LIG_Pex14_2	727	731	PF04695	0.810
LIG_PTB_Apo_2	366	373	PF02174	0.347
LIG_PTB_Apo_2	729	736	PF02174	0.751
LIG_PTB_Phospho_1	366	372	PF10480	0.348
LIG_PTB_Phospho_1	729	735	PF10480	0.757
LIG_REV1ctd_RIR_1	246	256	PF16727	0.488
LIG_REV1ctd_RIR_1	728	736	PF16727	0.796
LIG_SH2_CRK	200	204	PF00017	0.675
LIG_SH2_GRB2like	780	783	PF00017	0.488
LIG_SH2_NCK_1	200	204	PF00017	0.675
LIG_SH2_NCK_1	588	592	PF00017	0.632
LIG_SH2_SRC	588	591	PF00017	0.631
LIG_SH2_STAP1	350	354	PF00017	0.452
LIG_SH2_STAT3	195	198	PF00017	0.687
LIG_SH2_STAT5	350	353	PF00017	0.454
LIG_SH2_STAT5	379	382	PF00017	0.411
LIG_SH2_STAT5	399	402	PF00017	0.361
LIG_SH2_STAT5	427	430	PF00017	0.703
LIG_SH2_STAT5	739	742	PF00017	0.529
LIG_SH2_STAT5	804	807	PF00017	0.572
LIG_SH3_2	88	93	PF14604	0.640
LIG_SH3_3	487	493	PF00018	0.856
LIG_SH3_3	522	528	PF00018	0.818
LIG_SH3_3	85	91	PF00018	0.680
LIG_SH3_4	722	729	PF00018	0.609
LIG_SUMO_SIM_par_1	172	177	PF11976	0.488
LIG_SUMO_SIM_par_1	342	348	PF11976	0.479
LIG_SUMO_SIM_par_1	387	393	PF11976	0.326
LIG_SxIP_EBH_1	151	165	PF03271	0.635
LIG_TRAF2_1	146	149	PF00917	0.780
LIG_TRAF2_1	787	790	PF00917	0.524
LIG_WRC_WIRS_1	764	769	PF05994	0.494
MOD_CDK_SPK_2	84	89	PF00069	0.792
MOD_CDK_SPxxK_3	174	181	PF00069	0.497
MOD_CK1_1	261	267	PF00069	0.350
MOD_CK1_1	3	9	PF00069	0.754
MOD_CK1_1	433	439	PF00069	0.665
MOD_CK1_1	472	478	PF00069	0.840
MOD_CK1_1	517	523	PF00069	0.752
MOD_CK1_1	609	615	PF00069	0.869
MOD_CK1_1	642	648	PF00069	0.758
MOD_CK1_1	696	702	PF00069	0.860
MOD_CK1_1	750	756	PF00069	0.337
MOD_CK1_1	808	814	PF00069	0.580
MOD_CK1_1	834	840	PF00069	0.496
MOD_CK2_1	142	148	PF00069	0.779
MOD_CK2_1	738	744	PF00069	0.529
MOD_CK2_1	784	790	PF00069	0.531
MOD_CMANNOS	266	269	PF00535	0.646
MOD_Cter_Amidation	22	25	PF01082	0.444
MOD_Cter_Amidation	463	466	PF01082	0.453
MOD_GlcNHglycan	101	104	PF01048	0.521
MOD_GlcNHglycan	119	122	PF01048	0.423
MOD_GlcNHglycan	154	157	PF01048	0.550
MOD_GlcNHglycan	21	24	PF01048	0.432
MOD_GlcNHglycan	263	266	PF01048	0.665
MOD_GlcNHglycan	322	325	PF01048	0.494
MOD_GlcNHglycan	363	366	PF01048	0.579
MOD_GlcNHglycan	420	423	PF01048	0.466
MOD_GlcNHglycan	450	453	PF01048	0.428
MOD_GlcNHglycan	543	546	PF01048	0.647
MOD_GlcNHglycan	596	599	PF01048	0.567
MOD_GlcNHglycan	608	611	PF01048	0.438
MOD_GlcNHglycan	685	688	PF01048	0.667
MOD_GlcNHglycan	69	72	PF01048	0.507
MOD_GlcNHglycan	7	10	PF01048	0.561
MOD_GlcNHglycan	749	752	PF01048	0.240
MOD_GlcNHglycan	815	818	PF01048	0.641
MOD_GlcNHglycan	847	850	PF01048	0.800
MOD_GSK3_1	101	108	PF00069	0.671
MOD_GSK3_1	117	124	PF00069	0.642
MOD_GSK3_1	228	235	PF00069	0.548
MOD_GSK3_1	257	264	PF00069	0.441
MOD_GSK3_1	33	40	PF00069	0.678
MOD_GSK3_1	430	437	PF00069	0.645
MOD_GSK3_1	465	472	PF00069	0.739
MOD_GSK3_1	473	480	PF00069	0.715
MOD_GSK3_1	514	521	PF00069	0.792
MOD_GSK3_1	554	561	PF00069	0.748
MOD_GSK3_1	594	601	PF00069	0.820
MOD_GSK3_1	632	639	PF00069	0.804
MOD_GSK3_1	642	649	PF00069	0.679
MOD_GSK3_1	669	676	PF00069	0.828
MOD_GSK3_1	693	700	PF00069	0.730
MOD_GSK3_1	784	791	PF00069	0.529
MOD_GSK3_1	805	812	PF00069	0.573
MOD_GSK3_1	821	828	PF00069	0.441
MOD_GSK3_1	833	840	PF00069	0.482
MOD_N-GLC_1	217	222	PF02516	0.240
MOD_N-GLC_1	273	278	PF02516	0.644
MOD_N-GLC_1	431	436	PF02516	0.509
MOD_N-GLC_1	478	483	PF02516	0.445
MOD_N-GLC_1	518	523	PF02516	0.550
MOD_N-GLC_1	554	559	PF02516	0.454
MOD_N-GLC_1	632	637	PF02516	0.601
MOD_N-GLC_1	813	818	PF02516	0.638
MOD_N-GLC_1	845	850	PF02516	0.801
MOD_NEK2_1	169	174	PF00069	0.707
MOD_NEK2_1	217	222	PF00069	0.500
MOD_NEK2_1	241	246	PF00069	0.372
MOD_NEK2_1	247	252	PF00069	0.460
MOD_NEK2_1	255	260	PF00069	0.436
MOD_NEK2_1	333	338	PF00069	0.378
MOD_NEK2_1	349	354	PF00069	0.387
MOD_NEK2_1	390	395	PF00069	0.317
MOD_NEK2_1	431	436	PF00069	0.633
MOD_NEK2_1	576	581	PF00069	0.831
MOD_NEK2_1	596	601	PF00069	0.673
MOD_NEK2_1	673	678	PF00069	0.671
MOD_OFUCOSY	353	358	PF10250	0.662
MOD_PIKK_1	457	463	PF00454	0.796
MOD_PIKK_1	774	780	PF00454	0.502
MOD_PK_1	469	475	PF00069	0.816
MOD_PK_1	646	652	PF00069	0.763
MOD_PKA_1	465	471	PF00069	0.651
MOD_PKA_2	105	111	PF00069	0.666
MOD_PKA_2	152	158	PF00069	0.589
MOD_PKA_2	180	186	PF00069	0.710
MOD_PKA_2	318	324	PF00069	0.700
MOD_PKA_2	354	360	PF00069	0.470
MOD_PKA_2	403	409	PF00069	0.710
MOD_PKA_2	416	422	PF00069	0.589
MOD_PKA_2	456	462	PF00069	0.816
MOD_PKA_2	464	470	PF00069	0.689
MOD_PKA_2	669	675	PF00069	0.646
MOD_PKB_1	813	821	PF00069	0.526
MOD_Plk_1	217	223	PF00069	0.240
MOD_Plk_1	518	524	PF00069	0.826
MOD_Plk_1	530	536	PF00069	0.692
MOD_Plk_1	538	544	PF00069	0.618
MOD_Plk_1	584	590	PF00069	0.629
MOD_Plk_1	639	645	PF00069	0.853
MOD_Plk_1	65	71	PF00069	0.800
MOD_Plk_1	673	679	PF00069	0.819
MOD_Plk_1	694	700	PF00069	0.661
MOD_Plk_1	72	78	PF00069	0.725
MOD_Plk_1	825	831	PF00069	0.601
MOD_Plk_4	169	175	PF00069	0.708
MOD_Plk_4	217	223	PF00069	0.240
MOD_Plk_4	340	346	PF00069	0.467
MOD_Plk_4	395	401	PF00069	0.397
MOD_Plk_4	576	582	PF00069	0.810
MOD_Plk_4	639	645	PF00069	0.853
MOD_ProDKin_1	108	114	PF00069	0.705
MOD_ProDKin_1	174	180	PF00069	0.497
MOD_ProDKin_1	562	568	PF00069	0.782
MOD_ProDKin_1	788	794	PF00069	0.530
MOD_ProDKin_1	805	811	PF00069	0.417
MOD_ProDKin_1	831	837	PF00069	0.525
MOD_ProDKin_1	84	90	PF00069	0.794
MOD_SUMO_rev_2	148	152	PF00179	0.691
MOD_SUMO_rev_2	635	639	PF00179	0.650
TRG_AP2beta_CARGO_1	590	600	PF09066	0.652
TRG_DiLeu_BaEn_1	744	749	PF01217	0.467
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.782
TRG_DiLeu_BaLyEn_6	827	832	PF01217	0.441
TRG_ENDOCYTIC_2	200	203	PF00928	0.681
TRG_ENDOCYTIC_2	764	767	PF00928	0.435
TRG_ER_diArg_1	152	154	PF00400	0.684
TRG_ER_diArg_1	165	168	PF00400	0.682
TRG_ER_diArg_1	24	27	PF00400	0.640
TRG_ER_diArg_1	288	290	PF00400	0.488
TRG_ER_diArg_1	415	418	PF00400	0.655
TRG_ER_diArg_1	497	499	PF00400	0.721
TRG_ER_diArg_1	663	666	PF00400	0.818

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IQ50	Leishmania donovani	86%	100%
A4HFY4	Leishmania braziliensis	62%	96%
A4I2X7	Leishmania infantum	86%	100%
E9ADI7	Leishmania major	84%	100%