LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AZB2_LEIMU
TriTrypDb:
LmxM.27.2060
Length:
383

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: bmtom@gate.sinica.edu.tw
Publication title: Identification of macrosialin (CD68) on the surface of host macrophages as the receptor for the intercellular adhesive molecule (ICAM-L) of Leishmania amazonensis
Publication 1st author(s): Ng
Publication Identifier(s): 19540239
Host organism: -1
Interaction detection method(s): anti bait coimmunoprecipitation
Interaction type: physical association
Identification method participant A: western blot
Identification method participant B: western blot
ID(s) interactor A: Q9NGK0
ID(s) interactor B: P31996
Taxid interactor A: Leishmania amazonensis
Taxid interactor B: Mus musculus
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: prey

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AZB2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZB2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 104 108 PF00656 0.751
CLV_C14_Caspase3-7 228 232 PF00656 0.601
CLV_C14_Caspase3-7 36 40 PF00656 0.573
CLV_NRD_NRD_1 332 334 PF00675 0.765
CLV_NRD_NRD_1 349 351 PF00675 0.685
CLV_NRD_NRD_1 373 375 PF00675 0.783
CLV_PCSK_KEX2_1 330 332 PF00082 0.715
CLV_PCSK_KEX2_1 349 351 PF00082 0.688
CLV_PCSK_KEX2_1 360 362 PF00082 0.744
CLV_PCSK_PC1ET2_1 330 332 PF00082 0.715
CLV_PCSK_PC1ET2_1 360 362 PF00082 0.744
CLV_PCSK_SKI1_1 59 63 PF00082 0.473
CLV_PCSK_SKI1_1 68 72 PF00082 0.416
DEG_SPOP_SBC_1 112 116 PF00917 0.742
DOC_CYCLIN_yCln2_LP_2 71 77 PF00134 0.588
DOC_MAPK_MEF2A_6 143 152 PF00069 0.548
DOC_MAPK_MEF2A_6 45 53 PF00069 0.503
DOC_USP7_MATH_1 112 116 PF00917 0.677
DOC_USP7_MATH_1 165 169 PF00917 0.487
DOC_USP7_MATH_1 17 21 PF00917 0.681
DOC_USP7_MATH_1 172 176 PF00917 0.471
DOC_USP7_MATH_1 225 229 PF00917 0.724
DOC_USP7_MATH_1 236 240 PF00917 0.762
DOC_USP7_MATH_1 332 336 PF00917 0.786
DOC_USP7_MATH_1 337 341 PF00917 0.762
DOC_USP7_MATH_1 9 13 PF00917 0.761
DOC_USP7_UBL2_3 330 334 PF12436 0.780
DOC_WW_Pin1_4 117 122 PF00397 0.632
DOC_WW_Pin1_4 168 173 PF00397 0.588
DOC_WW_Pin1_4 20 25 PF00397 0.475
DOC_WW_Pin1_4 306 311 PF00397 0.527
DOC_WW_Pin1_4 343 348 PF00397 0.766
LIG_14-3-3_CanoR_1 193 202 PF00244 0.676
LIG_14-3-3_CanoR_1 262 268 PF00244 0.550
LIG_BIR_II_1 1 5 PF00653 0.680
LIG_BIR_III_2 109 113 PF00653 0.491
LIG_EVH1_2 311 315 PF00568 0.496
LIG_FHA_1 118 124 PF00498 0.616
LIG_FHA_1 181 187 PF00498 0.492
LIG_FHA_1 199 205 PF00498 0.649
LIG_FHA_1 36 42 PF00498 0.456
LIG_FHA_2 34 40 PF00498 0.549
LIG_Integrin_RGD_1 143 145 PF01839 0.623
LIG_LIR_Gen_1 119 130 PF02991 0.582
LIG_LIR_Nem_3 119 125 PF02991 0.597
LIG_NRBOX 66 72 PF00104 0.520
LIG_SH2_PTP2 122 125 PF00017 0.557
LIG_SH2_SRC 122 125 PF00017 0.557
LIG_SH2_STAP1 75 79 PF00017 0.546
LIG_SH2_STAT5 122 125 PF00017 0.503
LIG_SH2_STAT5 304 307 PF00017 0.656
LIG_SH3_3 176 182 PF00018 0.570
LIG_SH3_3 269 275 PF00018 0.546
LIG_SH3_3 46 52 PF00018 0.409
LIG_SUMO_SIM_par_1 182 187 PF11976 0.569
LIG_SUMO_SIM_par_1 200 209 PF11976 0.650
LIG_SUMO_SIM_par_1 278 284 PF11976 0.533
LIG_SUMO_SIM_par_1 350 355 PF11976 0.727
LIG_TRAF2_1 88 91 PF00917 0.692
LIG_TYR_ITSM 118 125 PF00017 0.608
LIG_WW_3 294 298 PF00397 0.568
MOD_CDK_SPxK_1 343 349 PF00069 0.764
MOD_CDK_SPxxK_3 343 350 PF00069 0.761
MOD_CK1_1 101 107 PF00069 0.642
MOD_CK1_1 114 120 PF00069 0.667
MOD_CK1_1 168 174 PF00069 0.558
MOD_CK1_1 20 26 PF00069 0.528
MOD_CK1_1 237 243 PF00069 0.798
MOD_CK1_1 335 341 PF00069 0.690
MOD_CK2_1 313 319 PF00069 0.765
MOD_CK2_1 85 91 PF00069 0.678
MOD_Cter_Amidation 5 8 PF01082 0.806
MOD_GlcNHglycan 100 103 PF01048 0.702
MOD_GlcNHglycan 128 131 PF01048 0.578
MOD_GlcNHglycan 186 189 PF01048 0.560
MOD_GlcNHglycan 19 22 PF01048 0.678
MOD_GlcNHglycan 226 230 PF01048 0.730
MOD_GlcNHglycan 235 239 PF01048 0.797
MOD_GlcNHglycan 316 319 PF01048 0.776
MOD_GlcNHglycan 337 340 PF01048 0.790
MOD_GlcNHglycan 76 80 PF01048 0.582
MOD_GSK3_1 111 118 PF00069 0.663
MOD_GSK3_1 168 175 PF00069 0.495
MOD_GSK3_1 180 187 PF00069 0.436
MOD_GSK3_1 237 244 PF00069 0.747
MOD_GSK3_1 335 342 PF00069 0.727
MOD_GSK3_1 85 92 PF00069 0.671
MOD_NEK2_1 234 239 PF00069 0.718
MOD_NEK2_1 261 266 PF00069 0.488
MOD_NEK2_1 62 67 PF00069 0.510
MOD_PIKK_1 85 91 PF00454 0.673
MOD_PK_1 350 356 PF00069 0.650
MOD_PKA_2 192 198 PF00069 0.661
MOD_PKA_2 261 267 PF00069 0.540
MOD_PKA_2 332 338 PF00069 0.755
MOD_Plk_4 150 156 PF00069 0.459
MOD_Plk_4 198 204 PF00069 0.617
MOD_Plk_4 211 217 PF00069 0.547
MOD_Plk_4 62 68 PF00069 0.461
MOD_ProDKin_1 117 123 PF00069 0.618
MOD_ProDKin_1 168 174 PF00069 0.599
MOD_ProDKin_1 20 26 PF00069 0.469
MOD_ProDKin_1 306 312 PF00069 0.532
MOD_ProDKin_1 343 349 PF00069 0.764
MOD_SUMO_for_1 220 223 PF00179 0.721
MOD_SUMO_for_1 359 362 PF00179 0.759
MOD_SUMO_rev_2 218 225 PF00179 0.741
TRG_ENDOCYTIC_2 122 125 PF00928 0.503
TRG_ER_diArg_1 349 351 PF00400 0.688
TRG_ER_diArg_1 377 380 PF00400 0.709
TRG_NLS_MonoExtC_3 328 333 PF00514 0.807
TRG_NLS_MonoExtN_4 327 334 PF00514 0.761
TRG_Pf-PMV_PEXEL_1 266 270 PF00026 0.560
TRG_Pf-PMV_PEXEL_1 54 58 PF00026 0.548
TRG_PTS1 380 383 PF00515 0.522

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMI6 Leptomonas seymouri 52% 100%
A0A0S4IML8 Bodo saltans 25% 100%
A0A1X0NRR0 Trypanosomatidae 33% 100%
A0A3S7X0X4 Leishmania donovani 87% 100%
A4HFY3 Leishmania braziliensis 75% 100%
A4I2X6 Leishmania infantum 87% 100%
E9ADI6 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS