Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AZA5_LEIMU

TriTrypDb:

LmxM.27.2010

Length:

251

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AZA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AZA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.528
CLV_PCSK_FUR_1	128	132	PF00082	0.488
CLV_PCSK_KEX2_1	130	132	PF00082	0.491
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.491
CLV_PCSK_SKI1_1	130	134	PF00082	0.571
CLV_PCSK_SKI1_1	50	54	PF00082	0.621
DEG_APCC_DBOX_1	163	171	PF00400	0.483
DOC_CKS1_1	65	70	PF01111	0.537
DOC_CYCLIN_yCln2_LP_2	9	15	PF00134	0.502
DOC_PP2B_LxvP_1	15	18	PF13499	0.548
DOC_USP7_MATH_1	178	182	PF00917	0.501
DOC_USP7_MATH_1	2	6	PF00917	0.556
DOC_USP7_MATH_1	20	24	PF00917	0.444
DOC_USP7_MATH_1	61	65	PF00917	0.646
DOC_USP7_MATH_1	89	93	PF00917	0.706
DOC_WW_Pin1_4	206	211	PF00397	0.648
DOC_WW_Pin1_4	59	64	PF00397	0.647
DOC_WW_Pin1_4	77	82	PF00397	0.545
DOC_WW_Pin1_4	8	13	PF00397	0.769
LIG_14-3-3_CanoR_1	123	132	PF00244	0.591
LIG_FHA_1	178	184	PF00498	0.405
LIG_FHA_2	106	112	PF00498	0.461
LIG_HCF-1_HBM_1	219	222	PF13415	0.611
LIG_LIR_Apic_2	219	225	PF02991	0.607
LIG_PDZ_Class_1	246	251	PF00595	0.564
LIG_SH2_CRK	222	226	PF00017	0.608
LIG_SH2_NCK_1	226	230	PF00017	0.507
LIG_SH2_STAP1	149	153	PF00017	0.478
LIG_SH2_STAT3	115	118	PF00017	0.446
LIG_SH2_STAT5	115	118	PF00017	0.446
LIG_SH2_STAT5	230	233	PF00017	0.619
LIG_SH3_1	226	232	PF00018	0.505
LIG_SH3_3	226	232	PF00018	0.617
LIG_SH3_3	70	76	PF00018	0.643
LIG_SH3_3	88	94	PF00018	0.482
MOD_CDK_SPxxK_3	59	66	PF00069	0.651
MOD_CK1_1	64	70	PF00069	0.535
MOD_DYRK1A_RPxSP_1	77	81	PF00069	0.550
MOD_GlcNHglycan	145	148	PF01048	0.508
MOD_GlcNHglycan	222	225	PF01048	0.587
MOD_GlcNHglycan	86	89	PF01048	0.743
MOD_GlcNHglycan	91	94	PF01048	0.650
MOD_GlcNHglycan	97	100	PF01048	0.526
MOD_GSK3_1	22	29	PF00069	0.514
MOD_GSK3_1	55	62	PF00069	0.650
MOD_N-GLC_1	176	181	PF02516	0.484
MOD_N-GLC_1	41	46	PF02516	0.610
MOD_NEK2_1	41	46	PF00069	0.610
MOD_NEK2_2	48	53	PF00069	0.643
MOD_PIKK_1	61	67	PF00454	0.647
MOD_PKA_1	130	136	PF00069	0.490
MOD_PKA_2	130	136	PF00069	0.663
MOD_Plk_1	140	146	PF00069	0.443
MOD_Plk_1	41	47	PF00069	0.581
MOD_Plk_2-3	105	111	PF00069	0.461
MOD_Plk_4	105	111	PF00069	0.470
MOD_ProDKin_1	206	212	PF00069	0.647
MOD_ProDKin_1	59	65	PF00069	0.649
MOD_ProDKin_1	77	83	PF00069	0.540
MOD_ProDKin_1	8	14	PF00069	0.763
MOD_SUMO_for_1	242	245	PF00179	0.527
TRG_ER_diArg_1	164	167	PF00400	0.484
TRG_ER_diArg_1	74	77	PF00400	0.531
TRG_Pf-PMV_PEXEL_1	158	163	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X0X1	Leishmania donovani	85%	100%
A4I308	Leishmania infantum	85%	100%
E9ADI1	Leishmania major	83%	100%